Manuscript: Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.

Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.

  • Christine Nazaret
  • Margit Heiske
  • Kevin Thurley
  • Jean-Pierre Mazat
J. Theor. Biol. 2009; 258 (3): 455-464
Abstract
Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.
Model Organism Tissue Process type
nazaret1 Homo sapiens metabolism