begin name
borisov1
end name

begin reactions
reaction1 {1.0}R + {1.0}EGF = {1.0}RE
reaction10 {1.0}RppShcGS = {1.0}Rp + {1.0}pShcGS
reaction100 {1.0}IRSpGS = {1.0}GS + {1.0}IRS
reaction101 {1.0}IRSpSHP2 = {1.0}IRS + {1.0}SHP2
reaction102 {1.0}mGABppSHP2 = {1.0}SHP2 + {1.0}mGAB
reaction103 {1.0}mGABppSHP2GS = {1.0}GS + {1.0}SHP2 + {1.0}mGAB
reaction104 {1.0}GABp = {1.0}GAB
reaction105 {1.0}GABpPI3K = {1.0}PI3K + {1.0}GAB
reaction106 {1.0}GABpGS = {1.0}GS + {1.0}GAB
reaction107 {1.0}GABpRasGAP = {1.0}RasGAP + {1.0}GAB
reaction108 {1.0}GABpSHP2 = {1.0}SHP2 + {1.0}GAB
reaction109 {1.0}GABppSHP2 = {1.0}SHP2 + {1.0}GAB
reaction11 {1.0}pShcGS = {1.0}GS + {1.0}pShc
reaction110 {1.0}GABppSHP2GS = {1.0}GS + {1.0}SHP2 + {1.0}GAB
reaction111 {1.0}mGABpRasGAP = {1.0}RasGAP + {1.0}mGAB
reaction112 {1.0}RpRasGAP = {1.0}Rp + {1.0}RasGAP
reaction113 {1.0}IRpRasGAP = {1.0}RasGAP + {1.0}IRp
reaction114 {1.0}RpRasGAP = {1.0}Rp + {1.0}RasGAP
reaction115 {1.0}IRpRasGAP = {1.0}RasGAP + {1.0}IRp
reaction117 {1.0}mGABp = {1.0}imGABp
reaction118 {1.0}imGABp = {1.0}imGAB
reaction12 {1.0}Rp + {1.0}PI3K = {1.0}RpPI3K
reaction13 {1.0}Rp + {1.0}RasGAP = {1.0}RpRasGAP
reaction17 {1.0}Rp = {1.0}Null
reaction18 {1.0}RpGS = {1.0}GS
reaction19 {1.0}RpShc = {1.0}Shc
reaction2 {2.0}RE = {1.0}Rd
reaction20 {1.0}RppShc = {1.0}pShc
reaction21 {1.0}RppShcGS = {1.0}pShcGS
reaction22 {1.0}RpPI3K = {1.0}PI3K
reaction23 {1.0}RpRasGAP = {1.0}RasGAP
reaction24 {1.0}I + {1.0}IR = {1.0}IRL
reaction25 {1.0}IRL = {1.0}IRp
reaction26 {1.0}PI3K + {1.0}IRp = {1.0}IRpPI3K
reaction27 {1.0}RasGAP + {1.0}IRp = {1.0}IRpRasGAP
reaction28 {1.0}IRp + {1.0}IRS = {1.0}IRpIRS
reaction29 {1.0}IRpIRS = {1.0}IRpIRSp
reaction3 {1.0}Rd = {1.0}Rp
reaction30 {1.0}IRpIRSp = {1.0}IRp + {1.0}IRSp
reaction31 {1.0}IRSp = {1.0}IRS
reaction34 {1.0}IRp = {1.0}Null
reaction35 {1.0}IRpPI3K = {1.0}PI3K
reaction36 {1.0}IRpRasGAP = {1.0}RasGAP
reaction37 {1.0}IRpIRS = {1.0}IRS
reaction38 {1.0}IRpIRSp = {1.0}IRSp
reaction4 {1.0}Rp + {1.0}GS = {1.0}RpGS
reaction40 {1.0}iSrc = {1.0}aSrc
reaction41 {1.0}aSrc = {1.0}iSrc
reaction42 {1.0}IRS + {1.0}PIP3 = {1.0}mIRS
reaction43 {1.0}mIRS = {1.0}mIRSp
reaction44 {1.0}mIRSp = {1.0}mIRS
reaction45 {1.0}GS + {1.0}mIRSp = {1.0}mIRSpGS
reaction46 {1.0}PI3K + {1.0}mIRSp = {1.0}mIRSpPI3K
