begin name
chassagnole4
end name

begin reactions
v1 {1.0}cglcex + {65.0}cpep = {65.0}cg6p + {65.0}cpyr
v10 {1.0}cfdp = {1.0}cdhap + {1.0}cgap
v11 {1.0}cgap = {1.0}cpgp
v12 {1.0}cdhap = {1.0}cgap
v13 {1.0}$X = {1.0}cgap + {1.0}cpyr
v14 {1.0}cdhap = {1.0}$X
v15 {1.0}cpgp = {1.0}cpg3
v16 {1.0}cpg3 = {1.0}$X
v17 {1.0}cpg3 = {1.0}cpg2
v18 {1.0}cpg2 = {1.0}cpep
v19 {1.0}cpep = {1.0}cpyr
v2 {1.0}cg6p = {1.0}cf6p
v20 {1.0}cpep = {1.0}$X
v21 {1.0}cpep = {1.0}$X
v22 {1.0}cpyr = {1.0}$X
v23 {1.0}ce4p + {1.0}cpep = {1.0}$X
v24 {1.0}cpyr = {1.0}$X
v25 {1.0}$X = {1.0}cpyr
v26 {1.0}cpg = {1.0}cribu5p
v27 {1.0}cribu5p = {1.0}crib5p
v28 {1.0}cribu5p = {1.0}cxyl5p
v29 {1.0}crib5p = {1.0}$X
v3 {1.0}cg6p = {1.0}cg1p
v30 {1.0}cg1p = {1.0}$X
v31 {1.0}cg6p = {1.0}$X
v32 {1.0}cf6p = {1.0}$X
v33 {1.0}cfdp = {1.0}$X
v34 {1.0}cgap = {1.0}$X
v35 {1.0}cdhap = {1.0}$X
v36 {1.0}cpgp = {1.0}$X
v37 {1.0}cpg3 = {1.0}$X
v38 {1.0}cpg2 = {1.0}$X
v39 {1.0}cpep = {1.0}$X
v4 {1.0}cg6p = {1.0}cpg
v40 {1.0}cribu5p = {1.0}$X
v41 {1.0}crib5p = {1.0}$X
v42 {1.0}cxyl5p = {1.0}$X
v43 {1.0}csed7p = {1.0}$X
v44 {1.0}cpyr = {1.0}$X
v45 {1.0}cpg = {1.0}$X
v46 {1.0}ce4p = {1.0}$X
v47 {1.0}cg1p = {1.0}$X
v48 {1.0}$X = {1.0}cglcex
v5 {1.0}cf6p = {1.0}cfdp
v6 {1.0}cgap + {1.0}csed7p = {1.0}ce4p + {1.0}cf6p
v7 {1.0}crib5p + {1.0}cxyl5p = {1.0}cgap + {1.0}csed7p
v8 {1.0}ce4p + {1.0}cxyl5p = {1.0}cf6p + {1.0}cgap
v9 {2.0}cf6p = {1.0}$X
end reactions

