#attila

FIX: sink source

#reactions
v_1:
 {1.0}source = {1.0}Mass
  mu*Mass*(1 - Mass/MaxMass)
v_10:
 {1.0}pBCKI = {1.0}pB + {1.0}CKI
  kdissb*pBCKI
v_11:
 {1.0}pBCKI = {1.0}BCKI
  V25*pBCKI
v_12:
 {1.0}BCKI = {1.0}pBCKI
  Vwee*BCKI
v_13:
 {1.0}BCKI = {1.0}CKI
  Vdb*BCKI
v_14:
 {1.0}BCKI = {1.0}CycB
  Vdi*BCKI
v_15:
 {1.0}pBCKI = {1.0}CKI
  Vdb*pBCKI
v_16:
 {1.0}pBCKI = {1.0}pB
  Vdi*pBCKI
v_17:
 {1.0}source = {1.0}CKI
  Vsi
v_18:
 {1.0}CKI = {1.0}sink
  Vdi*CKI
v_19:
 {1.0}CKI + {1.0}CycA = {1.0}TriA
  kassa*CKI*CycA
v_2:
 {1.0}source = {1.0}CycB
  Vsb
v_20:
 {1.0}TriA = {1.0}CKI + {1.0}CycA
  kdissa*TriA
v_21:
 {1.0}TriA = {1.0}CycA
  Vdi*TriA
v_22:
 {1.0}TriA = {1.0}CKI
  Vda*TriA
v_23:
 {1.0}CKI + {1.0}CycE = {1.0}TriE
  kasse*CKI*CycE
v_24:
 {1.0}TriE = {1.0}CKI + {1.0}CycE
  kdisse*TriE
v_25:
 {1.0}TriE = {1.0}CycE
  Vdi*TriE
v_26:
 {1.0}TriE = {1.0}CKI
  Vde*TriE
v_27:
 {1.0}source = {1.0}CycA
  Vsa
v_28:
 {1.0}CycA = {1.0}sink
  Vda*CycA
v_29:
 {1.0}source = {1.0}CycE
  Vse
v_3:
 {1.0}CycB = {1.0}sink
  Vdb*CycB
v_30:
 {1.0}CycE = {1.0}sink
  Vde*CycE
v_31:
 {1.0}source = {1.0}APCP
  Michaelis(CycB, Jaie, kaie, (1-APCP))
v_32:
 {1.0}APCP = {1.0}sink
  Michaelis(1.0, Jiie, kiie, APCP)
v_33:
 {1.0}source = {1.0}Cdc20in
  ks20p + ks20pp*CycB**n20/(J20**n20 + CycB**n20)
v_34:
 {1.0}Cdc20in = {1.0}sink
  kd20*Cdc20in
v_35:
 {1.0}Cdc20in = {1.0}Cdc20A
  Michaelis(APCP, Ja20, ka20, Cdc20in)
v_36:
 {1.0}Cdc20A = {1.0}Cdc20in
  Michaelis(1.0, Ji20, ki20, Cdc20A)
v_37:
 {1.0}Cdc20A = {1.0}sink
  kd20*Cdc20A
v_38:
 {1.0}source = {1.0}Cdh1
  Michaelis(Vah1, Jah1, 1.0, (1-Cdh1))
v_39:
 {1.0}Cdh1 = {1.0}sink
  Michaelis(Vih1, Jih1, 1.0, Cdh1)
v_4:
 {1.0}pB = {1.0}CycB
  V25*pB
v_5:
 {1.0}CycB = {1.0}pB
  Vwee*CycB
v_6:
 {1.0}CycB + {1.0}CKI = {1.0}BCKI
  kassb*CycB*CKI
v_7:
 {1.0}BCKI = {1.0}CycB + {1.0}CKI
  kdissb*BCKI
v_8:
 {1.0}pB = {1.0}sink
  Vdb*pB
v_9:
 {1.0}pB + {1.0}CKI = {1.0}pBCKI
  kassb*pB*CKI


