(* Generated by JWS Online *) (* This is an experimental feature of JWS Online. Please report any mistakes.*) (* Note that the following notable SBML entities or features are not supported in notebook outputyet: *) (* Events *) (* Constraints *) (* Units and UnitDefinitions *) (* AlgebraicRules *) (* conversionFactors *) variables = { ADP[t], ADP\[LetterSpace]cyt[t], AMP[t], ATP[t], ATP\[LetterSpace]cyt[t], Acetyl\[LetterSpace]CoA[t], Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[t], Ala[t], Asp[t], Asp\[LetterSpace]cyt[t], CO2[t], Cit[t], Cit\[LetterSpace]cyt[t], CoA[t], CoA\[LetterSpace]cyt[t], Cytc2p[t], Cytc3p[t], DHAP[t], DPG[t], ETFox[t], ETFred[t], F6P[t], FAD[t], FADH2[t], FBP[t], Fum[t], G3P[t], GAP[t], GDP[t], GLC[t], GTP[t], Glu[t], Glu\[LetterSpace]cyt[t], H2O[t], IsoCit[t], IsoCitcyt[t], LAC[t], Mal[t], Mal\[LetterSpace]cyt[t], NAD[t], NADH[t], NADH\[LetterSpace]cyt[t], NADPH[t], NADPH\[LetterSpace]cyt[t], NADP\[LetterSpace]cyt[t], NADP\[LetterSpace]p[t], NAD\[LetterSpace]p[t], OG[t], OG\[LetterSpace]cyt[t], OXA[t], OXA\[LetterSpace]cyt[t], PEP[t], PYR\[LetterSpace]cyt[t], Pi[t], Pyr[t], Q[t], QH2[t], SCoA[t], Suc[t] }; initialValues = { ADP[0] == 0.00045, ADP\[LetterSpace]cyt[0] == 0.000108367, AMP[0] == 2.61149*^-06, ATP[0] == 0.0045, ATP\[LetterSpace]cyt[0] == 0.00449064, Acetyl\[LetterSpace]CoA[0] == 3*^-05, Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[0] == 3*^-05, Ala[0] == 0.00344, Asp[0] == 0.00114, Asp\[LetterSpace]cyt[0] == 0.00114, CO2[0] == 0.00163, Cit[0] == 0.00042, Cit\[LetterSpace]cyt[0] == 0.00042, CoA[0] == 0.000272, CoA\[LetterSpace]cyt[0] == 0.000272, Cytc2p[0] == 0.00011, Cytc3p[0] == 0.003, DHAP[0] == 0.0076925, DPG[0] == 0.000299109, ETFox[0] == 0.00032, ETFred[0] == 0.00031, F6P[0] == 0.00065939, FAD[0] == 0.00101, FADH2[0] == 7.2*^-05, FBP[0] == 7.70135*^-06, Fum[0] == 6.5*^-05, G3P[0] == 0.0076925, GAP[0] == 1.90919*^-06, GDP[0] == 0.00045, GLC[0] == 1.12817*^-05, GTP[0] == 0.0045, Glu[0] == 0.00303, Glu\[LetterSpace]cyt[0] == 0.00303, H2O[0] == 0.001, IsoCit[0] == 0.00042, IsoCitcyt[0] == 0.00042, LAC[0] == 0.00033981, Mal[0] == 0.0005, Mal\[LetterSpace]cyt[0] == 0.0005, NAD[0] == 0.00362057, NADH[0] == 0.00072, NADH\[LetterSpace]cyt[0] == 0.000616118, NADPH[0] == 7.2*^-05, NADPH\[LetterSpace]cyt[0] == 0.000616118, NADP\[LetterSpace]cyt[0] == 0.00362057, NADP\[LetterSpace]p[0] == 0.0101, NAD\[LetterSpace]p[0] == 0.0101, OG[0] == 2.1*^-05, OG\[LetterSpace]cyt[0] == 2.1*^-05, OXA[0] == 4*^-06, OXA\[LetterSpace]cyt[0] == 4*^-06, PEP[0] == 2.1125*^-06, PYR\[LetterSpace]cyt[0] == 4.22702*^-06, Pi[0] == 0.004, Pyr[0] == 0.001025, Q[0] == 0.026, QH2[0] == 0.028, SCoA[0] == 0.0002941, Suc[0] == 0.00295 }; rates = { GAPflow, GLCflow, LACflow, hidden\[LetterSpace]1, v1, v10, v11, v12, v14, v15, v16, v17, v18, v2, v20, v21, v22, v24, v25, v26, v27, v28, v29, v3, v30, v31, v32, v33, v34, v35, v36, v37, v38, v39, v4, v40, v41, v42, v43, v44, v5, v6, v7, v8, v9 }; rateEquations = { GAPflow -> CYTOPLASM*flow*GAP[t], GLCflow -> CYTOPLASM*flow*(GLCflow\[LetterSpace]Glc\[LetterSpace]F/1000 - GLC[t]), LACflow -> CYTOPLASM*flow*LAC[t], hidden\[LetterSpace]1 -> CYTOPLASM*(-(hidden\[LetterSpace]1\[LetterSpace]k9b*ADP\[LetterSpace]cyt[t]^2) + hidden\[LetterSpace]1\[LetterSpace]k9f*AMP[t]*ATP\[LetterSpace]cyt[t]), v1 -> (CYTOPLASM*v1\[LetterSpace]V1*ATP\[LetterSpace]cyt[t]*GLC[t])/((v1\[LetterSpace]K1ATP + ATP\[LetterSpace]cyt[t])*(v1\[LetterSpace]K1GLC + GLC[t])), v10 -> (MATRIX*v10\[LetterSpace]V*v10\[LetterSpace]v10\[LetterSpace]CS*Acetyl\[LetterSpace]CoA[t]*OXA[t])/(v10\[LetterSpace]Kia*v10\[LetterSpace]Kib + v10\[LetterSpace]Kb*Acetyl\[LetterSpace]CoA[t] + v10\[LetterSpace]Ka*OXA[t] + Acetyl\[LetterSpace]CoA[t]*OXA[t]), v11 -> (MATRIX*v11\[LetterSpace]v11\[LetterSpace]ACO*(v11\[LetterSpace]KcF*v11\[LetterSpace]Kp*Cit[t] - v11\[LetterSpace]KcR*v11\[LetterSpace]Ks*IsoCit[t]))/(v11\[LetterSpace]Kp*v11\[LetterSpace]Ks + v11\[LetterSpace]Kp*Cit[t] + v11\[LetterSpace]Ks*IsoCit[t]), v12 -> (MATRIX*v12\[LetterSpace]KcF*v12\[LetterSpace]v12\[LetterSpace]IDHa*(v12\[LetterSpace]b*ADP[t]*IsoCit[t] + IsoCit[t]^2))/(v12\[LetterSpace]f + v12\[LetterSpace]d*ADP[t] + v12\[LetterSpace]c*IsoCit[t] + v12\[LetterSpace]e*ADP[t]*IsoCit[t] + IsoCit[t]^2), v14 -> (MATRIX*v14\[LetterSpace]KcF*v14\[LetterSpace]v14\[LetterSpace]OGDC*CoA[t]*NAD\[LetterSpace]p[t]*OG[t])/(v14\[LetterSpace]KmA*CoA[t]*NAD\[LetterSpace]p[t] + v14\[LetterSpace]KmC*CoA[t]*OG[t] + (v14\[LetterSpace]KmC*CoA[t]*NADH[t]*OG[t])/v14\[LetterSpace]Kir + v14\[LetterSpace]KmB*NAD\[LetterSpace]p[t]*OG[t] + CoA[t]*NAD\[LetterSpace]p[t]*OG[t] + (v14\[LetterSpace]Kib*v14\[LetterSpace]Kic*v14\[LetterSpace]KmA*v14\[LetterSpace]KmP*NADH[t]*SCoA[t])/(v14\[LetterSpace]Kip*v14\[LetterSpace]Kiq*v14\[LetterSpace]KmR) + (v14\[LetterSpace]Kib*v14\[LetterSpace]Kic*v14\[LetterSpace]KmA*v14\[LetterSpace]KmP*NADH[t]*OG[t]*SCoA[t])/(v14\[LetterSpace]Kia*v14\[LetterSpace]Kip*v14\[LetterSpace]Kiq*v14\[LetterSpace]KmR) + (v14\[LetterSpace]KmB*NAD\[LetterSpace]p[t]*OG[t]*SCoA[t])/v14\[LetterSpace]Kiq), v15 -> (MATRIX*(Pi*GDP[t]*SCoA[t] - (CoA[t]*GTP[t]*Suc[t])/v15\[LetterSpace]Keq)*(v15\[LetterSpace]Kc1*v15\[LetterSpace]v15\[LetterSpace]SCS + v15\[LetterSpace]Kc2*v15\[LetterSpace]v15\[LetterSpace]SCS*(Pi/v15\[LetterSpace]KmC2 + (v15\[LetterSpace]Kip*v15\[LetterSpace]KmC*Suc[t])/v15\[LetterSpace]KmC2)))/(Pi*v15\[LetterSpace]Kia*v15\[LetterSpace]KmB + (Pi*v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*CoA[t])/v15\[LetterSpace]Kir + Pi*v15\[LetterSpace]KmB*GDP[t] + (Pi*v15\[LetterSpace]KmB*CoA[t]*GDP[t])/v15\[LetterSpace]Kir + (Pi*v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*GTP[t])/v15\[LetterSpace]Kiq + (Pi*v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*CoA[t]*GTP[t])/(v15\[LetterSpace]Kir*v15\[LetterSpace]KmQ) + (v15\[LetterSpace]Kia*v15\[LetterSpace]Kic*v15\[LetterSpace]KmB*CoA[t]*GTP[t])/(v15\[LetterSpace]Kir*v15\[LetterSpace]KmQ) + Pi*v15\[LetterSpace]KmA*SCoA[t] + Pi*GDP[t]*SCoA[t] + v15\[LetterSpace]KmC*GDP[t]*SCoA[t] + (Pi^2*GDP[t]*SCoA[t])/v15\[LetterSpace]KmC2 + (Pi*v15\[LetterSpace]KmA*GTP[t]*SCoA[t])/v15\[LetterSpace]Kiq + (v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*Suc[t])/v15\[LetterSpace]Kip + (v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*CoA[t]*Suc[t])/(v15\[LetterSpace]Kip*v15\[LetterSpace]Kir) + (v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*GDP[t]*Suc[t])/v15\[LetterSpace]Kip + (v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*CoA[t]*GDP[t]*Suc[t])/(v15\[LetterSpace]Kip*v15\[LetterSpace]Kir) + (v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*GTP[t]*Suc[t])/(v15\[LetterSpace]Kip*v15\[LetterSpace]Kiq) + (v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*CoA[t]*GTP[t]*Suc[t])/(v15\[LetterSpace]Kip*v15\[LetterSpace]Kir*v15\[LetterSpace]KmQ) + (Pi*v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*CoA[t]*GTP[t]*Suc[t])/(v15\[LetterSpace]Kir*v15\[LetterSpace]KmP2*v15\[LetterSpace]KmQ) + (v15\[LetterSpace]KmA*v15\[LetterSpace]KmC*SCoA[t]*Suc[t])/v15\[LetterSpace]Kip + (v15\[LetterSpace]KmC*GDP[t]*SCoA[t]*Suc[t])/v15\[LetterSpace]Kip + (Pi*v15\[LetterSpace]KmC*GDP[t]*SCoA[t]*Suc[t])/(v15\[LetterSpace]Kip*v15\[LetterSpace]KmC2) + (v15\[LetterSpace]KmA*v15\[LetterSpace]KmC*GTP[t]*SCoA[t]*Suc[t])/(v15\[LetterSpace]Kip*v15\[LetterSpace]Kiq) + (v15\[LetterSpace]Kia*v15\[LetterSpace]KmB*v15\[LetterSpace]KmC*CoA[t]*GTP[t]*Suc[t]^2)/(v15\[LetterSpace]Kip*v15\[LetterSpace]Kir*v15\[LetterSpace]KmP2*v15\[LetterSpace]KmQ)), v16 -> (MATRIX*v16\[LetterSpace]KcF*v16\[LetterSpace]KcR*v16\[LetterSpace]v16\[LetterSpace]SDH*(-((Fum[t]*QH2[t])/v16\[LetterSpace]Keq) + Q[t]*Suc[t]))/((v16\[LetterSpace]KcF*v16\[LetterSpace]KmP2*Fum[t])/v16\[LetterSpace]Keq + v16\[LetterSpace]KcR*v16\[LetterSpace]KmS1*Q[t] + (v16\[LetterSpace]KcF*v16\[LetterSpace]KmP1*QH2[t])/v16\[LetterSpace]Keq + (v16\[LetterSpace]KcF*Fum[t]*QH2[t])/v16\[LetterSpace]Keq + (v16\[LetterSpace]KcR*v16\[LetterSpace]KmS1*Q[t]*QH2[t])/v16\[LetterSpace]KiP2 + v16\[LetterSpace]KcR*v16\[LetterSpace]KmS2*Suc[t] + (v16\[LetterSpace]KcF*v16\[LetterSpace]KmP2*Fum[t]*Suc[t])/(v16\[LetterSpace]Keq*v16\[LetterSpace]KiS1) + v16\[LetterSpace]KcR*Q[t]*Suc[t]), v17 -> (MATRIX*v17\[LetterSpace]v17\[LetterSpace]FM*(v17\[LetterSpace]KcF*v17\[LetterSpace]Kp*Fum[t] - v17\[LetterSpace]KcR*v17\[LetterSpace]Ks*Mal[t]))/(v17\[LetterSpace]Kp*v17\[LetterSpace]Ks + v17\[LetterSpace]Kp*Fum[t] + v17\[LetterSpace]Ks*Mal[t]), v18 -> (MATRIX*v18\[LetterSpace]v18\[LetterSpace]MDH*((v18\[LetterSpace]KcF*Mal[t]*NAD\[LetterSpace]p[t])/(v18\[LetterSpace]KiS1*v18\[LetterSpace]KmS2) - (v18\[LetterSpace]KcR*NADH[t]*OXA[t])/(v18\[LetterSpace]KiP2*v18\[LetterSpace]KmP1)))/(1 + Mal[t]/v18\[LetterSpace]KiS1 + NADH[t]/v18\[LetterSpace]KiP2 + (v18\[LetterSpace]KmS1*NAD\[LetterSpace]p[t])/(v18\[LetterSpace]KiS1*v18\[LetterSpace]KmS2) + (Mal[t]*NAD\[LetterSpace]p[t])/(v18\[LetterSpace]KiS1*v18\[LetterSpace]KmS2) + (v18\[LetterSpace]KmS1*NADH[t]*NAD\[LetterSpace]p[t])/(v18\[LetterSpace]KiP2*v18\[LetterSpace]KiS1*v18\[LetterSpace]KmS2) + (v18\[LetterSpace]KmP2*OXA[t])/(v18\[LetterSpace]KiP2*v18\[LetterSpace]KmP1) + (v18\[LetterSpace]KmP2*Mal[t]*OXA[t])/(v18\[LetterSpace]KiP2*v18\[LetterSpace]KiS1*v18\[LetterSpace]KmP1) + (v18\[LetterSpace]KiP2*NADH[t]*OXA[t])/v18\[LetterSpace]KmP1 + (Mal[t]*NAD\[LetterSpace]p[t]*OXA[t])/(v18\[LetterSpace]KiP1*v18\[LetterSpace]KiS1*v18\[LetterSpace]KmS2) + (NADH[t]*NAD\[LetterSpace]p[t]*OXA[t])/(v18\[LetterSpace]KiP2*v18\[LetterSpace]KiS2*v18\[LetterSpace]KmP1)), v2 -> (CYTOPLASM*v2\[LetterSpace]V2*ATP\[LetterSpace]cyt[t]*F6P[t]^2)/((v2\[LetterSpace]K2ATP + ATP\[LetterSpace]cyt[t])*(v2\[LetterSpace]K2*(1 + (v2\[LetterSpace]k2*ATP\[LetterSpace]cyt[t]^2)/AMP[t]^2) + F6P[t]^2)), v20 -> (MATRIX*v20\[LetterSpace]KcF*v20\[LetterSpace]KcR*v20\[LetterSpace]v20\[LetterSpace]AlaTA*(Ala[t]*OG[t] - (Glu[t]*Pyr[t])/v20\[LetterSpace]Keq))/(v20\[LetterSpace]KcR*v20\[LetterSpace]KmS2*Ala[t] + (v20\[LetterSpace]KcF*v20\[LetterSpace]KmP2*Glu[t])/v20\[LetterSpace]Keq + (v20\[LetterSpace]KcF*v20\[LetterSpace]KmP2*Ala[t]*Glu[t])/(v20\[LetterSpace]Keq*v20\[LetterSpace]KiS1) + v20\[LetterSpace]KcR*v20\[LetterSpace]KmS1*OG[t] + v20\[LetterSpace]KcR*Ala[t]*OG[t] + (v20\[LetterSpace]KcF*v20\[LetterSpace]KmP1*Pyr[t])/v20\[LetterSpace]Keq + (v20\[LetterSpace]KcF*Glu[t]*Pyr[t])/v20\[LetterSpace]Keq + (v20\[LetterSpace]KcR*v20\[LetterSpace]KmS1*OG[t]*Pyr[t])/v20\[LetterSpace]KiP2), v21 -> (MATRIX*v21\[LetterSpace]KcF*v21\[LetterSpace]KcR*v21\[LetterSpace]v21\[LetterSpace]AspTA*(-((Asp[t]*OG[t])/v21\[LetterSpace]Keq) + Glu[t]*OXA[t]))/((v21\[LetterSpace]KcF*v21\[LetterSpace]KmP2*Asp[t])/v21\[LetterSpace]Keq + v21\[LetterSpace]KcR*v21\[LetterSpace]KmS1*Glu[t] + (v21\[LetterSpace]KcF*v21\[LetterSpace]KmP1*OG[t])/v21\[LetterSpace]Keq + (v21\[LetterSpace]KcF*Asp[t]*OG[t])/v21\[LetterSpace]Keq + (v21\[LetterSpace]KcR*v21\[LetterSpace]KmS1*Glu[t]*OG[t])/v21\[LetterSpace]KiP2 + v21\[LetterSpace]KcR*v21\[LetterSpace]KmS2*OXA[t] + (v21\[LetterSpace]KcF*v21\[LetterSpace]KmP2*Asp[t]*OXA[t])/(v21\[LetterSpace]Keq*v21\[LetterSpace]KiS1) + v21\[LetterSpace]KcR*Glu[t]*OXA[t]), v22 -> (MATRIX*v22\[LetterSpace]v22\[LetterSpace]AGC*(-((v22\[LetterSpace]KcR*Asp\[LetterSpace]cyt[t]*Glu[t])/(v22\[LetterSpace]beta*v22\[LetterSpace]KiP1*v22\[LetterSpace]KiP2)) + (v22\[LetterSpace]KcF*Asp[t]*Glu\[LetterSpace]cyt[t])/(v22\[LetterSpace]alpha*v22\[LetterSpace]KiS1*v22\[LetterSpace]KiS2)))/(1 + Asp[t]/v22\[LetterSpace]KiS1 + Asp\[LetterSpace]cyt[t]/v22\[LetterSpace]KiP2 + Glu[t]/v22\[LetterSpace]KiP1 + (Asp[t]*Glu[t])/(v22\[LetterSpace]delta*v22\[LetterSpace]KiP1*v22\[LetterSpace]KiS1) + (Asp\[LetterSpace]cyt[t]*Glu[t])/(v22\[LetterSpace]beta*v22\[LetterSpace]KiP1*v22\[LetterSpace]KiP2) + Glu\[LetterSpace]cyt[t]/v22\[LetterSpace]KiS2 + (Asp[t]*Glu\[LetterSpace]cyt[t])/(v22\[LetterSpace]alpha*v22\[LetterSpace]KiS1*v22\[LetterSpace]KiS2) + (Asp\[LetterSpace]cyt[t]*Glu\[LetterSpace]cyt[t])/(v22\[LetterSpace]gamma*v22\[LetterSpace]KiP2*v22\[LetterSpace]KiS2)), v24 -> (MATRIX*v24\[LetterSpace]KcF*v24\[LetterSpace]KcR*v24\[LetterSpace]v24\[LetterSpace]Complex\[LetterSpace]I*(NADH[t]*Q[t] - (NAD\[LetterSpace]p[t]*QH2[t])/v24\[LetterSpace]Keq))/(v24\[LetterSpace]KcR*v24\[LetterSpace]KmS2*NADH[t] + (v24\[LetterSpace]KcF*v24\[LetterSpace]KmP2*NAD\[LetterSpace]p[t])/v24\[LetterSpace]Keq + (v24\[LetterSpace]KcF*v24\[LetterSpace]KmP2*NADH[t]*NAD\[LetterSpace]p[t])/(v24\[LetterSpace]Keq*v24\[LetterSpace]KiS1) + v24\[LetterSpace]KcR*v24\[LetterSpace]KmS1*Q[t] + v24\[LetterSpace]KcR*NADH[t]*Q[t] + (v24\[LetterSpace]KcF*v24\[LetterSpace]KmP1*QH2[t])/v24\[LetterSpace]Keq + (v24\[LetterSpace]KcF*NAD\[LetterSpace]p[t]*QH2[t])/v24\[LetterSpace]Keq + (v24\[LetterSpace]KcR*v24\[LetterSpace]KmS1*Q[t]*QH2[t])/v24\[LetterSpace]KiP2), v25 -> (MT\[LetterSpace]IMS*v25\[LetterSpace]KcF*v25\[LetterSpace]v25\[LetterSpace]Complex\[LetterSpace]III*Cytc3p[t]*QH2[t])/(v25\[LetterSpace]KmA*Cytc3p[t] + v25\[LetterSpace]KmB*QH2[t] + Cytc3p[t]*QH2[t] + Cytc2p[t]*(v25\[LetterSpace]Kb2*v25\[LetterSpace]KmA*v25\[LetterSpace]Kq2 + v25\[LetterSpace]KmA*v25\[LetterSpace]Kq2*Cytc3p[t] + (v25\[LetterSpace]Kb1*v25\[LetterSpace]KcF*v25\[LetterSpace]Kq1*QH2[t])/v25\[LetterSpace]k8 + (v25\[LetterSpace]KcF*v25\[LetterSpace]Kq1*Cytc3p[t]*QH2[t])/v25\[LetterSpace]k8)), v26 -> (MT\[LetterSpace]IMS*v26\[LetterSpace]KcF*v26\[LetterSpace]v26\[LetterSpace]Complex\[LetterSpace]IV*Cytc2p[t])/(v26\[LetterSpace]Ks + Cytc2p[t]), v27 -> (CYTOPLASM*v27\[LetterSpace]Kc*v27\[LetterSpace]Kid*v27\[LetterSpace]V*v27\[LetterSpace]v10\[LetterSpace]CS*Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t])/(v27\[LetterSpace]Kb*v27\[LetterSpace]Keq*v27\[LetterSpace]Kia*(v27\[LetterSpace]Kia*v27\[LetterSpace]Kib + v27\[LetterSpace]Kb*Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[t] + v27\[LetterSpace]Ka*OXA\[LetterSpace]cyt[t] + Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t])), v28 -> (MATRIX*v28\[LetterSpace]V*v28\[LetterSpace]v28\[LetterSpace]Complex\[LetterSpace]V*ADP[t])/(v28\[LetterSpace]Km + ADP[t] + ADP[t]^2/v28\[LetterSpace]Ki), v29 -> (CYTOPLASM*v29\[LetterSpace]v29\[LetterSpace]ACO*(v29\[LetterSpace]KcF*v29\[LetterSpace]Kp*Cit\[LetterSpace]cyt[t] - v29\[LetterSpace]KcR*v29\[LetterSpace]Ks*IsoCitcyt[t]))/(v29\[LetterSpace]Kp*v29\[LetterSpace]Ks + v29\[LetterSpace]Kp*Cit\[LetterSpace]cyt[t] + v29\[LetterSpace]Ks*IsoCitcyt[t]), v3 -> CYTOPLASM*(v3\[LetterSpace]k3f*FBP[t] - v3\[LetterSpace]k3b*GAP[t]^2), v30 -> (MATRIX*v30\[LetterSpace]v30\[LetterSpace]OGC*((v30\[LetterSpace]KcF*Mal\[LetterSpace]cyt[t]*OG[t])/(v30\[LetterSpace]alpha*v30\[LetterSpace]KiS1*v30\[LetterSpace]KiS2) - (v30\[LetterSpace]KcR*Mal[t]*OG\[LetterSpace]cyt[t])/(v30\[LetterSpace]beta*v30\[LetterSpace]KiP1*v30\[LetterSpace]KiP2)))/(1 + Mal[t]/v30\[LetterSpace]KiP1 + Mal\[LetterSpace]cyt[t]/v30\[LetterSpace]KiS2 + OG[t]/v30\[LetterSpace]KiS1 + (Mal[t]*OG[t])/(v30\[LetterSpace]delta*v30\[LetterSpace]KiP1*v30\[LetterSpace]KiS1) + (Mal\[LetterSpace]cyt[t]*OG[t])/(v30\[LetterSpace]alpha*v30\[LetterSpace]KiS1*v30\[LetterSpace]KiS2) + OG\[LetterSpace]cyt[t]/v30\[LetterSpace]KiP2 + (Mal[t]*OG\[LetterSpace]cyt[t])/(v30\[LetterSpace]beta*v30\[LetterSpace]KiP1*v30\[LetterSpace]KiP2) + (Mal\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t])/(v30\[LetterSpace]gamma*v30\[LetterSpace]KiP2*v30\[LetterSpace]KiS2)), v31 -> (CYTOPLASM*v31\[LetterSpace]v31\[LetterSpace]MDH*(-(v31\[LetterSpace]kminus1*v31\[LetterSpace]kminus2*v31\[LetterSpace]kminus3*v31\[LetterSpace]kminus4*Mal\[LetterSpace]cyt[t]*NAD[t]) + v31\[LetterSpace]k1*v31\[LetterSpace]k2*v31\[LetterSpace]k3*v31\[LetterSpace]k4*NADH\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t]))/(v31\[LetterSpace]k1 + v31\[LetterSpace]kminus2 + v31\[LetterSpace]k4*v31\[LetterSpace]kminus1*(v31\[LetterSpace]k3 + v31\[LetterSpace]kminus2) + v31\[LetterSpace]kminus1*v31\[LetterSpace]kminus2*v31\[LetterSpace]kminus3*Mal\[LetterSpace]cyt[t] + v31\[LetterSpace]kminus1*(v31\[LetterSpace]k3 + v31\[LetterSpace]kminus2)*v31\[LetterSpace]kminus4*NAD[t] + (v31\[LetterSpace]kminus1 + v31\[LetterSpace]kminus2)*v31\[LetterSpace]kminus3*v31\[LetterSpace]kminus4*Mal\[LetterSpace]cyt[t]*NAD[t] + v31\[LetterSpace]k1*v31\[LetterSpace]k4*(v31\[LetterSpace]k3 + v31\[LetterSpace]kminus2)*NADH\[LetterSpace]cyt[t] + v31\[LetterSpace]kminus3*Mal\[LetterSpace]cyt[t]*NADH\[LetterSpace]cyt[t] + v31\[LetterSpace]k2*v31\[LetterSpace]k3*v31\[LetterSpace]k4*OXA\[LetterSpace]cyt[t] + v31\[LetterSpace]k2*v31\[LetterSpace]k3*v31\[LetterSpace]kminus4*NAD[t]*OXA\[LetterSpace]cyt[t] + v31\[LetterSpace]k2*v31\[LetterSpace]kminus3*v31\[LetterSpace]kminus4*Mal\[LetterSpace]cyt[t]*NAD[t]*OXA\[LetterSpace]cyt[t] + v31\[LetterSpace]k1*v31\[LetterSpace]k2*(v31\[LetterSpace]k3 + v31\[LetterSpace]k4)*NADH\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t] + v31\[LetterSpace]k1*v31\[LetterSpace]k2*v31\[LetterSpace]kminus3*Mal\[LetterSpace]cyt[t]*NADH\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t]), v32 -> (CYTOPLASM*v32\[LetterSpace]KcF*v32\[LetterSpace]KcR*v32\[LetterSpace]v32\[LetterSpace]AspTA*(Asp\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t] - (Glu\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t])/v32\[LetterSpace]Keq))/(v32\[LetterSpace]KcR*v32\[LetterSpace]KmS2*Asp\[LetterSpace]cyt[t] + (v32\[LetterSpace]KcF*v32\[LetterSpace]KmP1*Glu\[LetterSpace]cyt[t])/v32\[LetterSpace]Keq + v32\[LetterSpace]KcR*v32\[LetterSpace]KmS1*OG\[LetterSpace]cyt[t] + v32\[LetterSpace]KcR*Asp\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t] + (v32\[LetterSpace]KcR*v32\[LetterSpace]KmS1*Glu\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t])/v32\[LetterSpace]KiP2 + (v32\[LetterSpace]KcF*v32\[LetterSpace]KmP2*OXA\[LetterSpace]cyt[t])/v32\[LetterSpace]Keq + (v32\[LetterSpace]KcF*v32\[LetterSpace]KmP2*Asp\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t])/(v32\[LetterSpace]Keq*v32\[LetterSpace]KiS1) + (v32\[LetterSpace]KcF*Glu\[LetterSpace]cyt[t]*OXA\[LetterSpace]cyt[t])/v32\[LetterSpace]Keq), v33 -> (MATRIX*v33\[LetterSpace]v33\[LetterSpace]CIC*((v33\[LetterSpace]KcF*Cit\[LetterSpace]cyt[t]*Mal[t])/(v33\[LetterSpace]alpha*v33\[LetterSpace]KiS1*v33\[LetterSpace]KiS2) - (v33\[LetterSpace]KcR*Cit[t]*Mal\[LetterSpace]cyt[t])/(v33\[LetterSpace]beta*v33\[LetterSpace]KiP1*v33\[LetterSpace]KiP2)))/(1 + Cit[t]/v33\[LetterSpace]KiP2 + Cit\[LetterSpace]cyt[t]/v33\[LetterSpace]KiS1 + Mal[t]/v33\[LetterSpace]KiS2 + (Cit[t]*Mal[t])/(v33\[LetterSpace]gamma*v33\[LetterSpace]KiP2*v33\[LetterSpace]KiS2) + (Cit\[LetterSpace]cyt[t]*Mal[t])/(v33\[LetterSpace]alpha*v33\[LetterSpace]KiS1*v33\[LetterSpace]KiS2) + Mal\[LetterSpace]cyt[t]/v33\[LetterSpace]KiP1 + (Cit[t]*Mal\[LetterSpace]cyt[t])/(v33\[LetterSpace]beta*v33\[LetterSpace]KiP1*v33\[LetterSpace]KiP2) + (Cit\[LetterSpace]cyt[t]*Mal\[LetterSpace]cyt[t])/(v33\[LetterSpace]delta*v33\[LetterSpace]KiP1*v33\[LetterSpace]KiS1)), v34 -> (MATRIX*v34\[LetterSpace]KcF*v34\[LetterSpace]KcR*v34\[LetterSpace]v34\[LetterSpace]ETF\[LetterSpace]QO*(ETFred[t]*Q[t] - (ETFox[t]*QH2[t])/v34\[LetterSpace]Keq))/((v34\[LetterSpace]KcF*v34\[LetterSpace]KmP2*ETFox[t])/v34\[LetterSpace]Keq + v34\[LetterSpace]KcR*v34\[LetterSpace]KmS2*ETFred[t] + (v34\[LetterSpace]KcF*v34\[LetterSpace]KmP2*ETFox[t]*ETFred[t])/(v34\[LetterSpace]Keq*v34\[LetterSpace]KiS1) + v34\[LetterSpace]KcR*v34\[LetterSpace]KmS1*Q[t] + v34\[LetterSpace]KcR*ETFred[t]*Q[t] + (v34\[LetterSpace]KcF*v34\[LetterSpace]KmP1*QH2[t])/v34\[LetterSpace]Keq + (v34\[LetterSpace]KcF*ETFox[t]*QH2[t])/v34\[LetterSpace]Keq + (v34\[LetterSpace]KcR*v34\[LetterSpace]KmS1*Q[t]*QH2[t])/v34\[LetterSpace]KiP2), v35 -> (MATRIX*v35\[LetterSpace]KcF*v35\[LetterSpace]KcR*v35\[LetterSpace]v35\[LetterSpace]ACD*(-((ETFred[t]*FAD[t])/v35\[LetterSpace]Keq) + ETFox[t]*FADH2[t]))/(v35\[LetterSpace]KcR*v35\[LetterSpace]KiS1*v35\[LetterSpace]KmS2 + v35\[LetterSpace]KcR*v35\[LetterSpace]KmS1*ETFox[t] + (v35\[LetterSpace]KcF*v35\[LetterSpace]KmP2*ETFred[t])/v35\[LetterSpace]Keq + (v35\[LetterSpace]KcF*v35\[LetterSpace]KmP1*FAD[t])/v35\[LetterSpace]Keq + (v35\[LetterSpace]KcR*v35\[LetterSpace]KmS1*ETFox[t]*FAD[t])/v35\[LetterSpace]KiP2 + (v35\[LetterSpace]KcF*ETFred[t]*FAD[t])/v35\[LetterSpace]Keq + (v35\[LetterSpace]KcF*ETFox[t]*ETFred[t]*FAD[t])/(v35\[LetterSpace]Keq*v35\[LetterSpace]KiS2) + v35\[LetterSpace]KcR*v35\[LetterSpace]KmS2*FADH2[t] + v35\[LetterSpace]KcR*ETFox[t]*FADH2[t] + (v35\[LetterSpace]KcF*v35\[LetterSpace]KmP2*ETFred[t]*FADH2[t])/(v35\[LetterSpace]Keq*v35\[LetterSpace]KiS1) + (v35\[LetterSpace]KcR*ETFox[t]*ETFred[t]*FADH2[t])/v35\[LetterSpace]KiP1), v36 -> (MATRIX*v36\[LetterSpace]KcF*v36\[LetterSpace]KcR*v36\[LetterSpace]v36\[LetterSpace]PC*(-((Pi*ADP[t]*OXA[t])/v36\[LetterSpace]Keq) + ATP[t]*CO2[t]*Pyr[t]))/((Pi*v36\[LetterSpace]KcF*v36\[LetterSpace]KmR*ADP[t])/v36\[LetterSpace]Keq + v36\[LetterSpace]KcR*v36\[LetterSpace]KmC*ATP[t]*CO2[t] + (Pi*v36\[LetterSpace]KcF*v36\[LetterSpace]KmQ*OXA[t])/v36\[LetterSpace]Keq + (v36\[LetterSpace]KcF*v36\[LetterSpace]Kip*v36\[LetterSpace]KmQ*OXA[t])/v36\[LetterSpace]Keq + (Pi*v36\[LetterSpace]KcF*ADP[t]*OXA[t])/v36\[LetterSpace]Keq + (v36\[LetterSpace]KcF*v36\[LetterSpace]KmP*ADP[t]*OXA[t])/v36\[LetterSpace]Keq + (v36\[LetterSpace]KcF*v36\[LetterSpace]KmP*ATP[t]*OXA[t])/v36\[LetterSpace]Keq + (v36\[LetterSpace]KcF*v36\[LetterSpace]Kiq*v36\[LetterSpace]KmP*CO2[t]*OXA[t])/(v36\[LetterSpace]Keq*v36\[LetterSpace]Kib) + (Pi*v36\[LetterSpace]KcF*v36\[LetterSpace]KmQ*CO2[t]*OXA[t])/(v36\[LetterSpace]Keq*v36\[LetterSpace]Kib) + (v36\[LetterSpace]KcF*v36\[LetterSpace]KmP*ADP[t]*CO2[t]*OXA[t])/(v36\[LetterSpace]Keq*v36\[LetterSpace]Kib) + (v36\[LetterSpace]KcR*v36\[LetterSpace]KmA*ATP[t]*CO2[t]*OXA[t])/v36\[LetterSpace]Kir + v36\[LetterSpace]KcR*v36\[LetterSpace]Kia*v36\[LetterSpace]KmB*Pyr[t] + (Pi*v36\[LetterSpace]KcR*v36\[LetterSpace]Kia*v36\[LetterSpace]KmB*Pyr[t])/v36\[LetterSpace]Kip + v36\[LetterSpace]KcR*v36\[LetterSpace]KmB*ADP[t]*Pyr[t] + (Pi*v36\[LetterSpace]KcF*v36\[LetterSpace]KmR*ADP[t]*Pyr[t])/(v36\[LetterSpace]Keq*v36\[LetterSpace]Kic) + v36\[LetterSpace]KcR*v36\[LetterSpace]KmB*ATP[t]*Pyr[t] + v36\[LetterSpace]KcR*v36\[LetterSpace]KmA*CO2[t]*Pyr[t] + (Pi*v36\[LetterSpace]KcR*v36\[LetterSpace]KmA*CO2[t]*Pyr[t])/v36\[LetterSpace]Kip + (v36\[LetterSpace]KcR*v36\[LetterSpace]KmA*ADP[t]*CO2[t]*Pyr[t])/v36\[LetterSpace]Kiq + v36\[LetterSpace]KcR*ATP[t]*CO2[t]*Pyr[t]), v37 -> (CYTOPLASM*v37\[LetterSpace]V*v37\[LetterSpace]v37\[LetterSpace]GUT2P*G3P[t])/(v37\[LetterSpace]K + G3P[t]), v38 -> (CYTOPLASM*v38\[LetterSpace]V*v38\[LetterSpace]v38\[LetterSpace]GUT2P*NADH\[LetterSpace]cyt[t])/(v38\[LetterSpace]K + NADH\[LetterSpace]cyt[t]), v39 -> (CYTOPLASM*v39\[LetterSpace]Kcat*v39\[LetterSpace]v39\[LetterSpace]MDH*Mal\[LetterSpace]cyt[t]*NADP\[LetterSpace]cyt[t])/((v39\[LetterSpace]Kmal + Mal\[LetterSpace]cyt[t])*(v39\[LetterSpace]Knadp + NADP\[LetterSpace]cyt[t])), v4 -> (CYTOPLASM*v4\[LetterSpace]V4*GAP[t]*NAD[t])/((v4\[LetterSpace]K4GAP + GAP[t])*(v4\[LetterSpace]K4NAD + NAD[t])), v40 -> (MATRIX*v40\[LetterSpace]V*v40\[LetterSpace]v40\[LetterSpace]AAC*ADP\[LetterSpace]cyt[t])/(v40\[LetterSpace]K + ADP\[LetterSpace]cyt[t]), v41 -> CYTOPLASM*v41\[LetterSpace]v41\[LetterSpace]IDHc*((IsoCitcyt[t]*NADP\[LetterSpace]cyt[t])/(v41\[LetterSpace]phi12 + v41\[LetterSpace]phi2*IsoCitcyt[t] + v41\[LetterSpace]phi1*NADP\[LetterSpace]cyt[t] + v41\[LetterSpace]phi0*IsoCitcyt[t]*NADP\[LetterSpace]cyt[t]) - (CO2[t]*NADPH\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t])/(v41\[LetterSpace]phir123 + v41\[LetterSpace]phir12*CO2[t] + v41\[LetterSpace]phir13*NADPH\[LetterSpace]cyt[t] + v41\[LetterSpace]phir1*CO2[t]*NADPH\[LetterSpace]cyt[t] + v41\[LetterSpace]phir23*OG\[LetterSpace]cyt[t] + v41\[LetterSpace]phir2*CO2[t]*OG\[LetterSpace]cyt[t] + v41\[LetterSpace]phir3*NADPH\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t] + v41\[LetterSpace]phir0*CO2[t]*NADPH\[LetterSpace]cyt[t]*OG\[LetterSpace]cyt[t])), v42 -> (MATRIX*v42\[LetterSpace]v42\[LetterSpace]CIC*((v42\[LetterSpace]KcF*IsoCitcyt[t]*Mal[t])/(v42\[LetterSpace]alpha*v42\[LetterSpace]KiS1*v42\[LetterSpace]KiS2) - (v42\[LetterSpace]KcR*IsoCit[t]*Mal\[LetterSpace]cyt[t])/(v42\[LetterSpace]beta*v42\[LetterSpace]KiP1*v42\[LetterSpace]KiP2)))/(1 + IsoCit[t]/v42\[LetterSpace]KiP2 + IsoCitcyt[t]/v42\[LetterSpace]KiS1 + Mal[t]/v42\[LetterSpace]KiS2 + (IsoCit[t]*Mal[t])/(v42\[LetterSpace]gamma*v42\[LetterSpace]KiP2*v42\[LetterSpace]KiS2) + (IsoCitcyt[t]*Mal[t])/(v42\[LetterSpace]alpha*v42\[LetterSpace]KiS1*v42\[LetterSpace]KiS2) + Mal\[LetterSpace]cyt[t]/v42\[LetterSpace]KiP1 + (IsoCit[t]*Mal\[LetterSpace]cyt[t])/(v42\[LetterSpace]beta*v42\[LetterSpace]KiP1*v42\[LetterSpace]KiP2) + (IsoCitcyt[t]*Mal\[LetterSpace]cyt[t])/(v42\[LetterSpace]delta*v42\[LetterSpace]KiP1*v42\[LetterSpace]KiS1)), v43 -> (MATRIX*v43\[LetterSpace]V*v43\[LetterSpace]v43\[LetterSpace]AAC*ATP[t])/(v43\[LetterSpace]K + ATP[t]), v44 -> (MATRIX*v44\[LetterSpace]Kcat*v44\[LetterSpace]v44\[LetterSpace]MDH*Mal[t])/(v44\[LetterSpace]Km + Mal[t]), v5 -> CYTOPLASM*(v5\[LetterSpace]k5f*ADP\[LetterSpace]cyt[t]*DPG[t] - v5\[LetterSpace]k5b*ATP\[LetterSpace]cyt[t]*PEP[t]), v6 -> (CYTOPLASM*v6\[LetterSpace]V6*ADP\[LetterSpace]cyt[t]*PEP[t])/((v6\[LetterSpace]K6ADP + ADP\[LetterSpace]cyt[t])*(v6\[LetterSpace]K6PEP + PEP[t])), v7 -> CYTOPLASM*(-(v7\[LetterSpace]k8b*LAC[t]*NAD[t]) + v7\[LetterSpace]k8f*NADH\[LetterSpace]cyt[t]*PYR\[LetterSpace]cyt[t]), v8 -> (MATRIX*v8\[LetterSpace]V*v8\[LetterSpace]v8\[LetterSpace]PYC*PYR\[LetterSpace]cyt[t])/(v8\[LetterSpace]K + PYR\[LetterSpace]cyt[t]), v9 -> (MATRIX*v9\[LetterSpace]KcF*v9\[LetterSpace]v9\[LetterSpace]PDC*CoA[t]*NAD\[LetterSpace]p[t]*Pyr[t])/((v9\[LetterSpace]Kib*v9\[LetterSpace]Kic*v9\[LetterSpace]KmA*v9\[LetterSpace]KmP*Acetyl\[LetterSpace]CoA[t]*NADH[t])/(v9\[LetterSpace]Kip*v9\[LetterSpace]Kiq*v9\[LetterSpace]KmR) + v9\[LetterSpace]KmA*CoA[t]*NAD\[LetterSpace]p[t] + v9\[LetterSpace]KmC*CoA[t]*Pyr[t] + (v9\[LetterSpace]Kib*v9\[LetterSpace]Kic*v9\[LetterSpace]KmA*v9\[LetterSpace]KmP*Acetyl\[LetterSpace]CoA[t]*NADH[t]*Pyr[t])/(v9\[LetterSpace]Kia*v9\[LetterSpace]Kip*v9\[LetterSpace]Kiq*v9\[LetterSpace]KmR) + (v9\[LetterSpace]KmC*CoA[t]*NADH[t]*Pyr[t])/v9\[LetterSpace]Kir + v9\[LetterSpace]KmB*NAD\[LetterSpace]p[t]*Pyr[t] + (v9\[LetterSpace]KmB*Acetyl\[LetterSpace]CoA[t]*NAD\[LetterSpace]p[t]*Pyr[t])/v9\[LetterSpace]Kiq + CoA[t]*NAD\[LetterSpace]p[t]*Pyr[t]) }; parameters = { flow -> 0.011, v24\[LetterSpace]KmS1 -> 9.2*^-06, GLCflow\[LetterSpace]Glc\[LetterSpace]F -> 64.941, v1\[LetterSpace]V1 -> 0.0005, v1\[LetterSpace]K1GLC -> 0.0001, v1\[LetterSpace]K1ATP -> 6.3*^-05, v2\[LetterSpace]V2 -> 0.0015, v2\[LetterSpace]K2 -> 1.6*^-09, v2\[LetterSpace]k2 -> 0.017, v2\[LetterSpace]K2ATP -> 1*^-05, v3\[LetterSpace]k3f -> 1.0, v3\[LetterSpace]k3b -> 0.05, v4\[LetterSpace]V4 -> 0.01, v4\[LetterSpace]K4GAP -> 0.001, v4\[LetterSpace]K4NAD -> 0.001, v5\[LetterSpace]k5f -> 1000.0, v5\[LetterSpace]k5b -> 500.0, v6\[LetterSpace]V6 -> 0.01, v6\[LetterSpace]K6PEP -> 0.0002, v6\[LetterSpace]K6ADP -> 0.0003, v7\[LetterSpace]k8f -> 1000.0, v7\[LetterSpace]k8b -> 0.143, hidden\[LetterSpace]1\[LetterSpace]k9f -> 10000.0, hidden\[LetterSpace]1\[LetterSpace]k9b -> 10000.0, v8\[LetterSpace]V -> 1*^-08, v8\[LetterSpace]K -> 1.5*^-07, v8\[LetterSpace]v8\[LetterSpace]PYC -> 0.00033211, v9\[LetterSpace]KmA -> 2.5*^-05, v9\[LetterSpace]KmB -> 1.3*^-05, v9\[LetterSpace]KmC -> 5*^-05, v9\[LetterSpace]KmP -> 5.9*^-07, v9\[LetterSpace]KmR -> 6.9*^-07, v9\[LetterSpace]Kia -> 0.00055, v9\[LetterSpace]Kib -> 0.0003, v9\[LetterSpace]Kic -> 0.00018, v9\[LetterSpace]Kip -> 6*^-05, v9\[LetterSpace]Kiq -> 3.5*^-05, v9\[LetterSpace]Kir -> 3.6*^-05, v9\[LetterSpace]KcF -> 856.0, v9\[LetterSpace]v9\[LetterSpace]PDC -> 3.8617*^-07, v10\[LetterSpace]V -> 0.005267, v10\[LetterSpace]Ka -> 1.18*^-05, v10\[LetterSpace]Kb -> 4.8*^-06, v10\[LetterSpace]Kia -> 1*^-05, v10\[LetterSpace]Kib -> 4*^-06, v10\[LetterSpace]v10\[LetterSpace]CS -> 3.8617*^-07, v11\[LetterSpace]Ks -> 0.0005, v11\[LetterSpace]Kp -> 0.00011, v11\[LetterSpace]KcF -> 20.47, v11\[LetterSpace]KcR -> 31.44, v11\[LetterSpace]v11\[LetterSpace]ACO -> 3.8617*^-07, v12\[LetterSpace]KcF -> 105.0, v12\[LetterSpace]b -> 29.6, v12\[LetterSpace]c -> 0.00023, v12\[LetterSpace]d -> 7.8*^-05, v12\[LetterSpace]e -> 0.00064, v12\[LetterSpace]f -> 0.00036, v12\[LetterSpace]v12\[LetterSpace]IDHa -> 3.8617*^-07, v14\[LetterSpace]KmA -> 0.00022, v14\[LetterSpace]KmB -> 2.5*^-05, v14\[LetterSpace]KmC -> 5*^-05, v14\[LetterSpace]KmP -> 0.0003, v14\[LetterSpace]KmR -> 0.0006, v14\[LetterSpace]Kia -> 0.00072, v14\[LetterSpace]Kib -> 0.00074, v14\[LetterSpace]Kic -> 0.0001, v14\[LetterSpace]Kip -> 1.1*^-06, v14\[LetterSpace]Kiq -> 8.1*^-05, v14\[LetterSpace]Kir -> 2.5*^-05, v14\[LetterSpace]KcF -> 177.0, v14\[LetterSpace]v14\[LetterSpace]OGDC -> 3.8617*^-07, v15\[LetterSpace]KmA -> 5*^-06, v15\[LetterSpace]KmB -> 3.5*^-05, v15\[LetterSpace]KmC -> 0.00045, v15\[LetterSpace]KmP -> 0.0006, v15\[LetterSpace]KmQ -> 7.5*^-06, v15\[LetterSpace]KmC2 -> 0.00045, v15\[LetterSpace]KmP2 -> 0.0006, v15\[LetterSpace]Keq -> 8.375, v15\[LetterSpace]Kia -> 0.0004, v15\[LetterSpace]Kib -> 2*^-05, v15\[LetterSpace]Kic -> 3*^-05, v15\[LetterSpace]Kip -> 0.07, v15\[LetterSpace]Kiq -> 5*^-06, v15\[LetterSpace]Kir -> 6.7*^-06, v15\[LetterSpace]Kc1 -> 100.0, v15\[LetterSpace]Kc2 -> 100.0, v15\[LetterSpace]v15\[LetterSpace]SCS -> 3.8617*^-07, v16\[LetterSpace]KmS1 -> 3*^-05, v16\[LetterSpace]KmS2 -> 6.9*^-05, v16\[LetterSpace]KmP1 -> 3*^-07, v16\[LetterSpace]KmP2 -> 1.5*^-06, v16\[LetterSpace]KiS1 -> 4.1*^-06, v16\[LetterSpace]KiP2 -> 5.6*^-06, v16\[LetterSpace]Keq -> 0.037, v16\[LetterSpace]KcF -> 69.3, v16\[LetterSpace]KcR -> 1.73, v16\[LetterSpace]v16\[LetterSpace]SDH -> 9.9211*^-05, v17\[LetterSpace]Kp -> 2.5*^-05, v17\[LetterSpace]Ks -> 5*^-06, v17\[LetterSpace]KcF -> 800.0, v17\[LetterSpace]KcR -> 900.0, v17\[LetterSpace]v17\[LetterSpace]FM -> 3.8617*^-07, v18\[LetterSpace]KmS1 -> 7.2*^-05, v18\[LetterSpace]KmS2 -> 0.00011, v18\[LetterSpace]KmP1 -> 0.0016, v18\[LetterSpace]KmP2 -> 0.00017, v18\[LetterSpace]KiS1 -> 1.1*^-05, v18\[LetterSpace]KiS2 -> 0.0001, v18\[LetterSpace]KiP1 -> 0.0071, v18\[LetterSpace]KiP2 -> 0.0019, v18\[LetterSpace]KcF -> 0.39, v18\[LetterSpace]KcR -> 0.04, v18\[LetterSpace]v18\[LetterSpace]MDH -> 3.8617*^-07, v20\[LetterSpace]KmS1 -> 0.002, v20\[LetterSpace]KmS2 -> 0.0004, v20\[LetterSpace]KmP1 -> 