begin name
conradie
end name

begin reactions
v1 {1.0}ERG = {1.0}$EXTERNAL
v10 {1.0}CA = {1.0}P27
v11 {1.0}CE = {1.0}CYCE + {1.0}P27
v12 {1.0}CA = {1.0}CYCA + {1.0}P27
v13 {1.0}CE = {1.0}P27
v14 {1.0}CYCE = {1.0}$EXTERNAL
v15 {1.0}P27 = {1.0}$EXTERNAL
v16 {1.0}CE = {1.0}CYCE
v17 {1.0}CD = {1.0}CYCD
v18 {1.0}CA = {1.0}CYCA
v19 {1.0}CYCB = {1.0}$EXTERNAL
v2 {1.0}DRG = {1.0}$EXTERNAL
v20 {1.0}$EXTERNAL = {1.0}CDh1
v21 {1.0}CDh1 = {1.0}$EXTERNAL
v22 {1.0}PPX = {1.0}$EXTERNAL
v23 {1.0}$EXTERNAL = {1.0}IEP
v24 {1.0}IEP = {1.0}$EXTERNAL
v25 {1.0}CDc20T = {1.0}$EXTERNAL
v26 {1.0}$EXTERNAL = {1.0}CDc20
v27 {1.0}CDc20 = {1.0}$EXTERNAL
v28 {1.0}CDc20 = {1.0}$EXTERNAL
v29 {1.0}var5 = {1.0}var1 + {1.0}var2
v3 {1.0}CD = {1.0}P27
v30 {1.0}var6 = {1.0}var1 + {1.0}var3
v31 {1.0}$EXTERNAL = {1.0}GM
v32 {1.0}GM = {1.0}$EXTERNAL
v33 {1.0}$EXTERNAL = {1.0}MASS
v34 {1.0}$EXTERNAL = {1.0}ERG
v35 {1.0}$EXTERNAL = {1.0}CDc20T
v36 {1.0}$EXTERNAL = {1.0}CYCA
v37 {1.0}$EXTERNAL = {1.0}PPX
v38 {1.0}$EXTERNAL = {1.0}CYCE
v39 {1.0}$EXTERNAL = {1.0}CYCD
v4 {1.0}CYCD = {1.0}$EXTERNAL
v40 {1.0}$EXTERNAL = {1.0}P27
v41 {1.0}$EXTERNAL = {1.0}DRG
v42 {1.0}$EXTERNAL = {1.0}CYCB
v43 {1.0}var4 = {1.0}var1
v44 {1.0}var1 = {1.0}var4
v45 {1.0}var5 = {1.0}var2 + {1.0}var4
v46 {1.0}var2 = {1.0}var3
v47 {1.0}var3 = {1.0}var2
v48 {1.0}var2 + {1.0}var4 = {1.0}var5
v49 {1.0}var6 = {1.0}var3 + {1.0}var4
v5 {1.0}CYCE + {1.0}P27 = {1.0}CE
v50 {1.0}var3 + {1.0}var4 = {1.0}var6
v51 {1.0}var6 = {1.0}var5
v52 {1.0}var5 = {1.0}var6
v6 {1.0}CYCA + {1.0}P27 = {1.0}CA
v7 {1.0}CYCD + {1.0}P27 = {1.0}CD
v8 {1.0}CD = {1.0}CYCD + {1.0}P27
v9 {1.0}CYCA = {1.0}$EXTERNAL
end reactions

