#borisov1



#reactions
reaction_1:
 {1.0}R + {1.0}EGF = {1.0}RE
  (k1 * R * EGF - k_1 * RE) * cell
reaction_10:
 {1.0}Rp_pShc_GS = {1.0}Rp + {1.0}pShc_GS
  (k_10 * Rp_pShc_GS - k10 * Rp * pShc_GS) * cell
reaction_100:
 {1.0}IRSp_GS = {1.0}GS + {1.0}IRS
  V31 * IRSp_GS / (Km31 + IRSp_GS) * cell
reaction_101:
 {1.0}IRSp_SHP2 = {1.0}IRS + {1.0}SHP2
  k48 * IRSp_SHP2 * cell
reaction_102:
 {1.0}mGABp_pSHP2 = {1.0}SHP2 + {1.0}mGAB
  k56 * mGABp_pSHP2 * cell
reaction_103:
 {1.0}mGABp_pSHP2_GS = {1.0}GS + {1.0}SHP2 + {1.0}mGAB
  k56 * mGABp_pSHP2_GS * cell
reaction_104:
 {1.0}GABp = {1.0}GAB
  V51 * GABp / (Km51 + GABp) * cell
reaction_105:
 {1.0}GABp_PI3K = {1.0}PI3K + {1.0}GAB
  V51 * GABp_PI3K / (Km51 + GABp_PI3K) * cell
reaction_106:
 {1.0}GABp_GS = {1.0}GS + {1.0}GAB
  V51 * GABp_GS / (Km51 + GABp_GS) * cell
reaction_107:
 {1.0}GABp_RasGAP = {1.0}RasGAP + {1.0}GAB
  V51 * GABp_RasGAP / (Km51 + GABp_RasGAP) * cell
reaction_108:
 {1.0}GABp_SHP2 = {1.0}SHP2 + {1.0}GAB
  k56 * GABp_SHP2 * cell
reaction_109:
 {1.0}GABp_pSHP2 = {1.0}SHP2 + {1.0}GAB
  k56 * GABp_pSHP2 * cell
reaction_11:
 {1.0}pShc_GS = {1.0}GS + {1.0}pShc
  (k_11 * pShc_GS - k11 * pShc * GS) * cell
reaction_110:
 {1.0}GABp_pSHP2_GS = {1.0}GS + {1.0}SHP2 + {1.0}GAB
  k56 * GABp_pSHP2_GS * cell
reaction_111:
 {1.0}mGABp_RasGAP = {1.0}RasGAP + {1.0}mGAB
  k111 * (mGABp_SHP2 + mGABp_pSHP2 + mGABp_pSHP2_GS + mIRSp_SHP2) * mGABp_RasGAP * cell
reaction_112:
 {1.0}Rp_RasGAP = {1.0}Rp + {1.0}RasGAP
  k111 * (mGABp_SHP2 + mGABp_pSHP2 + mGABp_pSHP2_GS) * Rp_RasGAP * cell
reaction_113:
 {1.0}IRp_RasGAP = {1.0}RasGAP + {1.0}IRp
  k111 * (mGABp_SHP2 + mGABp_pSHP2 + mGABp_pSHP2_GS) * IRp_RasGAP * cell
reaction_114:
 {1.0}Rp_RasGAP = {1.0}Rp + {1.0}RasGAP
  k111 * mIRSp_SHP2 * Rp_RasGAP * cell
reaction_115:
 {1.0}IRp_RasGAP = {1.0}RasGAP + {1.0}IRp
  k111 * mIRSp_SHP2 * IRp_RasGAP * cell
reaction_117:
 {1.0}mGABp = {1.0}imGABp
  (2 * kcat80 * mGABp * ppErk / (Km80 + mGABp) - k_80 * imGABp) * cell
reaction_118:
 {1.0}imGABp = {1.0}imGAB
  k118 * imGABp * cell
reaction_12:
 {1.0}Rp + {1.0}PI3K = {1.0}Rp_PI3K
  (k12 * Rp * PI3K - k_12 * Rp_PI3K) * cell
reaction_13:
 {1.0}Rp + {1.0}RasGAP = {1.0}Rp_RasGAP
  (k13 * Rp * RasGAP - k_13 * Rp_RasGAP) * cell
reaction_17:
