#bachmann



#reactions
reaction_1:
 {1.0}EpoRJAK2 = {1.0}EpoRpJAK2
  JAK2ActEpo * Epo * EpoRJAK2 / (SOCS3Inh * SOCS3 / SOCS3Eqc + 1) * cyt
reaction_10:
 {1.0}EpoRJAK2_CIS = $pool
  EpoRCISRemove * EpoRJAK2_CIS * (p12EpoRpJAK2 + p1EpoRpJAK2) / init_EpoRJAK2 * cyt
reaction_11:
 {1.0}SHP1 = {1.0}SHP1Act
  SHP1ActEpoR * SHP1 * (EpoRpJAK2 + p12EpoRpJAK2 + p1EpoRpJAK2 + p2EpoRpJAK2) / init_EpoRJAK2 * cyt
reaction_12:
 {1.0}SHP1Act = {1.0}SHP1
  SHP1Dea * SHP1Act * cyt
reaction_13:
 {1.0}STAT5 = {1.0}pSTAT5
  STAT5ActJAK2 * STAT5 * (EpoRpJAK2 + p12EpoRpJAK2 + p1EpoRpJAK2 + p2EpoRpJAK2) / (init_EpoRJAK2 * (SOCS3Inh * SOCS3 / SOCS3Eqc + 1)) * cyt
reaction_14:
 {1.0}STAT5 = {1.0}pSTAT5
  STAT5ActEpoR * STAT5 * pow(p12EpoRpJAK2 + p1EpoRpJAK2, 2) / (pow(init_EpoRJAK2, 2) * (CISInh * CIS / CISEqc + 1) * (SOCS3Inh * SOCS3 / SOCS3Eqc + 1)) * cyt
reaction_15:
 {1.0}pSTAT5 = {1.0}npSTAT5
  STAT5Imp * pSTAT5 * cyt
reaction_16:
 {1.0}npSTAT5 = {1.0}STAT5
  STAT5Exp * npSTAT5 * nuc
reaction_17:
 $pool = {1.0}CISnRNA1
  -(CISRNAEqc * CISRNATurn * npSTAT5 * (ActD - 1) / init_STAT5 * nuc)
reaction_18:
 {1.0}CISnRNA1 = {1.0}CISnRNA2
  CISRNADelay * CISnRNA1 * nuc
reaction_19:
 {1.0}CISnRNA2 = {1.0}CISnRNA3
  CISRNADelay * CISnRNA2 * nuc
reaction_2:
 {1.0}EpoRpJAK2 = {1.0}EpoRJAK2
  JAK2EpoRDeaSHP1 * SHP1Act * EpoRpJAK2 / init_SHP1 * cyt
reaction_20:
 {1.0}CISnRNA3 = {1.0}CISnRNA4
  CISRNADelay * CISnRNA3 * nuc
reaction_21:
 {1.0}CISnRNA4 = {1.0}CISnRNA5
  CISRNADelay * CISnRNA4 * nuc
reaction_22:
 {1.0}CISnRNA5 = {1.0}CISRNA
  CISRNADelay * CISnRNA5 * nuc
reaction_23:
 {1.0}CISRNA = $pool
  CISRNATurn * CISRNA * cyt
reaction_24:
 $pool = {1.0}CIS
  CISEqc * CISTurn * CISRNA / CISRNAEqc * cyt
reaction_25:
 {1.0}CIS = $pool
  CISTurn * CIS * cyt
reaction_26:
 $pool = {1.0}CIS
  CISoe * CISEqc * CISTurn * CISEqcOE
reaction_27:
 $pool = {1.0}SOCS3nRNA1
  -(SOCS3RNAEqc * SOCS3RNATurn * npSTAT5 * (ActD - 1) / init_STAT5 * nuc)
reaction_28:
 {1.0}SOCS3nRNA1 = {1.0}SOCS3nRNA2
  SOCS3RNADelay * SOCS3nRNA1 * nuc
reaction_29:
 {1.0}SOCS3nRNA2 = {1.0}SOCS3nRNA3
  SOCS3RNADelay * SOCS3nRNA2 * nuc
reaction_3:
 {1.0}EpoRpJAK2 = {1.0}p1EpoRpJAK2
  EpoRActJAK2 * EpoRpJAK2 / (SOCS3Inh * SOCS3 / SOCS3Eqc + 1) * cyt
reaction_30:
 {1.0}SOCS3nRNA3 = {1.0}SOCS3nRNA4
  SOCS3RNADelay * SOCS3nRNA3 * nuc
reaction_31:
 {1.0}SOCS3nRNA4 = {1.0}SOCS3nRNA5
  SOCS3RNADelay * SOCS3nRNA4 * nuc
reaction_32:
 {1.0}SOCS3nRNA5 = {1.0}SOCS3RNA
  SOCS3RNADelay * SOCS3nRNA5 * nuc
reaction_33:
 {1.0}SOCS3RNA = $pool
  SOCS3RNATurn * SOCS3RNA * cyt
reaction_34:
 $pool = {1.0}SOCS3
  SOCS3Eqc * SOCS3Turn * SOCS3RNA / SOCS3RNAEqc * cyt
reaction_35:
 {1.0}SOCS3 = $pool
  SOCS3Turn * SOCS3 * cyt
reaction_36:
 $pool = {1.0}SOCS3
  SOCS3oe * SOCS3Eqc * SOCS3Turn * SOCS3EqcOE
reaction_4:
 {1.0}EpoRpJAK2 = {1.0}p2EpoRpJAK2
  3 * EpoRActJAK2 * EpoRpJAK2 / ((SOCS3Inh * SOCS3 / SOCS3Eqc + 1) * (EpoRCISInh * EpoRJAK2_CIS + 1)) * cyt
reaction_5:
 {1.0}p1EpoRpJAK2 = {1.0}p12EpoRpJAK2
  3 * EpoRActJAK2 * p1EpoRpJAK2 / ((SOCS3Inh * SOCS3 / SOCS3Eqc + 1) * (EpoRCISInh * EpoRJAK2_CIS + 1)) * cyt
reaction_6:
 {1.0}p2EpoRpJAK2 = {1.0}p12EpoRpJAK2
  EpoRActJAK2 * p2EpoRpJAK2 / (SOCS3Inh * SOCS3 / SOCS3Eqc + 1) * cyt
reaction_7:
 {1.0}p1EpoRpJAK2 = {1.0}EpoRJAK2
  JAK2EpoRDeaSHP1 * SHP1Act * p1EpoRpJAK2 / init_SHP1 * cyt
reaction_8:
 {1.0}p2EpoRpJAK2 = {1.0}EpoRJAK2
  JAK2EpoRDeaSHP1 * SHP1Act * p2EpoRpJAK2 / init_SHP1 * cyt
reaction_9:
 {1.0}p12EpoRpJAK2 = {1.0}EpoRJAK2
  JAK2EpoRDeaSHP1 * SHP1Act * p12EpoRpJAK2 / init_SHP1 * cyt


