begin name
figueiredo1
end name

begin reactions
v1 {1.0}erk = {1.0}erkp
v10 {1.0}X2 = {1.0}X1 + {1.0}Ap
v11 {1.0}$extVar = {1.0}IL10m
v12 {1.0}IL10m = {1.0}$extVar
v13 {1.0}$extVar = {1.0}IL10i
v14 {1.0}IL10i = {1.0}$extVar
v15 {1.0}IL10i = {1.0}IL10e
v16 {1.0}IL10e = {1.0}$extVar
v2 {1.0}erkp = {1.0}erk
v3 {1.0}p38 = {1.0}p38p
v4 {1.0}p38p = {1.0}p38
v5 {1.0}A = {1.0}Ap
v6 {1.0}Ap = {1.0}A
v7 {1.0}X0 = {1.0}X1
v8 {1.0}X1 = {1.0}X0
v9 {1.0}X1 + {1.0}Ap = {1.0}X2
end reactions

begin rate equations
v1 = function1[k, stimulus, erk[t]]
v10 = k19*X2[t]
v11 = function2[k10, X2[t]]
v12 = k111*IL10m[t]
v13 = function2[k12, IL10m[t]]
v14 = k113*IL10i[t]
v15 = k114*IL10i[t]
v16 = k115*IL10e[t]
v2 = k1*erkp[t]
v3 = function1[k2, stimulus, p38[t]]
v4 = k13*p38p[t]
v5 = function1[k4, p38p[t], A[t]]
v6 = k15*Ap[t]
v7 = function1[k6, erkp[t], X0[t]]
v8 = k17*X1[t]
v9 = k18*Ap[t]*X1[t]
end rate equations

begin parameters
k = 99.2692
k1 = 0.1
k10 = 0.0372056
k111 = 1.0
k113 = 0.00178625
k114 = 1.13928
k115 = 1.13709
k12 = 2.39137
k13 = 1.64959
k15 = 0.0322928
k17 = 0.175939
k18 = 99.7689
k19 = 2.64996
k2 = 99.7742
k4 = 99.9658
k6 = 99.934
parameter1 = 0.006389035
parameter2 = 0.044448794
parameter3 = 0.001282198
stimulus = 1.0
extVar = 0.0
default = 1.0
end parameters

begin initial conditions
A[0] = Ai
Ap[0] = Api
IL10e[0] = IL10ei
IL10i[0] = IL10ii
IL10m[0] = IL10mi
X0[0] = X0i
X1[0] = X1i
X2[0] = X2i
erk[0] = erki
erkp[0] = erkpi
p38[0] = p38i
p38p[0] = p38pi
end initial conditions

begin initial values
Ai = 10.0
Api = 0.0
IL10ei = 0.0
IL10ii = 0.0
IL10mi = 0.0
X0i = 10.0
X1i = 0.0
X2i = 0.0
erki = 2.0
erkpi = 0.0
p38i = 2.0
p38pi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
function2[k_,Mvar_] := k*Mvar
function1[k_,Mvar_,S_] := k*Mvar*S
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units