reaction47 {1.0}mIRSp + {1.0}SHP2 = {1.0}mIRSpSHP2
reaction48 {1.0}mIRSpSHP2 = {1.0}mIRS + {1.0}SHP2
reaction49 {1.0}GAB + {1.0}PIP3 = {1.0}mGAB
reaction5 {1.0}Rp + {1.0}Shc = {1.0}RpShc
reaction50 {1.0}mGAB = {1.0}mGABp
reaction51 {1.0}mGABp = {1.0}mGAB
reaction52 {1.0}GS + {1.0}mGABp = {1.0}mGABpGS
reaction53 {1.0}PI3K + {1.0}mGABp = {1.0}mGABpPI3K
reaction54 {1.0}RasGAP + {1.0}mGABp = {1.0}mGABpRasGAP
reaction55 {1.0}SHP2 + {1.0}mGABp = {1.0}mGABpSHP2
reaction56 {1.0}mGABpSHP2 = {1.0}SHP2 + {1.0}mGAB
reaction57 {1.0}mGABpSHP2 = {1.0}mGABppSHP2
reaction58 {1.0}mGABppSHP2 = {1.0}mGABpSHP2
reaction59 {1.0}GS + {1.0}mGABppSHP2 = {1.0}mGABppSHP2GS
reaction6 {1.0}RpShc = {1.0}RppShc
reaction60 {1.0}$EXTERNAL = {1.0}PIP3
reaction61 {1.0}PIP3 = {1.0}Null
reaction62 {1.0}dRas = {1.0}tRas
reaction63 {1.0}tRas = {1.0}dRas
reaction64 {1.0}PI3K + {1.0}tRas = {1.0}tRasPI3K
reaction65 {1.0}Raf = {1.0}aRaf
reaction66 {1.0}aRaf = {1.0}aaRaf
reaction67 {1.0}aaRaf = {1.0}Raf
reaction68 {1.0}Mek = {1.0}ppMek
reaction69 {1.0}ppMek = {1.0}Mek
reaction7 {1.0}RppShc = {1.0}Rp + {1.0}pShc
reaction70 {1.0}Erk = {1.0}pErk
reaction71 {1.0}pErk = {1.0}ppErk
reaction72 {1.0}ppErk = {1.0}pErk
reaction73 {1.0}pErk = {1.0}Erk
reaction74 {1.0}PIP3 + {1.0}PDK1 = {1.0}mPDK1
reaction75 {1.0}Akt = {1.0}pAkt
reaction76 {1.0}pAkt = {1.0}Akt
reaction77 {1.0}mTOR = {1.0}amTOR
reaction78 {1.0}pAkt = {1.0}ppAkt
reaction79 {1.0}GS = {1.0}iGS
reaction8 {1.0}pShc = {1.0}Shc
reaction80 {1.0}mGAB = {1.0}imGAB
reaction81 {1.0}mIRS = {1.0}imIRS
reaction82 {1.0}Rp = {1.0}Ri
reaction83 {1.0}Ri = {1.0}Rd
reaction84 {1.0}IRp = {1.0}IRi
reaction85 {1.0}IRi = {1.0}IRL
reaction88 {1.0}mIRSp = {1.0}IRSp + {1.0}PIP3
reaction89 {1.0}mIRSpPI3K = {1.0}PIP3 + {1.0}IRSpPI3K
reaction9 {1.0}GS + {1.0}RppShc = {1.0}RppShcGS
reaction90 {1.0}mIRSpGS = {1.0}PIP3 + {1.0}IRSpGS
reaction91 {1.0}mIRSpSHP2 = {1.0}PIP3 + {1.0}IRSpSHP2
reaction92 {1.0}mGABp = {1.0}PIP3 + {1.0}GABp
reaction93 {1.0}mGABpPI3K = {1.0}PIP3 + {1.0}GABpPI3K
reaction94 {1.0}mGABpGS = {1.0}PIP3 + {1.0}GABpGS
reaction95 {1.0}mGABpRasGAP = {1.0}PIP3 + {1.0}GABpRasGAP
reaction96 {1.0}mGABpSHP2 = {1.0}PIP3 + {1.0}GABpSHP2
reaction97 {1.0}mGABppSHP2 = {1.0}PIP3 + {1.0}GABppSHP2
reaction98 {1.0}mGABppSHP2GS = {1.0}PIP3 + {1.0}GABppSHP2GS
reaction99 {1.0}IRSpPI3K = {1.0}PI3K + {1.0}IRS