begin rate equations
v1 = (rmaxPTS*cglcex[t]*cpep[t])/((1 + cg6p[t]^nPTSg6p/KPTSg6p)*(KPTSa1 + KPTSa3*cglcex[t] + (KPTSa2*cpep[t])/cpyr[t] + (cglcex[t]*cpep[t])/cpyr[t])*cpyr[t])
v10 = (rmaxALDO*(cfdp[t] - (cdhap[t]*cgap[t])/kALDOeq))/(kALDOfdp + (kALDOgap*cdhap[t])/(kALDOeq*VALDOblf) + cfdp[t] + (kALDOdhap*cgap[t])/(kALDOeq*VALDOblf) + (cdhap[t]*cgap[t])/(kALDOeq*VALDOblf) + (cfdp[t]*cgap[t])/kALDOgapinh)
v11 = (rmaxGAPDH*(cnad*cgap[t] - (cnadh*cpgp[t])/KGAPDHeq))/((cnad + KGAPDHnad*(1 + cnadh/KGAPDHnadh))*(cgap[t] + KGAPDHgap*(1 + cpgp[t]/KGAPDHpgp)))
v12 = (rmaxTIS*(cdhap[t] - cgap[t]/kTISeq))/(cdhap[t] + kTISdhap*(1 + cgap[t]/kTISgap))
v13 = rmaxTrpSynth
v14 = (rmaxG3PDH*cdhap[t])/(KG3PDHdhap + cdhap[t])
v15 = (rmaxPGK*(-((catp*cpg3[t])/KPGKeq) + cadp*cpgp[t]))/((cadp + KPGKadp*(1 + catp/KPGKatp))*(KPGKpgp*(1 + cpg3[t]/KPGKpg3) + cpgp[t]))
v16 = (rmaxSerSynth*cpg3[t])/(KSerSynthpg3 + cpg3[t])
v17 = (rmaxPGluMu*(-(cpg2[t]/KPGluMueq) + cpg3[t]))/(KPGluMupg3*(1 + cpg2[t]/KPGluMupg2) + cpg3[t])
v18 = (rmaxENO*(-(cpep[t]/KENOeq) + cpg2[t]))/(KENOpg2*(1 + cpep[t]/KENOpep) + cpg2[t])
v19 = (cadp*rmaxPK*cpep[t]*(1 + cpep[t]/KPKpep)^(-1 + nPK))/((cadp + KPKadp)*KPKpep*(LPK*((1 + catp/KPKatp)/(1 + camp/KPKamp + cfdp[t]/KPKfdp))^nPK + (1 + cpep[t]/KPKpep)^nPK))
v2 = (rmaxPGI*(-(cf6p[t]/KPGIeq) + cg6p[t]))/(cg6p[t] + KPGIg6p*(1 + cpg[t]/KPGIg6ppginh + cf6p[t]/(KPGIf6p*(1 + cpg[t]/KPGIf6ppginh))))
v20 = (rmaxpepCxylase*(1 + (cfdp[t]/KpepCxylasefdp)^npepCxylasefdp)*cpep[t])/(KpepCxylasepep + cpep[t])
v21 = (rmaxSynth1*cpep[t])/(KSynth1pep + cpep[t])
v22 = (rmaxSynth2*cpyr[t])/(KSynth2pyr + cpyr[t])
v23 = (rmaxDAHPS*ce4p[t]^nDAHPSe4p*cpep[t]^nDAHPSpep)/((KDAHPSe4p + ce4p[t]^nDAHPSe4p)*(KDAHPSpep + cpep[t]^nDAHPSpep))
v24 = (rmaxPDH*cpyr[t]^nPDH)/(KPDHpyr + cpyr[t]^nPDH)
v25 = rmaxMetSynth
v26 = (cnadp*rmaxPGDH*cpg[t])/((cnadp + (1 + catp/KPGDHatpinh)*KPGDHnadp*(1 + cnadph/KPGDHnadphinh))*(KPGDHpg + cpg[t]))
v27 = rmaxR5PI*(-(crib5p[t]/KR5PIeq) + cribu5p[t])
v28 = rmaxRu5P*(cribu5p[t] - cxyl5p[t]/KRu5Peq)
v29 = (rmaxRPPK*crib5p[t])/(KRPPKrib5p + crib5p[t])
v3 = (rmaxPGM*(-(cg1p[t]/KPGMeq) + cg6p[t]))/(KPGMg6p*(1 + cg1p[t]/KPGMg1p) + cg6p[t])
v30 = (catp*rmaxG1PAT*(1 + (cfdp[t]/KG1PATfdp)^nG1PATfdp)*cg1p[t])/((catp + KG1PATatp)*(KG1PATg1p + cg1p[t]))
v31 = mu*cg6p[t]
v32 = mu*cf6p[t]
v33 = mu*cfdp[t]
v34 = mu*cgap[t]
v35 = mu*cdhap[t]
v36 = mu*cpgp[t]
v37 = mu*cpg3[t]
v38 = mu*cpg2[t]
v39 = mu*cpep[t]
v4 = (cnadp*rmaxG6PDH*cg6p[t])/((1 + cnadph/KG6PDHnadphg6pinh)*(cnadp + KG6PDHnadp*(1 + cnadph/KG6PDHnadphnadpinh))*(KG6PDHg6p + cg6p[t]))
v40 = mu*cribu5p[t]
v41 = mu*crib5p[t]
v42 = mu*cxyl5p[t]
v43 = mu*csed7p[t]
v44 = mu*cpyr[t]
v45 = mu*cpg[t]
v46 = mu*ce4p[t]
v47 = mu*cg1p[t]
v48 = Dil*(cfeed - cglcex[t])
v5 = (catp*rmaxPFK*cf6p[t])/((catp + (1 + cadp/KPFKadpc)*KPFKatps)*(cf6p[t] + (KPFKf6ps*(1 + cadp/KPFKadpb + camp/KPFKampb + cpep[t]/KPFKpep))/(1 + cadp/KPFKadpa + camp/KPFKampa))*(1 + LPFK/(1 + ((1 + cadp/KPFKadpa + camp/KPFKampa)*cf6p[t])/(KPFKf6ps*(1 + cadp/KPFKadpb + camp/KPFKampb + cpep[t]/KPFKpep)))^nPFK))
v6 = rmaxTA*(-((ce4p[t]*cf6p[t])/KTAeq) + cgap[t]*csed7p[t])
v7 = rmaxTKa*(-((cgap[t]*csed7p[t])/KTKaeq) + crib5p[t]*cxyl5p[t])
v8 = rmaxTKb*(-((cf6p[t]*cgap[t])/KTKbeq) + ce4p[t]*cxyl5p[t])
v9 = rmaxMurSynth
end rate equations

