begin name
bungay3
end name

begin reactions
LB1 {1.0}IIf + {100.0}LIPID = {1.0}IIl
LB10 {1.0}IXaf + {100.0}LIPID = {1.0}IXal
LB11 {1.0}Xf + {100.0}LIPID = {1.0}Xl
LB12 {1.0}Xaf + {100.0}LIPID = {1.0}Xal
LB13 {1.0}APCf + {100.0}LIPID = {1.0}APCl
LB14 {1.0}PSf + {100.0}LIPID = {1.0}PSl
LB15 {1.0}VIIIaif + {100.0}LIPID = {1.0}VIIIail
LB16 {1.0}Vaif + {100.0}LIPID = {1.0}Vail
LB17 {1.0}PCf + {100.0}LIPID = {1.0}PCl
LB2 {1.0}mIIaf + {100.0}LIPID = {1.0}mIIal
LB3 {1.0}Vf + {100.0}LIPID = {1.0}Vl
LB4 {1.0}Vaf + {100.0}LIPID = {1.0}Val
LB5 {1.0}VIIf + {100.0}LIPID = {1.0}VIIl
LB6 {1.0}VIIaf + {100.0}LIPID = {1.0}VIIal
LB7 {1.0}VIIIf + {100.0}LIPID = {1.0}VIIIl
LB8 {1.0}VIIIaf + {100.0}LIPID = {1.0}VIIIal
LB9 {1.0}IXf + {100.0}LIPID = {1.0}IXl
R1 {1.0}VIIal + {1.0}TFl = {1.0}TFVIIal
R10 {1.0}Xal + {1.0}VIIIl = {1.0}VIIIXal
R10b {1.0}VIIIXal = {1.0}Xal + {1.0}VIIIal
R11 {1.0}IIaf + {1.0}Vl = {1.0}VIIal
R11b {1.0}VIIal = {1.0}IIaf + {1.0}Val
R12 {1.0}IIaf + {1.0}VIIIl = {1.0}VIIIIIal
R12b {1.0}VIIIIIal = {1.0}IIaf + {1.0}VIIIal
R13 {1.0}IIl + {1.0}XaVal = {1.0}XaVaIIl
R14 {1.0}mIIal + {1.0}XaVal = {1.0}XaVamIIal
R15 {1.0}XaVaIIl = {1.0}XaVamIIal
R15b {1.0}XaVamIIal = {1.0}IIaf + {1.0}XaVal
R16 {1.0}Xal + {1.0}VIIl = {1.0}VIIXal
R16b {1.0}VIIXal = {1.0}Xal + {1.0}VIIal
R17 {1.0}IIaf + {1.0}XIf = {1.0}XIIIal
R17b {1.0}XIIIal = {1.0}IIaf + {1.0}XIal
R18 {1.0}VIIIal + {1.0}APCPSl = {1.0}APCPSVIIIal
R18b {1.0}APCPSVIIIal = {1.0}VIIIail + {1.0}APCPSl
R19 {1.0}Val + {1.0}APCPSl = {1.0}APCPSVal
R19b {1.0}APCPSVal = {1.0}Vail + {1.0}APCPSl
R2 {1.0}VIIl + {1.0}TFl = {1.0}TFVIIl
R20 {1.0}Xaf + {1.0}TFPIf = {1.0}TFPIXal
R21 {1.0}TFVIIal + {1.0}TFPIXal = {1.0}TFPIXaTFVIIal
R22 {1.0}ATf + {1.0}IXaf = {1.0}IXaATf
R23 {1.0}ATf + {1.0}Xaf = {1.0}XaATf
R24 {1.0}ATf + {1.0}IIaf = {1.0}IIaATf
R25 {1.0}mIIal + {1.0}Vl = {1.0}VmIIal
R25b {1.0}VmIIal = {1.0}mIIal + {1.0}Val
R26 {1.0}mIIal + {1.0}VIIIl = {1.0}VIIImIIal
R26b {1.0}VIIImIIal = {1.0}mIIal + {1.0}VIIIal
R27 {1.0}TMl + {1.0}IIaf = {1.0}IIaTMl
R28 {1.0}PCl + {1.0}IIaTMl = {1.0}IIaTMPCl
