begin name
bruggeman1
end name

begin reactions
v1 {1.0}PII + {1.0}$UTP = {1.0}PIIUMP + {1.0}$PPi
v10 {1.0}GLN + {1.0}$NADPH + {1.0}$KG = {2.0}GLU + {1.0}$NADP
v11 {1.0}GLU + {1.0}ATP + {1.0}$NH = {1.0}GLN + {1.0}ADP
v12 {1.0}GLU = {1.0}AZGLU
v13 {1.0}AZGLU = {1.0}$AZglu
v14 {1.0}GLN = {1.0}AZGLN
v15 {1.0}AZGLN = {1.0}$AZgln
v16 {1.0}ADP = {1.0}ATP
v2 {1.0}PIIUMP = {1.0}PII + {1.0}$UMP
v3 {1.0}PIIUMP + {1.0}$UTP = {1.0}PIIUMP2 + {1.0}$PPi
v4 {1.0}PIIUMP2 = {1.0}PIIUMP + {1.0}$UMP
v5 {1.0}PIIUMP2 + {1.0}$UTP = {1.0}PIIUMP3 + {1.0}$PPi
v6 {1.0}PIIUMP3 = {1.0}PIIUMP2 + {1.0}$UMP
v7 {1.0}GS = {1.0}GSAMP
v8 {1.0}GSAMP = {1.0}GS
v9 {1.0}$NH + {1.0}$KG + {1.0}$NADPH = {1.0}GLU + {1.0}$NADP
end reactions