 {1.0}Rp = {1.0}Null
  k17 * Rp * cell
reaction_18:
 {1.0}Rp_GS = {1.0}GS
  k17 * Rp_GS * cell
reaction_19:
 {1.0}Rp_Shc = {1.0}Shc
  k17 * Rp_Shc * cell
reaction_2:
 {2.0}RE = {1.0}Rd
  (k2 * RE * RE - k_2 * Rd) * cell
reaction_20:
 {1.0}Rp_pShc = {1.0}pShc
  k17 * Rp_pShc * cell
reaction_21:
 {1.0}Rp_pShc_GS = {1.0}pShc_GS
  k17 * Rp_pShc_GS * cell
reaction_22:
 {1.0}Rp_PI3K = {1.0}PI3K
  k17 * Rp_PI3K * cell
reaction_23:
 {1.0}Rp_RasGAP = {1.0}RasGAP
  k17 * Rp_RasGAP * cell
reaction_24:
 {1.0}I + {1.0}IR = {1.0}IRL
  (k24 * IR * I - k_24 * IRL) * cell
reaction_25:
 {1.0}IRL = {1.0}IRp
  k25 * IRL * cell
reaction_26:
 {1.0}PI3K + {1.0}IRp = {1.0}IRp_PI3K
  (k26 * IRp * PI3K - k_26 * IRp_PI3K) * cell
reaction_27:
 {1.0}RasGAP + {1.0}IRp = {1.0}IRp_RasGAP
  (k27 * IRp * RasGAP - k_27 * IRp_RasGAP) * cell
reaction_28:
 {1.0}IRp + {1.0}IRS = {1.0}IRp_IRS
  (k28 * IRp * IRS - k_28 * IRp_IRS) * cell
reaction_29:
 {1.0}IRp_IRS = {1.0}IRp_IRSp
  k29 * IRp_IRS * cell
reaction_3:
 {1.0}Rd = {1.0}Rp
  k3 * Rd * cell
reaction_30:
 {1.0}IRp_IRSp = {1.0}IRp + {1.0}IRSp
  (k_30 * IRp_IRSp - k30 * IRp * IRSp) * cell
reaction_31:
 {1.0}IRSp = {1.0}IRS
  V31 * IRSp / (Km31 + IRSp) * cell
reaction_34:
 {1.0}IRp = {1.0}Null
  k17 * IRp * cell
reaction_35:
 {1.0}IRp_PI3K = {1.0}PI3K
  k17 * IRp_PI3K * cell
reaction_36:
 {1.0}IRp_RasGAP = {1.0}RasGAP
  k17 * IRp_RasGAP * cell
reaction_37:
 {1.0}IRp_IRS = {1.0}IRS
  k17 * IRp_IRS * cell
reaction_38:
 {1.0}IRp_IRSp = {1.0}IRSp
  k17 * IRp_IRSp * cell
reaction_4:
 {1.0}Rp + {1.0}GS = {1.0}Rp_GS
  (k4 * Rp * GS - k_4 * Rp_GS) * cell
reaction_40:
 {1.0}iSrc = {1.0}aSrc
  kcat40 * iSrc * (Rp + alpha40 * IRp) / (Km40 + iSrc) * cell
reaction_41:
 {1.0}aSrc = {1.0}iSrc
  V41 * aSrc / (Km41 + aSrc) * cell
reaction_42:
 {1.0}IRS + {1.0}PIP3 = {1.0}mIRS
  (k42 * IRS * PIP3 - k_42 * mIRS) * cell
reaction_43:
 {1.0}mIRS = {1.0}mIRSp
  kcat43 * mIRS * (IRp + alpha43 * Rp) / (Km43 + mIRS) * cell
reaction_44:
 {1.0}mIRSp = {1.0}mIRS
  V31 * mIRSp / (Km31 + mIRSp) * cell
reaction_45:
 {1.0}GS + {1.0}mIRSp = {1.0}mIRSp_GS
  (k45 * mIRSp * GS - k_45 * mIRSp_GS) * cell
reaction_46:
 {1.0}PI3K + {1.0}mIRSp = {1.0}mIRSp_PI3K
  (k46 * mIRSp * PI3K - k_46 * mIRSp_PI3K) * cell
reaction_47:
