begin name
hornberg1
end name

begin reactions
v1 {1.0}R = {1.0}Rin
v2 {1.0}Rin = {1.0}R
v3 {1.0}x1 = {1.0}x1p
v4 {1.0}x1p = {1.0}x1
v5 {1.0}x2 = {1.0}x2p
v6 {1.0}x2p = {1.0}x2
v7 {1.0}x3 = {1.0}x3p
v8 {1.0}x3p = {1.0}x3
end reactions

begin rate equations
v1 = (Vm1*R[t])/(Km1 + R[t])
v2 = (Vm2*Rin[t])/(Km2 + Rin[t])
v3 = (k3*R[t]*x1[t])/(Km3 + x1[t])
v4 = (Vm4*x1p[t])/(Km4 + x1p[t])
v5 = (k5*x1p[t]*x2[t])/(Km5 + x2[t])
v6 = (Vm6*x2p[t])/(Km6 + x2p[t])
v7 = (k7*x2p[t]*x3[t])/(Km7 + x3[t])
v8 = (Vm8*x3p[t])/(Km8*(1 + Inh/Ki8 + x3p[t]/Km8))
end rate equations

begin parameters
Ki8 = 1.0
Km1 = 0.1
Km2 = 0.1
Km3 = 0.1
Km4 = 1.0
Km5 = 0.1
Km6 = 1.0
Km7 = 0.1
Km8 = 1.0
Vm1 = 1.0
Vm2 = 0.01
Vm4 = 0.3
Vm6 = 0.3
Vm8 = 0.3
k3 = 1.0
k5 = 1.0
k7 = 1.0
Inh = 0.0
defaultcompartment = 1.0
end parameters

begin initial conditions
R[0] = Ri
Rin[0] = Rini
x1[0] = x1i
x1p[0] = x1pi
x2[0] = x2i
x2p[0] = x2pi
x3[0] = x3i
x3p[0] = x3pi
end initial conditions

begin initial values
Ri = 0.5
Rini = 0.0
x1i = 1.0
x1pi = 0.0
x2i = 1.0
x2pi = 0.0
x3i = 1.0
x3pi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units