begin name
bartholome1
end name

begin reactions
ABCC2 {1.0}x3 = {1.0}x5
OATP1B3 {1.0}x1 = {1.0}x3
blBSPbinding {1.0}x1 = {1.0}x2
blBSPdissoc {1.0}x2 = {1.0}x1
cellularBSPbinding {1.0}x3 = {1.0}x4
cellularBSPdissoc {1.0}x4 = {1.0}x3
endoexap {1.0}x3 = {1.0}x5
endoexbl {1.0}x3 = {1.0}x1
endoinbl {1.0}x1 = {1.0}x3
paracelltransp {1.0}x1 = {1.0}x5
end reactions

begin rate equations
ABCC2 = p2*x3[t]
OATP1B3 = p1*x1[t]
blBSPbinding = p6*x1[t]*(p8 - x2[t])
blBSPdissoc = p7*x2[t]
cellularBSPbinding = p9*x3[t]*(p11 - x4[t])
cellularBSPdissoc = p10*x4[t]
endoexap = p5*x3[t]
endoexbl = p4*x3[t]
endoinbl = p3*x1[t]
paracelltransp = p12*(x1[t]/basolat - x5[t]/apical)
end rate equations

begin parameters
p1 = 0.0025
p10 = 1.6
p11 = 1000.0
p12 = 0.0003
p2 = 0.0784
p3 = 0.0013
p4 = 0.0827
p5 = 0.0091
p6 = "6.4e-05"
p7 = 0.0397
p8 = 1000.0
p9 = 0.0098
apical = 1.5
basolat = 1.0
cell = 1.0
end parameters

begin initial conditions
x1[0] = x1i
x2[0] = x2i
x3[0] = x3i
x4[0] = x4i
x5[0] = x5i
end initial conditions

begin initial values
x1i = 88.0
x2i = 0.0
x3i = 0.0
x4i = 0.0
x5i = 0.0
end initial values

begin assignment rules
BSPcell := x3[t] + x4[t]
BSPtot := x1[t] + x2[t] + x3[t] + x4[t] + x5[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
BSP_cell http://identifiers.org/kegg.compound/C11363
BSP_cell http://identifiers.org/chebi/CHEBI:63836
BSP_tot http://identifiers.org/kegg.compound/C11363
BSP_tot http://identifiers.org/chebi/CHEBI:63836
x1 http://identifiers.org/kegg.compound/C11363
x1 http://identifiers.org/chebi/CHEBI:63836
x2 http://identifiers.org/kegg.compound/C11363
x2 http://identifiers.org/chebi/CHEBI:63836
x3 http://identifiers.org/kegg.compound/C11363
x3 http://identifiers.org/chebi/CHEBI:63836
x4 http://identifiers.org/kegg.compound/C11363
x4 http://identifiers.org/chebi/CHEBI:63836
x5 http://identifiers.org/kegg.compound/C11363
x5 http://identifiers.org/chebi/CHEBI:63836
end species annotations

begin units
end units