#hockin1



#reactions
R1:
 {1.0}TF + {1.0}VII = {1.0}TF_VII
  compartment_1 * (k2 * TF * VII - k1 * TF_VII)
R10:
 {1.0}IIa + {1.0}VIII = {1.0}IIa + {1.0}VIIIa
  compartment_1 * k17 * IIa * VIII
R11:
 {1.0}IXa + {1.0}VIIIa = {1.0}IXa_VIIIa
  compartment_1 * (k19 * IXa * VIIIa - k18 * IXa_VIIIa)
R12:
 {1.0}IXa_VIIIa + {1.0}X = {1.0}IXa_VIIIa_X
  compartment_1 * (k21 * IXa_VIIIa * X - k20 * IXa_VIIIa_X)
R12b:
 {1.0}IXa_VIIIa_X = {1.0}IXa_VIIIa + {1.0}Xa
  compartment_1 * k22 * IXa_VIIIa_X
R13:
 {1.0}VIIIa = {1.0}VIIIa1_L + {1.0}VIIIa2
  compartment_1 * (k24 * VIIIa - k23 * VIIIa1_L * VIIIa2)
R14:
 {1.0}IXa_VIIIa_X = {1.0}VIIIa1_L + {1.0}VIIIa2 + {1.0}X + {1.0}IXa
  compartment_1 * k25 * IXa_VIIIa_X
R15:
 {1.0}IXa_VIIIa = {1.0}VIIIa1_L + {1.0}VIIIa2 + {1.0}IXa
  compartment_1 * k25 * IXa_VIIIa
R16:
 {1.0}IIa + {1.0}V = {1.0}IIa + {1.0}Va
  compartment_1 * k26 * IIa * V
R17:
 {1.0}Xa + {1.0}Va = {1.0}Xa_Va
  compartment_1 * (k28 * Xa * Va - k27 * Xa_Va)
R18:
 {1.0}Xa_Va + {1.0}II = {1.0}Xa_Va_II
  compartment_1 * (k30 * Xa_Va * II - k29 * Xa_Va_II)
R18b:
 {1.0}Xa_Va_II = {1.0}Xa_Va + {1.0}mIIa
  compartment_1 * k31 * Xa_Va_II
R19:
 {1.0}mIIa + {1.0}Xa_Va = {1.0}IIa + {1.0}Xa_Va
  compartment_1 * k32 * mIIa * Xa_Va
R2:
 {1.0}TF + {1.0}VIIa = {1.0}TF_VIIa
  compartment_1 * (k4 * TF * VIIa - k3 * TF_VIIa)
R20:
 {1.0}Xa + {1.0}TFPI = {1.0}Xa_TFPI
  compartment_1 * (k34 * Xa * TFPI - k33 * Xa_TFPI)
R21:
 {1.0}TF_VIIa_Xa + {1.0}TFPI = {1.0}TF_VIIa_Xa_TFPI
  compartment_1 * (k36 * TF_VIIa_Xa * TFPI - k35 * TF_VIIa_Xa_TFPI)
R22:
 {1.0}TF_VIIa + {1.0}Xa_TFPI = {1.0}TF_VIIa_Xa_TFPI
  compartment_1 * k37 * TF_VIIa * Xa_TFPI
R23:
 {1.0}Xa + {1.0}ATIII = {1.0}Xa_ATIII
  compartment_1 * k38 * Xa * ATIII
R24:
 {1.0}mIIa + {1.0}ATIII = {1.0}mIIa_ATIII
  compartment_1 * k39 * mIIa * ATIII
R25:
 {1.0}IXa + {1.0}ATIII = {1.0}IXa_ATIII
  compartment_1 * k40 * IXa * ATIII
R26:
 {1.0}IIa + {1.0}ATIII = {1.0}IIa_ATIII
  compartment_1 * k41 * IIa * ATIII
R27:
 {1.0}TF_VIIa + {1.0}ATIII = {1.0}TF_VIIa_ATIII
  compartment_1 * k42 * TF_VIIa * ATIII
R3:
 {1.0}TF_VIIa + {1.0}VII = {1.0}TF_VIIa + {1.0}VIIa
  compartment_1 * k5 * TF_VIIa * VII
R4:
 {1.0}Xa + {1.0}VII = {1.0}Xa + {1.0}VIIa
  compartment_1 * k6 * Xa * VII
R5:
 {1.0}VII + {1.0}IIa = {1.0}IIa + {1.0}VIIa
  compartment_1 * k7 * IIa * VII
R6:
 {1.0}TF_VIIa + {1.0}X = {1.0}TF_VIIa_X
  compartment_1 * (k9 * TF_VIIa * X - k8 * TF_VIIa_X)
R6b:
 {1.0}TF_VIIa_X = {1.0}TF_VIIa_Xa
  compartment_1 * k10 * TF_VIIa_X
R7:
 {1.0}TF_VIIa + {1.0}Xa = {1.0}TF_VIIa_Xa
  compartment_1 * (k12 * TF_VIIa * Xa - k11 * TF_VIIa_Xa)
R8:
 {1.0}TF_VIIa + {1.0}IX = {1.0}TF_VIIa_IX
  compartment_1 * (k14 * TF_VIIa * IX - k13 * TF_VIIa_IX)
R8b:
 {1.0}TF_VIIa_IX = {1.0}TF_VIIa + {1.0}IXa
  compartment_1 * k15 * TF_VIIa_IX
R9:
 {1.0}Xa + {1.0}II = {1.0}Xa + {1.0}IIa
  compartment_1 * k16 * Xa * II


