#bartholome1



#reactions
ABCC2:
 {1.0}x3 = {1.0}x5
  p2 * x3
OATP1B3:
 {1.0}x1 = {1.0}x3
  p1 * x1
bl_BSP_binding:
 {1.0}x1 = {1.0}x2
  p6 * x1 * (p8 - x2)
bl_BSP_dissoc:
 {1.0}x2 = {1.0}x1
  p7 * x2
cellular_BSP_binding:
 {1.0}x3 = {1.0}x4
  p9 * x3 * (p11 - x4)
cellular_BSP_dissoc:
 {1.0}x4 = {1.0}x3
  p10 * x4
endo_ex_ap:
 {1.0}x3 = {1.0}x5
  p5 * x3
endo_ex_bl:
 {1.0}x3 = {1.0}x1
  p4 * x3
endo_in_bl:
 {1.0}x1 = {1.0}x3
  p3 * x1
paracell_transp:
 {1.0}x1 = {1.0}x5
  p12 * (x1 / basolat - x5 / apical)


#parameters
p1 = 0.0025
p10 = 1.6
p11 = 1000.0
p12 = 0.0003
p2 = 0.0784
p3 = 0.0013
p4 = 0.0827
p5 = 0.0091
p6 = 6.4e-05
p7 = 0.0397
p8 = 1000.0
p9 = 0.0098
apical = 1.5
basolat = 1.0
cell = 1.0


#initial values
x1 = 88.0
x2 = 0.0
x3 = 0.0
x4 = 0.0
x5 = 0.0


#assignment rules
!F BSP_cell = x3 + x4
!F BSP_tot = x1 + x2 + x3 + x4 + x5