begin rate equations
v1 = (kcatut*UT*UTP*PII[t])/(Kutipii*Kututp*(1 + GLN[t]/Kglnut)*(1 + UTP/Kututp + (PII[t] + PIIUMP[t] + PIIUMP2[t])/Kutipii + (UTP*(PII[t] + PIIUMP[t] + PIIUMP2[t]))/(Kutipii*Kututp) + (PPi*UTP*(PII[t] + PIIUMP[t] + PIIUMP2[t]))/(Kutipii*Kutippi*Kututp) + (Kutpii*(PIIUMP[t] + PIIUMP2[t] + PIIUMP3[t]))/(Kutipii*Kutpiiump)))
v10 = (KG*NADPH*Vgog*GLN[t])/(Kgoggln*Kgogkg*Kgognadph*(1 + NADP/Kgognadp + NADPH/Kgognadph)*(1 + AZGLU[t]/Kgogaz)*(1 + KG/Kgogkg + GLU[t]/Kgogglu)*(1 + GLN[t]/Kgoggln + GLU[t]/Kgogglu))
v11 = (aamp*camp*Vgs*(-((PI*ADP[t]*GLN[t])/Keq) + NH*ATP[t]*GLU[t]))/(Kgsatp*Kgsglu*Kgsnh*(1 + PI/Kgspi + ADP[t]/Kgsadp + (PI*ADP[t])/(Kgsadp*Kgspi) + ATP[t]/Kgsatp)*(1 + NH/Kgsnh + GLN[t]/Kgsgln + (NH*GLN[t])/(Kgsgln*Kgsnh) + GLU[t]/Kgsglu + (NH*GLU[t])/(Kgsglu*Kgsnh))*(1 + 12^n1amp*(GSAMP[t]/(bamp*GStot))^n1amp)*(1 + 12^n2amp*(GSAMP[t]/(damp*GStot))^n2amp))
v12 = (Vgludem*(-(AZGLU[t]/Kgludemeq) + GLU[t]))/(Kgludemglu*(1 + AZGLU[t]/Kgludemazglu + GLU[t]/Kgludemglu))
v13 = (Vazgludem*(-(azinter/Kazgludemeq) + AZGLU[t]))/(Kazgludemazglu*(1 + azinter/Kazgludemazinter + AZGLU[t]/Kazgludemazglu))
v14 = (Vglndem*(-(AZGLN[t]/Kglndemeq) + GLN[t]))/(Kglndemgln*(1 + AZGLN[t]/Kglndemazgln + GLN[t]/Kglndemgln))
v15 = (Vazglndem*(-(azinter/Kazglndemeq) + AZGLN[t]))/(Kazglndemazgln*(1 + azinter/Kazglndemazinter + AZGLN[t]/Kazglndemazgln))
v16 = (Vadp*ADP[t])/(Kadp + ADP[t])
v2 = (kcatur*UR*PIIUMP[t])/(Kurpiiump*(1 + Kglnur/GLN[t])*(1 + ((1 + UMP/Kurump)*(PIIUMP[t] + PIIUMP2[t] + PIIUMP3[t]))/Kurpiiump))
v3 = (kcatut*UT*UTP*PIIUMP[t])/(Kutipii*Kututp*(1 + GLN[t]/Kglnut)*(1 + UTP/Kututp + (PII[t] + PIIUMP[t] + PIIUMP2[t])/Kutipii + (UTP*(PII[t] + PIIUMP[t] + PIIUMP2[t]))/(Kutipii*Kututp) + (PPi*UTP*(PII[t] + PIIUMP[t] + PIIUMP2[t]))/(Kutipii*Kutippi*Kututp) + (Kutpii*(PIIUMP[t] + PIIUMP2[t] + PIIUMP3[t]))/(Kutipii*Kutpiiump)))
v4 = (kcatur*UR*PIIUMP2[t])/(Kurpiiump*(1 + Kglnur/GLN[t])*(1 + ((1 + UMP/Kurump)*(PIIUMP[t] + PIIUMP2[t] + PIIUMP3[t]))/Kurpiiump))
v5 = (kcatut*UT*UTP*PIIUMP2[t])/(Kutipii*Kututp*(1 + GLN[t]/Kglnut)*(1 + UTP/Kututp + (PII[t] + PIIUMP[t] + PIIUMP2[t])/Kutipii + (UTP*(PII[t] + PIIUMP[t] + PIIUMP2[t]))/(Kutipii*Kututp) + (PPi*UTP*(PII[t] + PIIUMP[t] + PIIUMP2[t]))/(Kutipii*Kutippi*Kututp) + (Kutpii*(PIIUMP[t] + PIIUMP2[t] + PIIUMP3[t]))/(Kutipii*Kutpiiump)))
v6 = (kcatur*UR*PIIUMP3[t])/(Kurpiiump*(1 + Kglnur/GLN[t])*(1 + ((1 + UMP/Kurump)*(PIIUMP[t] + PIIUMP2[t] + PIIUMP3[t]))/Kurpiiump))
v7 = (Vad*GS[t]*((b1*GLN[t])/Kadgln + (3*a1*KG*PII[t])/(Kadpiikg*Kd1*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))) + (3*c1*KG*GLN[t]*PII[t])/(Kadgln*Kadpiikg*Kd1*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3)))))/((Kadgs + GS[t])*(1 + GLN[t]/Kadgln + (3*KG*PII[t])/(Kadpiikg*Kd1*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))) + (3*KG*GLN[t]*PII[t])/(d1*Kadgln*Kadpiikg*Kd1*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3)))))
v8 = (Vdead*GSAMP[t]*((f1*GLN[t])/Kdeadgln + (3*e1*KG*PII[t])/(Kd1*Kdeadpiikg*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))) + (3*h1*KG*GLN[t]*PII[t])/(Kd1*Kdeadgln*Kdeadpiikg*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))) + (g1*KG^3*PIIUMP3[t])/(Kd1piiump*Kd2piiump*Kd3piiump*Kdeadpiiu*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))) + (j1*KG^3*GLN[t]*PIIUMP3[t])/(Kd1piiump*Kd2piiump*Kd3piiump*Kdeadgln*Kdeadpiiu*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))) + (3*i1*KG^4*PII[t]*PIIUMP3[t])/(Kd1*Kd1piiump*Kd2piiump*Kd3piiump*Kdeadpiikg*Kdeadpiiu*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))) + (3*k1*KG^4*GLN[t]*PII[t]*PIIUMP3[t])/(Kd1*Kd1piiump*Kd2piiump*Kd3piiump*Kdeadgln*Kdeadpiikg*Kdeadpiiu*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump)))))/((Kdeadgsa + GSAMP[t])*(1 + GLN[t]/Kdeadgln + (3*KG*PII[t])/(Kd1*Kdeadpiikg*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))) + (3*KG*GLN[t]*PII[t])/(Kd1*Kdeadgln*Kdeadpiikg*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))*l1) + (KG^3*PIIUMP3[t])/(Kd1piiump*Kd2piiump*Kd3piiump*Kdeadpiiu*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))) + (KG^3*GLN[t]*PIIUMP3[t])/(Kd1piiump*Kd2piiump*Kd3piiump*Kdeadgln*Kdeadpiiu*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))*n1) + (3*KG^4*PII[t]*PIIUMP3[t])/(Kd1*Kd1piiump*Kd2piiump*Kd3piiump*Kdeadpiikg*Kdeadpiiu*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))*m1) + (3*KG^4*GLN[t]*PII[t]*PIIUMP3[t])/(Kd1*Kd1piiump*Kd2piiump*Kd3piiump*Kdeadgln*Kdeadpiikg*Kdeadpiiu*(1 + (3*KG)/Kd1 + (3*KG^2)/(Kd1*Kd2) + KG^3/(Kd1*Kd2*Kd3))*(1 + (3*KG)/Kd1piiump + (3*KG^2)/(Kd1piiump*Kd2piiump) + KG^3/(Kd1piiump*Kd2piiump*Kd3piiump))*o1)))
v9 = (Vgdh*(KG*NADPH*NH - (NADP*GLU[t])/Keqgdh))/(Kgdhkg*Kgdhnadph*Kgdhnh*(1 + NADP/Kgdhnadp + NADPH/Kgdhnadph)*(1 + NH/Kgdhnh)*(1 + KG/Kgdhkg + GLU[t]/Kgdhglu))
end rate equations

