begin name
bhartiya1
end name

begin reactions
Enzymedilution {1.0}Enz = {1.0}$EXTERNAL
Enzymesynthesis {1.0}$EXTERNAL = {1.0}Enz
tryptophanconsumption {1.0}Ts = {1.0}$EXTERNAL
tryptophandilution {1.0}Ts = {1.0}$EXTERNAL
tryptophansynthesis {1.0}$EXTERNAL = {1.0}Ts
end reactions

begin rate equations
Enzymedilution = compartment*Enzymedilutionmu*Enz[t]
Enzymesynthesis = (compartment*Enzymesynthesisk1*Enzymesynthesiski1^EnzymesynthesisnH*EnzymesynthesisOt)/(Enzymesynthesiski1^EnzymesynthesisnH + Tt^EnzymesynthesisnH)
tryptophanconsumption = (compartment*tryptophanconsumptiong*Ts[t])/(tryptophanconsumptionKg + Ts[t])
tryptophandilution = compartment*tryptophandilutionmu*Ts[t]
tryptophansynthesis = (compartment*tryptophansynthesisk2*tryptophansynthesisKi2*Enz[t])/(tryptophansynthesisKi2 + Tt)
end rate equations

begin parameters
Tex = 0.14
Tomax = 100.0
eval = 0.9
fval = 380.0
Enzymesynthesisk1 = 65.0
Enzymesynthesiski1 = 3.53
EnzymesynthesisnH = 1.92
EnzymesynthesisOt = 0.0033
Enzymedilutionmu = 0.01
tryptophansynthesisk2 = 25.0
tryptophansynthesisKi2 = 810.0
tryptophanconsumptiong = 25.0
tryptophanconsumptionKg = 0.2
tryptophandilutionmu = 0.01
compartment = 1.0
end parameters

begin initial conditions
Enz[0] = Enzi
Ts[0] = Tsi
end initial conditions

begin initial values
Enzi = 0.0
Tsi = 0.0
end initial values

begin assignment rules
Tonorm := To/82
Ttnorm := Tt/82
Tsnorm := Ts[t]/82
Enznorm := Enz[t]
Tt := To + Ts[t]
To := (Tex*Tomax)/(eval + Tex*(1 + Ts[t]/fval))
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
Enz http://identifiers.org/uniprot/P00895
Ts http://identifiers.org/chebi/CHEBI:27897
Ts http://identifiers.org/kegg.compound/C00806
Tt http://identifiers.org/chebi/CHEBI:27897
Tt http://identifiers.org/kegg.compound/C00806
end species annotations

begin units
end units