#chassagnole4

FIX: X

#reactions
v_1:
 {1.0}cglcex + {65.0}cpep = {65.0}cg6p + {65.0}cpyr
  rmaxPTS*cglcex*cpep/cpyr/(KPTSa1+KPTSa2*cpep/cpyr+KPTSa3*cglcex+cglcex*cpep/cpyr)/(1+cg6p**nPTSg6p/KPTSg6p)
v_10:
 {1.0}cfdp = {1.0}cdhap + {1.0}cgap
  rmaxALDO*(cfdp-cgap*cdhap/kALDOeq)/(kALDOfdp+cfdp+kALDOgap/kALDOeq/VALDOblf*cdhap+kALDOdhap/kALDOeq/VALDOblf*cgap+cfdp*cgap/kALDOgapinh+cgap*cdhap/VALDOblf/kALDOeq)
v_11:
 {1.0}cgap = {1.0}cpgp
  rmaxGAPDH*(cgap*cnad-cpgp*cnadh/KGAPDHeq)/(KGAPDHgap*(1+cpgp/KGAPDHpgp)+cgap)/(KGAPDHnad*(1+cnadh/KGAPDHnadh)+cnad)
v_12:
 {1.0}cdhap = {1.0}cgap
  rmaxTIS*(cdhap-cgap/kTISeq)/(kTISdhap*(1+cgap/kTISgap)+cdhap)
v_13:
 {1.0}X = {1.0}cgap + {1.0}cpyr
  rmaxTrpSynth
v_14:
 {1.0}cdhap = {1.0}X
  rmaxG3PDH*cdhap/(KG3PDHdhap+cdhap)
v_15:
 {1.0}cpgp = {1.0}cpg3
  rmaxPGK*(cadp*cpgp-catp*cpg3/KPGKeq)/(KPGKadp*(1+catp/KPGKatp)+cadp)/(KPGKpgp*(1+cpg3/KPGKpg3)+cpgp)
v_16:
 {1.0}cpg3 = {1.0}X
  rmaxSerSynth*cpg3/(KSerSynthpg3+cpg3)
v_17:
 {1.0}cpg3 = {1.0}cpg2
  rmaxPGluMu*(cpg3-cpg2/KPGluMueq)/(KPGluMupg3*(1+cpg2/KPGluMupg2)+cpg3)
v_18:
 {1.0}cpg2 = {1.0}cpep
  rmaxENO*(cpg2-cpep/KENOeq)/(KENOpg2*(1+cpep/KENOpep)+cpg2)
v_19:
 {1.0}cpep = {1.0}cpyr
  rmaxPK*cpep/KPKpep*(cpep/KPKpep+1)**(nPK-1)/(LPK*((1+catp/KPKatp)/(cfdp/KPKfdp+camp/KPKamp+1))**nPK+(cpep/KPKpep+1)**nPK)*cadp/(cadp+KPKadp)
v_2:
 {1.0}cg6p = {1.0}cf6p
  rmaxPGI*(cg6p-cf6p/KPGIeq)/(KPGIg6p*(1+cf6p/KPGIf6p/(1+cpg/KPGIf6ppginh)+cpg/KPGIg6ppginh)+cg6p)
v_20:
 {1.0}cpep = {1.0}X
  rmaxpepCxylase*cpep*(1+(cfdp/KpepCxylasefdp)**npepCxylasefdp)/(KpepCxylasepep+cpep)
v_21:
 {1.0}cpep = {1.0}X
  rmaxSynth1*cpep/(KSynth1pep+cpep)
v_22:
 {1.0}cpyr = {1.0}X
  rmaxSynth2*cpyr/(KSynth2pyr+cpyr)
v_23:
 {1.0}ce4p + {1.0}cpep = {1.0}X
  rmaxDAHPS*ce4p**nDAHPSe4p*cpep**nDAHPSpep/(KDAHPSe4p+ce4p**nDAHPSe4p)/(KDAHPSpep+cpep**nDAHPSpep)
v_24:
 {1.0}cpyr = {1.0}X
  rmaxPDH*cpyr**nPDH/(KPDHpyr+cpyr**nPDH)
v_25:
 {1.0}X = {1.0}cpyr
  rmaxMetSynth
v_26:
 {1.0}cpg = {1.0}cribu5p
