Open conformation of Mad2

 u = 1 : kinetochore unattached
u = 0 : kinetochore attached Cytoplasm u k1f Mad1_CMad2 OMad2 k1r Mad1_CMad2_OMad2 Cytoplasm u k2f Mad1_CMad2_OMad2 Cdc20 Cytoplasm k3f Cdc20_CMad2 Cytoplasm u k4f Cdc20_CMad2 Bub3_BubR1 k4r MCC Cytoplasm u k5f Bub3_BubR1 Cdc20 k5r Bub3_BubR1_Cdc20 Cytoplasm kf6 OMad2 Cdc20 time 2000 const_val_0