begin name
dupont1
end name

begin reactions
reaction0000001 {1.0}$EXTERNAL = {1.0}z
reaction0000002 {1.0}$EXTERNAL = {1.0}z
reaction0000003 {1.0}y = {1.0}z
reaction0000004 {1.0}z = {1.0}y
reaction0000005 {1.0}y = {1.0}z
reaction0000006 {1.0}z = {1.0}$EXTERNAL
end reactions

begin rate equations
reaction0000001 = beta*Cytosol*v1
reaction0000002 = Cytosol*v0
reaction0000003 = Cytosol*kf*y[t]
reaction0000004 = (intracellularCastorepool*VM2*z[t]^n)/(K2^n + z[t]^n)
reaction0000005 = (Cytosol*VM3*y[t]^m*z[t]^p)/((KR^m + y[t]^m)*(KA^p + z[t]^p))
reaction0000006 = extracellular*k*z[t]
end rate equations

begin parameters
K2 = 1.0
KA = 0.9
KR = 2.0
VM2 = 65.0
VM3 = 500.0
flag = 0.0
k = 10.0
kf = 1.0
m = 2.0
n = 2.0
p = 4.0
tstim = 4.0
v0 = 1.0
v1 = 7.3
Cytosol = 1.0
extracellular = 1.0
intracellularCastorepool = 1.0
end parameters

begin initial conditions
y[0] = yi
z[0] = zi
end initial conditions

begin initial values
yi = 1.4
zi = 0.1
end initial values

begin assignment rules
beta := (0.96*flag)/E^(0.2*(t - tstim))
end assignment rules

begin function definitions
end function definitions

begin events
event_0000001 = (t > tstim, {flag -> 1}, 0)
end events

begin process annotations
end process annotations

begin species annotations
y http://identifiers.org/obo.chebi/CHEBI:29108
y http://identifiers.org/kegg.compound/C00076
z http://identifiers.org/obo.chebi/CHEBI:29108
z http://identifiers.org/kegg.compound/C00076
end species annotations

begin units
end units