 {1.0}mIRSp + {1.0}SHP2 = {1.0}mIRSp_SHP2
  (k47 * mIRSp * SHP2 - k_47 * mIRSp_SHP2) * cell
reaction_48:
 {1.0}mIRSp_SHP2 = {1.0}mIRS + {1.0}SHP2
  k48 * mIRSp_SHP2 * cell
reaction_49:
 {1.0}GAB + {1.0}PIP3 = {1.0}mGAB
  (k49 * GAB * PIP3 - k_49 * mGAB) * cell
reaction_5:
 {1.0}Rp + {1.0}Shc = {1.0}Rp_Shc
  (k5 * Rp * Shc - k_5 * Rp_Shc) * cell
reaction_50:
 {1.0}mGAB = {1.0}mGABp
  kcat50 * mGAB * (Rp + alpha50 * aSrc) / (Km50 + mGAB) * cell
reaction_51:
 {1.0}mGABp = {1.0}mGAB
  V51 * mGABp / (Km51 + mGABp) * cell
reaction_52:
 {1.0}GS + {1.0}mGABp = {1.0}mGABp_GS
  (k52 * mGABp * GS - k_52 * mGABp_GS) * cell
reaction_53:
 {1.0}PI3K + {1.0}mGABp = {1.0}mGABp_PI3K
  (k53 * mGABp * PI3K - k_53 * mGABp_PI3K) * cell
reaction_54:
 {1.0}RasGAP + {1.0}mGABp = {1.0}mGABp_RasGAP
  (k54 * mGABp * RasGAP - k_54 * mGABp_RasGAP) * cell
reaction_55:
 {1.0}SHP2 + {1.0}mGABp = {1.0}mGABp_SHP2
  (k55 * mGABp * SHP2 - k_55 * mGABp_SHP2) * cell
reaction_56:
 {1.0}mGABp_SHP2 = {1.0}SHP2 + {1.0}mGAB
  k56 * mGABp_SHP2 * cell
reaction_57:
 {1.0}mGABp_SHP2 = {1.0}mGABp_pSHP2
  kcat57 * mGABp_SHP2 * (Rp + aSrc) / (Km57 + mGABp_SHP2) * cell
reaction_58:
 {1.0}mGABp_pSHP2 = {1.0}mGABp_SHP2
  V58 * mGABp_pSHP2 / (Km58 + mGABp_pSHP2) * cell
reaction_59:
 {1.0}GS + {1.0}mGABp_pSHP2 = {1.0}mGABp_pSHP2_GS
  (k59 * mGABp_pSHP2 * GS - k_59 * mGABp_pSHP2_GS) * cell
reaction_6:
 {1.0}Rp_Shc = {1.0}Rp_pShc
  k6 * Rp_Shc * cell
reaction_60:
 $pool = {1.0}PIP3
  k60 * (Rp_PI3K + IRp_PI3K + mIRSp_PI3K + mGABp_PI3K + tRas_PI3K) * cell
reaction_61:
 {1.0}PIP3 = {1.0}Null
  k61 * PIP3 * cell
reaction_62:
 {1.0}dRas = {1.0}tRas
  kcat62 * dRas * (Rp_GS + Rp_pShc_GS + mIRSp_GS + mGABp_GS + mGABp_pSHP2_GS) / (Km62 + dRas) * cell
reaction_63:
 {1.0}tRas = {1.0}dRas
  kcat63 * tRas * (bRasGAP + mGABp_RasGAP + Rp_RasGAP + IRp_RasGAP) / (Km63 + tRas) * cell
reaction_64:
 {1.0}PI3K + {1.0}tRas = {1.0}tRas_PI3K
  (k64 * tRas * PI3K - k_64 * tRas_PI3K) * cell
reaction_65:
 {1.0}Raf = {1.0}aRaf
  kcat65 * tRas * Raf / (Km65 + Raf) * cell
reaction_66:
 {1.0}aRaf = {1.0}aaRaf
  kcat66 * aSrc * aRaf / (Km66 + aRaf) * cell
reaction_67:
 {1.0}aaRaf = {1.0}Raf
  (kcat67 * aaRaf * (PKA / (Km67 + aaRaf)) + alpha67 * aaRaf * (pAkt + beta67 * ppAkt)) * cell
reaction_68:
 {1.0}Mek = {1.0}ppMek
