begin name
attila
end name

begin reactions
v1 {1.0}$source = {1.0}Mass
v10 {1.0}pBCKI = {1.0}pB + {1.0}CKI
v11 {1.0}pBCKI = {1.0}BCKI
v12 {1.0}BCKI = {1.0}pBCKI
v13 {1.0}BCKI = {1.0}CKI
v14 {1.0}BCKI = {1.0}CycB
v15 {1.0}pBCKI = {1.0}CKI
v16 {1.0}pBCKI = {1.0}pB
v17 {1.0}$source = {1.0}CKI
v18 {1.0}CKI = {1.0}$sink
v19 {1.0}CKI + {1.0}CycA = {1.0}TriA
v2 {1.0}$source = {1.0}CycB
v20 {1.0}TriA = {1.0}CKI + {1.0}CycA
v21 {1.0}TriA = {1.0}CycA
v22 {1.0}TriA = {1.0}CKI
v23 {1.0}CKI + {1.0}CycE = {1.0}TriE
v24 {1.0}TriE = {1.0}CKI + {1.0}CycE
v25 {1.0}TriE = {1.0}CycE
v26 {1.0}TriE = {1.0}CKI
v27 {1.0}$source = {1.0}CycA
v28 {1.0}CycA = {1.0}$sink
v29 {1.0}$source = {1.0}CycE
v3 {1.0}CycB = {1.0}$sink
v30 {1.0}CycE = {1.0}$sink
v31 {1.0}$source = {1.0}APCP
v32 {1.0}APCP = {1.0}$sink
v33 {1.0}$source = {1.0}Cdc20in
v34 {1.0}Cdc20in = {1.0}$sink
v35 {1.0}Cdc20in = {1.0}Cdc20A
v36 {1.0}Cdc20A = {1.0}Cdc20in
v37 {1.0}Cdc20A = {1.0}$sink
v38 {1.0}$source = {1.0}Cdh1
v39 {1.0}Cdh1 = {1.0}$sink
v4 {1.0}pB = {1.0}CycB
v5 {1.0}CycB = {1.0}pB
v6 {1.0}CycB + {1.0}CKI = {1.0}BCKI
v7 {1.0}BCKI = {1.0}CycB + {1.0}CKI
v8 {1.0}pB = {1.0}$sink
v9 {1.0}pB + {1.0}CKI = {1.0}pBCKI
end reactions

begin rate equations
v1 = mu*Mass[t]*(1 - Mass[t]/MaxMass)
v10 = kdissb*pBCKI[t]
v11 = V25*pBCKI[t]
v12 = Vwee*BCKI[t]
v13 = Vdb*BCKI[t]
v14 = Vdi*BCKI[t]
v15 = Vdb*pBCKI[t]
v16 = Vdi*pBCKI[t]
v17 = Vsi
v18 = Vdi*CKI[t]
v19 = kassa*CKI[t]*CycA[t]
v2 = Vsb
v20 = kdissa*TriA[t]
v21 = Vdi*TriA[t]
v22 = Vda*TriA[t]
v23 = kasse*CKI[t]*CycE[t]
v24 = kdisse*TriE[t]
v25 = Vdi*TriE[t]
v26 = Vde*TriE[t]
v27 = Vsa
v28 = Vda*CycA[t]
v29 = Vse
v3 = Vdb*CycB[t]
v30 = Vde*CycE[t]
v31 = Michaelis[CycB[t], Jaie, kaie, 1 - APCP[t]]
v32 = Michaelis[1, Jiie, kiie, APCP[t]]
v33 = ks20p + (ks20pp*CycB[t]^n20)/(J20^n20 + CycB[t]^n20)
v34 = kd20*Cdc20in[t]
v35 = Michaelis[APCP[t], Ja20, ka20, Cdc20in[t]]
v36 = Michaelis[1, Ji20, ki20, Cdc20A[t]]
v37 = kd20*Cdc20A[t]
v38 = Michaelis[Vah1, Jah1, 1, 1 - Cdh1[t]]
v39 = Michaelis[Vih1, Jih1, 1, Cdh1[t]]
v4 = V25*pB[t]
v5 = Vwee*CycB[t]
v6 = kassb*CKI[t]*CycB[t]
v7 = kdissb*BCKI[t]
v8 = Vdb*pB[t]
v9 = kassb*CKI[t]*pB[t]
end rate equations

