(* Generated by JWS Online *) (* This is an experimental feature of JWS Online. Please report any mistakes.*) (* Note that the following notable SBML entities or features are not supported in notebook outputyet: *) (* Events *) (* Constraints *) (* Units and UnitDefinitions *) (* AlgebraicRules *) (* conversionFactors *) variables = { species\[LetterSpace]1[t], species\[LetterSpace]10[t], species\[LetterSpace]11[t], species\[LetterSpace]12[t], species\[LetterSpace]13[t], species\[LetterSpace]14[t], species\[LetterSpace]15[t], species\[LetterSpace]16[t], species\[LetterSpace]17[t], species\[LetterSpace]18[t], species\[LetterSpace]19[t], species\[LetterSpace]2[t], species\[LetterSpace]20[t], species\[LetterSpace]21[t], species\[LetterSpace]22[t], species\[LetterSpace]27[t], species\[LetterSpace]3[t], species\[LetterSpace]4[t], species\[LetterSpace]42[t], species\[LetterSpace]47[t], species\[LetterSpace]5[t], species\[LetterSpace]6[t], species\[LetterSpace]7[t], species\[LetterSpace]8[t], species\[LetterSpace]9[t] }; initialValues = { species\[LetterSpace]1[0] == 0.0, species\[LetterSpace]10[0] == 0.0, species\[LetterSpace]11[0] == 4.3225, species\[LetterSpace]12[0] == 0.0, species\[LetterSpace]13[0] == 12.1175, species\[LetterSpace]14[0] == 0.0, species\[LetterSpace]15[0] == 0.0, species\[LetterSpace]16[0] == 0.0, species\[LetterSpace]17[0] == 0.0, species\[LetterSpace]18[0] == 2.965, species\[LetterSpace]19[0] == 0.0, species\[LetterSpace]2[0] == 0.0, species\[LetterSpace]20[0] == 12.1175, species\[LetterSpace]21[0] == 0.0, species\[LetterSpace]22[0] == 0.0, species\[LetterSpace]27[0] == 144.13, species\[LetterSpace]3[0] == 0.0, species\[LetterSpace]4[0] == 0.0, species\[LetterSpace]42[0] == 2.965, species\[LetterSpace]47[0] == 127.0725, species\[LetterSpace]5[0] == 6.2175, species\[LetterSpace]6[0] == 10.0, species\[LetterSpace]7[0] == 0.0, species\[LetterSpace]8[0] == 0.0, species\[LetterSpace]9[0] == 73.2175 }; rates = { reaction\[LetterSpace]1, reaction\[LetterSpace]10, reaction\[LetterSpace]11, reaction\[LetterSpace]12, reaction\[LetterSpace]13, reaction\[LetterSpace]14, reaction\[LetterSpace]15, reaction\[LetterSpace]16, reaction\[LetterSpace]17, reaction\[LetterSpace]18, reaction\[LetterSpace]19, reaction\[LetterSpace]2, reaction\[LetterSpace]20, reaction\[LetterSpace]22, reaction\[LetterSpace]23, reaction\[LetterSpace]3, reaction\[LetterSpace]31, reaction\[LetterSpace]32, reaction\[LetterSpace]33, reaction\[LetterSpace]4, reaction\[LetterSpace]40, reaction\[LetterSpace]41, reaction\[LetterSpace]44, reaction\[LetterSpace]46, reaction\[LetterSpace]5, reaction\[LetterSpace]53, reaction\[LetterSpace]55, reaction\[LetterSpace]6, reaction\[LetterSpace]61, reaction\[LetterSpace]7, reaction\[LetterSpace]8, reaction\[LetterSpace]9 }; rateEquations = { reaction\[LetterSpace]1 -> compartment\[LetterSpace]2*reaction\[LetterSpace]1\[LetterSpace]k1*species\[LetterSpace]22[t], reaction\[LetterSpace]10 -> compartment\[LetterSpace]2*reaction\[LetterSpace]10\[LetterSpace]k1*species\[LetterSpace]10[t], reaction\[LetterSpace]11 -> compartment\[LetterSpace]2*reaction\[LetterSpace]11\[LetterSpace]k1*species\[LetterSpace]12[t], reaction\[LetterSpace]12 -> compartment\[LetterSpace]2*reaction\[LetterSpace]12\[LetterSpace]k1*species\[LetterSpace]2[t]*species\[LetterSpace]9[t], reaction\[LetterSpace]13 -> compartment\[LetterSpace]2*reaction\[LetterSpace]13\[LetterSpace]k1*species\[LetterSpace]14[t]*species\[LetterSpace]3[t], reaction\[LetterSpace]14 -> compartment\[LetterSpace]2*reaction\[LetterSpace]14\[LetterSpace]k1*species\[LetterSpace]14[t], reaction\[LetterSpace]15 -> reaction\[LetterSpace]15\[LetterSpace]k1*species\[LetterSpace]13[t]*species\[LetterSpace]21[t], reaction\[LetterSpace]16 -> compartment\[LetterSpace]2*reaction\[LetterSpace]16\[LetterSpace]k1*species\[LetterSpace]2[t]*species\[LetterSpace]47[t], reaction\[LetterSpace]17 -> compartment\[LetterSpace]2*reaction\[LetterSpace]17\[LetterSpace]k1*species\[LetterSpace]17[t], reaction\[LetterSpace]18 -> compartment\[LetterSpace]2*reaction\[LetterSpace]18\[LetterSpace]k1*species\[LetterSpace]16[t]*species\[LetterSpace]5[t], reaction\[LetterSpace]19 -> reaction\[LetterSpace]19\[LetterSpace]k1*species\[LetterSpace]18[t]*species\[LetterSpace]21[t], reaction\[LetterSpace]2 -> compartment\[LetterSpace]1*reaction\[LetterSpace]2\[LetterSpace]k1*species\[LetterSpace]21[t], reaction\[LetterSpace]20 -> compartment\[LetterSpace]2*reaction\[LetterSpace]20\[LetterSpace]k1*species\[LetterSpace]16[t], reaction\[LetterSpace]22 -> compartment\[LetterSpace]2*reaction\[LetterSpace]22\[LetterSpace]k1*species\[LetterSpace]17[t]*species\[LetterSpace]42[t], reaction\[LetterSpace]23 -> reaction\[LetterSpace]23\[LetterSpace]k1*species\[LetterSpace]21[t]*species\[LetterSpace]42[t], reaction\[LetterSpace]3 -> compartment\[LetterSpace]2*reaction\[LetterSpace]3\[LetterSpace]k1*species\[LetterSpace]4[t]*species\[LetterSpace]6[t], reaction\[LetterSpace]31 -> compartment\[LetterSpace]2*reaction\[LetterSpace]31\[LetterSpace]k1*species\[LetterSpace]27[t]*species\[LetterSpace]7[t], reaction\[LetterSpace]32 -> compartment\[LetterSpace]2*reaction\[LetterSpace]32\[LetterSpace]k1*species\[LetterSpace]22[t]*species\[LetterSpace]3[t], reaction\[LetterSpace]33 -> compartment\[LetterSpace]2*reaction\[LetterSpace]33\[LetterSpace]k1*species\[LetterSpace]3[t]*species\[LetterSpace]6[t], reaction\[LetterSpace]4 -> compartment\[LetterSpace]2*reaction\[LetterSpace]4\[LetterSpace]k1*species\[LetterSpace]1[t], reaction\[LetterSpace]40 -> compartment\[LetterSpace]2*reaction\[LetterSpace]40\[LetterSpace]k1*species\[LetterSpace]28*species\[LetterSpace]11[t], reaction\[LetterSpace]41 -> compartment\[LetterSpace]1*reaction\[LetterSpace]41\[LetterSpace]k1*species\[LetterSpace]41*species\[LetterSpace]20[t], reaction\[LetterSpace]44 -> compartment\[LetterSpace]2*reaction\[LetterSpace]44\[LetterSpace]k1*species\[LetterSpace]4[t], reaction\[LetterSpace]46 -> compartment\[LetterSpace]2*reaction\[LetterSpace]46\[LetterSpace]k1*species\[LetterSpace]17[t]*species\[LetterSpace]7[t], reaction\[LetterSpace]5 -> compartment\[LetterSpace]1*reaction\[LetterSpace]5\[LetterSpace]k1*species\[LetterSpace]15[t], reaction\[LetterSpace]53 -> compartment\[LetterSpace]2*reaction\[LetterSpace]53\[LetterSpace]k1*species\[LetterSpace]19[t], reaction\[LetterSpace]55 -> compartment\[LetterSpace]2*reaction\[LetterSpace]55\[LetterSpace]k1*species\[LetterSpace]7[t], reaction\[LetterSpace]6 -> compartment\[LetterSpace]2*reaction\[LetterSpace]6\[LetterSpace]k1*species\[LetterSpace]4[t]*species\[LetterSpace]9[t], reaction\[LetterSpace]61 -> compartment\[LetterSpace]2*reaction\[LetterSpace]61\[LetterSpace]k1*species\[LetterSpace]3[t], reaction\[LetterSpace]7 -> compartment\[LetterSpace]2*reaction\[LetterSpace]7\[LetterSpace]k1*species\[LetterSpace]2[t]*species\[LetterSpace]6[t], reaction\[LetterSpace]8 -> compartment\[LetterSpace]2*reaction\[LetterSpace]8\[LetterSpace]k1*species\[LetterSpace]3[t]*species\[LetterSpace]9[t], reaction\[LetterSpace]9 -> compartment\[LetterSpace]2*reaction\[LetterSpace]9\[LetterSpace]k1*species\[LetterSpace]8[t] }; parameters = { species\[LetterSpace]23 -> 2.965, species\[LetterSpace]28 -> 100.0, species\[LetterSpace]41 -> 100.0, reaction\[LetterSpace]9\[LetterSpace]k1 -> 0.00812537, reaction\[LetterSpace]16\[LetterSpace]k1 -> 0.00573896, reaction\[LetterSpace]17\[LetterSpace]k1 -> 0.00528455, reaction\[LetterSpace]22\[LetterSpace]k1 -> 1.0, reaction\[LetterSpace]23\[LetterSpace]k1 -> 0.134664, reaction\[LetterSpace]31\[LetterSpace]k1 -> 0.699505, reaction\[LetterSpace]32\[LetterSpace]k1 -> 4.50769, reaction\[LetterSpace]33\[LetterSpace]k1 -> 0.00627315, reaction\[LetterSpace]40\[LetterSpace]k1 -> 0.0513784, reaction\[LetterSpace]41\[LetterSpace]k1 -> 0.0253763, reaction\[LetterSpace]46\[LetterSpace]k1 -> 0.0001, reaction\[LetterSpace]53\[LetterSpace]k1 -> 0.000100001, reaction\[LetterSpace]55\[LetterSpace]k1 -> 0.00328283, reaction\[LetterSpace]44\[LetterSpace]k1 -> 7.52842, reaction\[LetterSpace]61\[LetterSpace]k1 -> 4.0739, reaction\[LetterSpace]1\[LetterSpace]k1 -> 0.0255714, reaction\[LetterSpace]2\[LetterSpace]k1 -> 0.149328, reaction\[LetterSpace]3\[LetterSpace]k1 -> 0.000100039, reaction\[LetterSpace]4\[LetterSpace]k1 -> 0.0999968, reaction\[LetterSpace]5\[LetterSpace]k1 -> 0.0309731, reaction\[LetterSpace]6\[LetterSpace]k1 -> 0.000100001, reaction\[LetterSpace]7\[LetterSpace]k1 -> 0.999989, reaction\[LetterSpace]8\[LetterSpace]k1 -> 0.0239178, reaction\[LetterSpace]10\[LetterSpace]k1 -> 0.999991, reaction\[LetterSpace]11\[LetterSpace]k1 -> 0.403706, reaction\[LetterSpace]12\[LetterSpace]k1 -> 0.073093, reaction\[LetterSpace]18\[LetterSpace]k1 -> 0.0318902, reaction\[LetterSpace]13\[LetterSpace]k1 -> 5.90372, reaction\[LetterSpace]14\[LetterSpace]k1 -> 1.0, reaction\[LetterSpace]15\[LetterSpace]k1 -> 0.1, reaction\[LetterSpace]19\[LetterSpace]k1 -> 0.999985, reaction\[LetterSpace]20\[LetterSpace]k1 -> 