begin name
bucher1
end name

begin reactions
ASLProt {1.0}ASLc = {1.0}ASLb
ASLoOHProt {1.0}ASLoOHc = {1.0}ASLoOHb
ASLpOHProt {1.0}ASLpOHc = {1.0}ASLpOHb
ASProt {1.0}ASc = {1.0}ASb
ASoOHProt {1.0}ASoOHc = {1.0}ASoOHb
ASpOHProt {1.0}ASpOHc = {1.0}ASpOHb
CRoOH {1.0}ASLoOHc = {1.0}ASoOHc
CRpOH {1.0}ASLpOHc = {1.0}ASpOHc
CYP3A4ASLoOH {1.0}ASLc = {1.0}ASLoOHc
CYP3A4ASLpOH {1.0}ASLc = {1.0}ASLpOHc
CYP3A4ASoOH {1.0}ASc = {1.0}ASoOHc
CYP3A4ASpOH {1.0}ASc = {1.0}ASpOHc
ExportAS {1.0}ASc = {1.0}ASm
ExportASL {1.0}ASLc = {1.0}ASLm
ExportASLoOH {1.0}ASLoOHc = {1.0}ASLoOHm
ExportASLpOH {1.0}ASLpOHc = {1.0}ASLpOHm
ExportASoOH {1.0}ASoOHc = {1.0}ASoOHm
ExportASpOH {1.0}ASpOHc = {1.0}ASpOHm
ImportAS {1.0}ASm = {1.0}ASc
ImportASL {1.0}ASLm = {1.0}ASLc
ImportASLoOH {1.0}ASLoOHm = {1.0}ASLoOHc
ImportASLpOH {1.0}ASLpOHm = {1.0}ASLpOHc
ImportASoOH {1.0}ASoOHm = {1.0}ASoOHc
ImportASpOH {1.0}ASpOHm = {1.0}ASpOHc
RASASLc {1.0}ASLc = {1.0}ASc
RASASLm {1.0}ASLm = {1.0}ASm
RoOHm {1.0}ASLoOHm = {1.0}ASoOHm
RpOHm {1.0}ASLpOHm = {1.0}ASpOHm
UGT1A3AS {1.0}ASc = {1.0}ASLc
end reactions

begin rate equations
ASLProt = Protk1*(-ASLb[t] + ((1 - fuASL)*ASLc[t])/fuASL)
ASLoOHProt = Protk1*(-ASLoOHb[t] + ((1 - fuASL)*ASLoOHc[t])/fuASL)
ASLpOHProt = Protk1*(-ASLpOHb[t] + ((1 - fuASL)*ASLpOHc[t])/fuASL)
ASProt = Protk1*(-ASb[t] + ((1 - fuAS)*ASc[t])/fuAS)
ASoOHProt = Protk1*(-ASoOHb[t] + ((1 - fuAS)*ASoOHc[t])/fuAS)
ASpOHProt = Protk1*(-ASpOHb[t] + ((1 - fuAS)*ASpOHc[t])/fuAS)
CRoOH = (kCRASLc + kPONOHc)*ASLoOHc[t]
CRpOH = (kCRASLc + kPONOHc)*ASLpOHc[t]
CYP3A4ASLoOH = (CYP3A4ASLoOHVmax*ASLc[t])/(CYP3A4ASLoOHKm1*(1 + ASLc[t]/CYP3A4ASLoOHKm1 + ASLc[t]/CYP3A4ASLpOHKm1 + ASc[t]/CYP3A4ASoOHKm1 + ASc[t]/CYP3A4ASpOHKm1))
CYP3A4ASLpOH = (CYP3A4ASLpOHVmax*ASLc[t])/(CYP3A4ASLpOHKm1*(1 + ASLc[t]/CYP3A4ASLoOHKm1 + ASLc[t]/CYP3A4ASLpOHKm1 + ASc[t]/CYP3A4ASoOHKm1 + ASc[t]/CYP3A4ASpOHKm1))
CYP3A4ASoOH = (CYP3A4ASoOHVmax*ASc[t])/(CYP3A4ASoOHKm1*(1 + ASLc[t]/CYP3A4ASLoOHKm1 + ASLc[t]/CYP3A4ASLpOHKm1 + ASc[t]/CYP3A4ASoOHKm1 + ASc[t]/CYP3A4ASpOHKm1))
CYP3A4ASpOH = (CYP3A4ASpOHVmax*ASc[t])/(CYP3A4ASpOHKm1*(1 + ASLc[t]/CYP3A4ASLoOHKm1 + ASLc[t]/CYP3A4ASLpOHKm1 + ASc[t]/CYP3A4ASoOHKm1 + ASc[t]/CYP3A4ASpOHKm1))
ExportAS = ExportASk*ASc[t]
ExportASL = ExportASLk*ASLc[t]
ExportASLoOH = ExportASLoOHk*ASLoOHc[t]
ExportASLpOH = ExportASLpOHk*ASLpOHc[t]
ExportASoOH = ExportASoOHk*ASoOHc[t]
ExportASpOH = ExportASpOHk*ASpOHc[t]
ImportAS = ImportASk*ASm[t]
ImportASL = ImportASLk*ASLm[t]
ImportASLoOH = ImportASLoOHk*ASLoOHm[t]
ImportASLpOH = ImportASLpOHk*ASLpOHm[t]
ImportASoOH = ImportASoOHk*ASoOHm[t]
ImportASpOH = ImportASpOHk*ASpOHm[t]
RASASLc = (kCRASLc + kPONASLc)*ASLc[t]
RASASLm = kCRASLm*ASLm[t]
RoOHm = kCRASLm*ASLoOHm[t]
RpOHm = kCRASLm*ASLpOHm[t]
UGT1A3AS = (UGT1A3ASVmax*ASc[t])/(UGT1A3ASKm1 + ASc[t] + ASc[t]^2/UGT1A3ASKI1)
end rate equations

