begin name
heldt1
end name

begin reactions
reaction1 {1.0}species3 + {1.0}species1 = {1.0}species2
reaction10 {1.0}species12 + {71.0}species13 = {1.0}species17
reaction11 {1.0}species9 + {8.5}species14 = {1.0}species15
reaction12 {1.0}species15 + {1.0}species31 = {1.0}species16
reaction13 {1.0}species17 = {1.0}species17 + {1.0}species18
reaction14 {1.0}species18 + {1.0}species11 = {1.0}species19
reaction15 {1.0}species19 + {71.0}species13 = {1.0}species9
reaction16 {1.0}species9 = {1.0}species9 + {1.0}species20
reaction17 {1.0}species9 = {1.0}species9 + {1.0}species21
reaction18 {1.0}species9 = {1.0}species9 + {1.0}species22
reaction19 {1.0}species9 = {1.0}species9 + {1.0}species23
reaction2 {1.0}species3 + {1.0}species4 = {1.0}species5
reaction20 {1.0}species9 = {1.0}species9 + {1.0}species24
reaction21 {1.0}species9 = {1.0}species9 + {1.0}species25
reaction22 {1.0}species9 = {1.0}species9 + {1.0}species26
reaction23 {1.0}species9 = {1.0}species9 + {1.0}species27
reaction24 {1.0}species21 = {1.0}species21 + {1.0}species28
reaction25 {1.0}species20 = {1.0}species20 + {1.0}species29
reaction26 {1.0}species22 = {1.0}species22 + {1.0}species30
reaction27 {1.0}species28 + {1.0}species29 + {1.0}species30 = {1.0}species11
reaction28 {1.0}species24 = {1.0}species24 + {1.0}species13
reaction29 {1.0}species26 = {1.0}species26 + {1.0}species14
reaction3 {1.0}species2 = {1.0}species6 + {1.0}species1
reaction30 {1.0}species27 = {1.0}species27 + {1.0}species31
reaction31 {1.0}species23 = {1.0}species23 + {1.0}species32
reaction32 {1.0}species25 = {1.0}species25 + {1.0}species33
reaction33 {1.0}species26 = {1.0}species26 + {1.0}species34
reaction34 {8.0}species16 + {37.0}species11 + {433.0}species13 + {2932.0}species14 + {157.0}species31 + {500.0}species32 + {100.0}species33 + {40.0}species34 = {1.0}species35
reaction35 {1.0}species9 = {1.0}$EXTERNAL
reaction36 {1.0}species10 = {1.0}$EXTERNAL
reaction37 {1.0}species18 = {1.0}$EXTERNAL
reaction38 {1.0}species12 = {1.0}$EXTERNAL
reaction39 {1.0}species19 = {1.0}$EXTERNAL
reaction4 {1.0}species5 = {1.0}species6 + {1.0}species4
reaction40 {1.0}species17 = {1.0}$EXTERNAL
reaction41 {1.0}species15 = {1.0}$EXTERNAL
reaction42 {1.0}species16 = {1.0}$EXTERNAL
reaction43 {1.0}species20 = {1.0}$EXTERNAL
reaction44 {1.0}species21 = {1.0}$EXTERNAL
reaction45 {1.0}species22 = {1.0}$EXTERNAL
reaction46 {1.0}species23 = {1.0}$EXTERNAL
reaction47 {1.0}species24 = {1.0}$EXTERNAL
reaction48 {1.0}species25 = {1.0}$EXTERNAL
reaction49 {1.0}species26 = {1.0}$EXTERNAL
reaction5 {1.0}species6 = {1.0}species7 + {8.0}species8
reaction50 {1.0}species27 = {1.0}$EXTERNAL
reaction6 {1.0}species6 = {1.0}$EXTERNAL
reaction7 {1.0}species8 = {1.0}species9
reaction8 {1.0}species9 = {1.0}species9 + {1.0}species10
reaction9 {1.0}species10 + {1.0}species11 = {1.0}species12
end reactions

