begin name clancy2 end name begin reactions reaction0000001 {1.0}IC3 = {1.0}IC2 reaction0000002 {1.0}IC2 = {1.0}IF reaction0000003 {1.0}IF = {1.0}IM1 reaction0000004 {1.0}IM1 = {1.0}IM2 reaction0000005 {1.0}C3 = {1.0}IC3 reaction0000006 {1.0}C2 = {1.0}C3 reaction0000007 {1.0}C2 = {1.0}IC2 reaction0000008 {1.0}C1 = {1.0}C2 reaction0000009 {1.0}C1 = {1.0}IF reaction0000010 {1.0}IF = {1.0}O reaction0000011 {1.0}O = {1.0}C1 end reactions begin rate equations reaction0000001 = cell*(-(b11*IC2[t]) + a11*IC3[t]) reaction0000002 = cell*(a12*IC2[t] - b12*IF[t]) reaction0000003 = cell*(a4*IF[t] - b4*IM1[t]) reaction0000004 = cell*(a5*IM1[t] - b5*IM2[t]) reaction0000005 = cell*(b3*C3[t] - a3*IC3[t]) reaction0000006 = cell*(b11*C2[t] - a11*C3[t]) reaction0000007 = cell*(b3*C2[t] - a3*IC2[t]) reaction0000008 = cell*(b12*C1[t] - a12*C2[t]) reaction0000009 = cell*(b3*C1[t] - a3*IF[t]) reaction0000010 = cell*(b2*IF[t] - a2*O[t]) reaction0000011 = cell*(-(a13*C1[t]) + b13*O[t]) end rate equations begin parameters Fara = 96485.0 Gna = 23.5 Rk = 8314.0 Temp = 310.0 nai = 15.0 nao = 140.0 scale = 1000.0 vhold = -80.0 vtest = -30.0 cell = 1.0 end parameters begin initial conditions C1[0] = C1i C2[0] = C2i C3[0] = C3i IC2[0] = IC2i IC3[0] = IC3i IF[0] = IFi IM1[0] = IM1i IM2[0] = IM2i O[0] = Oi end initial conditions begin initial values C1i = 0.0 C2i = 0.0 C3i = 1.0 IC2i = 0.0 IC3i = 0.0 IFi = 0.0 IM1i = 0.0 IM2i = 0.0 Oi = 0.0 end initial values begin assignment rules a11 := 3.802/(0.1027/E^(v/17) + 0.2/E^(v/150)) a12 := 3.802/(0.1027/E^(v/15) + 0.23/E^(v/150)) a2 := 9.178*E^(0.03369272237196765*v) b13 := 0.22/E^(0.04926108374384236*(-10 + v)) b3 := 0.0084 + v/50000 a4 := 0.09178000000000001*E^(0.03369272237196765*v) b4 := 3.7933*^-7/E^(0.12987012987012986*v) b5 := 7.5866*^-9/E^(0.12987012987012986*v) a5 := 0.00009661052631578948*E^(0.03369272237196765*v) Ena := (Rk*Temp*Log[nao/nai])/Fara b11 := 0.1917/E^(0.04926108374384236*v) b2 := (0.000060166489970363645*E^(0.04926108374384236*(-10 + v) - 0.0961774074981622*v))/((0.1027/E^(v/12) + 0.25/E^(v/150))*(0.0084 + v/50000)) b12 := 0.2/E^(0.04926108374384236*(-5 + v)) Ina := (Gna*(v - (Rk*Temp*Log[nao/nai])/Fara)*O[t])/(scale*(C1[t] + C2[t] + C3[t] + IC2[t] + IC3[t] + IF[t] + IM1[t] + IM2[t] + O[t])) a3 := 3.7933*^-7/E^(0.12987012987012986*v) a13 := 3.802/(0.1027/E^(v/12) + 0.25/E^(v/150)) v := Piecewise[{{vtest, 5 < t && t <= 300}}, vhold] end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units