end reactions

begin rate equations
reaction1 = cell*(k1*EGF[t]*R[t] - k1*RE[t])
reaction10 = cell*(-(k10*pShcGS[t]*Rp[t]) + k10*RppShcGS[t])
reaction100 = (cell*V31*IRSpGS[t])/(Km31 + IRSpGS[t])
reaction101 = cell*k48*IRSpSHP2[t]
reaction102 = cell*k56*mGABppSHP2[t]
reaction103 = cell*k56*mGABppSHP2GS[t]
reaction104 = (cell*V51*GABp[t])/(Km51 + GABp[t])
reaction105 = (cell*V51*GABpPI3K[t])/(Km51 + GABpPI3K[t])
reaction106 = (cell*V51*GABpGS[t])/(Km51 + GABpGS[t])
reaction107 = (cell*V51*GABpRasGAP[t])/(Km51 + GABpRasGAP[t])
reaction108 = cell*k56*GABpSHP2[t]
reaction109 = cell*k56*GABppSHP2[t]
reaction11 = cell*(-(k11*GS[t]*pShc[t]) + k11*pShcGS[t])
reaction110 = cell*k56*GABppSHP2GS[t]
reaction111 = cell*k111*mGABpRasGAP[t]*(mGABppSHP2[t] + mGABppSHP2GS[t] + mGABpSHP2[t] + mIRSpSHP2[t])
reaction112 = cell*k111*(mGABppSHP2[t] + mGABppSHP2GS[t] + mGABpSHP2[t])*RpRasGAP[t]
reaction113 = cell*k111*IRpRasGAP[t]*(mGABppSHP2[t] + mGABppSHP2GS[t] + mGABpSHP2[t])
reaction114 = cell*k111*mIRSpSHP2[t]*RpRasGAP[t]
reaction115 = cell*k111*IRpRasGAP[t]*mIRSpSHP2[t]
reaction117 = cell*(-(k80*imGABp[t]) + (2*kcat80*mGABp[t]*ppErk[t])/(Km80 + mGABp[t]))
reaction118 = cell*k118*imGABp[t]
reaction12 = cell*(k12*PI3K[t]*Rp[t] - k12*RpPI3K[t])
reaction13 = cell*(k13*RasGAP[t]*Rp[t] - k13*RpRasGAP[t])
reaction17 = cell*k17*Rp[t]
reaction18 = cell*k17*RpGS[t]
reaction19 = cell*k17*RpShc[t]
reaction2 = cell*(-(k2*Rd[t]) + k2*RE[t]^2)
reaction20 = cell*k17*RppShc[t]
reaction21 = cell*k17*RppShcGS[t]
reaction22 = cell*k17*RpPI3K[t]
reaction23 = cell*k17*RpRasGAP[t]
reaction24 = cell*(k24*I[t]*IR[t] - k24*IRL[t])
reaction25 = cell*k25*IRL[t]
reaction26 = cell*(-(k26*IRpPI3K[t]) + k26*IRp[t]*PI3K[t])
reaction27 = cell*(-(k27*IRpRasGAP[t]) + k27*IRp[t]*RasGAP[t])
reaction28 = cell*(-(k28*IRpIRS[t]) + k28*IRp[t]*IRS[t])
reaction29 = cell*k29*IRpIRS[t]
reaction3 = cell*k3*Rd[t]
reaction30 = cell*(k30*IRpIRSp[t] - k30*IRp[t]*IRSp[t])
reaction31 = (cell*V31*IRSp[t])/(Km31 + IRSp[t])
reaction34 = cell*k17*IRp[t]
reaction35 = cell*k17*IRpPI3K[t]
reaction36 = cell*k17*IRpRasGAP[t]
reaction37 = cell*k17*IRpIRS[t]
reaction38 = cell*k17*IRpIRSp[t]
reaction4 = cell*(k4*GS[t]*Rp[t] - k4*RpGS[t])
reaction40 = (cell*kcat40*iSrc[t]*(alpha40*IRp[t] + Rp[t]))/(Km40 + iSrc[t])
