CYTOPLASM GAP flow CYTOPLASM Glc_F 10 3 GLC flow CYTOPLASM LAC flow CYTOPLASM k9f AMP ATP_cyt k9b ADP_cyt 2 CYTOPLASM V1 ATP_cyt GLC K1GLC GLC K1ATP ATP_cyt MATRIX V Acetyl_CoA OXA v10_CS Acetyl_CoA OXA Ka OXA Kb Acetyl_CoA Kia Kib MATRIX KcF Kp Cit KcR Ks IsoCit v11_ACO Ks IsoCit Kp Cit Ks Kp MATRIX KcF v12_IDHa IsoCit IsoCit b ADP IsoCit IsoCit IsoCit c IsoCit d ADP e ADP IsoCit f MATRIX KcF v14_OGDC OG CoA NAD_p KmC OG CoA KmB OG NAD_p KmA CoA NAD_p OG CoA NAD_p KmA KmP Kib Kic KmR Kip Kiq SCoA NADH KmC Kir OG CoA NADH KmB Kiq OG NAD_p SCoA KmA KmP Kib Kic KmR Kip Kia Kiq OG SCoA NADH MATRIX GDP SCoA Suc GTP CoA Keq Kc1 v15_SCS Kc2 v15_SCS KmC Suc KmC2 Kip KmC2 Kia KmB KmB GDP KmA SCoA KmC GDP SCoA GDP SCoA GDP SCoA KmC2 Kia KmB KmC Suc Kip Kia KmB KmC Suc GTP Kip Kiq Kia KmB KmC Suc CoA Kip Kir Kia KmB Kic GTP CoA KmQ Kir Kia KmB KmC Suc GTP CoA Kip KmQ Kir Kia KmB KmC Suc Suc GTP CoA Kip KmP2 KmQ Kir Kia KmB GTP Kiq Kia KmB CoA Kir Kia KmB GTP CoA KmQ Kir Kia KmB Suc GTP CoA KmP2 KmQ Kir KmB KmC GDP Suc Kip KmA KmC SCoA Suc Kip KmC GDP SCoA Suc Kip KmC GDP SCoA Suc KmC2 Kip KmA SCoA GTP Kiq KmB GDP CoA Kir KmA KmC SCoA Suc GTP Kip Kiq KmB KmC GDP Suc CoA Kip Kir MATRIX KcF KcR v16_SDH Suc Q Fum QH2 Keq KcR KmS2 Suc KcR KmS1 Q KcF KmP2 Fum Keq KcF KmP1 QH2 Keq KcR Suc Q KcF KmP2 Suc Fum Keq KiS1 KcF Fum QH2 Keq KcR KmS1 Q QH2 KiP2 MATRIX KcF Kp Fum KcR Ks Mal v17_FM Ks Mal Kp Fum Ks Kp MATRIX KcF Mal NAD_p KiS1 KmS2 KcR OXA NADH KmP1 KiP2 v18_MDH 1 Mal KiS1 KmS1 NAD_p KiS1 KmS2 KmP2 OXA KmP1 KiP2 NADH KiP2 Mal NAD_p KiS1 KmS2 KmP2 Mal OXA KiS1 KmP1 KiP2 KmS1 NAD_p NADH KiS1 KmS2 KiP2 OXA NADH KmP1 KiP2 Mal NAD_p OXA KiS1 KmS2 KiP1 NAD_p OXA NADH KiS2 KmP1 KiP2 CYTOPLASM V2 ATP_cyt F6P 2 K2 1 k2 ATP_cyt AMP 2 F6P 2 K2ATP ATP_cyt MATRIX KcF KcR v20_AlaTA Ala OG Glu Pyr Keq KcR KmS2 Ala KcR KmS1 OG KcF KmP2 Glu Keq KcF KmP1 Pyr Keq KcR Ala OG KcF KmP2 Ala Glu Keq KiS1 KcF Glu Pyr Keq KcR KmS1 OG Pyr KiP2 MATRIX KcF KcR v21_AspTA OXA Glu Asp OG Keq KcR KmS2 OXA KcR KmS1 Glu KcF KmP2 Asp Keq KcF KmP1 OG Keq KcR OXA Glu KcF KmP2 OXA Asp Keq KiS1 KcF