begin name bray1 end name begin reactions complexr1 {1.0}TTW = {1.0}TT + {1.0}W complexr10 {1.0}TTWW = {1.0}TTW + {1.0}W complexr11 {1.0}WWAA = {1.0}W + {1.0}WAA complexr12 {1.0}TTWAA = {1.0}TTAA + {1.0}W complexr2 {1.0}WAA = {1.0}W + {1.0}AA complexr3 {1.0}TTWAA = {1.0}TT + {1.0}WAA complexr4 {1.0}TTWWAA = {1.0}TTW + {1.0}WAA complexr5 {1.0}TTWWAA = {1.0}TTWW + {1.0}AA complexr6 {1.0}TTWWAA = {1.0}TT + {1.0}WWAA complexr7 {1.0}TTAA = {1.0}TT + {1.0}AA complexr8 {1.0}TTWAA = {1.0}TTW + {1.0}AA complexr9 {1.0}TTWWAA = {1.0}TTWAA + {1.0}W phosphorylationr1 {1.0}TTWWAA = {1.0}TTWWAAp phosphorylationr10 {1.0}Bp = {1.0}B phosphorylationr2 {1.0}AA = {1.0}AAp phosphorylationr3 {1.0}WAA = {1.0}WAAp phosphorylationr4 {1.0}WWAA = {1.0}WWAAp phosphorylationr5 {1.0}TTAA = {1.0}TTAAp phosphorylationr6 {1.0}TTWAA = {1.0}TTWAAp phosphorylationr7 {1.0}Y = {1.0}Yp phosphorylationr8 {1.0}Yp = {1.0}Y phosphorylationr9 {1.0}Yp + {1.0}Z = {1.0}Y + {1.0}Z phosphotransferr1 {1.0}B + {1.0}AAp = {1.0}Bp + {1.0}AA phosphotransferr10 {1.0}Y + {1.0}TTAAp = {1.0}Yp + {1.0}TTAA phosphotransferr11 {1.0}Y + {1.0}TTWAAp = {1.0}Yp + {1.0}TTWAA phosphotransferr12 {1.0}Y + {1.0}TTWWAAp = {1.0}Yp + {1.0}TTWWAA phosphotransferr2 {1.0}B + {1.0}WAAp = {1.0}Bp + {1.0}WAA phosphotransferr3 {1.0}B + {1.0}WWAAp = {1.0}Bp + {1.0}WWAA phosphotransferr4 {1.0}B + {1.0}TTAAp = {1.0}Bp + {1.0}TTAA phosphotransferr5 {1.0}B + {1.0}TTWAAp = {1.0}Bp + {1.0}TTWAA phosphotransferr6 {1.0}B + {1.0}TTWWAAp = {1.0}Bp + {1.0}TTWWAA phosphotransferr7 {1.0}Y + {1.0}AAp = {1.0}Yp + {1.0}AA phosphotransferr8 {1.0}Y + {1.0}WAAp = {1.0}Yp + {1.0}WAA phosphotransferr9 {1.0}Y + {1.0}WWAAp = {1.0}Yp + {1.0}WWAA end reactions begin rate equations complexr1 = cell*(complexr1k1*TTW[t] - complexr1k2*TT[t]*W[t]) complexr10 = cell*(complexr10k1*TTWW[t] - complexr10k2*TTW[t]*W[t]) complexr11 = cell*(-(complexr11k2*W[t]*WAA[t]) + complexr11k1*WWAA[t]) complexr12 = cell*(complexr12k1*TTWAA[t] - complexr12k2*TTAA[t]*W[t]) complexr2 = cell*(-(complexr2k2*AA[t]*W[t]) + complexr2k1*WAA[t]) complexr3 = cell*(complexr3k1*TTWAA[t] - complexr3k2*TT[t]*WAA[t]) complexr4 = cell*(complexr4k1*TTWWAA[t] - complexr4k2*TTW[t]*WAA[t]) complexr5 = cell*(-(complexr5k2*AA[t]*TTWW[t]) + complexr5k1*TTWWAA[t]) complexr6 = cell*(complexr6k1*TTWWAA[t] - complexr6k2*TT[t]*WWAA[t]) complexr7 = cell*(-(complexr7k2*AA[t]*TT[t]) + complexr7k1*TTAA[t]) complexr8 = cell*(-(complexr8k2*AA[t]*TTW[t]) + complexr8k1*TTWAA[t]) complexr9 = cell*(complexr9k1*TTWWAA[t] - complexr9k2*TTWAA[t]*W[t]) phosphorylationr1 = cell*phosphorylationr1k1*TTWWAA[t] phosphorylationr10 = cell*phosphorylationr10k1*Bp[t] phosphorylationr2 = cell*phosphorylationr2k1*AA[t] phosphorylationr3 = cell*phosphorylationr3k1*WAA[t] phosphorylationr4 = cell*phosphorylationr4k1*WWAA[t] phosphorylationr5 = cell*phosphorylationr5k1*TTAA[t] phosphorylationr6 = cell*phosphorylationr6k1*TTWAA[t] phosphorylationr7 = cell*phosphorylationr7k1*Y[t] phosphorylationr8 = cell*phosphorylationr8k1*Yp[t] phosphorylationr9 = cell*phosphorylationr9k1*Yp[t]*Z[t] phosphotransferr1 = cell*phosphotransferr1k1*AAp[t]*B[t] phosphotransferr10 = cell*phosphotransferr10k1*TTAAp[t]*Y[t] phosphotransferr11 = cell*phosphotransferr11k1*TTWAAp[t]*Y[t] phosphotransferr12 = cell*phosphotransferr12k1*TTWWAAp[t]*Y[t] phosphotransferr2 = cell*phosphotransferr2k1*B[t]*WAAp[t] phosphotransferr3 = cell*phosphotransferr3k1*B[t]*WWAAp[t] phosphotransferr4 = cell*phosphotransferr4k1*B[t]*TTAAp[t] phosphotransferr5 = cell*phosphotransferr5k1*B[t]*TTWAAp[t] phosphotransferr6 = cell*phosphotransferr6k1*B[t]*TTWWAAp[t] phosphotransferr7 = cell*phosphotransferr7k1*AAp[t]*Y[t] phosphotransferr8 = cell*phosphotransferr8k1*WAAp[t]*Y[t] phosphotransferr9 = cell*phosphotransferr9k1*WWAAp[t]*Y[t] end rate equations begin parameters Hill = 4.0 complexr1k1 = 0.00365 complexr1k2 = 1000000.0 complexr2k1 = 0.00894 complexr2k2 = 1000000.0 complexr3k1 = 297.0 complexr3k2 = 1000000.0 complexr4k1 = 0.64 complexr4k2 = 1000000.0 complexr5k1 = 0.112 complexr5k2 = 1000000.0 complexr6k1 = 0.0229 complexr6k2 = 1000000.0 complexr7k1 = 39.3 complexr7k2 = 1000000.0 complexr8k1 = 727.0 complexr8k2 = 1000000.0 complexr9k1 = "7.87e-06" complexr9k2 = 1000000.0 complexr10k1 = 0.0511 complexr10k2 = 1000000.0 complexr11k1 = 0.102 complexr11k2 = 1000000.0 complexr12k1 = 0.0676 complexr12k2 = 1000000.0 phosphorylationr1k1 = 15.5 phosphorylationr2k1 = 0.0227 phosphorylationr3k1 = 0.0227 phosphorylationr4k1 = 0.0227 phosphorylationr5k1 = 0.0227 phosphorylationr6k1 = 0.0227 phosphorylationr7k1 = 0.00124 phosphorylationr8k1 = 0.037 phosphorylationr9k1 = 500000.0 phosphorylationr10k1 = 0.35 phosphotransferr1k1 = 6000000.0 phosphotransferr2k1 = 6000000.0 phosphotransferr3k1 = 6000000.0 phosphotransferr4k1 = 6000000.0 phosphotransferr5k1 = 6000000.0 phosphotransferr6k1 = 6000000.0 phosphotransferr7k1 = 30000000.0 phosphotransferr8k1 = 30000000.0 phosphotransferr9k1 = 30000000.0 phosphotransferr10k1 = 30000000.0 phosphotransferr11k1 = 30000000.0 phosphotransferr12k1 = 30000000.0 cell = 1.41 end parameters begin initial conditions AA[0] = AAi AAp[0] = AApi B[0] = Bi Bp[0] = Bpi SetYp[0] = SetYpi TT[0] = TTi TTAA[0] = TTAAi TTAAp[0] = TTAApi TTW[0] = TTWi TTWAA[0] = TTWAAi TTWAAp[0] = TTWAApi TTWW[0] = TTWWi TTWWAA[0] = TTWWAAi TTWWAAp[0] = TTWWAApi W[0] = Wi WAA[0] = WAAi WAAp[0] = WAApi WWAA[0] = WWAAi WWAAp[0] = WWAApi Y[0] = Yi Yp[0] = Ypi Z[0] = Zi end initial conditions begin initial values AAi = 2.5e-06 AApi = 0.0 Bi = 2e-06 Bpi = 0.0 SetYpi = 1.63e-06 TTi = 2.5e-06 TTAAi = 0.0 TTAApi = 0.0 TTWi = 0.0 TTWAAi = 0.0 TTWAApi = 0.0 TTWWi = 0.0 TTWWAAi = 0.0 TTWWAApi = 0.0 Wi = 5e-06 WAAi = 0.0 WAApi = 0.0 WWAAi = 0.0 WWAApi = 0.0 Yi = 1e-05 Ypi = 0.0 Zi = 2e-05 end initial values begin assignment rules Bias := 1 - Yp[t]^Hill/(2.333*SetYp[t]^Hill + Yp[t]^Hill) end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units