#chassagnole1



#reactions
vak:
 {1.0}atp + {1.0}asp = {1.0}aspp + {1.0}adp
  compartment * (vm11 * (asp * atp - aspp * adp / keqak) / ((k11 * (1 + pow(thr / k1thr, nak1)) / (1 + pow(thr / (alpha * k1thr), nak1)) + k11 * aspp / k1aspp + asp) * (k1atp * (1 + adp / k1adp) + atp)) + vm13 * (asp * atp - aspp * adp / keqak) / ((1 + pow(lys / k1lys, nak3)) * (k13 * (1 + aspp / k13aspp) + asp) * (k13atp * (1 + adp / k13adp) + atp)))
vasd:
 {1.0}nadph + {1.0}aspp = {1.0}nadp + {1.0}phos + {1.0}asa
  compartment * (vm2f * (aspp * nadph - asa * nadp * phos / k2eq) / ((k2aspp * (1 + asa / k2asa) * (1 + phos / k2p) + aspp) * (k2nadph * (1 + nadp / k2nadp) + nadph)))
vatpase:
 {1.0}atp = {1.0}adp + {1.0}phos
  compartment * prot * katpase
vhdh:
 {1.0}nadph + {1.0}asa = {1.0}hs + {1.0}nadp
  compartment * (vm3f * (asa * nadph - hs * nadp / k3eq) / ((1 + pow(thr / k3thr, nhdh1)) / (1 + pow(thr / (alpha3 * k3thr), nhdh1)) * (k3asa + asa + hs * k3asa / k3hs) * (k3nadph * (1 + nadp / k3nadp) + nadph)))
vhk:
 {1.0}hs + {1.0}atp = {1.0}hsp + {1.0}adp
  compartment * (vm4f * hs * atp / ((1 + lys / k4lys) * (atp + k4atp * (1 + hs / k4ihs)) * (hs + k4hs * (1 + thr / k4thr) * (1 + atp / k4iatp))))
vnadph_endo:
 {1.0}nadph = {1.0}nadp
  compartment * prot * knadph * nadph
vtsy:
 {1.0}hsp = {1.0}thr + {1.0}phos
  compartment * vm5 * hsp / (hsp + k5hsp)


#parameters
vak_vm11 = 0.15
vak_keqak = 0.00064
vak_k11 = 0.97
vak_k1thr = 0.167
vak_nak1 = 4.09
vak_alpha = 2.47
vak_k1aspp = 0.017
vak_k1atp = 0.98
vak_k1adp = 0.25
vak_vm13 = 0.0722
vak_lys = 0.46
vak_k1lys = 0.391
vak_nak3 = 2.8
vak_k13 = 0.32
vak_k13aspp = 0.017
vak_k13atp = 0.22
vak_k13adp = 0.25
vasd_vm2f = 0.1812
vasd_k2eq = 56.4150334574039
vasd_k2aspp = 0.022
vasd_k2asa = 0.11
vasd_k2p = 10.0
vasd_k2nadph = 0.029
vasd_k2nadp = 0.144
vhdh_vm3f = 1.001
vhdh_k3eq = 3162.27766016838
vhdh_k3thr = 0.097
vhdh_nhdh1 = 1.41
vhdh_alpha3 = 3.93
vhdh_k3asa = 0.24
vhdh_k3hs = 3.39
vhdh_k3nadph = 0.037
vhdh_k3nadp = 0.067
vtsy_vm5 = 0.0434
vtsy_k5hsp = 0.31
vhk_vm4f = 0.1
vhk_lys = 0.46
vhk_k4lys = 9.45
vhk_k4atp = 0.072
vhk_k4ihs = 4.7
vhk_k4hs = 0.11
vhk_k4thr = 1.09
vhk_k4iatp = 4.35
vnadph_endo_knadph = 5.4e-06
vnadph_endo_prot = 202.0
vatpase_katpase = 4.1e-05
vatpase_prot = 202.0
compartment = 1.0


#initial values
adp = 0.0
asa = 0.0
asp = 2.0
aspp = 0.0
atp = 10.0
hs = 0.0
hsp = 0.0
nadp = 0.0
nadph = 2.0
phos = 0.0
thr = 2.0


#assignment rules