begin name
chassagnole3
end name

begin reactions
v1 {1.0}$asp + {1.0}$atp = {1.0}aspp + {1.0}$adp
v2 {1.0}aspp + {1.0}$nadph = {1.0}asa + {1.0}$nadp + {1.0}$pi
v3 {1.0}asa + {1.0}$nadph = {1.0}hs + {1.0}$nadp
v4 {1.0}hs + {1.0}$atp = {1.0}hsp + {1.0}$adp
v5 {1.0}hsp = {1.0}$thr + {1.0}$pi
end reactions

begin rate equations
v1 = F1*((prot*vm11*(asp*atp - (adp*aspp[t])/keqak))/((atp + (1 + adp/k1adp)*k1atp)*(asp + (k11*(1 + (thr/k1thr)^nak1))/(1 + (thr/(alpha*k1thr))^nak1) + (k11*aspp[t])/k1aspp)) + (prot*vm13*(asp*atp - (adp*aspp[t])/keqak))/((atp + (1 + adp/k13adp)*k13atp)*(1 + (lys/k1lys)^nak3)*(asp + k13*(1 + aspp[t]/k13aspp))))
v2 = (prot*vm2f*(-((nadp*pi*asa[t])/k2eq) + nadph*aspp[t]))/((k2nadph*(1 + nadp/k2nadp) + nadph)*(k2aspp*(1 + pi/k2p)*(1 + asa[t]/k2asa) + aspp[t]))
v3 = (prot*(1 + (thr/(alpha3*k3thr))^nhdh1)*vm3f*(nadph*asa[t] - (nadp*hs[t])/k3eq))/((1 + asp/k3asp)*(k3nadph*(1 + nadp/k3nadp) + nadph)*(1 + (thr/k3thr)^nhdh1)*(k3asa + asa[t] + (k3asa*hs[t])/k3hs))
v4 = (atp*prot*vm4f*hs[t])/((1 + lys/k4lys)*(k4hs*(1 + atp/k4iatp)*(1 + thr/k4thr) + hs[t])*(atp + k4atp*(1 + hs[t]/k4ihs)))
v5 = (prot*vm5*hsp[t])/(k5hsp + hsp[t])
end rate equations

begin parameters
F1 = 1.0
alpha = 2.47
alpha3 = 3.93
k11 = 0.97
k13 = 0.323
k13adp = 0.25
k13aspp = 0.017
k13atp = 0.225
k1adp = 0.25
k1aspp = 0.017
k1atp = 0.98
k1lys = 0.391
k1thr = 0.167
k2asa = 0.11
k2aspp = 0.022
k2eq = 56.4150334574039
k2nadp = 0.144
k2nadph = 0.0287
k2p = 10.0
k3asa = 0.245
k3asp = 10.0
k3eq = 3162.27766016838
k3hs = 3.39
k3nadp = 0.067
k3nadph = 0.037
k3thr = 0.094
k4atp = 0.072
k4hs = 0.11
k4iatp = 4.35
k4ihs = 4.7
k4lys = 9.45
k4thr = 1.09
k5hsp = 0.307
keqak = 0.000639
lys = 0.46
nak1 = 4.09
nak3 = 2.78
nhdh1 = 1.41
pH = 7.5
prot = 1.0
vm11 = 0.68987
vm13 = 0.33488
vm2f = 0.920322
vm3f = 3.6707
vm4f = 0.54579
vm5 = 0.2392
adp = 0.17
asp = 1.34
atp = 1.31
nadp = 0.63
nadph = 0.56
pi = 5.0
thr = 3.49
defaultcompartment = 1.0
end parameters

begin initial conditions
asa[0] = asai
aspp[0] = asppi
hs[0] = hsi
hsp[0] = hspi
end initial conditions

begin initial values
asai = 0.0
asppi = 0.0
hsi = 0.0
hspi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units