begin rate equations
reaction1 = compartment1*(-(parameter3*species2[t]) + parameter1*species1[t]*species3[t])
reaction10 = compartment1*function1[parameter13, species12[t], species13[t]]
reaction11 = compartment1*function1[parameter14, species9[t], species14[t]]
reaction12 = compartment1*parameter15*species15[t]*species31[t]
reaction13 = compartment1*parameter10*species17[t]
reaction14 = compartment1*parameter12*species11[t]*species18[t]
reaction15 = compartment1*function1[parameter13, species19[t], species13[t]]
reaction16 = compartment1*parameter39*species9[t]
reaction17 = compartment1*parameter40*species9[t]
reaction18 = compartment1*parameter41*species9[t]
reaction19 = compartment1*parameter42*species9[t]
reaction2 = compartment1*(parameter2*species3[t]*species4[t] - parameter4*species5[t])
reaction20 = compartment1*parameter43*species9[t]
reaction21 = compartment1*parameter44*species9[t]
reaction22 = compartment1*parameter45*species9[t]
reaction23 = compartment1*parameter46*species9[t]
reaction24 = compartment1*parameter16*species21[t]
reaction25 = compartment1*parameter16*species20[t]
reaction26 = compartment1*parameter16*species22[t]
reaction27 = compartment1*parameter17*species28[t]*species29[t]*species30[t]
reaction28 = compartment1*parameter16*species24[t]
reaction29 = compartment1*parameter27*species26[t]
reaction3 = compartment1*parameter5*species2[t]
reaction30 = compartment1*parameter29*species27[t]
reaction31 = compartment1*parameter16*species23[t]
reaction32 = compartment1*parameter16*species25[t]
reaction33 = compartment1*parameter28*species26[t]
reaction34 = compartment1*function2[parameter18, species16[t], species11[t], reaction34KmB, species32[t], reaction34KmC, species13[t], reaction34KmD, species33[t], reaction34KmE, species14[t], reaction34KmF, species34[t], reaction34KmG, species31[t], reaction34KmH]
reaction35 = compartment1*parameter20*species9[t]
reaction36 = compartment1*parameter19*species10[t]
reaction37 = compartment1*parameter19*species18[t]
reaction38 = compartment1*parameter22*species12[t]
reaction39 = compartment1*parameter22*species19[t]
reaction4 = compartment1*parameter5*species5[t]
reaction40 = compartment1*parameter20*species17[t]
reaction41 = compartment1*parameter20*species15[t]
reaction42 = compartment1*parameter20*species16[t]
reaction43 = compartment1*parameter21*species20[t]
reaction44 = compartment1*parameter21*species21[t]
reaction45 = compartment1*parameter21*species22[t]
reaction46 = compartment1*parameter21*species23[t]
reaction47 = compartment1*parameter21*species24[t]
reaction48 = compartment1*parameter21*species25[t]
reaction49 = compartment1*parameter21*species26[t]
reaction5 = compartment1*parameter6*species6[t]
reaction50 = compartment1*parameter21*species27[t]
reaction6 = compartment1*parameter7*species6[t]
reaction7 = compartment1*parameter8*species8[t]
reaction8 = compartment1*parameter11*species9[t]
reaction9 = compartment1*parameter12*species10[t]*species11[t]
end rate equations

begin parameters
parameter1 = 0.0809
parameter10 = 13.86
parameter11 = 1.38
parameter12 = 1.0
parameter13 = 0.000301
parameter14 = "1.39e-06"
parameter15 = "1e-06"
parameter17 = 1.0
parameter18 = 0.0037
parameter19 = 36.36
parameter2 = 0.000455
parameter20 = 0.09
parameter21 = 0.33
parameter22 = 4.25
parameter23 = 0.51
parameter24 = 160.0
parameter25 = 0.02
parameter26 = 0.125
parameter30 = 2320.0
parameter31 = 2320.0
parameter32 = 2211.0
parameter33 = 1757.0
parameter34 = 1540.0
parameter35 = 1392.0
parameter36 = 1005.0
parameter37 = 868.0
parameter38 = 250000.0
parameter47 = 0.0113
parameter48 = "8.33e-05"
parameter5 = 4.8
parameter6 = 3.21
parameter8 = 6.0
parameter9 = 64800.0
reaction34KmB = 450.0
reaction34KmC = 5000.0
reaction34KmD = 10000.0
reaction34KmE = 1000.0
reaction34KmF = 30000.0
reaction34KmG = 400.0
reaction34KmH = 1650.0
compartment1 = 1.0
end parameters