Asp OG Keq KcR KmS1 Glu OG KiP2 MATRIX Asp Glu_cyt alpha KiS1 KiS2 KcF Glu Asp_cyt beta KiP1 KiP2 KcR v22_AGC 1 Asp KiS1 Glu_cyt KiS2 Glu KiP1 Asp_cyt KiP2 Asp Glu_cyt alpha KiS1 KiS2 Glu Asp_cyt beta KiP1 KiP2 Glu_cyt Asp_cyt gamma KiS2 KiP2 Asp Glu delta KiS1 KiP1 MATRIX KcF KcR v24_Complex_I NADH Q NAD_p QH2 Keq KcR KmS2 NADH KcR KmS1 Q KcF KmP2 NAD_p Keq KcF KmP1 QH2 Keq KcR NADH Q KcF KmP2 NADH NAD_p Keq KiS1 KcF NAD_p QH2 Keq KcR KmS1 Q QH2 KiP2 MT_IMS KcF v25_Complex_III QH2 Cytc3p KmA Kq2 Kb2 KmA Kq2 Cytc3p KcF k8 Kq1 QH2 Kb1 KcF k8 Kq1 QH2 Cytc3p Cytc2p KmA Cytc3p KmB QH2 QH2 Cytc3p MT_IMS KcF v26_Complex_IV Cytc2p Ks Cytc2p CYTOPLASM Kid Kc V Acetyl_CoA_cyt OXA_cyt v10_CS Acetyl_CoA_cyt OXA_cyt Ka OXA_cyt Kb Acetyl_CoA_cyt Kia Kib Keq Kia Kb MATRIX v28_Complex_V V ADP Km ADP ADP ADP Ki CYTOPLASM KcF Kp Cit_cyt KcR Ks IsoCitcyt v29_ACO Ks IsoCitcyt Kp Cit_cyt Ks Kp CYTOPLASM k3f FBP k3b GAP 2 MATRIX OG Mal_cyt alpha KiS1 KiS2 KcF Mal OG_cyt beta KiP1 KiP2 KcR v30_OGC 1 OG KiS1 Mal_cyt KiS2 Mal KiP1 OG_cyt KiP2 OG Mal_cyt alpha KiS1 KiS2 Mal OG_cyt beta KiP1 KiP2 Mal_cyt OG_cyt gamma KiS2 KiP2 OG Mal delta KiS1 KiP1 CYTOPLASM v31_MDH k1 k2 k3 k4 NADH_cyt OXA_cyt kminus1 kminus2 kminus3 kminus4 Mal_cyt NAD kminus1 kminus2 k3 k4 k1 kminus2 k3 k4 NADH_cyt kminus1 kminus2 k3 kminus4 NAD k2 k3 k4 OXA_cyt kminus1 kminus2 kminus3 Mal_cyt k1 k2 k3 k4 NADH_cyt OXA_cyt kminus1 kminus2 kminus3 kminus4 Mal_cyt NAD k1 kminus2 kminus3 NADH_cyt Mal_cyt k1 k2 kminus3 NADH_cyt OXA_cyt Mal_cyt k2 k3 kminus4 OXA_cyt NAD k2 kminus3 kminus4 OXA_cyt Mal_cyt NAD CYTOPLASM KcF KcR v32_AspTA Asp_cyt OG_cyt OXA_cyt Glu_cyt Keq KcR KmS2 Asp_cyt KcR KmS1 OG_cyt KcF KmP2 OXA_cyt Keq KcF KmP1 Glu_cyt Keq KcR Asp_cyt OG_cyt KcF KmP2 Asp_cyt OXA_cyt Keq KiS1 KcF OXA_cyt Glu_cyt Keq KcR KmS1 OG_cyt Glu_cyt KiP2 MATRIX Cit_cyt Mal alpha KiS1 KiS2 KcF Mal_cyt Cit beta KiP1 KiP2 KcR v33_CIC 1 Cit_cyt KiS1 Mal KiS2 Mal_cyt KiP1 Cit KiP2 Cit_cyt Mal alpha KiS1 KiS2 Mal_cyt Cit beta KiP1 KiP2 Mal Cit gamma KiS2 KiP2 Cit_cyt Mal_cyt delta KiS1 KiP1 MATRIX KcF KcR v34_ETF_QO ETFred