begin name
bai1
end name

begin reactions
E2Fdegradationviacellcycleprogression1 {1.0}theta1 = {1.0}$EXTERNAL
1 {1.0}$EXTERNAL = {1.0}D1
2 {1.0}RS1 = {1.0}theta1
cellcycleprogression1 {1.0}$EXTERNAL = {1.0}X1
cellcycleprogressionslow1 {1.0}X1 = {1.0}$EXTERNAL
cyclinD1 {1.0}D1 = {1.0}$EXTERNAL
cyclinEdegradation1 {1.0}E1 = {1.0}$EXTERNAL
cyclinEsynthesis1 {1.0}$EXTERNAL = {1.0}E1
null21 {1.0}RS1 = {1.0}theta1
null31 {1.0}$EXTERNAL = {1.0}theta1
pRBdeplation1 {1.0}R1 + {1.0}theta1 = {1.0}RS1
pRBsynthesis1 {1.0}$EXTERNAL = {1.0}R1
end reactions

begin rate equations
E2Fdegradationviacellcycleprogression1 = (cell*dtheta1*theta1[t]*X1[t])/(qtheta1 + X1[t])
1 = (aD1*cell*GF1)/(GF1 + k11^(-1))
2 = (cell*pD1*D1[t]*RS1[t])/(qD1 + D1[t] + RS1[t])
cellcycleprogression1 = cell*(aX1*E1[t] + f1*theta1[t] + g1*E1[t]*X1[t]^2)
cellcycleprogressionslow1 = cell*dX1*X1[t]
cyclinD1 = cell*dD1*D1[t]*E1[t]
cyclinEdegradation1 = cell*dE1*E1[t]*X1[t]
cyclinEsynthesis1 = aE1*cell*(GF1/(GF1 + k21^(-1)) + aF1*theta1[t])
null21 = (cell*pE1*E1[t]*RS1[t])/(qE1 + E1[t] + RS1[t])
null31 = atheta1*cell*(GF1/(GF1 + k31^(-1)) + fC11*theta1[t])
pRBdeplation1 = cell*MassAction21[pS1, R1[t], theta1[t]]
pRBsynthesis1 = (cell*pX1*(RT1 - RS1[t] - R1[t])*X1[t])/(qX1 + RT1 - RS1[t] - R1[t] + X1[t])
end rate equations

begin parameters
GF1 = 6.3
RT1 = 2.5
aD1 = 0.4
aE1 = 0.16
aF1 = 0.9
aX1 = 0.08
atheta1 = 0.05
dD1 = 0.4
dE1 = 0.2
dX1 = 1.04
dtheta1 = 0.12
fC11 = 0.003
f1 = 0.35
g1 = 0.528
k11 = 0.05
k21 = 1000.0
k31 = 1.5
pD1 = 0.48
pE1 = 0.096
pS1 = 0.6
pX1 = 0.48
qD1 = 0.6
qE1 = 0.6
qX1 = 0.8
qtheta1 = 0.3
cell = 1.0
end parameters

begin initial conditions
D1[0] = D1i
E1[0] = E1i
RS1[0] = RS1i
R1[0] = R1i
X1[0] = X1i
theta1[0] = theta1i
end initial conditions

begin initial values
D1i = 0.0
E1i = 0.0
RS1i = 0.0
R1i = 0.0
X1i = 0.0
theta1i = 0.0
end initial values

begin assignment rules
Rbphos := RT1 - RS1[t] - R1[t]
end assignment rules

begin function definitions
MassAction21[k1_,S1_,S2_] := k1*S1*S2
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units