begin parameters
CycD0 = 0.108
J20 = 10.0
Ja20 = 1.0
Ja25 = 0.1
Jafb = 0.1
Jafi = 1.0
Jah1 = 0.03
Jaie = 0.1
Jatf = 0.01
Jawee = 0.05
Ji20 = 1.0
Ji25 = 0.1
Jifb = 0.1
Jifi = 2.0
Jih1 = 0.03
Jiie = 0.1
Jitf = 0.01
Jiwee = 0.05
KEZ = 0.2
MaxMass = 10000.0
k14di = 12.0
k25p = 0.01
k25pp = 5.0
ka20 = 1.0
ka25p = 0.0
ka25pp = 1.0
kafb = 1.0
kafi = 6.0
kah1p = 0.02
kah1pp = 0.8
kaie = 0.1
kassa = 50.0
kassb = 60.0
kasse = 0.0
katfapp = 1.5
katfdpp = 3.0
katfepp = 0.38
katfp = 0.0
kaweep = 0.3
kaweepp = 0.0
kd20 = 0.05
kdap = 0.01
kdapp = 0.16
kdappp = 0.0
kdbcpp = 0.15
kdbhpp = 0.4
kdbp = 0.003
kdeapp = 0.0
kdebpp = 0.0
kdeepp = 0.0
kdep = 0.12
kdiapp = 0.1
kdibpp = 0.8
kdidpp = 0.1
kdiepp = 0.12
kdip = 0.002
kdissa = 0.06
kdissb = 0.05
kdisse = 0.0
ki20 = 0.16
ki25p = 0.3
ki25pp = 0.0
kifb = 0.15
kifibpp = 0.05
kifip = 0.008
kih1app = 0.35
kih1bpp = 0.1
kih1dpp = 0.005
kih1epp = 0.06
kih1p = 0.001
kiie = 0.15
kitfapp = 0.0
kitfbpp = 8.0
kitfp = 0.75
kiweep = 0.0
kiweepp = 1.0
ks20p = 0.001
ks20pp = 1.0
ksap = 0.0015
ksapp = 0.01
ksbp = 0.004
ksbpp = 0.04
ksep = 0.0
ksepp = 0.15
ksip = 0.018
ksipp = 0.18
kweep = 0.02
kweepp = 0.2
mu = 0.005776
n20 = 1.0
sink = 1.0
source = 1.0
defaultcompartment = 1.0
end parameters

begin initial conditions
APCP[0] = APCPi
BCKI[0] = BCKIi
CKI[0] = CKIi
Cdc20A[0] = Cdc20Ai
Cdc20in[0] = Cdc20ini
Cdh1[0] = Cdh1i
CycA[0] = CycAi
CycB[0] = CycBi
CycE[0] = CycEi
Mass[0] = Massi
TriA[0] = TriAi
TriE[0] = TriEi
pB[0] = pBi
pBCKI[0] = pBCKIi
end initial conditions

begin initial values
APCPi = 0.0759140253067017
BCKIi = 0.679449200630188
CKIi = 0.02882070094347
Cdc20Ai = 0.357272386550903
Cdc20ini = 0.770238757133484
Cdh1i = 0.718939363956451
CycAi = 0.0945030823349953
CycBi = 0.190358594059944
CycEi = 0.209202438592911
Massi = 1.33826780319214
TriAi = 0.349222421646118
TriEi = 0.0
pBi = 0.0123442625626922
pBCKIi = 0.0479593835771084
end initial values

begin assignment rules
Cdc25 := GK[ka25p + ka25pp*CycB[t], ki25p + Cdc14*ki25pp, Ja25, Ji25]
Vatf := CycD*katfdpp + katfp + katfapp*CycA[t] + katfepp*CycE[t]
Vah1 := kah1p + Cdc14*kah1pp
Vsi := ksip + ksipp*TFI
Cdc14 := Cdc20A[t]
CycD := CycD0*Mass[t]
TFI := GK[Cdc14*kafi, kifip + kifibpp*CycB[t], Jafi, Jifi]
Vdi := (CycD*kdidpp + kdip + kdiapp*CycA[t] + kdibpp*CycB[t] + kdiepp*CycE[t])/(1 + Cdc14*k14di)
Vwee := kweep + kweepp*Wee1
Vse := (ksep + ksepp*TFE)*Mass[t]
Vda := kdap + (kdapp + kdappp)*Cdc20A[t] + kdappp*Cdc20in[t]
V25 := k25p + Cdc25*k25pp
Vsa := (ksap + ksapp*TFE)*Mass[t]
TFE := GK[Vatf, Vitf, Jatf, Jitf]
TFB := GK[kafb*CycB[t], kifb, Jafb, Jifb]
Vsb := (ksbp + ksbpp*TFB)*Mass[t]
Vih1 := CycD*kih1dpp + kih1p + kih1app*CycA[t] + kih1bpp*CycB[t] + kih1epp*CycE[t]
Vitf := kitfp + kitfapp*CycA[t] + kitfbpp*CycB[t]
Vdb := kdbp + kdbcpp*Cdc20A[t] + kdbhpp*Cdh1[t]
Vde := kdep + kdeapp*CycA[t] + kdebpp*CycB[t] + kdeepp*CycE[t]
Wee1 := GK[kaweep + Cdc14*kaweepp, kiweep + kiweepp*CycB[t], Jawee, Jiwee]
end assignment rules

begin function definitions
Michaelis[M1_,J1_,k1_,S1_] := (k1*M1*S1)/(J1 + S1)
GK[a_,b_,c_,d_] := (2*a*d)/(-a + b + b*c + a*d + Sqrt[-4*a*(-a + b)*d + (-a + b + b*c + a*d)^2])
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units