begin parameters
Dil = "2.78e-05"
KDAHPSe4p = 0.035
KDAHPSpep = 0.0053
KENOeq = 6.73
KENOpep = 0.135
KENOpg2 = 0.1
KG1PATatp = 4.42
KG1PATfdp = 0.119
KG1PATg1p = 3.2
KG3PDHdhap = 1.0
KG6PDHg6p = 14.4
KG6PDHnadp = 0.0246
KG6PDHnadphg6pinh = 6.43
KG6PDHnadphnadpinh = 0.01
KGAPDHeq = 0.63
KGAPDHgap = 0.683
KGAPDHnad = 0.252
KGAPDHnadh = 1.09
KGAPDHpgp = "1.04e-05"
KPDHpyr = 1159.0
KPFKadpa = 128.0
KPFKadpb = 3.89
KPFKadpc = 4.14
KPFKampa = 19.1
KPFKampb = 3.2
KPFKatps = 0.123
KPFKf6ps = 0.325
KPFKpep = 3.26
KPGDHatpinh = 208.0
KPGDHnadp = 0.0506
KPGDHnadphinh = 0.0138
KPGDHpg = 37.5
KPGIeq = 0.1725
KPGIf6p = 0.266
KPGIf6ppginh = 0.2
KPGIg6p = 2.9
KPGIg6ppginh = 0.2
KPGKadp = 0.185
KPGKatp = 0.653
KPGKeq = 1934.4
KPGKpg3 = 0.473
KPGKpgp = 0.0468
KPGMeq = 0.196
KPGMg1p = 0.0136
KPGMg6p = 1.038
KPGluMueq = 0.188
KPGluMupg2 = 0.369
KPGluMupg3 = 0.2
KPKadp = 0.26
KPKamp = 0.2
KPKatp = 22.5
KPKfdp = 0.19
KPKpep = 0.31
KPTSa1 = 3082.3
KPTSa2 = 0.01
KPTSa3 = 245.3
KPTSg6p = 2.15
KR5PIeq = 4.0
KRPPKrib5p = 0.1
KRu5Peq = 1.4
KSerSynthpg3 = 1.0
KSynth1pep = 1.0
KSynth2pyr = 1.0
KTAeq = 1.05
KTKaeq = 1.2
KTKbeq = 10.0
KpepCxylasefdp = 0.7
KpepCxylasepep = 4.07
LPFK = 5629067.0
LPK = 1000.0
VALDOblf = 2.0
cadp = 0.595
camp = 0.955
catp = 4.27
cfeed = 110.96
cnad = 1.47
cnadh = 0.1
cnadp = 0.195
cnadph = 0.062
kALDOdhap = 0.088
kALDOeq = 0.144
kALDOfdp = 1.75
kALDOgap = 0.088
kALDOgapinh = 0.6
kTISdhap = 2.8
kTISeq = 1.39
kTISgap = 0.3
mu = "2.78e-05"
nDAHPSe4p = 2.6
nDAHPSpep = 2.2
nG1PATfdp = 1.2
nPDH = 3.68
nPFK = 11.1
nPK = 4.0
nPTSg6p = 3.66
npepCxylasefdp = 4.21
rmaxALDO = 17.41464425
rmaxDAHPS = 0.1079531227
rmaxENO = 330.4476151
rmaxG1PAT = 0.007525458026
rmaxG3PDH = 0.01162042696
rmaxG6PDH = 1.380196955
rmaxGAPDH = 921.5942861
rmaxMetSynth = 0.0022627
rmaxMurSynth = 0.00043711
rmaxPDH = 6.059531017
rmaxPFK = 1840.584747
rmaxPGDH = 16.23235977
rmaxPGI = 650.9878687
rmaxPGK = 3021.773771
rmaxPGM = 0.8398242773
rmaxPGluMu = 89.04965407
rmaxPK = 0.06113150238
rmaxPTS = 7829.78
rmaxR5PI = 4.83841193
rmaxRPPK = 0.01290045226
rmaxRu5P = 6.739029475
rmaxSerSynth = 0.025712107
rmaxSynth1 = 0.01953897003
rmaxSynth2 = 0.07361855055
rmaxTA = 10.87164108
rmaxTIS = 68.67474392
rmaxTKa = 9.473384783
rmaxTKb = 86.55855855
rmaxTrpSynth = 0.001037
rmaxpepCxylase = 0.1070205858
X = 1.0
defaultcompartment = 1.0
end parameters

begin initial conditions
cdhap[0] = cdhapi
ce4p[0] = ce4pi
cf6p[0] = cf6pi
cfdp[0] = cfdpi
cg1p[0] = cg1pi
cg6p[0] = cg6pi
cgap[0] = cgapi
cglcex[0] = cglcexi
cpep[0] = cpepi
cpg[0] = cpgi
cpg2[0] = cpg2i
cpg3[0] = cpg3i
cpgp[0] = cpgpi
cpyr[0] = cpyri
crib5p[0] = crib5pi
cribu5p[0] = cribu5pi
csed7p[0] = csed7pi
cxyl5p[0] = cxyl5pi
end initial conditions

begin initial values
cdhapi = 0.167
ce4pi = 0.098
cf6pi = 0.6
cfdpi = 0.272
cg1pi = 0.6525
cg6pi = 3.48
cgapi = 0.218
cglcexi = 0.0556
cpepi = 2.67
cpgi = 0.8075
cpg2i = 0.399
cpg3i = 2.131
cpgpi = 0.008
cpyri = 2.67
crib5pi = 0.398
cribu5pi = 0.111
csed7pi = 0.276
cxyl5pi = 0.138
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units