begin name
fung1
end name

begin reactions
RAcs {1.0}$EXTERNAL = {1.0}Acs
RLacI {1.0}$EXTERNAL = {1.0}LacI
RPta {1.0}$EXTERNAL = {1.0}Pta
RdAcs {1.0}Acs = {1.0}$EXTERNAL
RdLacI {1.0}LacI = {1.0}$EXTERNAL
RdPta {1.0}Pta = {1.0}$EXTERNAL
VAce {1.0}OAc = {1.0}HOAc
VAck {1.0}AcP = {1.0}OAc
VAcs {1.0}OAc = {1.0}AcCoA
VPta {1.0}AcCoA = {1.0}AcP
VTCA {1.0}AcCoA = {1.0}$EXTERNAL
Vgly {1.0}$EXTERNAL = {1.0}AcCoA
Vout {1.0}HOAc = {1.0}$HOAcE
end reactions

begin rate equations
RAcs = compartment*(alpha0 + (alpha2*(AcP[t]/Kg2)^n)/(1 + (AcP[t]/Kg2)^n))
RLacI = compartment*(alpha0 + (alpha1*(AcP[t]/Kg1)^n)/(1 + (AcP[t]/Kg1)^n))
RPta = alpha0 + alpha3/(1 + (LacI[t]/Kg3)^n)
RdAcs = compartment*kd*Acs[t]
RdLacI = compartment*kd*LacI[t]
RdPta = compartment*kd*Pta[t]
VAce = C*compartment*(-(Keq*HOAc[t]) + H*OAc[t])
VAck = compartment*(kAckf*AcP[t] - kAckr*OAc[t])
VAcs = (compartment*k2*Acs[t]*OAc[t])/(KM2 + OAc[t])
VPta = (compartment*k1*AcCoA[t]*Pta[t])/(KM1 + AcCoA[t])
VTCA = compartment*kTCA*AcCoA[t]
Vgly = compartment*S0
Vout = compartment*k3*(-HOAcE + HOAc[t])
end rate equations

begin parameters
C = 100.0
H = "1e-07"
KM1 = 0.06
KM2 = 0.1
Keq = 0.0005
Kg1 = 10.0
Kg2 = 10.0
Kg3 = 0.001
S0 = 0.5
alpha0 = 0.0
alpha1 = 0.1
alpha2 = 2.0
alpha3 = 2.0
k1 = 80.0
k2 = 0.8
k3 = 0.01
kAckf = 1.0
kAckr = 1.0
kTCA = 10.0
kd = 0.06
n = 2.0
HOAcE = 0.0
compartment = 1.0
end parameters

begin initial conditions
AcCoA[0] = AcCoAi
AcP[0] = AcPi
Acs[0] = Acsi
HOAc[0] = HOAci
LacI[0] = LacIi
OAc[0] = OAci
Pta[0] = Ptai
end initial conditions

begin initial values
AcCoAi = 0.0
AcPi = 0.0
Acsi = 0.0
HOAci = 0.0
LacIi = 0.0
OAci = 0.0
Ptai = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
V_Pta http://identifiers.org/ec-code/2.3.1.8
V_Pta http://identifiers.org/kegg.reaction/R00230
end process annotations

begin species annotations
AcCoA http://identifiers.org/obo.chebi/CHEBI:15351
AcCoA http://identifiers.org/kegg.compound/C00024
AcP http://identifiers.org/obo.chebi/CHEBI:15350
AcP http://identifiers.org/kegg.compound/C00227
Acs http://identifiers.org/uniprot/P27550
OAc http://identifiers.org/obo.chebi/CHEBI:30089
OAc http://identifiers.org/kegg.compound/C00033
Pta http://identifiers.org/uniprot/P0A9M8
end species annotations

begin units
end units