  rmaxPGDH*cpg*cnadp/(cpg+KPGDHpg)/(cnadp+KPGDHnadp*(1+cnadph/KPGDHnadphinh)*(1+catp/KPGDHatpinh))
v_27:
 {1.0}cribu5p = {1.0}crib5p
  rmaxR5PI*(cribu5p-crib5p/KR5PIeq)
v_28:
 {1.0}cribu5p = {1.0}cxyl5p
  rmaxRu5P*(cribu5p-cxyl5p/KRu5Peq)
v_29:
 {1.0}crib5p = {1.0}X
  rmaxRPPK*crib5p/(KRPPKrib5p+crib5p)
v_3:
 {1.0}cg6p = {1.0}cg1p
  rmaxPGM*(cg6p-cg1p/KPGMeq)/(KPGMg6p*(1+cg1p/KPGMg1p)+cg6p)
v_30:
 {1.0}cg1p = {1.0}X
  rmaxG1PAT*cg1p*catp*(1+(cfdp/KG1PATfdp)**nG1PATfdp)/(KG1PATatp+catp)/(KG1PATg1p+cg1p)
v_31:
 {1.0}cg6p = {1.0}X
  mu*cg6p
v_32:
 {1.0}cf6p = {1.0}X
  mu*cf6p
v_33:
 {1.0}cfdp = {1.0}X
  mu*cfdp
v_34:
 {1.0}cgap = {1.0}X
  mu*cgap
v_35:
 {1.0}cdhap = {1.0}X
  mu*cdhap
v_36:
 {1.0}cpgp = {1.0}X
  mu*cpgp
v_37:
 {1.0}cpg3 = {1.0}X
  mu*cpg3
v_38:
 {1.0}cpg2 = {1.0}X
  mu*cpg2
v_39:
 {1.0}cpep = {1.0}X
  mu*cpep
v_4:
 {1.0}cg6p = {1.0}cpg
  rmaxG6PDH*cg6p*cnadp/(cg6p+KG6PDHg6p)/(1+cnadph/KG6PDHnadphg6pinh)/(KG6PDHnadp*(1+cnadph/KG6PDHnadphnadpinh)+cnadp)
v_40:
 {1.0}cribu5p = {1.0}X
  mu*cribu5p
v_41:
 {1.0}crib5p = {1.0}X
  mu*crib5p
v_42:
 {1.0}cxyl5p = {1.0}X
  mu*cxyl5p
v_43:
 {1.0}csed7p = {1.0}X
  mu*csed7p
v_44:
 {1.0}cpyr = {1.0}X
  mu*cpyr
v_45:
 {1.0}cpg = {1.0}X
  mu*cpg
v_46:
 {1.0}ce4p = {1.0}X
  mu*ce4p
v_47:
 {1.0}cg1p = {1.0}X
  mu*cg1p
v_48:
 {1.0}X = {1.0}cglcex
  Dil*(cfeed-cglcex)
v_5:
 {1.0}cf6p = {1.0}cfdp
  rmaxPFK*catp/(catp+KPFKatps*(1+cadp/KPFKadpc))*cf6p/(cf6p+KPFKf6ps*(1+cpep/KPFKpep+cadp/KPFKadpb+camp/KPFKampb)/(1+cadp/KPFKadpa+camp/KPFKampa))/(1+LPFK/((1+cf6p/KPFKf6ps/(1+cpep/KPFKpep+cadp/KPFKadpb+camp/KPFKampb)*(1+cadp/KPFKadpa+camp/KPFKampa))**nPFK))
v_6:
 {1.0}cgap + {1.0}csed7p = {1.0}ce4p + {1.0}cf6p
  rmaxTA*(cgap*csed7p-ce4p*cf6p/KTAeq)
v_7:
 {1.0}crib5p + {1.0}cxyl5p = {1.0}cgap + {1.0}csed7p
  rmaxTKa*(crib5p*cxyl5p-csed7p*cgap/KTKaeq)
v_8:
 {1.0}ce4p + {1.0}cxyl5p = {1.0}cf6p + {1.0}cgap
  rmaxTKb*(cxyl5p*ce4p-cf6p*cgap/KTKbeq)
v_9:
 {2.0}cf6p = {1.0}X
  rmaxMurSynth


