r1
resource production
∅ = S
r2
resource consumption and cell growth 1
S = {10.0}N1
r3
resource consumption and cell growth 2
S = N2
r4
cell death 1
N1 = ∅
r5
cell death 2
N2 = ∅
Trigger: geq(time, 15)
Delay:
Assignments:
- N2 = 0.01
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
Cooperation and competition in the evolution of ATP-producing pathways.
Science 2001;
292
(5516):
504-507
- PubMed: 11283355
- DOI: 10.1126/science.1058079
- ISSN: 0036-8075
- URL: https://ncbi.nlm.nih.gov/pubmed/11283355
Abstract
Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production. This trade-off may result in an evolutionary dilemma, because cells with a higher rate but lower yield of ATP production may gain a selective advantage when competing for shared energy resources. Using an analysis of model simulations and biochemical observations, we show that ATP production with a low rate and high yield can be viewed as a form of cooperative resource use and may evolve in spatially structured environments. Furthermore, we argue that the high ATP yield of respiration may have facilitated the evolutionary transition from unicellular to undifferentiated multicellular organisms.
The SBML for this model was obtained from the BioModels database (BioModels ID: BIOMD0000000337)
Biomodels notes: The model reproduces figure 2 of the supplementary materials of the reference publication. The model was integrated and simulated using Copasi v4.6 (Build 32).
JWS Online curation: This model was curated by reproducing the figures as described in the BioModels Notes. No additional changes were made.