#parameters
CycD0 = 0.108
J20 = 10.0
Ja20 = 1.0
Ja25 = 0.1
Jafb = 0.1
Jafi = 1.0
Jah1 = 0.03
Jaie = 0.1
Jatf = 0.01
Jawee = 0.05
Ji20 = 1.0
Ji25 = 0.1
Jifb = 0.1
Jifi = 2.0
Jih1 = 0.03
Jiie = 0.1
Jitf = 0.01
Jiwee = 0.05
KEZ = 0.2
MaxMass = 10000.0
k14di = 12.0
k25p = 0.01
k25pp = 5.0
ka20 = 1.0
ka25p = 0.0
ka25pp = 1.0
kafb = 1.0
kafi = 6.0
kah1p = 0.02
kah1pp = 0.8
kaie = 0.1
kassa = 50.0
kassb = 60.0
kasse = 0.0
katfapp = 1.5
katfdpp = 3.0
katfepp = 0.38
katfp = 0.0
kaweep = 0.3
kaweepp = 0.0
kd20 = 0.05
kdap = 0.01
kdapp = 0.16
kdappp = 0.0
kdbcpp = 0.15
kdbhpp = 0.4
kdbp = 0.003
kdeapp = 0.0
kdebpp = 0.0
kdeepp = 0.0
kdep = 0.12
kdiapp = 0.1
kdibpp = 0.8
kdidpp = 0.1
kdiepp = 0.12
kdip = 0.002
kdissa = 0.06
kdissb = 0.05
kdisse = 0.0
ki20 = 0.16
ki25p = 0.3
ki25pp = 0.0
kifb = 0.15
kifibpp = 0.05
kifip = 0.008
kih1app = 0.35
kih1bpp = 0.1
kih1dpp = 0.005
kih1epp = 0.06
kih1p = 0.001
kiie = 0.15
kitfapp = 0.0
kitfbpp = 8.0
kitfp = 0.75
kiweep = 0.0
kiweepp = 1.0
ks20p = 0.001
ks20pp = 1.0
ksap = 0.0015
ksapp = 0.01
ksbp = 0.004
ksbpp = 0.04
ksep = 0.0
ksepp = 0.15
ksip = 0.018
ksipp = 0.18
kweep = 0.02
kweepp = 0.2
mu = 0.005776
n20 = 1.0
sink = 1.0
source = 1.0
default_compartment = 1.0


#initial values
APCP = 0.0759140253067017
BCKI = 0.679449200630188
CKI = 0.02882070094347
Cdc20A = 0.357272386550903
Cdc20in = 0.770238757133484
Cdh1 = 0.718939363956451
CycA = 0.0945030823349953
CycB = 0.190358594059944
CycE = 0.209202438592911
Mass = 1.33826780319214
TriA = 0.349222421646118
TriE = 0.0
pB = 0.0123442625626922
pBCKI = 0.0479593835771084


#assignment rules
!F Cdc25 = GK(ka25p + ka25pp*CycB, ki25p + ki25pp*Cdc14, Ja25, Ji25)
!F Vatf = katfp + katfapp*CycA + katfepp*CycE + katfdpp*CycD
!F Vah1 = kah1p + kah1pp*Cdc14
!F Vsi = ksip + ksipp*TFI
!F Cdc14 = Cdc20A
!F CycD = CycD0*Mass
!F TFI = GK(kafi*Cdc14, kifip + kifibpp*CycB, Jafi, Jifi)
!F Vdi = (kdip + kdiapp*CycA + kdibpp*CycB + kdiepp*CycE + kdidpp*CycD)/(1.0 + k14di*Cdc14)
!F Vwee = kweep + kweepp*Wee1
!F Vse = (ksep + ksepp*TFE)*Mass
!F Vda = kdap + (kdapp + kdappp)*Cdc20A + kdappp*Cdc20in
!F V25 = k25p + k25pp*Cdc25
!F Vsa = (ksap + ksapp*TFE)*Mass
!F TFE = GK(Vatf, Vitf, Jatf, Jitf)
!F TFB = GK(kafb*CycB, kifb, Jafb, Jifb)
!F Vsb = (ksbp + ksbpp*TFB)*Mass
!F Vih1 = kih1p + kih1app*CycA + kih1bpp*CycB + kih1epp*CycE + kih1dpp*CycD
!F Vitf = kitfp + kitfapp*CycA + kitfbpp*CycB
!F Vdb = kdbp + kdbhpp*Cdh1 + kdbcpp*Cdc20A
!F Vde = kdep + kdeepp*CycE + kdeapp*CycA + kdebpp*CycB
!F Wee1 = GK(kaweep + kaweepp*Cdc14, kiweep + kiweepp*CycB, Jawee, Jiwee)