R28b {1.0}IIaTMPCl = {1.0}APCl + {1.0}IIaTMl
R29 {1.0}ATf + {1.0}mIIaf = {1.0}mIIaATl
R3 {1.0}IXl + {1.0}TFVIIal = {1.0}TFVIIaIXl
R30 {1.0}PSl + {1.0}APCl = {1.0}APCPSl
R31 {1.0}IXl + {1.0}XIal = {1.0}XIaIXl
R31b {1.0}XIaIXl = {1.0}IXal + {1.0}XIal
R3b {1.0}TFVIIaIXl = {1.0}TFVIIal + {1.0}IXal
R4 {1.0}Xl + {1.0}TFVIIal = {1.0}TFVIIaXl
R4b {1.0}TFVIIaXl = {1.0}TFVIIaXal
R4c {1.0}TFVIIaXal = {1.0}Xal + {1.0}TFVIIal
R5 {1.0}Xal + {1.0}TFVIIl = {1.0}TFVIIXal
R5b {1.0}TFVIIXal = {1.0}Xal + {1.0}TFVIIal
R6 {1.0}VIIIal + {1.0}IXal = {1.0}IXaVIIIal
R7 {1.0}Val + {1.0}Xal = {1.0}XaVal
R8 {1.0}Xl + {1.0}IXaVIIIal = {1.0}IXaVIIIaXl
R8b {1.0}IXaVIIIaXl = {1.0}Xal + {1.0}IXaVIIIal
R9 {1.0}Xal + {1.0}Vl = {1.0}VXal
R9b {1.0}VXal = {1.0}Xal + {1.0}Val
end reactions

begin rate equations
LB1 = compartment*(-(koffII*IIl[t]) + (konII*IIf[t]*LIPID[t])/nva)
LB10 = compartment*(-(koffIXa*IXal[t]) + (konIXa*IXaf[t]*LIPID[t])/nva)
LB11 = compartment*((konX*LIPID[t]*Xf[t])/nva - koffX*Xl[t])
LB12 = (konXa*LIPID[t]*Xaf[t])/nva - koffXa*Xal[t]
LB13 = compartment*(-(koffAPC*APCl[t]) + (konAPC*APCf[t]*LIPID[t])/nva)
LB14 = compartment*((konPS*LIPID[t]*PSf[t])/nva - koffPS*PSl[t])
LB15 = compartment*((konVIIIai*LIPID[t]*VIIIaif[t])/nva - koffVIIIai*VIIIail[t])
LB16 = compartment*((konVai*LIPID[t]*Vaif[t])/nva - koffVai*Vail[t])
LB17 = compartment*((konPC*LIPID[t]*PCf[t])/nva - koffPC*PCl[t])
LB2 = compartment*((konmIIa*LIPID[t]*mIIaf[t])/nva - koffmIIa*mIIal[t])
LB3 = compartment*((konV*LIPID[t]*Vf[t])/nva - koffV*Vl[t])
LB4 = compartment*((konVa*LIPID[t]*Vaf[t])/nva - koffVa*Val[t])
LB5 = compartment*((konVII*LIPID[t]*VIIf[t])/nva - koffVII*VIIl[t])
LB6 = compartment*((konVIIa*LIPID[t]*VIIaf[t])/nva - koffVIIa*VIIal[t])
LB7 = compartment*((konVIII*LIPID[t]*VIIIf[t])/nva - koffVIII*VIIIl[t])
LB8 = compartment*((konVIIIa*LIPID[t]*VIIIaf[t])/nva - koffVIIIa*VIIIal[t])
LB9 = compartment*(-(koffIX*IXl[t]) + (konIX*IXf[t]*LIPID[t])/nva)
R1 = compartment*(-(k2*TFVIIal[t]) + k1*TFl[t]*VIIal[t])
R10 = -(k25*VIIIXal[t]) + k24*VIIIl[t]*Xal[t]
