Info! This is a derivative of the model wolf-user-5
v_1
glucose transporter
∅ = s1
v_10
s6o = ∅
v_11
at = ∅
v_2
s1 + {2.0}at = s2
v_3
s2 = {2.0}s3
v_4
s3 = na
v_5
s3 + na = s4 + at
v_6
s4 = s5 + at
v_7
s5 = s6
v_8
s6 = na
v_9
s6 = {0.1}s6o
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations.
Biophys. J. 2000;
78
(3):
1145-1153
- PubMed: 10692304
- PubMed Central: PMC1300717
- DOI: 10.1016/S0006-3495(00)76672-0
- ISSN: 0006-3495
- URL: http://ncbi.nlm.nih.gov/pubmed/10692304
Abstract
Under certain well-defined conditions, a population of yeast cells exhibits glycolytic oscillations that synchronize through intercellular acetaldehyde. This implies that the dynamic phenomenon of the oscillation propagates within and between cells. We here develop a method to establish by which route dynamics propagate through a biological reaction network. Application of the method to yeast demonstrates how the oscillations and the synchronization signal can be transduced. That transduction is not so much through the backbone of glycolysis, as via the Gibbs energy and redox coenzyme couples (ATP/ADP, and NADH/NAD), and via both intra- and intercellular acetaldehyde.
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