#achcar10 FIX: Glce Glye NADHc NADc Pic Pig Pyre #reactions AKc: {2.0}ADPc = {1.0}AMPc + {1.0}ATPc (AKcAKck1 * pow(ADPc, 2) - AKcAKck2 * AMPc * ATPc) / cytosol AKg: {44.5116}ADPg = {22.2558}AMPg + {22.2558}ATPg (AKgAKgk1 * pow(ADPg, 2) - AKgAKgk2 * AMPg * ATPg) / cytosol ALDc: {1.0}Fru16BPc = {1.0}DHAPc + {1.0}GA3Pc ALDcALDcVmax * Fru16BPc * (1 - DHAPc * GA3Pc / (ALDcALDgKeq * Fru16BPc)) / (ALDcALDgKmFru16BP * cytosol * (1 + ADPc / ALDcALDgKiADP + AMPc / ALDcALDgKiAMP + ATPc / ALDcALDgKiATP) * (1 + DHAPc / ALDcALDgKmDHAP + Fru16BPc / (ALDcALDgKmFru16BP * (1 + ADPc / ALDcALDgKiADP + AMPc / ALDcALDgKiAMP + ATPc / ALDcALDgKiATP)) + GA3Pc / ALDcALDgKmGA3P + DHAPc * GA3Pc / (ALDcALDgKmDHAP * ALDcALDgKmGA3P) + Fru16BPc * GA3Pc / (ALDcALDgKiGA3P * ALDcALDgKmFru16BP * (1 + ADPc / ALDcALDgKiADP + AMPc / ALDcALDgKiAMP + ATPc / ALDcALDgKiATP)))) ALDg: {22.2558}Fru16BPg = {22.2558}DHAPg + {22.2558}GA3Pg ALDgALDgVmax * Fru16BPg * (1 - DHAPg * GA3Pg / (ALDgALDgKeq * Fru16BPg)) / (ALDgALDgKmFru16BP * cytosol * (1 + ADPg / ALDgALDgKiADP + AMPg / ALDgALDgKiAMP + ATPg / ALDgALDgKiATP) * (1 + DHAPg / ALDgALDgKmDHAP + Fru16BPg / (ALDgALDgKmFru16BP * (1 + ADPg / ALDgALDgKiADP + AMPg / ALDgALDgKiAMP + ATPg / ALDgALDgKiATP)) + GA3Pg / ALDgALDgKmGA3P + DHAPg * GA3Pg / (ALDgALDgKmDHAP * ALDgALDgKmGA3P) + Fru16BPg * GA3Pg / (ALDgALDgKiGA3P * ALDgALDgKmFru16BP * (1 + ADPg / ALDgALDgKiADP + AMPg / ALDgALDgKiAMP + ATPg / ALDgALDgKiATP)))) ATPuc: {1.0}ATPc = {1.0}ADPc ATPucATPuck * ATPc / (cytosol * ADPc) DHAPtg: {1.0}DHAPc = {22.2558}DHAPg DHAPtgDHAPtgk * (DHAPc - DHAPg) / cytosol ENOc: {1.0}PGA2c = {1.0}PEPc ENOcENOcVmax * (1 - PEPc / (ENOcENOcKeq * PGA2c)) * PGA2c / (cytosol * ENOcENOcKmPGA2 * (1 + PEPc / ENOcENOcKmPEP + PGA2c / ENOcENOcKmPGA2)) G3PDHc: {1.0}DHAPc + {1.0}NADHc = {1.0}Gly3Pc + {1.0}NADc G3PDHcG3PDHcVmax * NADHc * DHAPc * (1 - NADc * Gly3Pc / (G3PDHcG3PDHgKeq * NADHc * DHAPc)) / (cytosol * G3PDHcG3PDHgKmDHAP * G3PDHcG3PDHgKmNADH * (1 + NADHc / G3PDHcG3PDHgKmNADH + NADc / G3PDHcG3PDHgKmNAD) * (1 + DHAPc / G3PDHcG3PDHgKmDHAP + Gly3Pc / G3PDHcG3PDHgKmGly3P)) G3PDHg: {22.2558}DHAPg + {22.2558}NADHg = {22.2558}Gly3Pg + {22.2558}NADg G3PDHgG3PDHgVmax * DHAPg * NADHg * (1 - Gly3Pg * NADg / (G3PDHgG3PDHgKeq * DHAPg * NADHg)) / (cytosol * G3PDHgG3PDHgKmDHAP * G3PDHgG3PDHgKmNADH * (1 + DHAPg / G3PDHgG3PDHgKmDHAP + Gly3Pg / G3PDHgG3PDHgKmGly3P) * (1 + NADHg / G3PDHgG3PDHgKmNADH + NADg / G3PDHgG3PDHgKmNAD)) G6PPc: {1.0}Glc6Pc = {1.0}Glcc G6PPcG6PPcVmax * Glc6Pc * (1 - Glcc / (G6PPcG6PPcKeq * Glc6Pc)) / (cytosol * G6PPcG6PPcKmGlc6P * (1 + Glc6Pc / G6PPcG6PPcKmGlc6P + Glcc / G6PPcG6PPcKmGlc)) GA3Ptg: {22.2558}GA3Pg = {1.0}GA3Pc GA3PtgGA3Ptgk * (-GA3Pc + GA3Pg) / cytosol GAPDHc: {1.0}GA3Pc + {1.0}NADc + {1.0}Pic = {1.0}BPGA13c + {1.0}NADHc GAPDHcGAPDHcVmax * NADc * GA3Pc * (1 - NADHc * BPGA13c / (GAPDHcGAPDHcKeq * NADc * GA3Pc)) / (cytosol * GAPDHcGAPDHcKmGA3P * GAPDHcGAPDHcKmNAD * (1 + NADHc / GAPDHcGAPDHcKmNADH + NADc / GAPDHcGAPDHcKmNAD) * (1 + GA3Pc / GAPDHcGAPDHcKmGA3P + BPGA13c / GAPDHcGAPDHcKmBPGA13)) GAPDHg: {1.0}Pig + {22.2558}GA3Pg + {22.2558}NADg = {22.2558}BPGA13g + {22.2558}NADHg GAPDHgGAPDHgVmax * GA3Pg * NADg * (1 - NADHg * BPGA13g / (GAPDHgGAPDHgKeq * GA3Pg * NADg)) / (cytosol * GAPDHgGAPDHgKmGA3P * GAPDHgGAPDHgKmNAD * (1 + NADHg / GAPDHgGAPDHgKmNADH + NADg / GAPDHgGAPDHgKmNAD) * (1 + GA3Pg / GAPDHgGAPDHgKmGA3P + BPGA13g / GAPDHgGAPDHgKmBPGA13)) GKc: {1.0}ADPc + {1.0}Gly3Pc = {1.0}ATPc + {1.0}Glyc GKcGKcVmax * ADPc * Gly3Pc * (1 - ATPc * Glyc / (GKcGKgKeq * ADPc * Gly3Pc)) / (cytosol * GKcGKgKmADP * GKcGKgKmGly3P * (1 + ADPc / GKcGKgKmADP + ATPc / GKcGKgKmATP) * (1 + Gly3Pc / GKcGKgKmGly3P + Glyc / GKcGKgKmGly)) GKg: {22.2558}ADPg + {22.2558}Gly3Pg = {22.2558}ATPg + {22.2558}Glyg GKgGKgVmax * ADPg * Gly3Pg * (1 - ATPg * Glyg / (GKgGKgKeq * ADPg * Gly3Pg)) / (cytosol * GKgGKgKmADP * GKgGKgKmGly3P * (1 + ADPg / GKgGKgKmADP + ATPg / GKgGKgKmATP) * (1 + Gly3Pg / GKgGKgKmGly3P + Glyg / GKgGKgKmGly)) GPOc: {1.0}Gly3Pc = {1.0}DHAPc GPOcGPOcVmax * Gly3Pc / (cytosol * GPOcGPOcKmGly3P * (1 + (1 + SHAM / GPOcGPOcKiSHAM) * Gly3Pc / GPOcGPOcKmGly3P)) GlcTc: {1.0}Glce = {1.0}Glcc GlcTcGlcTcVmax * (Glce - Glcc) / (cytosol * (GlcTcGlcTcKmGlc + Glce + Glcc + GlcTcGlcTcalpha * Glce * Glcc / GlcTcGlcTcKmGlc)) GlcTg: {1.0}Glcc = {22.2558}Glcg (GlcTgGlcTgk * Glcc - GlcTgGlcTgk * Glcg) / cytosol Gly3Ptg: {22.2558}Gly3Pg = {1.0}Gly3Pc Gly3PtgGly3Ptgk * (-Gly3Pc + Gly3Pg) / cytosol GlyTc: {1.0}Glyc = {1.0}Glye (GlyTcGlyTck * (-Glye + Glyc) + GlyTcGlyTcVrmax * GlyTcGlyTcy * (-Glye + Glyc) / (GlyTcGlyTcKmGlye * GlyTcGlyTcy + GlyTcGlyTcy * Glye + Glyc + GlyTcGlyTcx * (1 - GlyTcGlyTcx + GlyTcGlyTcy) * Glye * Glyc / (GlyTcGlyTcKmGlye * GlyTcGlyTcy))) / cytosol Glytg: {22.2558}Glyg = {1.0}Glyc GlytgGlytgk * (-Glyc + Glyg) / cytosol HXKc: {1.0}ATPc + {1.0}Glcc = {1.0}ADPc + {1.0}Glc6Pc HXKcHXKcVmax * ATPc * (1 - ADPc * Glc6Pc / (HXKcHXKgKeq * ATPc * Glcc)) * Glcc / (cytosol * HXKcHXKgKmATP * HXKcHXKgKmGlc * (1 + ADPc / HXKcHXKgKmADP + ATPc / HXKcHXKgKmATP) * (1 + Glc6Pc / HXKcHXKgKmGlc6P + Glcc / HXKcHXKgKmGlc)) HXKg: {22.2558}ATPg + {22.2558}Glcg = {22.2558}ADPg + {22.2558}Glc6Pg HXKgHXKgVmax * ATPg * (1 - ADPg * Glc6Pg / (HXKgHXKgKeq * ATPg * Glcg)) * Glcg / (cytosol * HXKgHXKgKmATP * HXKgHXKgKmGlc * (1 + ADPg / HXKgHXKgKmADP + ATPg / HXKgHXKgKmATP) * (1 + Glc6Pg / HXKgHXKgKmGlc6P + Glcg / HXKgHXKgKmGlc)) PFKc: {1.0}ATPc + {1.0}Fru6Pc = {1.0}ADPc + {1.0}Fru16BPc PFKcPFKcVmax * PFKcPFKgKi1 * ATPc * (1 - ADPc * Fru16BPc / (PFKcPFKgKeq * ATPc * Fru6Pc)) * Fru6Pc / (cytosol * PFKcPFKgKmATP * PFKcPFKgKmFru6P * (PFKcPFKgKi1 + Fru16BPc) * (PFKcPFKgKsATP / PFKcPFKgKmATP + ADPc / PFKcPFKgKmADP + ATPc / PFKcPFKgKmATP + ADPc * Fru16BPc / (PFKcPFKgKi2 * PFKcPFKgKmADP) + Fru6Pc / PFKcPFKgKmFru6P + ATPc * Fru6Pc / (PFKcPFKgKmATP * PFKcPFKgKmFru6P))) PFKg: {22.2558}ATPg + {22.2558}Fru6Pg = {22.2558}ADPg + {22.2558}Fru16BPg PFKgPFKgKi1 * PFKgPFKgVmax * ATPg * (1 - ADPg * Fru16BPg / (PFKgPFKgKeq * ATPg * Fru6Pg)) * Fru6Pg / (cytosol * PFKgPFKgKmATP * PFKgPFKgKmFru6P * (PFKgPFKgKi1 + Fru16BPg) * (PFKgPFKgKsATP / PFKgPFKgKmATP + ADPg / PFKgPFKgKmADP + ATPg / PFKgPFKgKmATP + ADPg * Fru16BPg / (PFKgPFKgKi2 * PFKgPFKgKmADP) + Fru6Pg / PFKgPFKgKmFru6P + ATPg * Fru6Pg / (PFKgPFKgKmATP * PFKgPFKgKmFru6P))) PGA3Tg: {22.2558}PGA3g = {1.0}PGA3c (-(PGA3TgPGA3Tgk * PGA3c) + PGA3TgPGA3Tgk * PGA3g) / cytosol PGAMc: {1.0}PGA3c = {1.0}PGA2c PGAMcPGAMcVmax * (1 - PGA2c / (PGAMcPGAMcKeq * PGA3c)) * PGA3c / (cytosol * PGAMcPGAMcKmPGA3 * (1 + PGA2c / PGAMcPGAMcKmPGA2 + PGA3c / PGAMcPGAMcKmPGA3)) PGIc: {1.0}Glc6Pc = {1.0}Fru6Pc PGIcPGIcVmax * (1 - Fru6Pc / (PGIcPGIgKeq * Glc6Pc)) * Glc6Pc / (cytosol * PGIcPGIgKmGlc6P * (1 + Fru6Pc / PGIcPGIgKmFru6P + Glc6Pc / PGIcPGIgKmGlc6P)) PGIg: {22.2558}Glc6Pg = {22.2558}Fru6Pg PGIgPGIgVmax * (1 - Fru6Pg / (PGIgPGIgKeq * Glc6Pg)) * Glc6Pg / (cytosol * PGIgPGIgKmGlc6P * (1 + Fru6Pg / PGIgPGIgKmFru6P + Glc6Pg / PGIgPGIgKmGlc6P)) PGKc: {1.0}BPGA13c + {1.0}ADPc = {1.0}PGA3c + {1.0}ATPc PGKcPGKcVmax * ADPc * BPGA13c * (1 - ATPc * PGA3c / (PGKcPGKgKeq * ADPc * BPGA13c)) / (cytosol * PGKcPGKgKmADP * PGKcPGKgKmBPGA13 * (1 + ADPc / PGKcPGKgKmADP + ATPc / PGKcPGKgKmATP) * (1 + BPGA13c / PGKcPGKgKmBPGA13 + PGA3c / PGKcPGKgKmPGA3)) PGKg: {22.2558}BPGA13g + {22.2558}ADPg = {22.2558}PGA3g + {22.2558}ATPg PGKgPGKgVmax * ADPg * BPGA13g * (1 - ATPg * PGA3g / (PGKgPGKgKeq * ADPg * BPGA13g)) / (cytosol * PGKgPGKgKmADP * PGKgPGKgKmBPGA13 * (1 + ADPg / PGKgPGKgKmADP + ATPg / PGKgPGKgKmATP) * (1 + BPGA13g / PGKgPGKgKmBPGA13 + PGA3g / PGKgPGKgKmPGA3)) PYKc: {1.0}ADPc + {1.0}PEPc = {1.0}ATPc + {1.0}Pyrc PYKcPYKcVmax * ADPc * pow(PEPc / (PYKcPYKcKmPEP * (1 + ADPc / PYKcPYKcKiADP + ATPc / PYKcPYKcKiATP)), PYKcPYKcn) * (1 - ATPc * Pyrc / (PYKcPYKcKeq * ADPc * PEPc)) / (cytosol * PYKcPYKcKmADP * (1 + ADPc / PYKcPYKcKmADP + ATPc / PYKcPYKcKmATP) * (1 + pow(PEPc / (PYKcPYKcKmPEP * (1 + ADPc / PYKcPYKcKiADP + ATPc / PYKcPYKcKiATP)), PYKcPYKcn) + Pyrc / PYKcPYKcKmPyr)) PyrTc: {1.0}Pyrc = {1.0}Pyre PyrTcPyrTcVmax * Pyrc / (cytosol * PyrTcPyrTcKmPyr * (1 + Pyrc / PyrTcPyrTcKmPyr)) TPIc: {1.0}DHAPc = {1.0}GA3Pc TPIcTPIcVmax * DHAPc * (1 - GA3Pc / (TPIcTPIgKeq * DHAPc)) / (cytosol * TPIcTPIgKmDHAP * (1 + DHAPc / TPIcTPIgKmDHAP + GA3Pc / TPIcTPIgKmGA3P)) TPIg: {22.2558}DHAPg = {22.2558}GA3Pg TPIgTPIgVmax * DHAPg * (1 - GA3Pg / (TPIgTPIgKeq * DHAPg)) / (cytosol * TPIgTPIgKmDHAP * (1 + DHAPg / TPIgTPIgKmDHAP + GA3Pg / TPIgTPIgKmGA3P)) #parameters AKcAKck1 = 442.0 AKcAKck2 = 1000.0 AKgAKgk1 = 442.0 AKgAKgk2 = 1000.0 ALDcALDcVmax = 0.056 ALDcALDgKeq = 0.084 ALDcALDgKiADP = 1.51 ALDcALDgKiAMP = 3.65 ALDcALDgKiATP = 0.68 ALDcALDgKiGA3P = 0.098 ALDcALDgKmDHAP = 0.015 ALDcALDgKmFru16BP = 0.009 ALDcALDgKmGA3P = 0.067 ALDgALDgKeq = 0.084 ALDgALDgKiADP = 1.51 ALDgALDgKiAMP = 3.65 ALDgALDgKiATP = 0.68 ALDgALDgKiGA3P = 0.098 ALDgALDgKmDHAP = 0.015 ALDgALDgKmFru16BP = 0.009 ALDgALDgKmGA3P = 0.067 ALDgALDgVmax = 560.0 ATPucATPuck = 50.0 DHAPtgDHAPtgk = 1000.0 ENOcENOcKeq = 4.12 ENOcENOcKmPEP = 0.24 ENOcENOcKmPGA2 = 0.054 ENOcENOcVmax = 598.0 EXTERNAL = 0.0 G3PDHcG3PDHcVmax = 0.047 G3PDHcG3PDHgKeq = 17085.0 G3PDHcG3PDHgKmDHAP = 0.1 G3PDHcG3PDHgKmGly3P = 2.0 G3PDHcG3PDHgKmNAD = 0.4 G3PDHcG3PDHgKmNADH = 0.01 G3PDHgG3PDHgKeq = 17085.0 G3PDHgG3PDHgKmDHAP = 0.1 G3PDHgG3PDHgKmGly3P = 2.0 G3PDHgG3PDHgKmNAD = 0.4 G3PDHgG3PDHgKmNADH = 0.01 G3PDHgG3PDHgVmax = 465.0 G6PPcG6PPcKeq = 268.0 G6PPcG6PPcKmGlc = 5.0 G6PPcG6PPcKmGlc6P = 5.0 G6PPcG6PPcVmax = 1.0 GA3PtgGA3Ptgk = 1000.0 GAPDHcGAPDHcKeq = 0.066 GAPDHcGAPDHcKmBPGA13 = 0.14 GAPDHcGAPDHcKmGA3P = 0.17 GAPDHcGAPDHcKmNAD = 0.04 GAPDHcGAPDHcKmNADH = 0.007 GAPDHcGAPDHcVmax = 144.18 GAPDHgGAPDHgKeq = 0.066 GAPDHgGAPDHgKmBPGA13 = 0.1 GAPDHgGAPDHgKmGA3P = 0.15 GAPDHgGAPDHgKmNAD = 0.45 GAPDHgGAPDHgKmNADH = 0.02 GAPDHgGAPDHgVmax = 576.72 GKcGKcVmax = 0.02 GKcGKgKeq = 0.000837 GKcGKgKmADP = 0.56 GKcGKgKmATP = 0.24 GKcGKgKmGly = 0.44 GKcGKgKmGly3P = 3.83 GKgGKgKeq = 0.000837 GKgGKgKmADP = 0.56 GKgGKgKmATP = 0.24 GKgGKgKmGly = 0.44 GKgGKgKmGly3P = 3.83 GKgGKgVmax = 200.0 GPOcGPOcKiSHAM = 0.021 GPOcGPOcKmGly3P = 1.7 GPOcGPOcVmax = 368.0 GlcTcGlcTcKmGlc = 1.1 GlcTcGlcTcVmax = 111.7 GlcTcGlcTcalpha = 0.75 GlcTgGlcTgk = 250000.0 Gly3PtgGly3Ptgk = 1000.0 GlyTcGlyTcKmGlye = 0.17 GlyTcGlyTcVrmax = 85.0 GlyTcGlyTck = 8.5 GlyTcGlyTcx = 1.0 GlyTcGlyTcy = 1.0 GlytgGlytgk = 1000.0 HXKcHXKcVmax = 0.1929 HXKcHXKgKeq = 759.0 HXKcHXKgKmADP = 0.126 HXKcHXKgKmATP = 