begin parameters
ATPtot = 5.37
GStot = 0.014
Kadgln = 0.9714
Kadgs = 0.001703
Kadp = 0.5
Kadpiikg = "1.052e-05"
Kazglndemazgln = 1.0
Kazglndemazinter = 0.5
Kazglndemeq = 10000000000.0
Kazgludemazglu = 0.3
Kazgludemazinter = 0.5
Kazgludemeq = 10000000000.0
Kd1 = 0.005
Kd1piiump = 0.025
Kd2 = 0.15
Kd2piiump = 0.15
Kd3 = 0.15
Kd3piiump = 0.15
Kdeadgln = 0.04444
Kdeadgsa = 0.0002015
Kdeadpiikg = "2.274e-06"
Kdeadpiiu = "1.805e-05"
Keq = 460.0
Keqgdh = 1290.0
Kgdhazglu = 2.5
Kgdhglu = 10.0
Kgdhkg = 0.32
Kgdhnadp = 0.042
Kgdhnadph = 0.04
Kgdhnh = 1.1
Kglndemazgln = 0.25
Kglndemeq = 10000000000.0
Kglndemgln = 2.0
Kglnur = 0.07
Kglnut = 0.07
Kgludemazglu = 0.5
Kgludemeq = 10000000000.0
Kgludemglu = 8.0
Kgogaz = 0.65
Kgoggln = 0.175
Kgogglu = 11.0
Kgogkg = 0.007
Kgognadp = 0.0037
Kgognadph = 0.0015
Kgsadp = 0.0585
Kgsatp = 0.35
Kgseq = 460.0
Kgsgln = 5.65
Kgsglu = 4.1
Kgsnh = 0.1
Kgspi = 3.7
Kurpiiump = 0.0023
Kurump = 8.4
Kutipii = 0.0018
Kutippi = 0.1135
Kutpii = 0.003
Kutpiiump = 0.0035
Kututp = 0.04
PI = 10.0
PIItot = 0.003
UR = 0.0006
UT = 0.0006
Vad = 0.5
Vadp = 100.0
Vazglndem = 20.0
Vazgludem = 30.0
Vdead = 0.5
Vgdh = 360.0
Vglndem = 70.0
Vgludem = 120.0
Vgog = 85.0
Vgs = 600.0
a1 = "1e-22"
aamp = 10.0
azinter = 0.1
b1 = 0.5166
bamp = 2.3667
c1 = 0.5974
camp = 0.1012
d1 = 0.0387
damp = 10.8688
e1 = "1e-22"
f1 = 2.766
g1 = 3.323
h1 = 0.2148
i1 = "1e-22"
j1 = "1e-22"
k1 = "1e-22"
kcatur = 5.5
kcatut = 137.0
l1 = 0.02316
m1 = 0.8821
n1 = 8.491
n1amp = 1.1456
n2amp = 19.2166
o1 = 0.8791
AZgln = 1.0
AZglu = 1.0
KG = 0.2
NADP = 0.05
NADPH = 0.15
NH = 0.05
PPi = 0.05
UMP = 0.01
UTP = 0.5
defaultcompartment = 1.0
end parameters

begin initial conditions
ADP[0] = ADPi
ATP[0] = ATPi
AZGLN[0] = AZGLNi
AZGLU[0] = AZGLUi
GLN[0] = GLNi
GLU[0] = GLUi
GS[0] = GSi
GSAMP[0] = GSAMPi
PII[0] = PIIi
PIIUMP[0] = PIIUMPi
PIIUMP2[0] = PIIUMP2i
PIIUMP3[0] = PIIUMP3i
end initial conditions

begin initial values
ADPi = 2.685
ATPi = 2.685
AZGLNi = 1.0
AZGLUi = 1.0
GLNi = 1.0
GLUi = 1.0
GSi = 0.014
GSAMPi = 0.0
PIIi = 0.003
PIIUMPi = 0.0
PIIUMP2i = 0.0
PIIUMP3i = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units