#heldt1



#reactions
reaction_1:
 {1.0}species_3 + {1.0}species_1 = {1.0}species_2
  compartment_1 * (parameter_1 * species_3 * species_1 - parameter_3 * species_2)
reaction_10:
 {1.0}species_12 + {71.0}species_13 = {1.0}species_17
  compartment_1 * function_1(parameter_13, species_12, species_13)
reaction_11:
 {1.0}species_9 + {8.5}species_14 = {1.0}species_15
  compartment_1 * function_1(parameter_14, species_9, species_14)
reaction_12:
 {1.0}species_15 + {1.0}species_31 = {1.0}species_16
  compartment_1 * parameter_15 * species_15 * species_31
reaction_13:
 {1.0}species_17 = {1.0}species_17 + {1.0}species_18
  compartment_1 * parameter_10 * species_17
reaction_14:
 {1.0}species_18 + {1.0}species_11 = {1.0}species_19
  compartment_1 * parameter_12 * species_18 * species_11
reaction_15:
 {1.0}species_19 + {71.0}species_13 = {1.0}species_9
  compartment_1 * function_1(parameter_13, species_19, species_13)
reaction_16:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_20
  compartment_1 * parameter_39 * species_9
reaction_17:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_21
  compartment_1 * parameter_40 * species_9
reaction_18:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_22
  compartment_1 * parameter_41 * species_9
reaction_19:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_23
  compartment_1 * parameter_42 * species_9
reaction_2:
 {1.0}species_3 + {1.0}species_4 = {1.0}species_5
  compartment_1 * (parameter_2 * species_3 * species_4 - parameter_4 * species_5)
reaction_20:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_24
  compartment_1 * parameter_43 * species_9
reaction_21:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_25
  compartment_1 * parameter_44 * species_9
reaction_22:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_26
  compartment_1 * parameter_45 * species_9
reaction_23:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_27
  compartment_1 * parameter_46 * species_9
reaction_24:
 {1.0}species_21 = {1.0}species_21 + {1.0}species_28
  compartment_1 * parameter_16 * species_21
reaction_25:
 {1.0}species_20 = {1.0}species_20 + {1.0}species_29
  compartment_1 * parameter_16 * species_20
reaction_26:
 {1.0}species_22 = {1.0}species_22 + {1.0}species_30
  compartment_1 * parameter_16 * species_22
reaction_27:
 {1.0}species_28 + {1.0}species_29 + {1.0}species_30 = {1.0}species_11
  compartment_1 * parameter_17 * species_28 * species_29 * species_30
reaction_28:
 {1.0}species_24 = {1.0}species_24 + {1.0}species_13
  compartment_1 * parameter_16 * species_24
reaction_29:
 {1.0}species_26 = {1.0}species_26 + {1.0}species_14
  compartment_1 * parameter_27 * species_26
reaction_3:
 {1.0}species_2 = {1.0}species_6 + {1.0}species_1
  compartment_1 * parameter_5 * species_2
reaction_30:
 {1.0}species_27 = {1.0}species_27 + {1.0}species_31
  compartment_1 * parameter_29 * species_27
reaction_31:
 {1.0}species_23 = {1.0}species_23 + {1.0}species_32
  compartment_1 * parameter_16 * species_23
reaction_32:
 {1.0}species_25 = {1.0}species_25 + {1.0}species_33
  compartment_1 * parameter_16 * species_25
reaction_33:
 {1.0}species_26 = {1.0}species_26 + {1.0}species_34
  compartment_1 * parameter_28 * species_26
reaction_34:
 {8.0}species_16 + {37.0}species_11 + {433.0}species_13 + {2932.0}species_14 + {157.0}species_31 + {500.0}species_32 + {100.0}species_33 + {40.0}species_34 = {1.0}species_35
  compartment_1 * function_2(parameter_18, species_16, species_11, KmB, species_32, KmC, species_13, KmD, species_33, KmE, species_14, KmF, species_34, KmG, species_31, KmH)
reaction_35:
 {1.0}species_9 = $pool
  compartment_1 * parameter_20 * species_9
reaction_36:
 {1.0}species_10 = $pool
  compartment_1 * parameter_19 * species_10
reaction_37:
 {1.0}species_18 = $pool
  compartment_1 * parameter_19 * species_18
reaction_38:
 {1.0}species_12 = $pool
  compartment_1 * parameter_22 * species_12
reaction_39:
 {1.0}species_19 = $pool
  compartment_1 * parameter_22 * species_19
reaction_4:
 {1.0}species_5 = {1.0}species_6 + {1.0}species_4
  compartment_1 * parameter_5 * species_5
reaction_40:
 {1.0}species_17 = $pool
  compartment_1 * parameter_20 * species_17
reaction_41:
 {1.0}species_15 = $pool
  compartment_1 * parameter_20 * species_15
reaction_42:
 {1.0}species_16 = $pool
  compartment_1 * parameter_20 * species_16
reaction_43:
 {1.0}species_20 = $pool
  compartment_1 * parameter_21 * species_20
reaction_44:
 {1.0}species_21 = $pool
  compartment_1 * parameter_21 * species_21
reaction_45:
 {1.0}species_22 = $pool
  compartment_1 * parameter_21 * species_22
reaction_46:
 {1.0}species_23 = $pool
  compartment_1 * parameter_21 * species_23
reaction_47:
 {1.0}species_24 = $pool
  compartment_1 * parameter_21 * species_24
reaction_48:
 {1.0}species_25 = $pool
  compartment_1 * parameter_21 * species_25
reaction_49:
 {1.0}species_26 = $pool
  compartment_1 * parameter_21 * species_26
reaction_5:
 {1.0}species_6 = {1.0}species_7 + {8.0}species_8
  compartment_1 * parameter_6 * species_6
reaction_50:
 {1.0}species_27 = $pool
  compartment_1 * parameter_21 * species_27
reaction_6:
 {1.0}species_6 = $pool
  compartment_1 * parameter_7 * species_6
reaction_7:
 {1.0}species_8 = {1.0}species_9
  compartment_1 * parameter_8 * species_8
reaction_8:
 {1.0}species_9 = {1.0}species_9 + {1.0}species_10
  compartment_1 * parameter_11 * species_9
reaction_9:
 {1.0}species_10 + {1.0}species_11 = {1.0}species_12
  compartment_1 * parameter_12 * species_10 * species_11