0.116 HXKcHXKgKmGlc = 0.1 HXKcHXKgKmGlc6P = 12.0 HXKgHXKgKeq = 759.0 HXKgHXKgKmADP = 0.126 HXKgHXKgKmATP = 0.116 HXKgHXKgKmGlc = 0.1 HXKgHXKgKmGlc6P = 12.0 HXKgHXKgVmax = 1929.0 O2c = 1.0 PFKcPFKcVmax = 0.1708 PFKcPFKgKeq = 1035.0 PFKcPFKgKi1 = 15.8 PFKcPFKgKi2 = 10.7 PFKcPFKgKmADP = 1.0 PFKcPFKgKmATP = 0.0648 PFKcPFKgKmFru6P = 0.999 PFKcPFKgKsATP = 0.0393 PFKgPFKgKeq = 1035.0 PFKgPFKgKi1 = 15.8 PFKgPFKgKi2 = 10.7 PFKgPFKgKmADP = 1.0 PFKgPFKgKmATP = 0.0648 PFKgPFKgKmFru6P = 0.999 PFKgPFKgKsATP = 0.0393 PFKgPFKgVmax = 1708.0 PGA3TgPGA3Tgk = 250.0 PGAMcPGAMcKeq = 0.17 PGAMcPGAMcKmPGA2 = 0.16 PGAMcPGAMcKmPGA3 = 0.15 PGAMcPGAMcVmax = 225.0 PGIcPGIcVmax = 0.1305 PGIcPGIgKeq = 0.46 PGIcPGIgKmFru6P = 0.12 PGIcPGIgKmGlc6P = 0.4 PGIgPGIgKeq = 0.46 PGIgPGIgKmFru6P = 0.12 PGIgPGIgKmGlc6P = 0.4 PGIgPGIgVmax = 1305.0 PGKcPGKcVmax = 0.0286 PGKcPGKgKeq = 3376.0 PGKcPGKgKmADP = 0.1 PGKcPGKgKmATP = 0.29 PGKcPGKgKmBPGA13 = 0.003 PGKcPGKgKmPGA3 = 1.62 PGKgPGKgKeq = 3376.0 PGKgPGKgKmADP = 0.1 PGKgPGKgKmATP = 0.29 PGKgPGKgKmBPGA13 = 0.003 PGKgPGKgKmPGA3 = 1.62 PGKgPGKgVmax = 2862.0 PYKcPYKcKeq = 10800.0 PYKcPYKcKiADP = 0.64 PYKcPYKcKiATP = 0.57 PYKcPYKcKmADP = 0.114 PYKcPYKcKmATP = 15.0 PYKcPYKcKmPEP = 0.34 PYKcPYKcKmPyr = 50.0 PYKcPYKcVmax = 1020.0 PYKcPYKcn = 2.5 PyrTcPyrTcKmPyr = 1.96 PyrTcPyrTcVmax = 230.0 SHAM = 0.0 TPIcTPIcVmax = 0.09993 TPIcTPIgKeq = 0.046 TPIcTPIgKmDHAP = 1.2 TPIcTPIgKmGA3P = 0.25 TPIgTPIgKeq = 0.046 TPIgTPIgKmDHAP = 1.2 TPIgTPIgKmGA3P = 0.25 TPIgTPIgVmax = 999.3 cytosol = 5.4549 default = 1.0 glycosome = 0.2451 Glce = 5.0 Glye = 1e-06 NADHc = 0.0005 NADc = 0.36 Pic = 0.0 Pig = 0.0 Pyre = 0.0 default_compartment = 1.0 #initial values ADPc = 0.77 ADPg = 0.77 AMPc = 0.83 AMPg = 0.83 ATPc = 2.25 ATPg = 2.25 BPGA13c = 0.01 BPGA13g = 0.4 DHAPc = 4.6 DHAPg = 4.6 Fru16BPc = 0.01 Fru16BPg = 13.0 Fru6Pc = 0.2 Fru6Pg = 0.2 GA3Pc = 0.01 GA3Pg = 0.14 Glc6Pc = 0.8 Glc6Pg = 0.8 Glcc = 0.01 Glcg = 0.01 Gly3Pc = 1.5 Gly3Pg = 1.5 Glyc = 1e-06 Glyg = 1e-06 NADHg = 0.1 NADg = 3.9 PEPc = 1.4 PGA2c = 0.5 PGA3c = 17.0 PGA3g = 17.0 Pyrc = 14.0 #assignment rules