  kcat68 * aaRaf * Mek / (Km68 + Mek) * cell
reaction_69:
 {1.0}ppMek = {1.0}Mek
  V69 * ppMek / (Km69 + ppMek) * cell
reaction_7:
 {1.0}Rp_pShc = {1.0}Rp + {1.0}pShc
  (k_7 * Rp_pShc - k7 * Rp * pShc) * cell
reaction_70:
 {1.0}Erk = {1.0}pErk
  kcat70 * Erk * ppMek / (Km70 + Erk + pErk * (Km70 / Km71)) * cell
reaction_71:
 {1.0}pErk = {1.0}ppErk
  kcat71 * pErk * ppMek / (Km71 + pErk + Erk * (Km71 / Km70)) * cell
reaction_72:
 {1.0}ppErk = {1.0}pErk
  V72 * ppErk / (Km72 + ppErk + pErk * (Km72 / Km73)) * cell
reaction_73:
 {1.0}pErk = {1.0}Erk
  V73 * pErk / (Km73 + pErk + ppErk * (Km73 / Km72)) * cell
reaction_74:
 {1.0}PIP3 + {1.0}PDK1 = {1.0}mPDK1
  (k74 * PDK1 * PIP3 - k_74 * mPDK1) * cell
reaction_75:
 {1.0}Akt = {1.0}pAkt
  kcat75 * mPDK1 * Akt / (Km75 + Akt) * cell
reaction_76:
 {1.0}pAkt = {1.0}Akt
  V76 * pAkt / (Km76 + pAkt) * cell
reaction_77:
 {1.0}mTOR = {1.0}amTOR
  (kcat77 * mTOR * ((alpha77 * pAkt + ppAkt) / (Km77 + mTOR)) - k_77 * amTOR) * cell
reaction_78:
 {1.0}pAkt = {1.0}ppAkt
  (kcat78 * amTOR * (pAkt / (Km78 + pAkt)) - k_78 * ppAkt) * cell
reaction_79:
 {1.0}GS = {1.0}iGS
  (kcat79 * ppErk * (GS / (Km79 + GS)) - k_79 * iGS) * cell
reaction_8:
 {1.0}pShc = {1.0}Shc
  V8 * pShc / (Km8 + pShc) * cell
reaction_80:
 {1.0}mGAB = {1.0}imGAB
  (kcat80 * mGAB * (ppErk / (Km80 + mGAB)) - k_80 * imGAB) * cell
reaction_81:
 {1.0}mIRS = {1.0}imIRS
  (kcat81 * mIRS * (amTOR / (Km81 + mIRS)) - k_81 * imIRS) * cell
reaction_82:
 {1.0}Rp = {1.0}Ri
  V_82 * Rp / (Km82 + Rp) * cell
reaction_83:
 {1.0}Ri = {1.0}Rd
  k83 * Ri * cell
reaction_84:
 {1.0}IRp = {1.0}IRi
  V_84 * IRp / (Km84 + IRp) * cell
reaction_85:
 {1.0}IRi = {1.0}IRL
  k85 * IRi * cell
reaction_88:
 {1.0}mIRSp = {1.0}IRSp + {1.0}PIP3
  (k_42 * mIRSp - k42 * PIP3 * IRSp) * cell
reaction_89:
 {1.0}mIRSp_PI3K = {1.0}PIP3 + {1.0}IRSp_PI3K
  (k_42 * mIRSp_PI3K - k42 * PIP3 * IRSp_PI3K) * cell
reaction_9:
 {1.0}GS + {1.0}Rp_pShc = {1.0}Rp_pShc_GS
  (k9 * Rp_pShc * GS - k_9 * Rp_pShc_GS) * cell
reaction_90:
 {1.0}mIRSp_GS = {1.0}PIP3 + {1.0}IRSp_GS
  (k_42 * mIRSp_GS - k42 * PIP3 * IRSp_GS) * cell
reaction_91:
 {1.0}mIRSp_SHP2 = {1.0}PIP3 + {1.0}IRSp_SHP2
  (k_42 * mIRSp_SHP2 - k42 * PIP3 * IRSp_SHP2) * cell
reaction_92:
 {1.0}mGABp = {1.0}PIP3 + {1.0}GABp