0.032, v20\[LetterSpace]KmP2 -> 0.0004, v20\[LetterSpace]KiS1 -> 0.0087, v20\[LetterSpace]KiP2 -> 0.012, v20\[LetterSpace]Keq -> 0.69, v20\[LetterSpace]KcF -> 337.0, v20\[LetterSpace]KcR -> 0.15, v20\[LetterSpace]v20\[LetterSpace]AlaTA -> 3.8617*^-07, v21\[LetterSpace]KmS1 -> 0.0009, v21\[LetterSpace]KmS2 -> 0.0001, v21\[LetterSpace]KmP1 -> 4*^-05, v21\[LetterSpace]KmP2 -> 0.004, v21\[LetterSpace]KiS1 -> 0.002, v21\[LetterSpace]KiP2 -> 0.0083, v21\[LetterSpace]Keq -> 6.2, v21\[LetterSpace]KcF -> 300.0, v21\[LetterSpace]KcR -> 1000.0, v21\[LetterSpace]v21\[LetterSpace]AspTA -> 3.8617*^-07, v22\[LetterSpace]KiS1 -> 8*^-05, v22\[LetterSpace]KiS2 -> 0.0032, v22\[LetterSpace]KiP1 -> 0.00018, v22\[LetterSpace]KiP2 -> 0.0028, v22\[LetterSpace]KcF -> 10.0, v22\[LetterSpace]KcR -> 10.0, v22\[LetterSpace]alpha -> 1.0, v22\[LetterSpace]beta -> 1.0, v22\[LetterSpace]gamma -> 1.0, v22\[LetterSpace]delta -> 1.0, v22\[LetterSpace]v22\[LetterSpace]AGC -> 0.00033211, v24\[LetterSpace]KmS2 -> 0.00026, v24\[LetterSpace]KmP1 -> 9.9*^-06, v24\[LetterSpace]KmP2 -> 5.9*^-05, v24\[LetterSpace]KiS1 -> 2.1*^-08, v24\[LetterSpace]KiP2 -> 9.8*^-08, v24\[LetterSpace]Keq -> 407.9, v24\[LetterSpace]KcF -> 498.0, v24\[LetterSpace]KcR -> 229.0, v24\[LetterSpace]v24\[LetterSpace]Complex\[LetterSpace]I -> 0.00033211, v25\[LetterSpace]KmA -> 2.8*^-05, v25\[LetterSpace]KmB -> 3*^-06, v25\[LetterSpace]Kb1 -> 5.4*^-06, v25\[LetterSpace]Kb2 -> 5.7*^-06, v25\[LetterSpace]Kq1 -> 2.8*^-06, v25\[LetterSpace]Kq2 -> 1.9*^-06, v25\[LetterSpace]k8 -> 622.1, v25\[LetterSpace]KcF -> 426.8, v25\[LetterSpace]v25\[LetterSpace]Complex\[LetterSpace]III -> 9.963*^-09, v26\[LetterSpace]Ks -> 0.00011, v26\[LetterSpace]KcF -> 0.000935, v26\[LetterSpace]v26\[LetterSpace]Complex\[LetterSpace]IV -> 0.002325, v27\[LetterSpace]V -> 0.004833, v27\[LetterSpace]Ka -> 5*^-06, v27\[LetterSpace]Kb -> 4.5*^-06, v27\[LetterSpace]Kc -> 3.9*^-05, v27\[LetterSpace]Kia -> 5*^-06, v27\[LetterSpace]Kib -> 4.5*^-06, v27\[LetterSpace]Kid -> 0.0043, v27\[LetterSpace]Keq -> 18000000.0, v27\[LetterSpace]v10\[LetterSpace]CS -> 3.8617*^-07, v28\[LetterSpace]V -> 0.075, v28\[LetterSpace]Km -> 0.0045, v28\[LetterSpace]Ki -> 0.047, v28\[LetterSpace]v28\[LetterSpace]Complex\[LetterSpace]V -> 0.0033211, v29\[LetterSpace]Ks -> 0.0005, v29\[LetterSpace]Kp -> 0.00011, v29\[LetterSpace]KcF -> 20.47, v29\[LetterSpace]KcR -> 31.44, v29\[LetterSpace]v29\[LetterSpace]ACO -> 3.8617*^-07, v30\[LetterSpace]KiS1 -> 0.0003, v30\[LetterSpace]KiS2 -> 0.0007, v30\[LetterSpace]KiP1 -> 0.0014, v30\[LetterSpace]KiP2 -> 0.00017, v30\[LetterSpace]KcF -> 3.675, v30\[LetterSpace]KcR -> 4.83, v30\[LetterSpace]alpha -> 1.0, v30\[LetterSpace]beta -> 1.0, v30\[LetterSpace]gamma -> 1.0, v30\[LetterSpace]delta -> 1.0, v30\[LetterSpace]v30\[LetterSpace]OGC -> 0.00033211, v31\[LetterSpace]k1 -> 34000000.0, v31\[LetterSpace]k2 -> 35000000.0, v31\[LetterSpace]k3 -> 4650.0, v31\[LetterSpace]k4 -> 214.0, v31\[LetterSpace]kminus1 -> 26.0, v31\[LetterSpace]kminus2 -> 1400.0, v31\[LetterSpace]kminus3 -> 570000.0, v31\[LetterSpace]kminus4 -> 260000.0, v31\[LetterSpace]v31\[LetterSpace]MDH -> 3.8617*^-07, v32\[LetterSpace]KmS1 -> 0.0009, v32\[LetterSpace]KmS2 -> 0.0001, v32\[LetterSpace]KmP1 -> 4*^-05, v32\[LetterSpace]KmP2 -> 0.004, v32\[LetterSpace]KiS1 -> 0.002, v32\[LetterSpace]KiP2 -> 0.0083, v32\[LetterSpace]Keq -> 6.2, v32\[LetterSpace]KcF -> 300.0, v32\[LetterSpace]KcR -> 1000.0, v32\[LetterSpace]v32\[LetterSpace]AspTA -> 3.8617*^-07, v33\[LetterSpace]KiS1 -> 0.00013, v33\[LetterSpace]KiS2 -> 0.00044, v33\[LetterSpace]KiP1 -> 0.00033, v33\[LetterSpace]KiP2 -> 4.18*^-05, v33\[LetterSpace]KcF -> 5.6, v33\[LetterSpace]KcR -> 3.5, v33\[LetterSpace]alpha -> 1.0, v33\[LetterSpace]beta -> 1.0, v33\[LetterSpace]gamma -> 1.0, v33\[LetterSpace]delta -> 1.0, v33\[LetterSpace]v33\[LetterSpace]CIC -> 0.00033211, v34\[LetterSpace]KmS1 -> 3.1*^-07, v34\[LetterSpace]KmS2 -> 3.9*^-07, v34\[LetterSpace]KmP1 -> 3.2*^-07, v34\[LetterSpace]KmP2 -> 4.2*^-09, v34\[LetterSpace]KiS1 -> 3.1*^-07, v34\[LetterSpace]KiP2 -> 3*^-07, v34\[LetterSpace]Keq -> 0.66, v34\[LetterSpace]KcF -> 78.0, v34\[LetterSpace]KcR -> 101.0, v34\[LetterSpace]v34\[LetterSpace]ETF\[LetterSpace]QO -> 3.3211*^-05, v35\[LetterSpace]KmS1 -> 3.9*^-05, v35\[LetterSpace]KmS2 -> 1.2*^-07, v35\[LetterSpace]KmP1 -> 1.08*^-06, v35\[LetterSpace]KmP2 -> 2.42*^-05, v35\[LetterSpace]KiS1 -> 7.6*^-05, v35\[LetterSpace]KiS2 -> 2.4*^-07, v35\[LetterSpace]KiP1 -> 7.53*^-05, v35\[LetterSpace]KiP2 -> 1.19*^-05, v35\[LetterSpace]Keq -> 8.99, v35\[LetterSpace]KcF -> 2.18, v35\[LetterSpace]KcR -> 0.3, v35\[LetterSpace]v35\[LetterSpace]ACD -> 3.3211*^-05, v36\[LetterSpace]KmA -> 0.00011, v36\[LetterSpace]KmB -> 0.00163, v36\[LetterSpace]KmC -> 0.00037, v36\[LetterSpace]KmP -> 0.016, v36\[LetterSpace]KmQ -> 0.00024, v36\[LetterSpace]KmR -> 5.1*^-05, v36\[LetterSpace]Keq -> 9.0, v36\[LetterSpace]Kia -> 0.00015, v36\[LetterSpace]Kib -> 0.0016, v36\[LetterSpace]Kic -> 0.00013, v36\[LetterSpace]Kip -> 0.0079, v36\[LetterSpace]Kiq -> 0.00019, v36\[LetterSpace]Kir -> 0.00024, v36\[LetterSpace]KcF -> 200.0, v36\[LetterSpace]KcR -> 20.0, v36\[LetterSpace]v36\[LetterSpace]PC -> 3.8617*^-07, v37\[LetterSpace]K -> 3.4*^-05, v37\[LetterSpace]V -> 3.99*^-08, v37\[LetterSpace]v37\[LetterSpace]GUT2P -> 0.001, v38\[LetterSpace]K -> 34.0, v38\[LetterSpace]V -> 0.0399, v38\[LetterSpace]v38\[LetterSpace]GUT2P -> 0.001, v40\[LetterSpace]V -> 0.1667, v40\[LetterSpace]K -> 0.012, v40\[LetterSpace]v40\[LetterSpace]AAC -> 0.00033211, v41\[LetterSpace]phi0 -> 0.051, v41\[LetterSpace]phi1 -> 9.5*^-08, v41\[LetterSpace]phi2 -> 9.6*^-07, v41\[LetterSpace]phi12 -> 9*^-08, v41\[LetterSpace]phir0 -> 0.066, v41\[LetterSpace]phir1 -> 3.7*^-07, v41\[LetterSpace]phir2 -> 2.9*^-05, v41\[LetterSpace]phir3 -> 0.00025, v41\[LetterSpace]phir12 -> 6*^-12, v41\[LetterSpace]phir13 -> 1.3*^-10, v41\[LetterSpace]phir23 -> 9.4*^-08, v41\[LetterSpace]phir123 -> 4.6*^-14, v41\[LetterSpace]v41\[LetterSpace]IDHc -> 3.8617*^-07, v42\[LetterSpace]KiS1 -> 0.00013, v42\[LetterSpace]KiS2 -> 0.00044, v42\[LetterSpace]KiP1 -> 0.00033, v42\[LetterSpace]KiP2 -> 4.18*^-05, v42\[LetterSpace]KcF -> 5.6, v42\[LetterSpace]KcR -> 3.5, v42\[LetterSpace]alpha -> 1.0, v42\[LetterSpace]beta -> 1.0, v42\[LetterSpace]gamma -> 1.0, v42\[LetterSpace]delta -> 1.0, v42\[LetterSpace]v42\[LetterSpace]CIC -> 0.00033211, v43\[LetterSpace]V -> 1.11667, v43\[LetterSpace]K -> 0.005, v43\[LetterSpace]v43\[LetterSpace]AAC -> 0.00033211, v39\[LetterSpace]Kcat -> 0.333, v39\[LetterSpace]Kmal -> 0.000125, v39\[LetterSpace]Knadp -> 0.011, v39\[LetterSpace]v39\[LetterSpace]MDH -> 3.8617*^-07, v44\[LetterSpace]Kcat -> 130.5, v44\[LetterSpace]Km -> 0.01295, v44\[LetterSpace]v44\[LetterSpace]MDH -> 3.8617*^-07, CYTOPLASM -> 1.0, MATRIX -> 1.0, MT\[LetterSpace]IM -> 1.0, MT\[LetterSpace]IMS -> 1.0 }; assignments = { }; events = { }; speciesAnnotations = { ADP[t]->"http://identifiers.org/kegg.compound/C0008", ADP\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C0008", AMP[t]->"http://identifiers.org/kegg.compound/C00020", AMP[t]->"http://identifiers.org/chebi/CHEBI:16027", ATP[t]->"http://identifiers.org/kegg.compound/C0002", ATP\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C0002", Acetyl\[LetterSpace]CoA[t]->"http://identifiers.org/kegg.compound/C00024", Acetyl\[LetterSpace]CoA[t]->"http://identifiers.org/chebi/CHEBI:15351", Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00024", Acetyl\[LetterSpace]CoA\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:15351", Ala[t]->"http://identifiers.org/kegg.compound/C00041", Ala[t]->"http://identifiers.org/chebi/CHEBI:16977", Asp[t]->"http://identifiers.org/kegg.compound/C00049", Asp[t]->"http://identifiers.org/chebi/CHEBI:17053", Asp\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00049", Asp\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:17053", CO2[t]->"http://identifiers.org/kegg.compound/C00011", CO2[t]->"http://identifiers.org/chebi/CHEBI:16526", Cit[t]->"http://identifiers.org/kegg.compound/C00158", Cit[t]->"http://identifiers.org/chebi/CHEBI:30769", Cit\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00158", Cit\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:30769", CoA[t]->"http://identifiers.org/kegg.compound/C00010", CoA[t]->"http://identifiers.org/chebi/CHEBI:15346", CoA\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00010", CoA\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:15346", Cytc2p[t]->"http://identifiers.org/chebi/CHEBI:15991", Cytc2p[t]->"http://identifiers.org/kegg.compound/C00125", Cytc3p[t]->"http://identifiers.org/chebi/CHEBI:16928", Cytc3p[t]->"http://identifiers.org/kegg.compound/C00126", DHAP[t]->"http://identifiers.org/kegg.compound/C00111", DHAP[t]->"http://identifiers.org/chebi/CHEBI:16108", DPG[t]->"http://identifiers.org/kegg.compound/C00236", DPG[t]->"http://identifiers.org/chebi/CHEBI:16001", ETFox[t]->"http://identifiers.org/kegg.compound/C04253", ETFred[t]->"http://identifiers.org/kegg.compound/C04570", F6P[t]->"http://identifiers.org/kegg.compound/C00085", F6P[t]->"http://identifiers.org/chebi/CHEBI:15946", FAD[t]->"http://identifiers.org/kegg.compound/C00016", FAD[t]->"http://identifiers.org/chebi/CHEBI:16238", FADH2[t]->"http://identifiers.org/kegg.compound/C01352", FADH2[t]->"http://identifiers.org/chebi/CHEBI:17877", FBP[t]->"http://identifiers.org/kegg.compound/C00354", FBP[t]->"http://identifiers.org/chebi/CHEBI:16905", Fum[t]->"http://identifiers.org/kegg.compound/C00122", Fum[t]->"http://identifiers.org/chebi/CHEBI:18012", G3P[t]->"http://identifiers.org/kegg.compound/C00093", G3P[t]->"http://identifiers.org/chebi/CHEBI:15978", GAP[t]->"http://identifiers.org/kegg.compound/C00118", GAP[t]->"http://identifiers.org/chebi/CHEBI:29052", GDP[t]->"http://identifiers.org/kegg.compound/C00035", GDP[t]->"http://identifiers.org/chebi/CHEBI:17552", GLC[t]->"http://identifiers.org/kegg.compound/C00267", GLC[t]->"http://identifiers.org/chebi/CHEBI:17925", GTP[t]->"http://identifiers.org/kegg.compound/C00044", GTP[t]->"http://identifiers.org/chebi/CHEBI:15996", Glu[t]->"http://identifiers.org/kegg.compound/C00025", Glu[t]->"http://identifiers.org/chebi/CHEBI:16015", Glu\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00025", Glu\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:16015", H2O[t]->"http://identifiers.org/kegg.compound/C00001", H2O[t]->"http://identifiers.org/chebi/CHEBI:15377", IsoCit[t]->"http://identifiers.org/kegg.compound/C00311", IsoCit[t]->"http://identifiers.org/chebi/CHEBI:30887", IsoCitcyt[t]->"http://identifiers.org/kegg.compound/C00311", IsoCitcyt[t]->"http://identifiers.org/chebi/CHEBI:30887", LAC[t]->"http://identifiers.org/kegg.compound/C00186", LAC[t]->"http://identifiers.org/chebi/CHEBI:422", Mal[t]->"http://identifiers.org/kegg.compound/C00149", Mal[t]->"http://identifiers.org/chebi/CHEBI:30797", Mal\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00149", Mal\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:30797", NAD[t]->"http://identifiers.org/chebi/CHEBI:15846", NAD[t]->"http://identifiers.org/kegg.compound/C00003", NADH[t]->"http://identifiers.org/kegg.compound/C00004", NADH[t]->"http://identifiers.org/chebi/CHEBI:16908", NADH\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:16908", NADH\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00004", NADPH[t]->"http://identifiers.org/kegg.compound/C00005", NADPH[t]->"http://identifiers.org/chebi/CHEBI:16474", NADPH\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:16474", NADPH\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00005", NADP\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:18009", NADP\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00006", NADP\[LetterSpace]p[t]->"http://identifiers.org/kegg.compound/C00006", NADP\[LetterSpace]p[t]->"http://identifiers.org/chebi/CHEBI:18009", NAD\[LetterSpace]p[t]->"http://identifiers.org/kegg.compound/C00003", NAD\[LetterSpace]p[t]->"http://identifiers.org/chebi/CHEBI:15846", OG[t]->"http://identifiers.org/kegg.compound/C00026", OG[t]->"http://identifiers.org/chebi/CHEBI:30915", OG\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