R10b = compartment*k26*VIIIXal[t]
R11 = compartment*(-(k28*VIIal[t]) + k27*IIaf[t]*Vl[t])
R11b = compartment*k29*VIIal[t]
R12 = compartment*(-(k31*VIIIIIal[t]) + k30*IIaf[t]*VIIIl[t])
R12b = compartment*k32*VIIIIIal[t]
R13 = compartment*(-(k34*XaVaIIl[t]) + k33*IIl[t]*XaVal[t])
R14 = compartment*(k35*mIIal[t]*XaVal[t] - k36*XaVamIIal[t])
R15 = compartment*k37*XaVaIIl[t]
R15b = compartment*k38*XaVamIIal[t]
R16 = compartment*(-(k40*VIIXal[t]) + k39*VIIl[t]*Xal[t])
R16b = compartment*k41*VIIXal[t]
R17 = compartment*(k42*IIaf[t]*XIf[t] - k43*XIIIal[t])
R17b = compartment*k44*XIIIal[t]
R18 = compartment*(-(k46*APCPSVIIIal[t]) + k45*APCPSl[t]*VIIIal[t])
R18b = compartment*k47*APCPSVIIIal[t]
R19 = compartment*(-(k49*APCPSVal[t]) + k48*APCPSl[t]*Val[t])
R19b = compartment*k50*APCPSVal[t]
R2 = compartment*(-(k4*TFVIIl[t]) + k3*TFl[t]*VIIl[t])
R20 = compartment*(-(k52*TFPIXal[t]) + k51*TFPIf[t]*Xaf[t])
R21 = compartment*(-(k54*TFPIXaTFVIIal[t]) + k53*TFPIXal[t]*TFVIIal[t])
R22 = compartment*k55*ATf[t]*IXaf[t]
R23 = compartment*k56*ATf[t]*Xaf[t]
R24 = compartment*k57*ATf[t]*IIaf[t]
R25 = compartment*(k58*mIIal[t]*Vl[t] - k59*VmIIal[t])
R25b = compartment*k60*VmIIal[t]
R26 = compartment*(k61*mIIal[t]*VIIIl[t] - k62*VIIImIIal[t])
R26b = compartment*k63*VIIImIIal[t]
R27 = compartment*(-(k65*IIaTMl[t]) + k64*IIaf[t]*TMl[t])
R28 = compartment*(-(k67*IIaTMPCl[t]) + k66*IIaTMl[t]*PCl[t])
R28b = compartment*k68*IIaTMPCl[t]
R29 = compartment*k69*ATf[t]*mIIaf[t]
R3 = compartment*(-(k6*TFVIIaIXl[t]) + k5*IXl[t]*TFVIIal[t])
R30 = compartment*(-(k71*APCPSl[t]) + k70*APCl[t]*PSl[t])
R31 = compartment*(-(k73*XIaIXl[t]) + k72*IXl[t]*XIal[t])
R31b = compartment*k74*XIaIXl[t]
R3b = compartment*k7*TFVIIaIXl[t]
R4 = compartment*(-(k9*TFVIIaXl[t]) + k8*TFVIIal[t]*Xl[t])
R4b = compartment*k10*TFVIIaXl[t]
R4c = compartment*k75*TFVIIaXal[t]
R5 = compartment*(-(k12*TFVIIXal[t]) + k11*TFVIIl[t]*Xal[t])
R5b = compartment*k13*TFVIIXal[t]
R6 = compartment*(-(k15*IXaVIIIal[t]) + k14*IXal[t]*VIIIal[t])
R7 = compartment*(k16*Val[t]*Xal[t] - k17*XaVal[t])
