$20\times 0.00166112956810631\mathrm{PDE4\_P\_cyto}$ $\mathrm{kcat\_PPase\_mek}\times 0.00166112956810631\mathrm{PP2A\_cyto}$ $1.34\times 0.00166112956810631\mathrm{GRK\_bg\_cyto}$ $\mathrm{kcat\_pp\_ptp\_pp\_ptp}\times 0.00166112956810631\mathrm{PTP\_PP\_cyto}$ $5\times 0.00166112956810631\mathrm{PP\_PDE\_cyto}$ $\mathrm{kcat\_PPase\_MAPK}\times 0.00166112956810631\mathrm{PP2A\_cyto}$ $\mathrm{kcat\_PTP}\times 0.00166112956810631\mathrm{PTP\_cyto}$ $\mathrm{kcat\_PTP\_PKA}\times 0.00166112956810631\mathrm{PTP\_PKA\_cyto}$ $0.105\times 0.00166112956810631\mathrm{B\_Raf\_active\_cyto}$ $10\times 0.00166112956810631\mathrm{PKA\_cyto}$ $0.104\times 0.00166112956810631\mathrm{GRK\_cyto}$ $0.2\mathrm{AC\_cyto\_mem}$ $\mathrm{kcat\_PKA\_P\_PTP}\times 0.00166112956810631\mathrm{PKA\_cyto}$ $8\times 0.00166112956810631\mathrm{PDE\_high\_km\_cyto}$ $8.5\mathrm{AC\_active\_cyto\_mem}$ $\mathrm{kcat\_PKA\_activates\_Raf}\times 0.00166112956810631\mathrm{PKA\_cyto}$ $0.15\times 0.00166112956810631\mathrm{MEK\_active\_cyto}$ $8\times 0.00166112956810631\mathrm{PDE4\_cyto}$ $\mathrm{kcat\_PPase\_Raf}\times 0.00166112956810631\mathrm{PP2A\_cyto}$ $(\mathrm{Kf}\times 0.00166112956810631\mathrm{c2\_R2C2\_cyto}\times 0.00166112956810631\mathrm{cAMP\_cyto}+-(\mathrm{Kr}\times 0.00166112956810631\mathrm{c3\_R2C2\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf}\times 0.00166112956810631\mathrm{c3\_R2C2\_cyto}\times 0.00166112956810631\mathrm{cAMP\_cyto}+-(\mathrm{Kr}\times 0.00166112956810631\mathrm{PKA\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf\_AC\_activation}\times 0.00166112956810631\mathrm{G\_a\_s\_cyto}\mathrm{AC\_cyto\_mem}+-(\mathrm{Kr\_AC\_activation}\mathrm{AC\_active\_cyto\_mem}))\mathrm{cyto\_mem}$ $\mathrm{Vmax\_AC\_active\_AC\_active}\times 0.00166112956810631\mathrm{ATP\_cyto}\frac{1}{\mathrm{Km\_AC\_active}+0.00166112956810631\mathrm{ATP\_cyto}}\mathrm{cyto\_mem}$ $\mathrm{Vmax\_AC\_basal\_AC\_basal}\times 0.00166112956810631\mathrm{ATP\_cyto}\frac{1}{\mathrm{Km\_AC\_basal}+0.00166112956810631\mathrm{ATP\_cyto}}\mathrm{cyto\_mem}$ $(\mathrm{Kf}\times 0.00166112956810631\mathrm{R2C2\_cyto}\times 0.00166112956810631\mathrm{cAMP\_cyto}+-(\mathrm{Kr}\times 0.00166112956810631\mathrm{c\_R2C2\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf}\times 0.00166112956810631\mathrm{c\_R2C2\_cyto}\times 0.00166112956810631\mathrm{cAMP\_cyto}+-(\mathrm{Kr}\times 0.00166112956810631\mathrm{c2\_R2C2\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_grk\_GRK}\mathrm{iso\_BAR\_cyto\_mem}\frac{1}{\mathrm{Km\_grk}+\mathrm{iso\_BAR\_cyto\_mem}}\mathrm{cyto\_mem}$ $\mathrm{Vmax\_GRK\_bg\_GRK\_bg}\mathrm{iso\_BAR\_cyto\_mem}\frac{1}{\mathrm{Km\_GRK\_bg}+\mathrm{iso\_BAR\_cyto\_mem}}\mathrm{cyto\_mem}$ $(\mathrm{Kf\_GTPase}\times 0.00166112956810631\mathrm{G\_a\_s\_cyto}+-(\mathrm{Kr\_GTPase}\times 0.00166112956810631\mathrm{G\_GDP\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf\_G\_binds\_BAR}\mathrm{BAR\_cyto\_mem}\times 0.00166112956810631\mathrm{G\_protein\_cyto}+-(\mathrm{Kr\_G\_binds\_BAR}\mathrm{BAR\_G\_cyto\_mem}))\mathrm{cyto\_mem}$ $(\mathrm{Kf\_G\_binds\_iso\_BAR}\mathrm{iso\_BAR\_cyto\_mem}\times 0.00166112956810631\mathrm{G\_protein\_cyto}+-(\mathrm{Kr\_G\_binds\_iso\_BAR}\mathrm{iso\_BAR\_G\_cyto\_mem}))\mathrm{cyto\_mem}$ $\mathrm{Vmax\_MEK\_activates\_MAPK}\times 0.00166112956810631\mathrm{MAPK\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{MAPK\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PDE4\_PDE4}\times 