begin name
blum1
end name

begin reactions
reaction0 {1.0}H + {1.0}R = {1.0}HR
reaction1 {2.0}HR = {1.0}HRRH
reaction2 {1.0}HRRH + {1.0}GQ = {1.0}E
reaction3 {1.0}IP3 = {1.0}$EXTERNAL
reaction4 {1.0}$EXTERNAL = {1.0}IP3
end reactions

begin rate equations
reaction0 = cell*(-(reaction0k2*HR[t]) + reaction0k1*H[t]*R[t])
reaction1 = cell*(reaction1k1*HR[t]^2 - reaction1k2*HRRH[t])
reaction2 = cell*(-(reaction2k2*E[t]) + reaction2k1*GQ[t]*HRRH[t])
reaction3 = cell*reaction3k1*IP3[t]
reaction4 = cell*reaction4k*E[t]
end rate equations

begin parameters
alpha = 2.0
beta = 4.0
reaction0k1 = 2.5
reaction0k2 = 5.0
reaction1k1 = 2500.0
reaction1k2 = 5.0
reaction2k1 = 4000.0
reaction2k2 = 200.0
reaction3k1 = 10.0
reaction4k = 20000000.0
cell = 1.0
end parameters

begin initial conditions
E[0] = Ei
GQ[0] = GQi
H[0] = Hi
HR[0] = HRi
HRRH[0] = HRRHi
IP3[0] = IP3i
R[0] = Ri
end initial conditions

begin initial values
Ei = 0.0
GQi = 0.1
Hi = 1.0
HRi = 0.0
HRRHi = 0.0
IP3i = 0.0
Ri = 0.01
end initial values

begin assignment rules
CHO := (0.001*alpha*(0.3 + 0.3*beta*E^(1 - beta*t)*t)*IP3[t])/(1 + 0.001*alpha*IP3[t])
end assignment rules

begin function definitions
end function definitions

begin events
RemovalH = (t > 5, {H[t] -> 0}, 0)
end events

begin process annotations
end process annotations

begin species annotations
E http://identifiers.org/pirsf/PIRSF005483
end species annotations

begin units
end units