#parameters
ActD = 0.0
CISEqc = 432.871
CISEqcOE = 0.530261
CISInh = 784653000.0
CISRNADelay = 0.144775
CISRNAEqc = 1.0
CISRNATurn = 1000.0
CISTurn = 0.00839842
CISoe = 0.0
EpoRActJAK2 = 0.267308
EpoRCISInh = 1000000.0
EpoRCISRemove = 5.42932
JAK2ActEpo = 633253.0
JAK2EpoRDeaSHP1 = 142.722
SHP1ActEpoR = 0.001
SHP1Dea = 0.00816391
SOCS3Eqc = 173.653
SOCS3EqcOE = 0.679157
SOCS3Inh = 10.408
SOCS3RNADelay = 1.06465
SOCS3RNAEqc = 1.0
SOCS3RNATurn = 0.00830844
SOCS3Turn = 10000.0
SOCS3oe = 0.0
STAT5ActEpoR = 38.9757
STAT5ActJAK2 = 0.0780965
STAT5Exp = 0.0745155
STAT5Imp = 0.0268889
epo_level = 1.24997e-07
init_EpoRJAK2 = 3.97622
init_SHP1 = 26.7251
init_STAT5 = 79.7535
cyt = 0.4
nuc = 0.275


#initial values
CIS = 0.0
CISRNA = 0.0
CISnRNA1 = 0.0
CISnRNA2 = 0.0
CISnRNA3 = 0.0
CISnRNA4 = 0.0
CISnRNA5 = 0.0
Epo = 1.24997e-07
EpoRJAK2 = 3.97622
EpoRJAK2_CIS = 0.0
EpoRpJAK2 = 0.0
SHP1 = 26.7251
SHP1Act = 0.0
SOCS3 = 0.0
SOCS3RNA = 0.0
SOCS3nRNA1 = 0.0
SOCS3nRNA2 = 0.0
SOCS3nRNA3 = 0.0
SOCS3nRNA4 = 0.0
SOCS3nRNA5 = 0.0
STAT5 = 79.7535
npSTAT5 = 0.0
p12EpoRpJAK2 = 0.0
p1EpoRpJAK2 = 0.0
p2EpoRpJAK2 = 0.0
pSTAT5 = 0.0


#assignment rules