reaction41 = (cell*V41*aSrc[t])/(Km41 + aSrc[t])
reaction42 = cell*(-(k42*mIRS[t]) + k42*IRS[t]*PIP3[t])
reaction43 = (cell*kcat43*mIRS[t]*(IRp[t] + alpha43*Rp[t]))/(Km43 + mIRS[t])
reaction44 = (cell*V31*mIRSp[t])/(Km31 + mIRSp[t])
reaction45 = cell*(k45*GS[t]*mIRSp[t] - k45*mIRSpGS[t])
reaction46 = cell*(-(k46*mIRSpPI3K[t]) + k46*mIRSp[t]*PI3K[t])
reaction47 = cell*(-(k47*mIRSpSHP2[t]) + k47*mIRSp[t]*SHP2[t])
reaction48 = cell*k48*mIRSpSHP2[t]
reaction49 = cell*(-(k49*mGAB[t]) + k49*GAB[t]*PIP3[t])
reaction5 = cell*(-(k5*RpShc[t]) + k5*Rp[t]*Shc[t])
reaction50 = (cell*kcat50*mGAB[t]*(alpha50*aSrc[t] + Rp[t]))/(Km50 + mGAB[t])
reaction51 = (cell*V51*mGABp[t])/(Km51 + mGABp[t])
reaction52 = cell*(k52*GS[t]*mGABp[t] - k52*mGABpGS[t])
reaction53 = cell*(-(k53*mGABpPI3K[t]) + k53*mGABp[t]*PI3K[t])
reaction54 = cell*(-(k54*mGABpRasGAP[t]) + k54*mGABp[t]*RasGAP[t])
reaction55 = cell*(-(k55*mGABpSHP2[t]) + k55*mGABp[t]*SHP2[t])
reaction56 = cell*k56*mGABpSHP2[t]
reaction57 = (cell*kcat57*mGABpSHP2[t]*(aSrc[t] + Rp[t]))/(Km57 + mGABpSHP2[t])
reaction58 = (cell*V58*mGABppSHP2[t])/(Km58 + mGABppSHP2[t])
reaction59 = cell*(k59*GS[t]*mGABppSHP2[t] - k59*mGABppSHP2GS[t])
reaction6 = cell*k6*RpShc[t]
reaction60 = cell*k60*(IRpPI3K[t] + mGABpPI3K[t] + mIRSpPI3K[t] + RpPI3K[t] + tRasPI3K[t])
reaction61 = cell*k61*PIP3[t]
reaction62 = (cell*kcat62*dRas[t]*(mGABpGS[t] + mGABppSHP2GS[t] + mIRSpGS[t] + RpGS[t] + RppShcGS[t]))/(Km62 + dRas[t])
reaction63 = (cell*kcat63*(bRasGAP[t] + IRpRasGAP[t] + mGABpRasGAP[t] + RpRasGAP[t])*tRas[t])/(Km63 + tRas[t])
reaction64 = cell*(k64*PI3K[t]*tRas[t] - k64*tRasPI3K[t])
reaction65 = (cell*kcat65*Raf[t]*tRas[t])/(Km65 + Raf[t])
reaction66 = (cell*kcat66*aRaf[t]*aSrc[t])/(Km66 + aRaf[t])
reaction67 = cell*((kcat67*aaRaf[t]*PKA[t])/(Km67 + aaRaf[t]) + alpha67*aaRaf[t]*(pAkt[t] + beta67*ppAkt[t]))
reaction68 = (cell*kcat68*aaRaf[t]*Mek[t])/(Km68 + Mek[t])
reaction69 = (cell*V69*ppMek[t])/(Km69 + ppMek[t])
reaction7 = cell*(-(k7*pShc[t]*Rp[t]) + k7*RppShc[t])
reaction70 = (cell*kcat70*Erk[t]*ppMek[t])/(Km70 + Erk[t] + (Km70*pErk[t])/Km71)
reaction71 = (cell*kcat71*pErk[t]*ppMek[t])/(Km71 + (Km71*Erk[t])/Km70 + pErk[t])
reaction72 = (cell*V72*ppErk[t])/(Km72 + (Km72*pErk[t])/Km73 + ppErk[t])
reaction73 = (cell*V73*pErk[t])/(Km73 + pErk[t] + (Km73*ppErk[t])/Km72)
