begin name
chassagnole1
end name

begin reactions
vak {1.0}atp + {1.0}asp = {1.0}aspp + {1.0}adp
vasd {1.0}nadph + {1.0}aspp = {1.0}nadp + {1.0}phos + {1.0}asa
vatpase {1.0}atp = {1.0}adp + {1.0}phos
vhdh {1.0}nadph + {1.0}asa = {1.0}hs + {1.0}nadp
vhk {1.0}hs + {1.0}atp = {1.0}hsp + {1.0}adp
vnadphendo {1.0}nadph = {1.0}nadp
vtsy {1.0}hsp = {1.0}thr + {1.0}phos
end reactions

begin rate equations
vak = compartment*((vakvm13*(-((adp[t]*aspp[t])/vakkeqak) + asp[t]*atp[t]))/((1 + (vaklys/vakk1lys)^vaknak3)*(asp[t] + vakk13*(1 + aspp[t]/vakk13aspp))*(vakk13atp*(1 + adp[t]/vakk13adp) + atp[t])) + (vakvm11*(-((adp[t]*aspp[t])/vakkeqak) + asp[t]*atp[t]))/((vakk1atp*(1 + adp[t]/vakk1adp) + atp[t])*(asp[t] + (vakk11*aspp[t])/vakk1aspp + (vakk11*(1 + (thr[t]/vakk1thr)^vaknak1))/(1 + (thr[t]/(vakalpha*vakk1thr))^vaknak1))))
vasd = (compartment*vasdvm2f*(aspp[t]*nadph[t] - (asa[t]*nadp[t]*phos[t])/vasdk2eq))/((vasdk2nadph*(1 + nadp[t]/vasdk2nadp) + nadph[t])*(aspp[t] + vasdk2aspp*(1 + asa[t]/vasdk2asa)*(1 + phos[t]/vasdk2p)))
vatpase = compartment*vatpasekatpase*vatpaseprot
vhdh = (compartment*vhdhvm3f*(-((hs[t]*nadp[t])/vhdhk3eq) + asa[t]*nadph[t])*(1 + (thr[t]/(vhdhalpha3*vhdhk3thr))^vhdhnhdh1))/((vhdhk3asa + asa[t] + (vhdhk3asa*hs[t])/vhdhk3hs)*(vhdhk3nadph*(1 + nadp[t]/vhdhk3nadp) + nadph[t])*(1 + (thr[t]/vhdhk3thr)^vhdhnhdh1))
vhk = (compartment*vhkvm4f*atp[t]*hs[t])/((1 + vhklys/vhkk4lys)*(atp[t] + vhkk4atp*(1 + hs[t]/vhkk4ihs))*(hs[t] + vhkk4hs*(1 + atp[t]/vhkk4iatp)*(1 + thr[t]/vhkk4thr)))
vnadphendo = compartment*vnadphendoknadph*vnadphendoprot*nadph[t]
vtsy = (compartment*vtsyvm5*hsp[t])/(vtsyk5hsp + hsp[t])
end rate equations

begin parameters
vakvm11 = 0.15
vakkeqak = 0.00064
vakk11 = 0.97
vakk1thr = 0.167
vaknak1 = 4.09
vakalpha = 2.47
vakk1aspp = 0.017
vakk1atp = 0.98
vakk1adp = 0.25
vakvm13 = 0.0722
vaklys = 0.46
vakk1lys = 0.391
vaknak3 = 2.8
vakk13 = 0.32
vakk13aspp = 0.017
vakk13atp = 0.22
vakk13adp = 0.25
vasdvm2f = 0.1812
vasdk2eq = 56.4150334574039
vasdk2aspp = 0.022
vasdk2asa = 0.11
vasdk2p = 10.0
vasdk2nadph = 0.029
vasdk2nadp = 0.144
vhdhvm3f = 1.001
vhdhk3eq = 3162.27766016838
vhdhk3thr = 0.097
vhdhnhdh1 = 1.41
vhdhalpha3 = 3.93
vhdhk3asa = 0.24
vhdhk3hs = 3.39
vhdhk3nadph = 0.037
vhdhk3nadp = 0.067
vtsyvm5 = 0.0434
vtsyk5hsp = 0.31
vhkvm4f = 0.1
vhklys = 0.46
vhkk4lys = 9.45
vhkk4atp = 0.072
vhkk4ihs = 4.7
vhkk4hs = 0.11
vhkk4thr = 1.09
vhkk4iatp = 4.35
vnadphendoknadph = "5.4e-06"
vnadphendoprot = 202.0
vatpasekatpase = "4.1e-05"
vatpaseprot = 202.0
compartment = 1.0
end parameters

begin initial conditions
adp[0] = adpi
asa[0] = asai
asp[0] = aspi
aspp[0] = asppi
atp[0] = atpi
hs[0] = hsi
hsp[0] = hspi
nadp[0] = nadpi
nadph[0] = nadphi
phos[0] = phosi
thr[0] = thri
end initial conditions

begin initial values
adpi = 0.0
asai = 0.0
aspi = 2.0
asppi = 0.0
atpi = 10.0
hsi = 0.0
hspi = 0.0
nadpi = 0.0
nadphi = 2.0
phosi = 0.0
thri = 2.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
vak http://identifiers.org/kegg.reaction/R00480
vak http://identifiers.org/ec-code/2.7.2.4
vak http://identifiers.org/obo.go/GO:0004072
vatpase http://identifiers.org/obo.go/GO:0016887
vtsy http://identifiers.org/kegg.reaction/R01466
vtsy http://identifiers.org/ec-code/4.2.3.1
vtsy http://identifiers.org/obo.go/GO:0004795
end process annotations

begin species annotations
adp http://identifiers.org/obo.chebi/CHEBI:16761
adp http://identifiers.org/kegg.compound/C00008
asa http://identifiers.org/obo.chebi/CHEBI:18051
asa http://identifiers.org/kegg.compound/C00441
asp http://identifiers.org/obo.chebi/CHEBI:17053
asp http://identifiers.org/kegg.compound/C00049
aspp http://identifiers.org/obo.chebi/CHEBI:15836
aspp http://identifiers.org/kegg.compound/C03082
atp http://identifiers.org/obo.chebi/CHEBI:15422
atp http://identifiers.org/kegg.compound/C00002
hs http://identifiers.org/obo.chebi/CHEBI:15699
hs http://identifiers.org/kegg.compound/C00263
hsp http://identifiers.org/obo.chebi/CHEBI:15961
hsp http://identifiers.org/kegg.compound/C01102
nadp http://identifiers.org/obo.chebi/CHEBI:18009
nadp http://identifiers.org/kegg.compound/C00006
nadph http://identifiers.org/obo.chebi/CHEBI:16474
nadph http://identifiers.org/kegg.compound/C00005
phos http://identifiers.org/obo.chebi/CHEBI:18367
phos http://identifiers.org/kegg.compound/C00009
thr http://identifiers.org/obo.chebi/CHEBI:16857
thr http://identifiers.org/kegg.compound/C00188
end species annotations

begin units
end units