c represents concentration of ribosomes C

alpha

alpha represents the basal synthesis rate of c

c kappa c

kappa represents the concentration of c rliciting half-maximal activation of its positive feedback

kd c phi c delta gamma c

phi represents the applied anitbiotic concentration

the parameter delta lumps the effects of multiple reactions: it increases with decreasing rates of intrinsic or antibiotic-induced degradation of C (ribosomes), increasing dissociation between the antibiotic and C, and increasing export rate of the antibiotic.

gamma represents the bacterial density