reaction74 = cell*(-(k74*mPDK1[t]) + k74*PDK1[t]*PIP3[t])
reaction75 = (cell*kcat75*Akt[t]*mPDK1[t])/(Km75 + Akt[t])
reaction76 = (cell*V76*pAkt[t])/(Km76 + pAkt[t])
reaction77 = cell*(-(k77*amTOR[t]) + (kcat77*mTOR[t]*(alpha77*pAkt[t] + ppAkt[t]))/(Km77 + mTOR[t]))
reaction78 = cell*((kcat78*amTOR[t]*pAkt[t])/(Km78 + pAkt[t]) - k78*ppAkt[t])
reaction79 = cell*(-(k79*iGS[t]) + (kcat79*GS[t]*ppErk[t])/(Km79 + GS[t]))
reaction8 = (cell*V8*pShc[t])/(Km8 + pShc[t])
reaction80 = cell*(-(k80*imGAB[t]) + (kcat80*mGAB[t]*ppErk[t])/(Km80 + mGAB[t]))
reaction81 = cell*(-(k81*imIRS[t]) + (kcat81*amTOR[t]*mIRS[t])/(Km81 + mIRS[t]))
reaction82 = (cell*V82*Rp[t])/(Km82 + Rp[t])
reaction83 = cell*k83*Ri[t]
reaction84 = (cell*V84*IRp[t])/(Km84 + IRp[t])
reaction85 = cell*k85*IRi[t]
reaction88 = cell*(k42*mIRSp[t] - k42*IRSp[t]*PIP3[t])
reaction89 = cell*(k42*mIRSpPI3K[t] - k42*IRSpPI3K[t]*PIP3[t])
reaction9 = cell*(k9*GS[t]*RppShc[t] - k9*RppShcGS[t])
reaction90 = cell*(k42*mIRSpGS[t] - k42*IRSpGS[t]*PIP3[t])
reaction91 = cell*(k42*mIRSpSHP2[t] - k42*IRSpSHP2[t]*PIP3[t])
reaction92 = cell*(k42*mGABp[t] - k42*GABp[t]*PIP3[t])
reaction93 = cell*(k42*mGABpPI3K[t] - k42*GABpPI3K[t]*PIP3[t])
reaction94 = cell*(k42*mGABpGS[t] - k42*GABpGS[t]*PIP3[t])
reaction95 = cell*(k42*mGABpRasGAP[t] - k49*GABpRasGAP[t]*PIP3[t])
reaction96 = cell*(k42*mGABpSHP2[t] - k42*GABpSHP2[t]*PIP3[t])
reaction97 = cell*(k42*mGABppSHP2[t] - k42*GABppSHP2[t]*PIP3[t])
reaction98 = cell*(k42*mGABppSHP2GS[t] - k42*GABppSHP2GS[t]*PIP3[t])
reaction99 = (cell*V31*IRSpPI3K[t])/(Km31 + IRSpPI3K[t])
end rate equations

begin parameters
Kd1 = 0.58824
Kd10 = 400.0
Kd12 = 12.45
Kd13 = 200.0
Kd2 = 15.0
Kd24 = 0.029412
Kd26 = 124.5
Kd27 = 2000000.0
Kd28 = 3.75
Kd30 = 10.0
Kd4 = 10.0
Kd42 = 10.0
Kd45 = 100000.0
Kd46 = 1.0
Kd47 = 1000.0
Kd49 = 1.0
Kd5 = 10.0
Kd52 = 1.0
Kd53 = 2.5
Kd54 = 66666.0
Kd55 = 100.0
Kd59 = 20.0
Kd7 = 400.0
Kd74 = 100.0
Kd9 = 10.0
Km31 = 143.3
Km40 = 110.0
Km41 = 50.0
Km43 = 150.0
Km50 = 150.0
Km51 = 130.0
Km57 = 150.0
Km58 = 130.0
Km62 = 50.0
Km63 = 50.0
Km65 = 400.0
Km66 = 10.0
Km67 = 10000.0
Km68 = 50.0
Km69 = 675.299
Km70 = 500.0
Km71 = 500.0
Km72 = 500.0
Km73 = 500.0
Km75 = 500.0
Km76 = 1.0
Km77 = 100.0
Km78 = 100.0
Km79 = 5000.0
Km8 = 100.0
Km80 = 700.0
Km81 = 300.0
Km82 = 50.0
Km84 = 266.0