begin initial conditions
species1[0] = species1i
species10[0] = species10i
species11[0] = species11i
species12[0] = species12i
species13[0] = species13i
species14[0] = species14i
species15[0] = species15i
species16[0] = species16i
species17[0] = species17i
species18[0] = species18i
species19[0] = species19i
species2[0] = species2i
species20[0] = species20i
species21[0] = species21i
species22[0] = species22i
species23[0] = species23i
species24[0] = species24i
species25[0] = species25i
species26[0] = species26i
species27[0] = species27i
species28[0] = species28i
species29[0] = species29i
species3[0] = species3i
species30[0] = species30i
species31[0] = species31i
species32[0] = species32i
species33[0] = species33i
species34[0] = species34i
species35[0] = species35i
species4[0] = species4i
species5[0] = species5i
species6[0] = species6i
species7[0] = species7i
species8[0] = species8i
species9[0] = species9i
end initial conditions

begin initial values
species1i = 150.0
species10i = 0.0
species11i = 0.0
species12i = 0.0
species13i = 0.0
species14i = 0.0
species15i = 0.0
species16i = 0.0
species17i = 0.0
species18i = 0.0
species19i = 0.0
species2i = 0.0
species20i = 0.0
species21i = 0.0
species22i = 0.0
species23i = 0.0
species24i = 0.0
species25i = 0.0
species26i = 0.0
species27i = 0.0
species28i = 0.0
species29i = 0.0
species3i = 10.0
species30i = 0.0
species31i = 0.0
species32i = 0.0
species33i = 0.0
species34i = 0.0
species35i = 0.0
species4i = 1000.0
species5i = 0.0
species6i = 0.0
species7i = 0.0
species8i = 0.0
species9i = 0.0
end initial values

begin assignment rules
parameter7 := ((1 - parameter23)*parameter6)/parameter23
parameter4 := parameter2/parameter48
parameter3 := parameter1/parameter47
parameter16 := parameter9/parameter24
species37 := species36/8
species39 := species38/8
species36 := species10[t] + species12[t] + species17[t]
species38 := species15[t] + species16[t] + species18[t] + species19[t] + 8*(species2[t] + species5[t] + species6[t]) + species8[t] + species9[t]
parameter45 := parameter38/(8*parameter36)
parameter29 := (parameter26*parameter9)/parameter24
parameter28 := (parameter25*parameter9)/parameter24
parameter42 := parameter38/(8*parameter33)
parameter39 := parameter38/(8*parameter30)
parameter41 := parameter38/(8*parameter32)
parameter40 := parameter38/(8*parameter31)
parameter46 := parameter38/(8*parameter37)
parameter27 := ((1 - parameter25)*parameter9)/parameter24
parameter44 := parameter38/(8*parameter35)
parameter43 := parameter38/(8*parameter34)
end assignment rules

begin function definitions
function2[k_,substrateA_,substrateB_,KmB_,substrateC_,KmC_,substrateD_,KmD_,substrateE_,KmE_,substrateF_,KmF_,substrateG_,KmG_,substrateH_,KmH_] := (k*substrateA*substrateB*substrateC*substrateD*substrateE*substrateF*substrateG*substrateH)/((KmB + substrateB)*(KmC + substrateC)*(KmD + substrateD)*(KmE + substrateE)*(KmF + substrateF)*(KmG + substrateG)*(KmH + substrateH))
function1[k_,substratea_,substrateb_] := k*substratea*substrateb
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units