0.000232165, compartment\[LetterSpace]1 -> 1.0, compartment\[LetterSpace]2 -> 1.0 }; assignments = { }; events = { }; speciesAnnotations = { species\[LetterSpace]10[t]->"http://identifiers.org/uniprot/Q96B36", species\[LetterSpace]11[t]->"http://identifiers.org/uniprot/P42345", species\[LetterSpace]12[t]->"http://identifiers.org/uniprot/Q96B36", species\[LetterSpace]13[t]->"http://identifiers.org/uniprot/P49137", species\[LetterSpace]13[t]->"http://identifiers.org/uniprot/P78527", species\[LetterSpace]13[t]->"http://identifiers.org/uniprot/Q13315", species\[LetterSpace]13[t]->"http://identifiers.org/uniprot/Q13153", species\[LetterSpace]14[t]->"http://identifiers.org/uniprot/P78527", species\[LetterSpace]14[t]->"http://identifiers.org/uniprot/Q13315", species\[LetterSpace]14[t]->"http://identifiers.org/uniprot/Q13153", species\[LetterSpace]14[t]->"http://identifiers.org/uniprot/P49137", species\[LetterSpace]15[t]->"http://identifiers.org/uniprot/P06213", species\[LetterSpace]17[t]->"http://identifiers.org/uniprot/P23443", species\[LetterSpace]2[t]->"http://identifiers.org/uniprot/P42345", species\[LetterSpace]20[t]->"http://identifiers.org/uniprot/P06213", species\[LetterSpace]21[t]->"http://identifiers.org/uniprot/P06213", species\[LetterSpace]22[t]->"http://identifiers.org/uniprot/P42345", species\[LetterSpace]27[t]->"http://identifiers.org/uniprot/P31749", species\[LetterSpace]3[t]->"http://identifiers.org/uniprot/P31749", species\[LetterSpace]4[t]->"http://identifiers.org/uniprot/P31749", species\[LetterSpace]41[t]->"http://identifiers.org/uniprot/P01308", species\[LetterSpace]47[t]->"http://identifiers.org/uniprot/P23443", species\[LetterSpace]5[t]->"http://identifiers.org/uniprot/P42345", species\[LetterSpace]9[t]->"http://identifiers.org/uniprot/Q96B36" }; reactionAnnotations = { }; units = { {"time" -> "", "metabolite" -> "", "extent" -> ""} }; (* Time evolution *) odes = { species\[LetterSpace]1'[t] == 1.0*reaction\[LetterSpace]53 -1.0*reaction\[LetterSpace]4, species\[LetterSpace]10'[t] == 1.0*reaction\[LetterSpace]6 +1.0*reaction\[LetterSpace]8 -1.0*reaction\[LetterSpace]10, species\[LetterSpace]11'[t] == 1.0*reaction\[LetterSpace]7 -1.0*reaction\[LetterSpace]40, species\[LetterSpace]12'[t] == 1.0*reaction\[LetterSpace]12 -1.0*reaction\[LetterSpace]11, species\[LetterSpace]13'[t] == 1.0*reaction\[LetterSpace]14 -1.0*reaction\[LetterSpace]15, species\[LetterSpace]14'[t] == 1.0*reaction\[LetterSpace]13 +1.0*reaction\[LetterSpace]15 -1.0*reaction\[LetterSpace]13 -1.0*reaction\[LetterSpace]14, species\[LetterSpace]15'[t] == 1.0*reaction\[LetterSpace]2 -1.0*reaction\[LetterSpace]5, species\[LetterSpace]16'[t] == 1.0*reaction\[LetterSpace]18 +1.0*reaction\[LetterSpace]19 -1.0*reaction\[LetterSpace]18 -1.0*reaction\[LetterSpace]20, species\[LetterSpace]17'[t] == 1.0*reaction\[LetterSpace]16 +1.0*reaction\[LetterSpace]22 +1.0*reaction\[LetterSpace]46 -1.0*reaction\[LetterSpace]17 -1.0*reaction\[LetterSpace]22 -1.0*reaction\[LetterSpace]46, species\[LetterSpace]18'[t] == 