0.00166112956810631\mathrm{cAMP\_cyto}\frac{1}{\mathrm{Km\_PDE4}+0.00166112956810631\mathrm{cAMP\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PKA\_P\_PDE}\times 0.00166112956810631\mathrm{PDE4\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{PDE4\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PKA\_P\_PTP}\times 0.00166112956810631\mathrm{PTP\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{PTP\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PKA\_activates\_Raf}\times 0.00166112956810631\mathrm{B\_Raf\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{B\_Raf\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PPase\_MAPK}\times 0.00166112956810631\mathrm{MAPK\_active\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{MAPK\_active\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PPase\_Raf}\times 0.00166112956810631\mathrm{B\_Raf\_active\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{B\_Raf\_active\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PPase\_mek}\times 0.00166112956810631\mathrm{MEK\_active\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{MEK\_active\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PTP}\times 0.00166112956810631\mathrm{MAPK\_active\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{MAPK\_active\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_PTP\_PKA}\times 0.00166112956810631\mathrm{MAPK\_active\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{MAPK\_active\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_Raf\_activates\_MEK}\times 0.00166112956810631\mathrm{MEK\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{MEK\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf\_activate\_Gs}\mathrm{iso\_BAR\_G\_cyto\_mem}-\mathrm{Kr\_activate\_Gs}\mathrm{iso\_BAR\_cyto\_mem}\times 0.00166112956810631\mathrm{bg\_cyto}\times 0.00166112956810631\mathrm{G\_a\_s\_cyto})\mathrm{cyto\_mem}$ $(\mathrm{Kf\_bg\_binds\_GRK}\times 0.00166112956810631\mathrm{GRK\_cyto}\times 0.00166112956810631\mathrm{bg\_cyto}+-(\mathrm{Kr\_bg\_binds\_GRK}\times 0.00166112956810631\mathrm{GRK\_bg\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_highKM\_PDE}\times 0.00166112956810631\mathrm{cAMP\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{cAMP\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf}\mathrm{BAR\_cyto\_mem}\times 0.00166112956810631\mathrm{iso\_extra}+-(\mathrm{Kr}\mathrm{iso\_BAR\_cyto\_mem}))\mathrm{cyto\_mem}$ $(\mathrm{Kf}\times 0.00166112956810631\mathrm{iso\_extra}\mathrm{BAR\_G\_cyto\_mem}+-(\mathrm{Kr}\mathrm{iso\_BAR\_G\_cyto\_mem}))\mathrm{cyto\_mem}$ $\mathrm{Vmax\_pde4\_p\_pde4\_p}\times 0.00166112956810631\mathrm{cAMP\_cyto}\frac{1}{\mathrm{Km\_pde4\_p}+0.00166112956810631\mathrm{cAMP\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_pp2a\_4\_pp2a\_4}\times 0.00166112956810631\mathrm{PDE4\_P\_cyto}\frac{1}{\mathrm{Km\_pp2a\_4}+0.00166112956810631\mathrm{PDE4\_P\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $\mathrm{Vmax\_pp\_ptp}\times 0.00166112956810631\mathrm{PTP\_PKA\_cyto}\frac{1}{\mathrm{Km}+0.00166112956810631\mathrm{PTP\_PKA\_cyto}}\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$ $(\mathrm{Kf\_trimer}\times 0.00166112956810631\mathrm{bg\_cyto}\times 0.00166112956810631\mathrm{G\_GDP\_cyto}+-(\mathrm{Kr\_trimer}\times 0.00166112956810631\mathrm{G\_protein\_cyto}))\mathrm{cyto}\times 1\frac{1}{\mathrm{KMOLE}}$