begin name
figueiredo4
end name

begin reactions
v1 {1.0}erk = {1.0}erkp
v10 {1.0}X2 = {1.0}X1 + {1.0}Ap
v11 {1.0}$extVar = {1.0}IL10m
v12 {1.0}IL10m = {1.0}$extVar
v13 {1.0}$extVar = {1.0}IL10i
v14 {1.0}IL10i = {1.0}$extVar
v15 {1.0}IL10i = {1.0}IL10e
v16 {1.0}IL10e = {1.0}$extVar
v17 {1.0}erkp = {1.0}dusp
v2 {1.0}erkp = {1.0}erk
v3 {1.0}p38 = {1.0}p38p
v4 {1.0}p38p = {1.0}p38
v5 {1.0}A = {1.0}Ap
v6 {1.0}Ap = {1.0}A
v7 {1.0}X0 = {1.0}X1
v8 {1.0}X1 = {1.0}X0
v9 {1.0}X1 + {1.0}Ap = {1.0}X2
end reactions

begin rate equations
v1 = function3[k, stimulus, erk[t], Ki, dusp[t], h]
v10 = k19*X2[t]
v11 = function5[k10, X2[t]]
v12 = k111*IL10m[t]
v13 = function5[k12, IL10m[t]]
v14 = k113*IL10i[t]
v15 = k114*IL10i[t]
v16 = k115*IL10e[t]
v17 = k116*erkp[t]
v2 = k1*erkp[t]
v3 = function4[k2, stimulus, p38[t]]
v4 = k13*p38p[t]
v5 = function4[k4, p38p[t], A[t]]
v6 = k15*Ap[t]
v7 = function4[k6, erkp[t], X0[t]]
v8 = k17*X1[t]
v9 = k18*Ap[t]*X1[t]
end rate equations

begin parameters
Ki = 40.8504
h = 2.14702
k = 10.9349
k1 = 0.311361
k10 = 32.2813
k111 = 0.699176
k113 = 0.001
k114 = 0.0792189
k115 = 12.0329
k116 = 0.634692
k12 = 54.0458
k13 = 0.00640955
k15 = 4.12481
k17 = 31.2592
k18 = 52.7563
k19 = 33.1177
k2 = 1.72266
k4 = 5.2251
k6 = 0.0108484
parameter4 = 0.006389035
parameter5 = 0.044448794
parameter6 = 0.001282198
stimulus = 1.0
extVar = 0.0
default = 1.0
end parameters

begin initial conditions
A[0] = Ai
Ap[0] = Api
IL10e[0] = IL10ei
IL10i[0] = IL10ii
IL10m[0] = IL10mi
X0[0] = X0i
X1[0] = X1i
X2[0] = X2i
dusp[0] = duspi
erk[0] = erki
erkp[0] = erkpi
p38[0] = p38i
p38p[0] = p38pi
end initial conditions

begin initial values
Ai = 10.0
Api = 0.0
IL10ei = 0.0
IL10ii = 0.0
IL10mi = 0.0
X0i = 10.0
X1i = 0.0
X2i = 0.0
duspi = 0.0
erki = 2.0
erkpi = 0.0
p38i = 2.0
p38pi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
function4[k_,Mvar_,S_] := k*Mvar*S
function5[k_,Mvar_] := k*Mvar
function3[k_,Mvar_,S_,Ki_,Ivar_,h_] := (k*Mvar*S)/(1 + Ivar^h*Ki)
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units