#parameters
k1 = 0.0031
k10 = 6.0
k11 = 19.0
k12 = 22000000.0
k13 = 2.4
k14 = 10000000.0
k15 = 1.8
k16 = 7500.0
k17 = 20000000.0
k18 = 0.005
k19 = 10000000.0
k2 = 3200000.0
k20 = 0.001
k21 = 100000000.0
k22 = 8.2
k23 = 22000.0
k24 = 0.006
k25 = 0.001
k26 = 20000000.0
k27 = 0.2
k28 = 400000000.0
k29 = 103.0
k3 = 0.0031
k30 = 100000000.0
k31 = 63.5
k32 = 15000000.0
k33 = 0.00036
k34 = 900000.0
k35 = 0.00011
k36 = 320000000.0
k37 = 50000000.0
k38 = 1500.0
k39 = 7100.0
k4 = 23000000.0
k40 = 490.0
k41 = 7100.0
k42 = 230.0
k5 = 440000.0
k6 = 13000000.0
k7 = 23000.0
k8 = 1.05
k9 = 25000000.0
compartment_1 = 1.0


#initial values
ATIII = 3.4e-06
II = 1.4e-06
IIa = 0.0
IIa_ATIII = 0.0
IX = 9e-08
IXa = 0.0
IXa_ATIII = 0.0
IXa_VIIIa = 0.0
IXa_VIIIa_X = 0.0
TF = 2.5e-11
TFPI = 2.5e-09
TF_VII = 0.0
TF_VIIa = 0.0
TF_VIIa_ATIII = 0.0
TF_VIIa_IX = 0.0
TF_VIIa_X = 0.0
TF_VIIa_Xa = 0.0
TF_VIIa_Xa_TFPI = 0.0
V = 2e-08
VII = 1e-08
VIII = 7e-10
VIIIa = 0.0
VIIIa1_L = 0.0
VIIIa2 = 0.0
VIIa = 1e-10
Va = 0.0
X = 1.6e-07
Xa = 0.0
Xa_ATIII = 0.0
Xa_TFPI = 0.0
Xa_Va = 0.0
Xa_Va_II = 0.0
mIIa = 0.0
mIIa_ATIII = 0.0


#assignment rules
!F IIa_plus_1_2mIIa = IIa + 1.2 * mIIa