begin parameters
CYP3A4ASLoOHKm1 = 3900.0
CYP3A4ASLoOHVmax = 39.1342
CYP3A4ASLpOHKm1 = 1400.0
CYP3A4ASLpOHVmax = 17.4446
CYP3A4ASoOHKm1 = 29700.0
CYP3A4ASoOHVmax = 47.4985
CYP3A4ASpOHKm1 = 25600.0
CYP3A4ASpOHVmax = 15.7336
ExportASLk = 0.021822
ExportASLoOHk = 0.0026674
ExportASLpOHk = 0.0011319
ExportASk = 0.002166
ExportASoOHk = 0.0015983
ExportASpOHk = 0.00079526
ImportASLk = 0.2754
ImportASLoOHk = 0.026122
ImportASLpOHk = 0.033729
ImportASk = 0.020335
ImportASoOHk = 0.00038875
ImportASpOHk = 0.0039614
Protk1 = 8.52
UGT1A3ASKI1 = 75000.0
UGT1A3ASKm1 = 12000.0
UGT1A3ASVmax = 13.5862
fuAS = 0.22
fuASL = 0.22
kCRASLc = "3.55e-05"
kCRASLm = 0.005
kPONASLc = 0.0043734
kPONOHc = 0.0039829
cell = 0.0142
compartment = 1.0
medium = 2.0
end parameters

begin initial conditions
ASLb[0] = ASLbi
ASLc[0] = ASLci
ASLm[0] = ASLmi
ASLoOHb[0] = ASLoOHbi
ASLoOHc[0] = ASLoOHci
ASLoOHm[0] = ASLoOHmi
ASLpOHb[0] = ASLpOHbi
ASLpOHc[0] = ASLpOHci
ASLpOHm[0] = ASLpOHmi
ASb[0] = ASbi
ASc[0] = ASci
ASm[0] = ASmi
ASoOHb[0] = ASoOHbi
ASoOHc[0] = ASoOHci
ASoOHm[0] = ASoOHmi
ASpOHb[0] = ASpOHbi
ASpOHc[0] = ASpOHci
ASpOHm[0] = ASpOHmi
end initial conditions

begin initial values
ASLbi = 0.0
ASLci = 0.0
ASLmi = 30.56
ASLoOHbi = 0.0
ASLoOHci = 0.0
ASLoOHmi = 0.0
ASLpOHbi = 0.0
ASLpOHci = 0.0
ASLpOHmi = 0.0
ASbi = 0.0
ASci = 0.0
ASmi = 8797.15
ASoOHbi = 0.0
ASoOHci = 0.0
ASoOHmi = 0.0
ASpOHbi = 0.0
ASpOHci = 0.0
ASpOHmi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units