$\mathrm{Lacin}\mathrm{Lacout}\mathrm{Vmf}\mathrm{Keq}\mathrm{Klacin}\mathrm{Klacout}\mapsto \frac{\mathrm{Vmf}(\mathrm{Lacin}-\frac{\mathrm{Lacout}}{\mathrm{Keq}})}{\mathrm{Klacin}(1+\frac{\mathrm{Lacout}}{\mathrm{Klacout}})+\mathrm{Lacin}}$ $\mathrm{Gluout}\mathrm{Gluin}\mathrm{Vmf}\mathrm{f1}\mathrm{Keq}\mathrm{Kgluout}\mathrm{Kgluin}\mathrm{f2}\mathrm{Keq1}\mathrm{Kgluout1}\mathrm{Kgluin1}\mapsto \mathrm{Vmf}(\frac{\mathrm{f1}(\mathrm{Gluout}-\frac{\mathrm{Gluin}}{\mathrm{Keq}})}{\mathrm{Kgluout}(1+\frac{\mathrm{Gluin}}{\mathrm{Kgluin}})+\mathrm{Gluout}}+\frac{\mathrm{f2}(\mathrm{Gluout}-\frac{\mathrm{Gluin}}{\mathrm{Keq1}})}{\mathrm{Kgluout1}(1+\frac{\mathrm{Gluin}}{\mathrm{Kgluin1}})+\mathrm{Gluout}})$ $ABPQ\mathrm{Vmf}\mathrm{alfa}\mathrm{Ka}\mathrm{Kb}\mathrm{Vmr}\mathrm{beta}\mathrm{Kp}\mathrm{Kq}\mapsto \frac{\mathrm{Vmf}\frac{AB}{\mathrm{alfa}\mathrm{Ka}\mathrm{Kb}}-\mathrm{Vmr}\frac{PQ}{\mathrm{beta}\mathrm{Kp}\mathrm{Kq}}}{1+\frac{A}{\mathrm{Ka}}+\frac{B}{\mathrm{Kb}}+\frac{AB}{\mathrm{alfa}\mathrm{Ka}\mathrm{Kb}}+\frac{PQ}{\mathrm{beta}\mathrm{Kp}\mathrm{Kq}}+\frac{P}{\mathrm{Kp}}+\frac{Q}{\mathrm{Kq}}}$ $\mathrm{substrate}\mathrm{product}\mathrm{Kms}\mathrm{Kmp}\mathrm{Vf}\mathrm{Vr}\mapsto \frac{\frac{\mathrm{Vf}\mathrm{substrate}}{\mathrm{Kms}}-\frac{\mathrm{Vr}\mathrm{product}}{\mathrm{Kmp}}}{1+\frac{\mathrm{substrate}}{\mathrm{Kms}}+\frac{\mathrm{product}}{\mathrm{Kmp}}}$ $v\mapsto v$ $ABPQ\mathrm{Vmax}\mathrm{Kpep}\mathrm{Kadp}\mathrm{Keq}\mathrm{Kpyr}\mathrm{Katp}\mapsto \frac{\mathrm{Vmax}(\frac{AB}{\mathrm{Kpep}\mathrm{Kadp}}-\frac{PQ}{\mathrm{Kpep}\mathrm{Kadp}\mathrm{Keq}})}{(1+\frac{A}{\mathrm{Kpep}}+\frac{P}{\mathrm{Kpyr}})(1+\frac{B}{\mathrm{Kadp}}+\frac{Q}{\mathrm{Katp}})}$ $\mathrm{G6P}\mathrm{F6P}\mathrm{ERY4P}\mathrm{FBP}\mathrm{PG}\mathrm{Vmf}\mathrm{Kg6p}\mathrm{Vmr}\mathrm{Kf6p}\mathrm{Kery4p}\mathrm{Kfbp}\mathrm{Kpg}\mapsto \frac{\mathrm{Vmf}\frac{\mathrm{G6P}}{\mathrm{Kg6p}}-\mathrm{Vmr}\frac{\mathrm{F6P}}{\mathrm{Kf6p}}}{1+\frac{\mathrm{G6P}}{\mathrm{Kg6p}}+\frac{\mathrm{F6P}}{\mathrm{Kf6p}}+\frac{\mathrm{ERY4P}}{\mathrm{Kery4p}}+\frac{\mathrm{FBP}}{\mathrm{Kfbp}}+\frac{\mathrm{PG}}{\mathrm{Kpg}}}$ $\mathrm{NAD}\mathrm{G3P}P\mathrm{DPG}\mathrm{NADH}\mathrm{Vmf}\mathrm{Knad}\mathrm{Kg3p}\mathrm{Kp}\mathrm{Vmr}\mathrm{Kdpg}\mathrm{Knadh}\mapsto \frac{\mathrm{Vmf}\frac{\mathrm{NAD}\mathrm{G3P}P}{\mathrm{Knad}\mathrm{Kg3p}\mathrm{Kp}}-\mathrm{Vmr}\frac{\mathrm{DPG}\mathrm{NADH}}{\mathrm{Kdpg}\mathrm{Knadh}}}{1+\frac{\mathrm{NAD}}{\mathrm{Knad}}+\frac{\mathrm{NAD}\mathrm{G3P}}{\mathrm{Knad}\mathrm{Kg3p}}+\frac{\mathrm{NAD}\mathrm{G3P}P}{\mathrm{Knad}\mathrm{Kg3p}\mathrm{Kp}}+\frac{\mathrm{DPG}\mathrm{NADH}}{\mathrm{Kdpg}\mathrm{Knadh}}+\frac{\mathrm{NADH}}{\mathrm{Knadh}}}$ $\mathrm{ATP}\mathrm{F6P}\mathrm{ADP}\mathrm{FBP}\mathrm{F26BP}\mathrm{CIT}\mathrm{Vm}\mathrm{Katp}\mathrm{beta}\mathrm{alfa}\mathrm{Kf26bp}\mathrm{Kf6p}L\mathrm{Kcit}\mathrm{Kiatp}\mathrm{Kadp}\mathrm{Kfbp}\mathrm{Keq}\mapsto \mathrm{Vm}\frac{\frac{\mathrm{ATP}}{\mathrm{Katp}}}{1+\frac{\mathrm{ATP}}{\mathrm{Katp}}}\frac{1+\frac{\mathrm{beta}\mathrm{F26BP}}{\mathrm{alfa}\mathrm{Kf26bp}}}{1+\frac{\mathrm{F26BP}}{\mathrm{alfa}\mathrm{Kf26bp}}}(\frac{\frac{\mathrm{F6P}(1+\frac{\mathrm{F26BP}}{\mathrm{alfa}\mathrm{Kf26bp}})}{\mathrm{Kf6p}(1+\frac{\mathrm{F26BP}}{\mathrm{Kf26bp}})}(1+\frac{\mathrm{F6P}(1+\frac{\mathrm{F26BP}}{\mathrm{alfa}\mathrm{Kf26bp}})}{\mathrm{Kf6p}(1+\frac{\mathrm{F26BP}}{\mathrm{Kf26bp}})})^3}{\frac{L(1+\frac{\mathrm{CIT}}{\mathrm{Kcit}})^4(1+\frac{\mathrm{ATP}}{\mathrm{Kiatp}})^4}{(1+\frac{\mathrm{F26BP}}{\mathrm{Kf26bp}})^4}+(1+\frac{\mathrm{F6P}(1+\frac{\mathrm{F26BP}}{\mathrm{alfa}\mathrm{Kf26bp}})}{\mathrm{Kf6p}(1+\frac{\mathrm{F26BP}}{\mathrm{Kf26bp}})})^4}-\frac{\frac{\mathrm{ADP}\mathrm{FBP}}{\mathrm{Kadp}\mathrm{Kfbp}\mathrm{Keq}}}{\frac{\mathrm{ADP}}{\mathrm{Kadp}}+\frac{\mathrm{FBP}}{\mathrm{Kfbp}}+\frac{\mathrm{ADP}\mathrm{FBP}}{\mathrm{Kadp}\mathrm{Kfbp}}+1})$ $\mathrm{FBP}\mathrm{DHAP}\mathrm{G3P}\mathrm{Vmf}\mathrm{Kfbp}\mathrm{Vmr}\mathrm{Kdhap}\mathrm{Kg3p}\mapsto \frac{\mathrm{Vmf}\frac{\mathrm{FBP}}{\mathrm{Kfbp}}-\mathrm{Vmr}\frac{\mathrm{DHAP}\mathrm{G3P}}{\mathrm{Kdhap}\mathrm{Kg3p}}}{1+\frac{\mathrm{FBP}}{\mathrm{Kfbp}}+\frac{\mathrm{DHAP}}{\mathrm{Kdhap}}+\frac{\mathrm{G3P}}{\mathrm{Kg3p}}+\frac{\mathrm{DHAP}\mathrm{G3P}}{\mathrm{Kdhap}\mathrm{Kg3p}}}$ $ABPQ\mathrm{Vm}\mathrm{f1}\mathrm{Ka}\mathrm{Kb}\mathrm{Keq}\mathrm{Kp}\mathrm{Kq}\mathrm{f2}\mathrm{Ka2}\mapsto \mathrm{Vm}(\frac{\frac{\mathrm{f1}}{\mathrm{Ka}\mathrm{Kb}}(AB-\frac{PQ}{\mathrm{Keq}})}{1+\frac{A}{\mathrm{Ka}}+\frac{B}{\mathrm{Kb}}+\frac{AB}{\mathrm{Ka}\mathrm{Kb}}+\frac{P}{\mathrm{Kp}}+\frac{Q}{\mathrm{Kq}}+\frac{PQ}{\mathrm{Kp}\mathrm{Kq}}+\frac{AQ}{\mathrm{Ka}\mathrm{Kq}}+\frac{PB}{\mathrm{Kp}\mathrm{Kb}}}+\frac{\frac{\mathrm{f2}}{\mathrm{Ka2}\mathrm{Kb}}(AB-\frac{PQ}{\mathrm{Keq}})}{1+\frac{A}{\mathrm{Ka2}}+\frac{B}{\mathrm{Kb}}+\frac{AB}{\mathrm{Ka2}\mathrm{Kb}}+\frac{P}{\mathrm{Kp}}+\frac{Q}{\mathrm{Kq}}+\frac{PQ}{\mathrm{Kp}\mathrm{Kq}}+\frac{AQ}{\mathrm{Ka2}\mathrm{Kq}}+\frac{PB}{\mathrm{Kp}\mathrm{Kb}}})$ $\mathrm{compartment}(\mathrm{k1}\mathrm{ATP}\mathrm{AMP}-\mathrm{k2}\mathrm{ADP}^2)$ $\mathrm{compartment}\mathrm{ALDO\_rate\_equation}(\mathrm{FBP}, \mathrm{DHAP}, \mathrm{G3P}, \mathrm{Vmf}, \mathrm{Kfbp}, \mathrm{Vmr}, \mathrm{Kdhap}, \mathrm{Kg3p})$ $\mathrm{compartment}\mathrm{k1}\mathrm{ATP}$ $\mathrm{compartment}(\mathrm{k1}\mathrm{NADH}-\mathrm{k2}\mathrm{NAD})$ $\mathrm{compartment}\mathrm{Reversible\_Michaelis\_Menten}(\mathrm{\_2PG}, \mathrm{PEP}, \mathrm{Kms}, \mathrm{Kmp}, \mathrm{Vf}, \mathrm{Vr})$ $\mathrm{compartment}\mathrm{GAPDH\_0}(\mathrm{NAD}, \mathrm{G3P}, \mathrm{Pi}, \mathrm{\_13BPG}, \mathrm{NADH}, \mathrm{Vmf}, \mathrm{Knad}, \mathrm{Kg3p}, \mathrm{Kp}, \mathrm{Vmr}, \mathrm{Kdpg}, \mathrm{Knadh})$ $\mathrm{compartment}\mathrm{GLUT\_isoforms\_rate\_equation}(\mathrm{Gluout}, \mathrm{Gluin}, \mathrm{Vmf}, \mathrm{f1}, \mathrm{Keq}, \mathrm{Kgluout}, \mathrm{Kgluin}, \mathrm{f2}, \mathrm{Keq1}, \mathrm{Kgluout1}, \mathrm{Kgluin1})$ $\mathrm{compartment}\mathrm{Constant\_flux\_\_irreversible}(v)$ $\mathrm{compartment}\mathrm{Constant\_flux\_\_irreversible}(v)$ $\mathrm{compartment}\mathrm{HK\_isoforms\_rate\_equation}(\mathrm{Gluin}, \mathrm{ATP}, \mathrm{G6P}, \mathrm{ADP}, \mathrm{Vm}, \mathrm{f1}, \mathrm{Ka}, \mathrm{Kb}, \mathrm{Keq}, \mathrm{Kp}, \mathrm{Kq}, \mathrm{f2}, \mathrm{Ka2})$ $\mathrm{compartment}\mathrm{HPI\_rate\_equation}(\mathrm{G6P}, \mathrm{F6P}, \mathrm{Ery4P}, \mathrm{FBP}, \mathrm{\_6PG}, \mathrm{Vmf}, \mathrm{Kg6p}, \mathrm{Vmr}, \mathrm{Kf6p}, \mathrm{Kery4p}, \mathrm{Kfbp}, \mathrm{Kpg})$ $\mathrm{compartment}\mathrm{Random\_Bi\_Bi\_reversible\_Michaelis\_Menten}(\mathrm{NADH}, \mathrm{Pyr}, \mathrm{Lacin}, \mathrm{NAD}, \mathrm{Vmf}, \mathrm{alfa}, \mathrm{Ka}, \mathrm{Kb}, \mathrm{Vmr}, \mathrm{beta}, \mathrm{Kp}, \mathrm{Kq})$ $\mathrm{compartment}\mathrm{MCT1\_0}(\mathrm{Lacin}, \mathrm{Lacout}, \mathrm{Vmf}, \mathrm{Keq}, \mathrm{Klacin}, \mathrm{Klacout})$ $\mathrm{compartment}\mathrm{Constant\_flux\_\_irreversible}(v)$ $\mathrm{compartment}\mathrm{Constant\_flux\_\_irreversible}(v)$ $\mathrm{compartment}\mathrm{PFK\_1\_rate\_equation}(\mathrm{F6P}, \mathrm{ATP}, \mathrm{FBP}, \mathrm{ADP}, \mathrm{F26BP}, \mathrm{Cit}, \mathrm{Vm}, \mathrm{Katp}, \mathrm{beta}, \mathrm{alfa}, \mathrm{Kf26bp}, \mathrm{Kf6p}, L, \mathrm{Kcit}, \mathrm{Kiatp}, \mathrm{Kadp}, \mathrm{Kfbp}, \mathrm{Keq})$ $\mathrm{compartment}\mathrm{Reversible\_Michaelis\_Menten}(\mathrm{\_3PG}, \mathrm{\_2PG}, \mathrm{Kms}, \mathrm{Kmp}, \mathrm{Vf}, \mathrm{Vr})$ $\mathrm{compartment}\mathrm{Random\_Bi\_Bi\_reversible\_Michaelis\_Menten}(\mathrm{\_13BPG}, \mathrm{ADP}, \mathrm{\_3PG}, \mathrm{ATP}, \mathrm{Vmf}, \mathrm{alfa}, \mathrm{Ka}, \mathrm{Kb}, \mathrm{Vmr}, \mathrm{beta}, \mathrm{Kp}, \mathrm{Kq})$ $\mathrm{compartment}\mathrm{Constant\_flux\_\_irreversible}(v)$ $\mathrm{compartment}\mathrm{PYK\_kinetics}(\mathrm{PEP}, \mathrm{ADP}, \mathrm{Pyr}, \mathrm{ATP}, \mathrm{Vmax}, \mathrm{Kpep}, \mathrm{Kadp}, \mathrm{Keq}, \mathrm{Kpyr}, \mathrm{Katp})$ $\mathrm{compartment}\mathrm{Constant\_flux\_\_irreversible}(v)$ $\mathrm{compartment}\mathrm{Reversible\_Michaelis\_Menten}(\mathrm{DHAP}, \mathrm{G3P}, \mathrm{Kms}, \mathrm{Kmp}, \mathrm{Vf}, \mathrm{Vr})$