begin rate equations
v1 = v1k16*ERG[t]
v10 = K30*CA[t]*CDc20[t]
v11 = K25R*CE[t]
v12 = K25R*CA[t]
v13 = V8*CE[t]
v14 = V8*CYCE[t]
v15 = V6*P27[t]
v16 = V6*CE[t]
v17 = V6*CD[t]
v18 = V6*CA[t]
v19 = V2*CYCB[t]
v2 = v2k18*DRG[t]
v20 = ((v20K3a + v20K3*CDc20[t])*(1 - CDh1[t]))/(1 + v20J3 - CDh1[t])
v21 = (V4*CDh1[t])/(v21J4 + CDh1[t])
v22 = v22K34*PPX[t]
v23 = (v23K31*CYCB[t]*(1 - IEP[t]))/(1 + v23J31 - IEP[t])
v24 = (v24K32*IEP[t]*PPX[t])/(v24J32 + IEP[t])
v25 = K12*CDc20T[t]
v26 = (v26K13*(-CDc20[t] + CDc20T[t])*IEP[t])/(v26J13 - CDc20[t] + CDc20T[t])
v27 = (v27K14*CDc20[t])/(v27J14 + CDc20[t])
v28 = K12*CDc20[t]
v29 = K20*(LA*CYCA[t] + LB*CYCB[t] + LD*(CD[t] + CYCD[t]) + LE*CYCE[t])*var5[t]
v3 = K10*CD[t]
v30 = K20*(LA*CYCA[t] + LB*CYCB[t] + LD*(CD[t] + CYCD[t]) + LE*CYCE[t])*var6[t]
v31 = r31switch*v31K27*MASS[t]
v32 = v32K28*GM[t]
v33 = eps*v33MU*GM[t]
v34 = (eps*v34k15)/(1 + DRG[t]^2/v34J15^2)
v35 = eps*(v35K11a + v35K11*CYCB[t])
v36 = eps*v36K29*MASS[t]*var2[t]
v37 = eps*v37K33
v38 = eps*(v38K7a + v38K7*var2[t])
v39 = eps*v39K9*DRG[t]
v4 = K10*CYCD[t]
v40 = eps*v40K5
v41 = eps*((v41k17*DRG[t]^2)/(v41J17^2*(1 + DRG[t]^2/v41J17^2)) + v41k17a*ERG[t])
v42 = eps*(v42K1a + (v42K1*CYCB[t]^2)/(v42J1^2*(1 + CYCB[t]^2/v42J1^2)))
v43 = K20*(LA*CYCA[t] + LB*CYCB[t] + LD*(CD[t] + CYCD[t]) + LE*CYCE[t])*var4[t]
v44 = (PP1A*v44K19 + (-PP1A + PP1T)*v44K19a)*var1[t]
v45 = K26R*var5[t]
v46 = (K23a + K23*(CYCA[t] + CYCB[t]))*var2[t]
v47 = K22*var3[t]
v48 = K26*var2[t]*var4[t]
v49 = K26R*var6[t]
v5 = K25*CYCE[t]*P27[t]
v50 = K26*var3[t]*var4[t]
v51 = K22*var6[t]
v52 = (K23a + K23*(CYCA[t] + CYCB[t]))*var5[t]
v6 = K25*CYCA[t]*P27[t]
v7 = v7k24*CYCD[t]*P27[t]
v8 = v8k24r*CD[t]
v9 = K30*CDc20[t]*CYCA[t]
end rate equations

begin parameters
E2FT = 5.0
FB = 2.0
FE = 25.0
Flag = 1.0
GA = 0.3
GB = 1.0
GE = 0.0
HA = 0.5
HB = 1.0
HE = 0.5
J8 = 0.1
K10 = 5.0
K12 = 1.5
K2 = 20.0
K20 = 10.0
K21 = 1.0
K22 = 1.0
K23 = 1.0
K23a = 0.005
K25 = 1000.0
K25R = 10.0
K26 = 10000.0
K26R = 200.0
K2a = 0.05
K2aa = 1.0
K30 = 20.0
K4 = 40.0
K6 = 100.0
K6a = 10.0
K8 = 2.0
K8a = 0.1
LA = 3.0
LB = 5.0
LD = 3.3
LE = 5.0
PP1T = 1.0
RBT = 10.0
YB = 0.05
YE = 1.0
eps = 1.0
r31switch = 1.0
v2k18 = 10.0
v7k24 = 1000.0
v8k24r = 10.0
v20J3 = 0.01
v20K3 = 140.0
v20K3a = 7.5
v21J4 = 0.01
v22K34 = 0.05
v23J31 = 0.01
v23K31 = 0.7
v24J32 = 0.01
v24K32 = 1.8
v26J13 = 0.005
v26K13 = 5.0
v27J14 = 0.005
v27K14 = 2.5
v31K27 = 0.2
v32K28 = 0.2
v33MU = 0.061
v34J15 = 0.1
v34k15 = 0.25
v35K11 = 1.5
v35K11a = 0.0
v36K29 = 0.05
v37K33 = 0.05
v38K7 = 0.6
v38K7a = 0.0
v39K9 = 2.5
v40K5 = 20.0
v41J17 = 0.3
v41k17 = 10.0
v41k17a = 0.35
v42J1 = 0.1
v42K1 = 0.6
v42K1a = 0.1
v44K19 = 20.0
v44K19a = 0.0
v1k16 = 0.25
cell = 1.0
end parameters