R8 = compartment*(-(k19*IXaVIIIaXl[t]) + k18*IXaVIIIal[t]*Xl[t])
R8b = compartment*k20*IXaVIIIaXl[t]
R9 = compartment*(-(k22*VXal[t]) + k21*Vl[t]*Xal[t])
R9b = compartment*k23*VXal[t]
end rate equations

begin parameters
k1 = 0.5
k10 = 1.5
k11 = 0.05
k12 = 44.8
k13 = 15.2
k14 = 0.1
k15 = 0.2
k16 = 1.0
k17 = 1.0
k18 = 0.1
k19 = 10.7
k2 = 0.005
k20 = 8.3
k21 = 0.1
k22 = 1.0
k23 = 0.043
k24 = 0.1
k25 = 2.1
k26 = 0.023
k27 = 0.1
k28 = 6.94
k29 = 0.23
k3 = 0.005
k30 = 0.1
k31 = 13.8
k32 = 0.9
k33 = 0.1
k34 = 100.0
k35 = 0.1
k36 = 66.0
k37 = 13.0
k38 = 15.0
k39 = 0.05
k4 = 0.005
k40 = 44.8
k41 = 15.2
k42 = 0.1
k43 = 10.0
k44 = 1.43
k45 = 0.1
k46 = 1.6
k47 = 0.4
k48 = 0.1
k49 = 1.6
k5 = 0.01
k50 = 0.4
k51 = 0.016
k52 = 0.00033
k53 = 0.01
k54 = 0.0011
k55 = "4.9e-07"
k56 = "2.3e-06"
k57 = "6.83e-05"
k58 = 0.1
k59 = 6.94
k6 = 2.09
k60 = 1.035
k61 = 0.1
k62 = 13.8
k63 = 0.9
k64 = 1.0
k65 = 0.5
k66 = 0.1
k67 = 6.4
k68 = 3.6
k69 = "6.83e-06"
k7 = 0.34
k70 = 0.1
k71 = 0.5
k72 = 0.01
k73 = 1.417
k74 = 0.183
k75 = 1.0
k8 = 0.1
k9 = 32.5
koffAPC = 3.5
koffII = 1.0
koffIX = 0.115
koffIXa = 0.115
koffPC = 11.5
koffPS = 0.2
koffV = 0.145
koffVII = 0.66
koffVIII = 0.1
koffVIIIa = 0.335
koffVIIIai = 0.335
koffVIIa = 0.227
koffVa = 0.17
koffVai = 0.17
koffX = 1.9
koffXa = 3.3
koffmIIa = 0.475
konAPC = 0.05
konII = 0.0043
konIX = 0.05
konIXa = 0.05
konPC = 0.05
konPS = 0.05
konV = 0.05
konVII = 0.05
konVIII = 0.05
konVIIIa = 0.05
konVIIIai = 0.05
konVIIa = 0.05
konVa = 0.057
konVai = 0.057
konX = 0.01
konXa = 0.029
konmIIa = 0.05
nva = 100.0
compartment = 1.0
end parameters

begin initial conditions
APCPSVIIIal[0] = APCPSVIIIali
APCPSVal[0] = APCPSVali
APCPSl[0] = APCPSli
APCf[0] = APCfi
APCl[0] = APCli
ATf[0] = ATfi
IIf[0] = IIfi
IIl[0] = IIli
IIaATf[0] = IIaATfi
IIaTMPCl[0] = IIaTMPCli
IIaTMl[0] = IIaTMli
IIaf[0] = IIafi
IXf[0] = IXfi
IXl[0] = IXli
IXaATf[0] = IXaATfi
IXaVIIIaXl[0] = IXaVIIIaXli
IXaVIIIal[0] = IXaVIIIali
IXaf[0] = IXafi
IXal[0] = IXali
LIPID[0] = LIPIDi
PCf[0] = PCfi
PCl[0] = PCli
PSf[0] = PSfi
PSl[0] = PSli