#parameters
parameter_1 = 0.0809
parameter_10 = 13.86
parameter_11 = 1.38
parameter_12 = 1.0
parameter_13 = 0.000301
parameter_14 = 1.39e-06
parameter_15 = 1e-06
parameter_17 = 1.0
parameter_18 = 0.0037
parameter_19 = 36.36
parameter_2 = 0.000455
parameter_20 = 0.09
parameter_21 = 0.33
parameter_22 = 4.25
parameter_23 = 0.51
parameter_24 = 160.0
parameter_25 = 0.02
parameter_26 = 0.125
parameter_30 = 2320.0
parameter_31 = 2320.0
parameter_32 = 2211.0
parameter_33 = 1757.0
parameter_34 = 1540.0
parameter_35 = 1392.0
parameter_36 = 1005.0
parameter_37 = 868.0
parameter_38 = 250000.0
parameter_47 = 0.0113
parameter_48 = 8.33e-05
parameter_5 = 4.8
parameter_6 = 3.21
parameter_8 = 6.0
parameter_9 = 64800.0
reaction_34_KmB = 450.0
reaction_34_KmC = 5000.0
reaction_34_KmD = 10000.0
reaction_34_KmE = 1000.0
reaction_34_KmF = 30000.0
reaction_34_KmG = 400.0
reaction_34_KmH = 1650.0
compartment_1 = 1.0


#initial values
species_1 = 150.0
species_10 = 0.0
species_11 = 0.0
species_12 = 0.0
species_13 = 0.0
species_14 = 0.0
species_15 = 0.0
species_16 = 0.0
species_17 = 0.0
species_18 = 0.0
species_19 = 0.0
species_2 = 0.0
species_20 = 0.0
species_21 = 0.0
species_22 = 0.0
species_23 = 0.0
species_24 = 0.0
species_25 = 0.0
species_26 = 0.0
species_27 = 0.0
species_28 = 0.0
species_29 = 0.0
species_3 = 10.0
species_30 = 0.0
species_31 = 0.0
species_32 = 0.0
species_33 = 0.0
species_34 = 0.0
species_35 = 0.0
species_4 = 1000.0
species_5 = 0.0
species_6 = 0.0
species_7 = 0.0
species_8 = 0.0
species_9 = 0.0


#assignment rules
!F parameter_7 = (1.0 - parameter_23) / parameter_23 * parameter_6
!F parameter_4 = parameter_2 / parameter_48
!F parameter_3 = parameter_1 / parameter_47
!F parameter_16 = parameter_9 / parameter_24
!F species_37 = species_36 / 8.0
!F species_39 = species_38 / 8.0
!F species_36 = species_10 + species_12 + species_17
!F species_38 = 8.0 * (species_2 + species_5 + species_6) + species_8 + species_9 + species_18 + species_19 + species_15 + species_16
!F parameter_45 = parameter_38 / parameter_36 / 8.0
!F parameter_29 = parameter_9 / parameter_24 * parameter_26
!F parameter_28 = parameter_9 / parameter_24 * parameter_25
!F parameter_42 = parameter_38 / parameter_33 / 8.0
!F parameter_39 = parameter_38 / parameter_30 / 8.0
!F parameter_41 = parameter_38 / parameter_32 / 8.0
!F parameter_40 = parameter_38 / parameter_31 / 8.0
!F parameter_46 = parameter_38 / parameter_37 / 8.0
!F parameter_27 = parameter_9 / parameter_24 * (1.0 - parameter_25)
!F parameter_44 = parameter_38 / parameter_35 / 8.0
!F parameter_43 = parameter_38 / parameter_34 / 8.0