00026", OG\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:30915", OXA[t]->"http://identifiers.org/kegg.compound/C00036", OXA[t]->"http://identifiers.org/chebi/CHEBI:30744", OXA\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00036", OXA\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:30744", PEP[t]->"http://identifiers.org/kegg.compound/C00074", PEP[t]->"http://identifiers.org/chebi/CHEBI:18021", PYR\[LetterSpace]cyt[t]->"http://identifiers.org/kegg.compound/C00022", PYR\[LetterSpace]cyt[t]->"http://identifiers.org/chebi/CHEBI:32816", Pi[t]->"http://identifiers.org/kegg.compound/C00009", Pi[t]->"http://identifiers.org/chebi/CHEBI:18367", Pyr[t]->"http://identifiers.org/kegg.compound/C00022", Pyr[t]->"http://identifiers.org/chebi/CHEBI:32816", Q[t]->"http://identifiers.org/chebi/CHEBI:16389", Q[t]->"http://identifiers.org/kegg.compound/C00399", QH2[t]->"http://identifiers.org/chebi/CHEBI:17976", QH2[t]->"http://identifiers.org/kegg.compound/C00390", SCoA[t]->"http://identifiers.org/kegg.compound/C00091", SCoA[t]->"http://identifiers.org/chebi/CHEBI:15380", Suc[t]->"http://identifiers.org/kegg.compound/C00042", Suc[t]->"http://identifiers.org/chebi/CHEBI:15741" }; reactionAnnotations = { v1->"http://identifiers.org/ec-code/2.7.1.2", v10->"http://identifiers.org/ec-code/2.3.3.3", v10->"http://identifiers.org/ec-code/2.3.3.1", v11->"http://identifiers.org/ec-code/4.2.1.3", v12->"http://identifiers.org/ec-code/1.1.1.41", v14->"http://identifiers.org/ec-code/1.2.4.2", v15->"http://identifiers.org/ec-code/6.2.1.4", v16->"http://identifiers.org/ec-code/1.3.5.1", v17->"http://identifiers.org/ec-code/4.2.1.2", v18->"http://identifiers.org/ec-code/1.1.1.37", v2->"http://identifiers.org/ec-code/2.7.1.11", v20->"http://identifiers.org/ec-code/2.6.1.2", v21->"http://identifiers.org/ec-code/2.6.1.1", v24->"http://identifiers.org/ec-code/2.7.4.6", v25->"http://identifiers.org/ec-code/1.10.2.2", v26->"http://identifiers.org/ec-code/1.9.3.1", v27->"http://identifiers.org/ec-code/2.3.3.3", v27->"http://identifiers.org/ec-code/2.3.3.1", v28->"http://identifiers.org/ec-code/3.6.1.3", v28->"http://identifiers.org/ec-code/3.6.1.5", v29->"http://identifiers.org/ec-code/4.2.1.3", v3->"http://identifiers.org/ec-code/4.1.2.13", v31->"http://identifiers.org/ec-code/1.1.1.37", v32->"http://identifiers.org/ec-code/2.6.1.1", v34->"http://identifiers.org/ec-code/1.5.5.1", v35->"http://identifiers.org/ec-code/1.8.1.7", v36->"http://identifiers.org/ec-code/6.4.1.1", v37->"http://identifiers.org/ec-code/1.1.99.5", v38->"http://identifiers.org/ec-code/1.1.1.8", v39->"http://identifiers.org/ec-code/1.1.1.40", v4->"http://identifiers.org/ec-code/1.2.1.12", v41->"http://identifiers.org/ec-code/1.1.1.42", v44->"http://identifiers.org/ec-code/1.1.1.40", v5->"http://identifiers.org/ec-code/5.4.2.4", v5->"http://identifiers.org/ec-code/5.4.2.1", v6->"http://identifiers.org/ec-code/2.7.1.40", v7->"http://identifiers.org/ec-code/1.1.1.27", v9->"http://identifiers.org/ec-code/1.2.4.1" }; units = { {"time" -> "", "metabolite" -> "", "extent" -> ""} }; (* Time evolution *) odes = { ADP'[t] == 1.0*v36 +1.0*v40 -1.0*v28, ADP\[LetterSpace]cyt'[t] == 1.0*v1 +1.0*v2 +2.0*hidden\[LetterSpace]1 -1.0*v5 -1.0*v6 -1.0*v40, AMP'[t] == -1.0*hidden\[LetterSpace]1, ATP'[t] == 1.0*v28 -1.0*v36 -1.0*v43, ATP\[LetterSpace]cyt'[t] == 1.0*v5 +1.0*v6 +1.0*v43 -1.0*v1 -1.0*v2 -1.0*hidden\[LetterSpace]1, Acetyl\[LetterSpace]CoA'[t] == 1.0*v9 -1.0*v10, Acetyl\[LetterSpace]CoA\[LetterSpace]cyt'[t] == 1.0*v27 , Ala'[t] == -1.0*v20, Asp'[t] == 1.0*v21 -1.0*v22, Asp\[LetterSpace]cyt'[t] == 1.0*v22 -1.0*v32, CO2'[t] == 1.0*v9 +1.0*v14 -1.0*v36, Cit'[t] == 1.0*v10 +1.0*v33 -1.0*v11, Cit\[LetterSpace]cyt'[t] == -1.0*v27 -1.0*v29 -1.0*v33, CoA'[t] == 1.0*v10 +1.0*v15 -1.0*v9 -1.0*v14, CoA\[LetterSpace]cyt'[t] == -1.0*v27, Cytc2p'[t] == 2.0*v25 -1.0*v26, Cytc3p'[t] == 1.0*v26 -2.0*v25, DHAP'[t] == 1.0*v37 -1.0*v38, DPG'[t] == 1.0*v4 -1.0*v5, ETFox'[t] == 1.0*v34 -1.0*v35, ETFred'[t] == 1.0*v35 -1.0*v34, F6P'[t] == 1.0*v1 -1.0*v2, FAD'[t] == 1.0*v35 -1.0*v37, FADH2'[t] == 1.0*v37 -1.0*v35, FBP'[t] == 1.0*v2 -1.0*v3, Fum'[t] == 1.0*v16 -1.0*v17, G3P'[t] == 1.0*v38 -1.0*v37, GAP'[t] == 2.0*v3 -1.0*GAPflow -1.0*v4, GDP'[t] == -1.0*v15, GLC'[t] == 1.0*GLCflow -1.0*v1, GTP'[t] == 1.0*v15 , Glu'[t] == 1.0*v20 +1.0*v22 -1.0*v21, Glu\[LetterSpace]cyt'[t] == 1.0*v32 -1.0*v22, H2O'[t] == 1.0*v28 , IsoCit'[t] == 1.0*v11 +1.0*v42 -1.0*v12, IsoCitcyt'[t] == 1.0*v29 -1.0*v41 -1.0*v42, LAC'[t] == 1.0*v7 -1.0*LACflow, Mal'[t] == 1.0*v17 +1.0*v30 -1.0*v18 -1.0*v33 -1.0*v42 -1.0*v44, Mal\[LetterSpace]cyt'[t] == 1.0*v31 +1.0*v33 +1.0*v42 -1.0*v30 -1.0*v39, NAD'[t] == 1.0*v7 +1.0*v31 +1.0*v38 -1.0*v4, NADH'[t] == 1.0*v9 +1.0*v12 +1.0*v14 +1.0*v18 -1.0*v24, NADH\[LetterSpace]cyt'[t] == 1.0*v4 -1.0*v7 -1.0*v31 -1.0*v38, NADPH'[t] == 1.0*v44 , NADPH\[LetterSpace]cyt'[t] == 1.0*v41 +1.0*v39 , NADP\[LetterSpace]cyt'[t] == -1.0*v41 -1.0*v39, NADP\[LetterSpace]p'[t] == -1.0*v44, NAD\[LetterSpace]p'[t] == 1.0*v24 -1.0*v9 -1.0*v12 -1.0*v14 -1.0*v18, OG'[t] == 1.0*v12 +1.0*v21 -1.0*v14 -1.0*v20 -1.0*v30, OG\[LetterSpace]cyt'[t] == 1.0*v30 +1.0*v41 -1.0*v32, OXA'[t] == 1.0*v18 +1.0*v36 -1.0*v10 -1.0*v21, OXA\[LetterSpace]cyt'[t] == 1.0*v27 +1.0*v32 -1.0*v31, PEP'[t] == 1.0*v5 -1.0*v6, PYR\[LetterSpace]cyt'[t] == 1.0*v6 +1.0*v39 -1.0*v7 -1.0*v8, Pi'[t] == 1.0*v36 -1.0*v15 -1.0*v28, Pyr'[t] == 1.0*v8 +1.0*v20 +1.0*v44 -1.0*v9 -1.0*v36, Q'[t] == 1.0*v25 -1.0*v16 -1.0*v24 -1.0*v34, QH2'[t] == 1.0*v16 +1.0*v24 +1.0*v34 -1.0*v25, SCoA'[t] == 1.0*v14 -1.0*v15, Suc'[t] == 1.0*v15 -1.0*v16 }; timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}]; (* Steady-state solution initialized with result of time evolution *) findRootEquations = odes /.D[_[t],t]->0; findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2]; steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100] fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations (* Plot the time evolution of the variables *) plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]