TFPIXaTFVIIal[0] = TFPIXaTFVIIali
TFPIXal[0] = TFPIXali
TFPIf[0] = TFPIfi
TFVIIXal[0] = TFVIIXali
TFVIIl[0] = TFVIIli
TFVIIaIXl[0] = TFVIIaIXli
TFVIIaIXal[0] = TFVIIaIXali
TFVIIaXl[0] = TFVIIaXli
TFVIIaXal[0] = TFVIIaXali
TFVIIal[0] = TFVIIali
TFl[0] = TFli
TMl[0] = TMli
VIIIIIal[0] = VIIIIIali
VIIIXal[0] = VIIIXali
VIIIf[0] = VIIIfi
VIIIl[0] = VIIIli
VIIImIIal[0] = VIIImIIali
VIIIaf[0] = VIIIafi
VIIIal[0] = VIIIali
VIIIaif[0] = VIIIaifi
VIIIail[0] = VIIIaili
VIIXal[0] = VIIXali
VIIf[0] = VIIfi
VIIl[0] = VIIli
VIIaf[0] = VIIafi
VIIal[0] = VIIali
VIIal[0] = VIIali
VXal[0] = VXali
Vf[0] = Vfi
Vl[0] = Vli
VmIIal[0] = VmIIali
Vaf[0] = Vafi
Val[0] = Vali
Vaif[0] = Vaifi
Vail[0] = Vaili
XIIIal[0] = XIIIali
XIf[0] = XIfi
XIaIXl[0] = XIaIXli
XIal[0] = XIali
Xf[0] = Xfi
Xl[0] = Xli
XaATf[0] = XaATfi
XaVaIIl[0] = XaVaIIli
XaVal[0] = XaVali
XaVamIIal[0] = XaVamIIali
Xaf[0] = Xafi
Xal[0] = Xali
mIIaATl[0] = mIIaATli
mIIaf[0] = mIIafi
mIIal[0] = mIIali
end initial conditions

begin initial values
APCPSVIIIali = 0.0
APCPSVali = 0.0
APCPSli = 0.0
APCfi = 0.0
APCli = 0.0
ATfi = 3400.0
IIfi = 1400.0
IIli = 0.0
IIaATfi = 0.0
IIaTMPCli = 0.0
IIaTMli = 0.0
IIafi = 0.0
IXfi = 90.0
IXli = 0.0
IXaATfi = 0.0
IXaVIIIaXli = 0.0
IXaVIIIali = 0.0
IXafi = 0.0
IXali = 0.0
LIPIDi = 849079.0
PCfi = 60.0
PCli = 0.0
PSfi = 300.0
PSli = 0.0
TFPIXaTFVIIali = 0.0
TFPIXali = 0.0
TFPIfi = 2.5
TFVIIXali = 0.0
TFVIIli = 0.0
TFVIIaIXli = 0.0
TFVIIaIXali = 0.0
TFVIIaXli = 0.0
TFVIIaXali = 0.0
TFVIIali = 0.0
TFli = 0.005
TMli = 1.0
VIIIIIali = 0.0
VIIIXali = 0.0
VIIIfi = 0.7
VIIIli = 0.0
VIIImIIali = 0.0
VIIIafi = 0.0
VIIIali = 0.0
VIIIaifi = 0.0
VIIIaili = 0.0
VIIXali = 0.0
VIIfi = 10.0
VIIli = 0.0
VIIafi = 0.1
VIIali = 0.0
VIIali = 0.0
VXali = 0.0
Vfi = 20.0
Vli = 0.0
VmIIali = 0.0
Vafi = 0.0
Vali = 0.0
Vaifi = 0.0
Vaili = 0.0
XIIIali = 0.0
XIfi = 30.0
XIaIXli = 0.0
XIali = 0.0
Xfi = 170.0
Xli = 0.0
XaATfi = 0.0
XaVaIIli = 0.0
XaVali = 0.0
XaVamIIali = 0.0
Xafi = 0.0
Xali = 0.0
mIIaATli = 0.0
mIIafi = 0.0
mIIali = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units