  (k_42 * mGABp - k42 * PIP3 * GABp) * cell
reaction_93:
 {1.0}mGABp_PI3K = {1.0}PIP3 + {1.0}GABp_PI3K
  (k_42 * mGABp_PI3K - k42 * PIP3 * GABp_PI3K) * cell
reaction_94:
 {1.0}mGABp_GS = {1.0}PIP3 + {1.0}GABp_GS
  (k_42 * mGABp_GS - k42 * PIP3 * GABp_GS) * cell
reaction_95:
 {1.0}mGABp_RasGAP = {1.0}PIP3 + {1.0}GABp_RasGAP
  (k_42 * mGABp_RasGAP - k49 * PIP3 * GABp_RasGAP) * cell
reaction_96:
 {1.0}mGABp_SHP2 = {1.0}PIP3 + {1.0}GABp_SHP2
  (k_42 * mGABp_SHP2 - k42 * PIP3 * GABp_SHP2) * cell
reaction_97:
 {1.0}mGABp_pSHP2 = {1.0}PIP3 + {1.0}GABp_pSHP2
  (k_42 * mGABp_pSHP2 - k42 * PIP3 * GABp_pSHP2) * cell
reaction_98:
 {1.0}mGABp_pSHP2_GS = {1.0}PIP3 + {1.0}GABp_pSHP2_GS
  (k_42 * mGABp_pSHP2_GS - k42 * PIP3 * GABp_pSHP2_GS) * cell
reaction_99:
 {1.0}IRSp_PI3K = {1.0}PI3K + {1.0}IRS
  V31 * IRSp_PI3K / (Km31 + IRSp_PI3K) * cell


#parameters
Kd1 = 0.58824
Kd10 = 400.0
Kd12 = 12.45
Kd13 = 200.0
Kd2 = 15.0
Kd24 = 0.029412
Kd26 = 124.5
Kd27 = 2000000.0
Kd28 = 3.75
Kd30 = 10.0
Kd4 = 10.0
Kd42 = 10.0
Kd45 = 100000.0
Kd46 = 1.0
Kd47 = 1000.0
Kd49 = 1.0
Kd5 = 10.0
Kd52 = 1.0
Kd53 = 2.5
Kd54 = 66666.0
Kd55 = 100.0
Kd59 = 20.0
Kd7 = 400.0
Kd74 = 100.0
Kd9 = 10.0
Km31 = 143.3
Km40 = 110.0
Km41 = 50.0
Km43 = 150.0
Km50 = 150.0
Km51 = 130.0
Km57 = 150.0
Km58 = 130.0
Km62 = 50.0
Km63 = 50.0
Km65 = 400.0
Km66 = 10.0
Km67 = 10000.0
Km68 = 50.0
Km69 = 675.299
Km70 = 500.0
Km71 = 500.0
Km72 = 500.0
Km73 = 500.0
Km75 = 500.0
Km76 = 1.0
Km77 = 100.0
Km78 = 100.0
Km79 = 5000.0
Km8 = 100.0
Km80 = 700.0
Km81 = 300.0
Km82 = 50.0
Km84 = 266.0
V31 = 333.0
V41 = 6.66
V51 = 333.0
V58 = 2.0
V69 = 16.6
V72 = 33.3
V73 = 23.33
V76 = 16.66
V8 = 200.0
V_82 = 133.0
V_84 = 333.0
alpha40 = 0.00025
alpha43 = 0.05
alpha50 = 0.0001
alpha67 = 1e-06
alpha77 = 0.5
beta67 = 2.0
k1 = 0.068
k10 = 0.0004
k111 = 0.0133
k118 = 0.001
k12 = 0.00933
k13 = 6.66e-06
k17 = 0.000185
k2 = 0.033
k24 = 0.011322
k25 = 1.66
k26 = 0.00933
k27 = 6.66e-08
k28 = 0.1066
k29 = 0.66
k3 = 0.4
k30 = 0.0066
k4 = 0.000666
k42 = 0.00666
k45 = 0.000666
k46 = 0.00666
k47 = 0.000666
k48 = 0.666
k49 = 0.000666
k5 = 0.0133
k52 = 0.002
k53 = 0.0133
k54 = 1e-05
k55 = 0.000666
k56 = 0.666
k59 = 0.01
k6 = 0.333
k60 = 4.66
k61 = 3.33
k64 = 0.0
k7 = 0.000666
k74 = 0.00666
