#bhartiya1



#reactions
Enzyme_dilution:
 {1.0}Enz = $pool
  compartment * mu * Enz
Enzyme_synthesis:
 $pool = {1.0}Enz
  compartment * k1 * pow(ki1, nH) * Ot / (pow(ki1, nH) + pow(Tt, nH))
tryptophan_consumption:
 {1.0}Ts = $pool
  compartment * g * Ts / (Kg + Ts)
tryptophan_dilution:
 {1.0}Ts = $pool
  compartment * mu * Ts
tryptophan_synthesis:
 $pool = {1.0}Ts
  compartment * k2 * Enz * Ki2 / (Ki2 + Tt)


#parameters
Tex = 0.14
Tomax = 100.0
e_val = 0.9
f_val = 380.0
Enzyme_synthesis_k1 = 65.0
Enzyme_synthesis_ki1 = 3.53
Enzyme_synthesis_nH = 1.92
Enzyme_synthesis_Ot = 0.0033
Enzyme_dilution_mu = 0.01
tryptophan_synthesis_k2 = 25.0
tryptophan_synthesis_Ki2 = 810.0
tryptophan_consumption_g = 25.0
tryptophan_consumption_Kg = 0.2
tryptophan_dilution_mu = 0.01
compartment = 1.0


#initial values
Enz = 0.0
Ts = 0.0


#assignment rules
!F To_norm = To / 82.0
!F Tt_norm = Tt / 82.0
!F Ts_norm = Ts / 82.0
!F Enz_norm = Enz / 1.0
!F Tt = To + Ts
!F To = Tomax * Tex / (Tex * (1.0 + Ts / f_val) + e_val)