#parameters
Dil = 2.78e-05
KDAHPSe4p = 0.035
KDAHPSpep = 0.0053
KENOeq = 6.73
KENOpep = 0.135
KENOpg2 = 0.1
KG1PATatp = 4.42
KG1PATfdp = 0.119
KG1PATg1p = 3.2
KG3PDHdhap = 1.0
KG6PDHg6p = 14.4
KG6PDHnadp = 0.0246
KG6PDHnadphg6pinh = 6.43
KG6PDHnadphnadpinh = 0.01
KGAPDHeq = 0.63
KGAPDHgap = 0.683
KGAPDHnad = 0.252
KGAPDHnadh = 1.09
KGAPDHpgp = 1.04e-05
KPDHpyr = 1159.0
KPFKadpa = 128.0
KPFKadpb = 3.89
KPFKadpc = 4.14
KPFKampa = 19.1
KPFKampb = 3.2
KPFKatps = 0.123
KPFKf6ps = 0.325
KPFKpep = 3.26
KPGDHatpinh = 208.0
KPGDHnadp = 0.0506
KPGDHnadphinh = 0.0138
KPGDHpg = 37.5
KPGIeq = 0.1725
KPGIf6p = 0.266
KPGIf6ppginh = 0.2
KPGIg6p = 2.9
KPGIg6ppginh = 0.2
KPGKadp = 0.185
KPGKatp = 0.653
KPGKeq = 1934.4
KPGKpg3 = 0.473
KPGKpgp = 0.0468
KPGMeq = 0.196
KPGMg1p = 0.0136
KPGMg6p = 1.038
KPGluMueq = 0.188
KPGluMupg2 = 0.369
KPGluMupg3 = 0.2
KPKadp = 0.26
KPKamp = 0.2
KPKatp = 22.5
KPKfdp = 0.19
KPKpep = 0.31
KPTSa1 = 3082.3
KPTSa2 = 0.01
KPTSa3 = 245.3
KPTSg6p = 2.15
KR5PIeq = 4.0
KRPPKrib5p = 0.1
KRu5Peq = 1.4
KSerSynthpg3 = 1.0
KSynth1pep = 1.0
KSynth2pyr = 1.0
KTAeq = 1.05
KTKaeq = 1.2
KTKbeq = 10.0
KpepCxylasefdp = 0.7
KpepCxylasepep = 4.07
LPFK = 5629067.0
LPK = 1000.0
VALDOblf = 2.0
cadp = 0.595
camp = 0.955
catp = 4.27
cfeed = 110.96
cnad = 1.47
cnadh = 0.1
cnadp = 0.195
cnadph = 0.062
kALDOdhap = 0.088
kALDOeq = 0.144
kALDOfdp = 1.75
kALDOgap = 0.088
kALDOgapinh = 0.6
kTISdhap = 2.8
kTISeq = 1.39
kTISgap = 0.3
mu = 2.78e-05
nDAHPSe4p = 2.6
nDAHPSpep = 2.2
nG1PATfdp = 1.2
nPDH = 3.68
nPFK = 11.1
nPK = 4.0
nPTSg6p = 3.66
npepCxylasefdp = 4.21
rmaxALDO = 17.41464425
rmaxDAHPS = 0.1079531227
rmaxENO = 330.4476151
rmaxG1PAT = 0.007525458026
rmaxG3PDH = 0.01162042696
rmaxG6PDH = 1.380196955
rmaxGAPDH = 921.5942861
rmaxMetSynth = 0.0022627
rmaxMurSynth = 0.00043711
rmaxPDH = 6.059531017
rmaxPFK = 1840.584747
rmaxPGDH = 16.23235977
rmaxPGI = 650.9878687
rmaxPGK = 3021.773771
rmaxPGM = 0.8398242773
rmaxPGluMu = 89.04965407
rmaxPK = 0.06113150238
rmaxPTS = 7829.78
rmaxR5PI = 4.83841193
rmaxRPPK = 0.01290045226
rmaxRu5P = 6.739029475
rmaxSerSynth = 0.025712107
rmaxSynth1 = 0.01953897003
rmaxSynth2 = 0.07361855055
rmaxTA = 10.87164108
rmaxTIS = 68.67474392
rmaxTKa = 9.473384783
rmaxTKb = 86.55855855
rmaxTrpSynth = 0.001037
rmaxpepCxylase = 0.1070205858
X = 1.0
default_compartment = 1.0


#initial values
cdhap = 0.167
ce4p = 0.098
cf6p = 0.6
cfdp = 0.272
cg1p = 0.6525
cg6p = 3.48
cgap = 0.218
cglcex = 0.0556
cpep = 2.67
cpg = 0.8075
cpg2 = 0.399
cpg3 = 2.131
cpgp = 0.008
cpyr = 2.67
crib5p = 0.398
cribu5p = 0.111
csed7p = 0.276
cxyl5p = 0.138


#assignment rules