k83 = 0.0166
k85 = 0.0166
k9 = 0.00666
k_64 = 2.5
k_77 = 0.666
k_78 = 0.666
k_79 = 6.66e-05
k_80 = 6.66e-05
k_81 = 6.66e-05
kcat40 = 6.6
kcat43 = 33.3
kcat50 = 3333.0
kcat57 = 0.133
kcat62 = 5.33
kcat63 = 20000.0
kcat65 = 0.1
kcat66 = 3.33
kcat67 = 0.666
kcat68 = 0.133
kcat70 = 0.333
kcat71 = 0.666
kcat75 = 4.66
kcat77 = 0.666
kcat78 = 0.666
kcat79 = 0.0466
kcat80 = 0.04
kcat81 = 0.166
cell = 1.0
extra = 34.0


#initial values
Akt = 100.0
EGF = 1.0
Erk = 400.0
GAB = 225.0
GABp = 0.0
GABp_GS = 0.0
GABp_PI3K = 0.0
GABp_RasGAP = 0.0
GABp_SHP2 = 0.0
GABp_pSHP2 = 0.0
GABp_pSHP2_GS = 0.0
GS = 200.0
I = 0.0
IR = 150.0
IRL = 0.0
IRS = 300.0
IRSp = 0.0
IRSp_GS = 0.0
IRSp_PI3K = 0.0
IRSp_SHP2 = 0.0
IRi = 0.0
IRp = 0.0
IRp_IRS = 0.0
IRp_IRSp = 0.0
IRp_PI3K = 0.0
IRp_RasGAP = 0.0
Mek = 200.0
Null = 0.0
PDK1 = 100.0
PI3K = 200.0
PIP3 = 0.0
PKA = 100.0
R = 100.0
RE = 0.0
Raf = 100.0
RasGAP = 50.0
Rd = 0.0
Ri = 0.0
Rp = 0.0
Rp_GS = 0.0
Rp_PI3K = 0.0
Rp_RasGAP = 0.0
Rp_Shc = 0.0
Rp_pShc = 0.0
Rp_pShc_GS = 0.0
SHP2 = 300.0
Shc = 270.0
aPX = 0.0
aPX_GS = 0.0
aRaf = 0.0
aSrc = 0.0
aaRaf = 0.0
amTOR = 0.0
bRasGAP = 1e-05
dRas = 150.0
iGS = 0.0
iPX = 200.0
iSrc = 518.0
imGAB = 0.0
imGABp = 0.0
imIRS = 0.0
mGAB = 0.0
mGABp = 0.0
mGABp_GS = 0.0
mGABp_PI3K = 0.0
mGABp_RasGAP = 0.0
mGABp_SHP2 = 0.0
mGABp_pSHP2 = 0.0
mGABp_pSHP2_GS = 0.0
mIRS = 0.0
mIRSp = 0.0
mIRSp_GS = 0.0
mIRSp_PI3K = 0.0
mIRSp_SHP2 = 0.0
mPDK1 = 0.0
mTOR = 100.0
pAkt = 0.0
pErk = 0.0
pShc = 0.0
pShc_GS = 0.0
ppAkt = 0.0
ppErk = 0.0
ppMek = 0.0
tRas = 0.0
tRas_PI3K = 0.0


#assignment rules
!F k_5 = Kd5 * k5
!F k_4 = Kd4 * k4
!F k_2 = Kd2 * k2
!F k_1 = Kd1 * k1
!F k_10 = Kd10 * k10
!F k_9 = Kd9 * k9
!F k_7 = Kd7 * k7
!F k_74 = k74 * Kd74
!F k_59 = Kd59 * k59
!F k_55 = Kd55 * k55
!F k_54 = Kd54 * k54
!F k_53 = Kd53 * k53
!F k_52 = k52 * Kd52
!F k_49 = Kd49 * k49
!F k_47 = Kd47 * k47
!F k_46 = Kd46 * k46
!F k_45 = k45 * Kd45
!F k_42 = Kd42 * k42
!F k_30 = Kd30 * k30
!F k_28 = Kd28 * k28
!F k_27 = Kd27 * k27
!F k_26 = Kd26 * k26
!F k_24 = Kd24 * k24
!F k_13 = Kd13 * k13
!F k_12 = Kd12 * k12
!F k11 = k9
!F k_11 = k_9
!F EGF_tot = EGF + (RE + 2.0 * (Rd + Rp + Ri + Rp_GS + Rp_Shc + Rp_pShc + Rp_pShc_GS + Rp_PI3K + Rp_RasGAP)) * (cell / extra)
!F phosphorylated_Akt = pAkt + ppAkt