V31 = 333.0
V41 = 6.66
V51 = 333.0
V58 = 2.0
V69 = 16.6
V72 = 33.3
V73 = 23.33
V76 = 16.66
V8 = 200.0
V82 = 133.0
V84 = 333.0
alpha40 = 0.00025
alpha43 = 0.05
alpha50 = 0.0001
alpha67 = "1e-06"
alpha77 = 0.5
beta67 = 2.0
k1 = 0.068
k10 = 0.0004
k111 = 0.0133
k118 = 0.001
k12 = 0.00933
k13 = "6.66e-06"
k17 = 0.000185
k2 = 0.033
k24 = 0.011322
k25 = 1.66
k26 = 0.00933
k27 = "6.66e-08"
k28 = 0.1066
k29 = 0.66
k3 = 0.4
k30 = 0.0066
k4 = 0.000666
k42 = 0.00666
k45 = 0.000666
k46 = 0.00666
k47 = 0.000666
k48 = 0.666
k49 = 0.000666
k5 = 0.0133
k52 = 0.002
k53 = 0.0133
k54 = "1e-05"
k55 = 0.000666
k56 = 0.666
k59 = 0.01
k6 = 0.333
k60 = 4.66
k61 = 3.33
k64 = 0.0
k7 = 0.000666
k74 = 0.00666
k83 = 0.0166
k85 = 0.0166
k9 = 0.00666
k64 = 2.5
k77 = 0.666
k78 = 0.666
k79 = "6.66e-05"
k80 = "6.66e-05"
k81 = "6.66e-05"
kcat40 = 6.6
kcat43 = 33.3
kcat50 = 3333.0
kcat57 = 0.133
kcat62 = 5.33
kcat63 = 20000.0
kcat65 = 0.1
kcat66 = 3.33
kcat67 = 0.666
kcat68 = 0.133
kcat70 = 0.333
kcat71 = 0.666
kcat75 = 4.66
kcat77 = 0.666
kcat78 = 0.666
kcat79 = 0.0466
kcat80 = 0.04
kcat81 = 0.166
cell = 1.0
extra = 34.0
end parameters

begin initial conditions
Akt[0] = Akti
EGF[0] = EGFi
Erk[0] = Erki
GAB[0] = GABi
GABp[0] = GABpi
GABpGS[0] = GABpGSi
GABpPI3K[0] = GABpPI3Ki
GABpRasGAP[0] = GABpRasGAPi
GABpSHP2[0] = GABpSHP2i
GABppSHP2[0] = GABppSHP2i
GABppSHP2GS[0] = GABppSHP2GSi
GS[0] = GSi
I[0] = Ii
IR[0] = IRi
IRL[0] = IRLi
IRS[0] = IRSi
IRSp[0] = IRSpi
IRSpGS[0] = IRSpGSi
IRSpPI3K[0] = IRSpPI3Ki
IRSpSHP2[0] = IRSpSHP2i
IRi[0] = IRii
IRp[0] = IRpi
IRpIRS[0] = IRpIRSi
IRpIRSp[0] = IRpIRSpi
IRpPI3K[0] = IRpPI3Ki
IRpRasGAP[0] = IRpRasGAPi
Mek[0] = Meki
Null[0] = Nulli
PDK1[0] = PDK1i
PI3K[0] = PI3Ki
PIP3[0] = PIP3i
PKA[0] = PKAi
R[0] = Ri
RE[0] = REi
Raf[0] = Rafi
RasGAP[0] = RasGAPi
Rd[0] = Rdi
Ri[0] = Rii
Rp[0] = Rpi
RpGS[0] = RpGSi
RpPI3K[0] = RpPI3Ki
RpRasGAP[0] = RpRasGAPi
RpShc[0] = RpShci
RppShc[0] = RppShci
RppShcGS[0] = RppShcGSi
SHP2[0] = SHP2i
Shc[0] = Shci
aPX[0] = aPXi
aPXGS[0] = aPXGSi
aRaf[0] = aRafi
aSrc[0] = aSrci
aaRaf[0] = aaRafi
amTOR[0] = amTORi
bRasGAP[0] = bRasGAPi
dRas[0] = dRasi
iGS[0] = iGSi
iPX[0] = iPXi
iSrc[0] = iSrci
imGAB[0] = imGABi
imGABp[0] = imGABpi
imIRS[0] = imIRSi
mGAB[0] = mGABi
mGABp[0] = mGABpi
mGABpGS[0] = mGABpGSi
mGABpPI3K[0] = mGABpPI3Ki
