k substrateA substrateB KmB substrateC KmC substrateD KmD substrateE KmE substrateF KmF substrateG KmG substrateH KmH k substrateA substrateB substrateC substrateD substrateE substrateF substrateG substrateH substrateB KmB substrateC KmC substrateD KmD substrateE KmE substrateF KmF substrateG KmG substrateH KmH k substratea substrateb k substratea substrateb 
free high-affinity binding sites (sites)
 
nascent cRNA (molecules)
 
viral polymerase complex (molecules)
 
complex of viral polymerase and cRNA (molecules)
 
NP proteins (molecules)
 
M1 proteins (molecules)
 
M1-vRNP complexes in the nucleus (virions)
 
M1-vRNP complexes in the cytoplasm (virions)
 
cRNPs (molecules)
 
nascent vRNA (molecules)
 
complex of viral polymerase and vRNA (molecules)
 
virions attached to high-affinity binding sites (virions)
 
mRNA of segment 1 (molecules)
 
mRNA of segment 2 (molecules)
 
mRNA of segment 3 (molecules)
 
mRNA of segment 4 (molecules)
 
mRNA of segment 5 (molecules)
 
mRNA of segment 6 (molecules)
 
unspliced mRNA of segment 7 (molecules)
 
unspliced mRNA of segment 8 (molecules)
 
PB1 proteins (molecules)
 
PB2 proteins (molecules)
 
virions in the extracellular medium (virions)
 
PA proteins (molecules)
 
NEP proteins (molecules)
 
HA proteins (molecules)
 
NA proteins (molecules)
 
M2 proteins (molecules)
 
total amount of released virions (virions)
 
total amount of cRNA in the cell considering all segments (molecules)
 
total amount of cRNA in the cell considering an arbitrary segment (molecules)
 
total amount of vRNA in the cell considering all segments (molecules)
 
total amount of vRNA in the cell considering an arbitrary segments (molecules)
 
free low-affinity binding sites (sites)
 
virions attached to low-affinity binding sites (virions)
 
virions in endosomes (virions)
 
total amount of virions fused with endosomes (virions)
 
parental vRNPs in the cytoplasm (virions)
 
vRNPs in the nucleus (virions)
 
attachment rate of virus particles to high-affinity binding sites (1/(site*h))
 
synthesis rate of vRNAs (1/h)
 
synthesis rate of cRNAs (1/h)
 
binding rate of polymerase complexes to cRNA and vRNA (1/(h*molecule))
 
binding rate of NP to RdRp-cRNA and RdRp-vRNA complexes (1/(h*molecule))
 
binding rate of M1 to nuclear vRNPs (1/(h*molecule))
 
combined rate of NEP binding to M1-vRNP complexes and subsequent transport out of the nucleus (1/(molecule*h))
 
fraction of protein synthesis rate and distance between two adjacent ribosomes (1/h)
 
formation rate of functional polymerase complexes from the three subunits (1/(h*molecule^2))
 
release rate of progeny virions from the cell (virions/(molecule*h))
 
degradation rate of nascent cRNA and vRNA (1/h)
 
attachment rate of virus particles to low-affinity binding sites (1/(site*h))
 
degradation rate of RNPs (1/h)
 
degradation rate of mRNA (1/h)
 
degradation rate of RdRp-cRNA and RdRp-vRNA complexes (1/h)
 
fraction of fusion-competent virions (-)
 
distance between two adjacent ribosomes on an mRNA (nucleotides)
 
fraction of spliced M2 mRNAs compared to total mRNAs of segment 7 (-)
 
fraction of spliced NEP mRNAs compared to total mRNAs of segment 8 (-)
 
synthesis rate of M1 proteins (1/h)
 
synthesis rate of M2 proteins (1/h)
 
synthesis rate of NEP proteins (1/h)
 
dissociation rate of virions from high-affinity binding sites (1/h)
 
length of segment 1's mRNA encoding PB2 (nucleotides)
 
length of segment 2's mRNA encoding PB1 (nucleotides)
 
length of segment 3's mRNA encoding PA (nucleotides)
 
length of segment 4's mRNA encoding HA (nucleotides)
 
length of segment 5's mRNA encoding NP (nucleotides)
 
length of segment 6's mRNA encoding NA (nucleotides)
 
length of segment 7's unspliced mRNA encoding M1 (nucleotides)
 
