kinactATM ATMA kactATM damDNA ATMI kdam IR krepair damDNA kGADD45 p21 kdegGADD45 GADD45 kdegMdm2 Mdm2 kdegATMMdm2 Mdm2_P ksynMdm2 Mdm2_mRNA kdephosMdm2 Mdm2_P kdegMdm2mRNA Mdm2_mRNA ksynMdm2mRNA p53 ksynMdm2mRNA p53_P kphosMdm2 Mdm2 ATMA kbinMdm2p53 p53 Mdm2 krelMdm2p53 Mdm2_p53 kdamROS ROS kgenROSp38 p38_P kp38ROS kremROS ROS kdamBasalROS basalROS ksynp21step1 p21_mRNA ksynp21step2 p21step1 ksynp21step3 p21step2 kdegp21 p21 kdegp21mRNA p21_mRNA ksynp21mRNAp53 p53 ksynp21mRNAp53P p53_P kphosp38 p38 GADD45 kdephosp38 p38_P kdegp53 Mdm2_p53 kdegp53mdm2ind p53_P kdegp53mdm2ind p53 ksynp53 p53_mRNA kdephosp53 p53_P kdegp53mRNA p53_mRNA ksynp53mRNA Source kphosp53 p53 ATMA time 691200 0.6 time 172800 200 time 172860 0