mGABpRasGAP[0] = mGABpRasGAPi
mGABpSHP2[0] = mGABpSHP2i
mGABppSHP2[0] = mGABppSHP2i
mGABppSHP2GS[0] = mGABppSHP2GSi
mIRS[0] = mIRSi
mIRSp[0] = mIRSpi
mIRSpGS[0] = mIRSpGSi
mIRSpPI3K[0] = mIRSpPI3Ki
mIRSpSHP2[0] = mIRSpSHP2i
mPDK1[0] = mPDK1i
mTOR[0] = mTORi
pAkt[0] = pAkti
pErk[0] = pErki
pShc[0] = pShci
pShcGS[0] = pShcGSi
ppAkt[0] = ppAkti
ppErk[0] = ppErki
ppMek[0] = ppMeki
tRas[0] = tRasi
tRasPI3K[0] = tRasPI3Ki
end initial conditions

begin initial values
Akti = 100.0
EGFi = 1.0
Erki = 400.0
GABi = 225.0
GABpi = 0.0
GABpGSi = 0.0
GABpPI3Ki = 0.0
GABpRasGAPi = 0.0
GABpSHP2i = 0.0
GABppSHP2i = 0.0
GABppSHP2GSi = 0.0
GSi = 200.0
Ii = 0.0
IRi = 150.0
IRLi = 0.0
IRSi = 300.0
IRSpi = 0.0
IRSpGSi = 0.0
IRSpPI3Ki = 0.0
IRSpSHP2i = 0.0
IRii = 0.0
IRpi = 0.0
IRpIRSi = 0.0
IRpIRSpi = 0.0
IRpPI3Ki = 0.0
IRpRasGAPi = 0.0
Meki = 200.0
Nulli = 0.0
PDK1i = 100.0
PI3Ki = 200.0
PIP3i = 0.0
PKAi = 100.0
Ri = 100.0
REi = 0.0
Rafi = 100.0
RasGAPi = 50.0
Rdi = 0.0
Rii = 0.0
Rpi = 0.0
RpGSi = 0.0
RpPI3Ki = 0.0
RpRasGAPi = 0.0
RpShci = 0.0
RppShci = 0.0
RppShcGSi = 0.0
SHP2i = 300.0
Shci = 270.0
aPXi = 0.0
aPXGSi = 0.0
aRafi = 0.0
aSrci = 0.0
aaRafi = 0.0
amTORi = 0.0
bRasGAPi = 1e-05
dRasi = 150.0
iGSi = 0.0
iPXi = 200.0
iSrci = 518.0
imGABi = 0.0
imGABpi = 0.0
imIRSi = 0.0
mGABi = 0.0
mGABpi = 0.0
mGABpGSi = 0.0
mGABpPI3Ki = 0.0
mGABpRasGAPi = 0.0
mGABpSHP2i = 0.0
mGABppSHP2i = 0.0
mGABppSHP2GSi = 0.0
mIRSi = 0.0
mIRSpi = 0.0
mIRSpGSi = 0.0
mIRSpPI3Ki = 0.0
mIRSpSHP2i = 0.0
mPDK1i = 0.0
mTORi = 100.0
pAkti = 0.0
pErki = 0.0
pShci = 0.0
pShcGSi = 0.0
ppAkti = 0.0
ppErki = 0.0
ppMeki = 0.0
tRasi = 0.0
tRasPI3Ki = 0.0
end initial values

begin assignment rules
k5 := k5*Kd5
k4 := k4*Kd4
k2 := k2*Kd2
k1 := k1*Kd1
k10 := k10*Kd10
k9 := k9*Kd9
k7 := k7*Kd7
k74 := k74*Kd74
k59 := k59*Kd59
k55 := k55*Kd55
k54 := k54*Kd54
k53 := k53*Kd53
k52 := k52*Kd52
k49 := k49*Kd49
k47 := k47*Kd47
k46 := k46*Kd46
k45 := k45*Kd45
k42 := k42*Kd42
k30 := k30*Kd30
k28 := k28*Kd28
k27 := k27*Kd27
k26 := k26*Kd26
k24 := k24*Kd24
k13 := k13*Kd13
k12 := k12*Kd12
k11 := k9
k11 := k9
EGFtot := EGF[t] + (cell*(RE[t] + 2*(Rd[t] + Ri[t] + Rp[t] + RpGS[t] + RpPI3K[t] + RppShc[t] + RppShcGS[t] + RpRasGAP[t] + RpShc[t])))/extra
phosphorylatedAkt := pAkt[t] + ppAkt[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units