1.0*reaction\[LetterSpace]20 -1.0*reaction\[LetterSpace]19, species\[LetterSpace]19'[t] == 1.0*reaction\[LetterSpace]22 +1.0*reaction\[LetterSpace]46 -1.0*reaction\[LetterSpace]53, species\[LetterSpace]2'[t] == 1.0*reaction\[LetterSpace]16 +1.0*reaction\[LetterSpace]40 +1.0*reaction\[LetterSpace]12 -1.0*reaction\[LetterSpace]16 -1.0*reaction\[LetterSpace]7 -1.0*reaction\[LetterSpace]12, species\[LetterSpace]20'[t] == 1.0*reaction\[LetterSpace]5 -1.0*reaction\[LetterSpace]41, species\[LetterSpace]21'[t] == 1.0*reaction\[LetterSpace]23 +1.0*reaction\[LetterSpace]41 +1.0*reaction\[LetterSpace]15 +1.0*reaction\[LetterSpace]19 -1.0*reaction\[LetterSpace]23 -1.0*reaction\[LetterSpace]2 -1.0*reaction\[LetterSpace]15 -1.0*reaction\[LetterSpace]19, species\[LetterSpace]22'[t] == 1.0*reaction\[LetterSpace]32 +1.0*reaction\[LetterSpace]18 -1.0*reaction\[LetterSpace]32 -1.0*reaction\[LetterSpace]1, species\[LetterSpace]27'[t] == 1.0*reaction\[LetterSpace]61 -1.0*reaction\[LetterSpace]31, species\[LetterSpace]3'[t] == 1.0*reaction\[LetterSpace]31 +1.0*reaction\[LetterSpace]33 +1.0*reaction\[LetterSpace]44 +1.0*reaction\[LetterSpace]8 -1.0*reaction\[LetterSpace]32 -1.0*reaction\[LetterSpace]33 -1.0*reaction\[LetterSpace]61 -1.0*reaction\[LetterSpace]8 -1.0*reaction\[LetterSpace]13, species\[LetterSpace]4'[t] == 1.0*reaction\[LetterSpace]32 +1.0*reaction\[LetterSpace]3 +1.0*reaction\[LetterSpace]6 +1.0*reaction\[LetterSpace]13 -1.0*reaction\[LetterSpace]44 -1.0*reaction\[LetterSpace]3 -1.0*reaction\[LetterSpace]6, species\[LetterSpace]42'[t] == 1.0*reaction\[LetterSpace]55 +1.0*reaction\[LetterSpace]4 -1.0*reaction\[LetterSpace]22 -1.0*reaction\[LetterSpace]23, species\[LetterSpace]47'[t] == 1.0*reaction\[LetterSpace]17 -1.0*reaction\[LetterSpace]16, species\[LetterSpace]5'[t] == 1.0*reaction\[LetterSpace]1 -1.0*reaction\[LetterSpace]18, species\[LetterSpace]6'[t] == 1.0*reaction\[LetterSpace]9 +1.0*reaction\[LetterSpace]7 -1.0*reaction\[LetterSpace]33 -1.0*reaction\[LetterSpace]3 -1.0*reaction\[LetterSpace]7, species\[LetterSpace]7'[t] == 1.0*reaction\[LetterSpace]23 +1.0*reaction\[LetterSpace]31 -1.0*reaction\[LetterSpace]31 -1.0*reaction\[LetterSpace]46 -1.0*reaction\[LetterSpace]55, species\[LetterSpace]8'[t] == 1.0*reaction\[LetterSpace]33 +1.0*reaction\[LetterSpace]3 -1.0*reaction\[LetterSpace]9, species\[LetterSpace]9'[t] == 1.0*reaction\[LetterSpace]10 +1.0*reaction\[LetterSpace]11 -1.0*reaction\[LetterSpace]6 -1.0*reaction\[LetterSpace]8 -1.0*reaction\[LetterSpace]12 }; timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}]; (* Steady-state solution initialized with result of time evolution *) findRootEquations = odes /.D[_[t],t]->0; findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2]; steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100] fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations (* Plot the time evolution of the variables *) plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]