begin name
becker1
end name

begin reactions
reaction1 {1.0}$EXTERNAL = {1.0}EpoR
reaction2 {1.0}EpoR = {1.0}$EXTERNAL
reaction3 {1.0}Epo + {1.0}EpoR = {1.0}EpoEpoR
reaction4 {1.0}EpoEpoR = {1.0}Epo + {1.0}EpoR
reaction5 {1.0}EpoEpoR = {1.0}EpoEpoRi
reaction6 {1.0}EpoEpoRi = {1.0}Epo + {1.0}EpoR
reaction7 {1.0}EpoEpoRi = {1.0}dEpoi
reaction8 {1.0}EpoEpoRi = {1.0}dEpoe
end reactions

begin rate equations
reaction1 = Bmax*cell*kt
reaction2 = cell*kt*EpoR[t]
reaction3 = cell*kon*Epo[t]*EpoR[t]
reaction4 = cell*koff*EpoEpoR[t]
reaction5 = cell*ke*EpoEpoR[t]
reaction6 = cell*kex*EpoEpoRi[t]
reaction7 = cell*kdi*EpoEpoRi[t]
reaction8 = cell*kde*EpoEpoRi[t]
end rate equations

begin parameters
Bmax = 516.0
kde = 0.0164042
kdi = 0.00317871
ke = 0.0748267
kex = 0.00993805
koff = 0.0172135
kon = 0.00010496
kt = 0.0329366
cell = 1.0
cellsurface = 1.0
medium = 1.0
end parameters

begin initial conditions
Epo[0] = Epoi
EpoR[0] = EpoRi
EpoEpoR[0] = EpoEpoRi
EpoEpoRi[0] = EpoEpoRii
dEpoe[0] = dEpoei
dEpoi[0] = dEpoii
end initial conditions

begin initial values
Epoi = 2030.19
EpoRi = 516.0
EpoEpoRi = 0.0
EpoEpoRii = 0.0
dEpoei = 0.0
dEpoii = 0.0
end initial values

begin assignment rules
Epocells := dEpoi[t] + EpoEpoRi[t]
Epomedium := dEpoe[t] + Epo[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units