length of segment 8's unspliced mRNA encoding NS1 (nucleotides)
 
synthesis rate of mRNAs (nucleotides/h)
 
synthesis rate of segment 1's mRNA (1/h)
 
dissociation rate of virions from low-affinity binding sites (1/h)
 
synthesis rate of segment 2's mRNA (1/h)
 
synthesis rate of segment 3's mRNA (1/h)
 
synthesis rate of segment 4's mRNA (1/h)
 
synthesis rate of segment 5's mRNA (1/h)
 
synthesis rate of segment 6's mRNA (1/h)
 
synthesis rate of segment 7's mRNA (1/h)
 
synthesis rate of segment 8's mRNA (1/h)
 
equilibrium constant for the attachment of virions to the high-affinity binding sites (1/site)
 
equilibrium constant for the attachment of virions to the low-affinity binding sites (1/site)
 
endocytosis rate of virions bound to high-affinity or low-affinity binding sites (1/h)
 
fusion rate of virions in late endosomes (1/h)
 
degradation rate of virions which do not fuse with the endosomal membrane (1/h)
 
nuclear import rate of cytoplasmic vRNPs which are not bound to M1 (1/h)
 
synthesis rate of proteins (nucleotides/h)
 1 parameter_23 parameter_23 parameter_6 parameter_2 parameter_48 parameter_1 parameter_47 parameter_9 parameter_24 species_36 8 species_38 8 species_10 species_12 species_17 8 species_2 species_5 species_6 species_8 species_9 species_18 species_19 species_15 species_16 parameter_38 parameter_36 8 parameter_9 parameter_24 parameter_26 parameter_9 parameter_24 parameter_25 parameter_38 parameter_33 8 parameter_38 parameter_30 8 parameter_38 parameter_32 8 parameter_38 parameter_31 8 parameter_38 parameter_37 8 parameter_9 parameter_24 1 parameter_25 parameter_38 parameter_35 8 parameter_38 parameter_34 8 compartment_1 parameter_1 species_3 species_1 parameter_3 species_2 compartment_1 function_1 parameter_13 species_12 species_13 compartment_1 function_1 parameter_14 species_9 species_14 compartment_1 parameter_15 species_15 species_31 compartment_1 parameter_10 species_17 compartment_1 parameter_12 species_18 species_11 compartment_1 function_1 parameter_13 species_19 species_13 compartment_1 parameter_39 species_9 compartment_1 parameter_40 species_9 compartment_1 parameter_41 species_9 compartment_1 parameter_42 species_9 compartment_1 parameter_2 species_3 species_4 parameter_4 species_5 compartment_1 parameter_43 species_9 compartment_1 parameter_44 species_9 compartment_1 parameter_45 species_9 compartment_1 parameter_46 species_9 compartment_1 parameter_16 species_21 compartment_1 parameter_16 species_20 compartment_1 parameter_16 species_22 compartment_1 parameter_17 species_28 species_29 species_30 compartment_1 parameter_16 species_24 compartment_1 parameter_27 species_26 compartment_1 parameter_5 species_2 compartment_1 parameter_29 species_27 compartment_1 parameter_16 species_23 compartment_1 parameter_16 species_25 compartment_1 parameter_28 species_26 compartment_1 function_2 parameter_18 species_16 species_11 KmB species_32 KmC species_13 KmD species_33 KmE species_14 KmF species_34 KmG species_31 KmH compartment_1 parameter_20 species_9 compartment_1 parameter_19 species_10 compartment_1 parameter_19 species_18 compartment_1 parameter_22 species_12 compartment_1 parameter_22 species_19 compartment_1 parameter_5 species_5 compartment_1 parameter_20 species_17 compartment_1 parameter_20 species_15 compartment_1 parameter_20 species_16 compartment_1 parameter_21 species_20 compartment_1 parameter_21 species_21 compartment_1 parameter_21 species_22 compartment_1 parameter_21 species_23 compartment_1 parameter_21 species_24 compartment_1 parameter_21 species_25 compartment_1 parameter_21 species_26 compartment_1 parameter_6 species_6 compartment_1 parameter_21 species_27 compartment_1 parameter_7 species_6 compartment_1 parameter_8 species_8 compartment_1 parameter_11 species_9 compartment_1 parameter_12 species_10 species_11