begin initial conditions
CA[0] = CAi
CD[0] = CDi
CDc20[0] = CDc20i
CDc20T[0] = CDc20Ti
CDh1[0] = CDh1i
CE[0] = CEi
CYCA[0] = CYCAi
CYCB[0] = CYCBi
CYCD[0] = CYCDi
CYCE[0] = CYCEi
DRG[0] = DRGi
ERG[0] = ERGi
GM[0] = GMi
IEP[0] = IEPi
MASS[0] = MASSi
P27[0] = P27i
PPX[0] = PPXi
var1[0] = var1i
var2[0] = var2i
var3[0] = var3i
var4[0] = var4i
var5[0] = var5i
var6[0] = var6i
end initial conditions

begin initial values
CAi = 0.0356927
CDi = 0.010976
CDc20i = 0.00220177
CDc20Ti = 2.36733
CDh1i = 0.000653278
CEi = 0.000542587
CYCAi = 1.4094
CYCBi = 2.72898
CYCDi = 0.43929
CYCEi = 0.0229112
DRGi = 0.900533
ERGi = 0.0121809
GMi = 1.35565
IEPi = 0.154655
MASSi = 1.68776
P27i = 0.00922806
PPXi = 1.0
var1i = 9.97574
var2i = 0.989986
var3i = 3.98594
var4i = 0.000190871
var5i = 0.00478911
var6i = 0.0192822
end initial values

begin assignment rules
PP1A := PP1T/(1 + K21*(FB*CYCB[t] + FE*(CYCA[t] + CYCE[t])))
CYCET := CE[t] + CYCE[t]
V2 := K2aa*CDc20[t] + K2a*(1 - CDh1[t]) + K2*CDh1[t]
V4 := K4*(GA*CYCA[t] + GB*CYCB[t] + GE*CYCE[t])
V6 := K6a + K6*(HA*CYCA[t] + HB*CYCB[t] + HE*CYCE[t])
V8 := K8a + (K8*(YB*CYCB[t] + YE*(CYCA[t] + CYCE[t])))/(CYCET + J8)
CYCDT := CD[t] + CYCD[t]
CYCAT := CA[t] + CYCA[t]
P27T := CA[t] + CD[t] + CE[t] + P27[t]
end assignment rules

begin function definitions
end function definitions

begin events
checkEvent = (CDh1[t] < 0.2 && Flag == 2, {Flag -> 1}, 0)
r31Ifpart1 = ((var4[t] + var5[t] + var6[t])/(var1[t] + var4[t] + var5[t] + var6[t]) > 0.8, {r31switch -> 0}, 0)
divisionEvent = (CDh1[t] > 0.2 && Flag == 1, {GM[t] -> 0.5*GM[t], MASS[t] -> 0.5*MASS[t], Flag -> 2}, 0)
r31Ifpart2 = ((var4[t] + var5[t] + var6[t])/(var1[t] + var4[t] + var5[t] + var6[t]) < 0.8, {r31switch -> 1}, 0)
end events

begin process annotations
end process annotations

begin species annotations
CDc20 urn:miriam:uniprot:P26309
CDc20T urn:miriam:uniprot:P26309
CDh1 urn:miriam:uniprot:P12830
IEP urn:miriam:go:GO%3A0005680
MASS urn:miriam:go:GO%3A0016049
P27 urn:miriam:uniprot:P46527
PPX urn:miriam:uniprot:P38698
var1 urn:miriam:uniprot:P06400
var2 urn:miriam:uniprot:Q01094
var3 urn:miriam:uniprot:Q01094
var4 urn:miriam:uniprot:P06400
end species annotations

begin units
end units