Q ETFox QH2 Keq KcR KmS2 ETFred KcR KmS1 Q KcF KmP2 ETFox Keq KcF KmP1 QH2 Keq KcR ETFred Q KcF KmP2 ETFred ETFox Keq KiS1 KcF ETFox QH2 Keq KcR KmS1 Q QH2 KiP2 MATRIX KcF KcR v35_ACD FADH2 ETFox ETFred FAD Keq KcR KiS1 KmS2 KcR KmS2 FADH2 KcR KmS1 ETFox KcF KmP2 ETFred Keq KcF KmP1 FAD Keq KcR FADH2 ETFox KcF KmP2 FADH2 ETFred Keq KiS1 KcF ETFred FAD Keq KcR KmS1 ETFox FAD KiP2 KcR FADH2 ETFox ETFred KiP1 KcF ETFox ETFred FAD KiS2 Keq MATRIX KcF KcR v36_PC ATP CO2 Pyr ADP OXA Keq Kia KmB KcR Pyr KmC KcR ATP CO2 KmA KcR CO2 Pyr KmB KcR ATP Pyr KcR ATP CO2 Pyr Kip KmQ KcF OXA Keq KmQ KcF OXA Keq KmP KcF ADP OXA Keq KmR KcF ADP Keq KcF ADP OXA Keq Kia KmB KcR Pyr Kip Kia KmB KcR Pyr ADP Kia Kiq KmP KcF CO2 OXA Kib Keq Kia KmP KcF ATP OXA Kia Keq KmA KcR ATP CO2 OXA Kir KmR KcF Pyr ADP Kic Keq KmA KcR CO2 Pyr ADP Kiq KmA KcR CO2 Pyr Kip KmP KcF CO2 ADP OXA Kib Keq KmQ KcF CO2 OXA Kib Keq CYTOPLASM V v37_GUT2P G3P K G3P CYTOPLASM V v38_GUT2P NADH_cyt K NADH_cyt CYTOPLASM v39_MDH Kcat Mal_cyt NADP_cyt Kmal Mal_cyt Knadp NADP_cyt CYTOPLASM V4 NAD GAP K4GAP GAP K4NAD NAD MATRIX V v40_AAC ADP_cyt K ADP_cyt CYTOPLASM v41_IDHc IsoCitcyt NADP_cyt phi0 IsoCitcyt NADP_cyt phi1 NADP_cyt phi2 IsoCitcyt phi12 OG_cyt NADPH_cyt CO2 phir0 OG_cyt NADPH_cyt CO2 phir1 NADPH_cyt CO2 phir2 OG_cyt CO2 phir3 OG_cyt NADPH_cyt phir12 CO2 phir13 NADPH_cyt phir23 OG_cyt phir123 MATRIX IsoCitcyt Mal alpha KiS1 KiS2 KcF Mal_cyt IsoCit beta KiP1 KiP2 KcR v42_CIC 1 IsoCitcyt KiS1 Mal KiS2 Mal_cyt KiP1 IsoCit KiP2 IsoCitcyt Mal alpha KiS1 KiS2 Mal_cyt IsoCit beta KiP1 KiP2 Mal IsoCit gamma KiS2 KiP2 IsoCitcyt Mal_cyt delta KiS1 KiP1 MATRIX V v43_AAC ATP K ATP MATRIX v44_MDH Kcat Mal Km Mal CYTOPLASM k5f DPG ADP_cyt k5b PEP ATP_cyt CYTOPLASM V6 ADP_cyt PEP K6PEP PEP K6ADP ADP_cyt CYTOPLASM k8f NADH_cyt PYR_cyt k8b NAD LAC MATRIX V PYR_cyt v8_PYC K PYR_cyt MATRIX KcF v9_PDC Pyr CoA NAD_p KmC Pyr CoA KmB Pyr NAD_p KmA CoA NAD_p Pyr CoA NAD_p KmA KmP Kib Kic KmR Kip Kiq Acetyl_CoA NADH KmC Kir Pyr CoA NADH KmB Kiq Pyr NAD_p Acetyl_CoA KmA KmP Kib Kic KmR Kip Kia Kiq Pyr Acetyl_CoA NADH