#fuss1



#reactions
CSK_translocation:
 {1.0}CSK_cytoplasm + {1.0}Cbp_P = {1.0}Cbp_P_CSK
  (Cbp_P * kCSKon * CSK_cytoplasm - kCSKoff * Cbp_P_CSK) * default
Cbp_phosphorylation:
 {1.0}Cbp = {1.0}Cbp_P
  kCbp * src_activity * Cbp * default
PTP_phosphorylation:
 {1.0}PTP = {1.0}PTP_pY789
  default * ((kPTP * src_activity + p3) * PTP - p2 * PTP_pY789)
v1:
 {1.0}srci = {1.0}srco
  (k2 * ptp_activity * srci - k1 * Cbp_P_CSK * srco) * default
v2:
 {1.0}srco = {1.0}srca
  (k3 * src_activity * srco - p1 * srca) * default
v3:
 {1.0}srca = {1.0}srcc
  (k1 * Cbp_P_CSK * srca - k2 * ptp_activity * srcc) * default
v4:
 {1.0}srcc = {1.0}srci
  default * k4 * p1 * srcc


#parameters
Kser = 1.0
PTP_background = 0.0
acsk0 = 0.0
k1 = 1.0
k2 = 0.8
k3 = 1.0
k4 = 10.0
kCSKoff = 0.01
kCSKon = 0.1
kCbp = 1.0
kPTP = 1.0
p1 = 0.05
p2 = 0.15
p3 = 0.035
rho_srca = 1.0
rho_srcc = 1.0
rho_srco = 0.0
src_background = 0.0001
default = 1.0


#initial values
CSK_cytoplasm = 1.0
Cbp = 1.0
Cbp_P = 0.0
Cbp_P_CSK = 0.0
PTP = 1.0
PTP_pY789 = 0.0
srca = 0.0
srcc = 0.0
srci = 1.0
srco = 0.0


#assignment rules
!F ptp_activity = PTP_background + Kser * PTP_pY789
!F src_activity = rho_srco * srco + rho_srca * srca + src_background + rho_srcc * srcc