Akt PI3K_inhibitor active_PI3K c1 kdphos_pAkt kphos_PI3KAkt pAkt kphos_PI3KAkt active_PI3K PI3K_inhibitor c1 Akt kdphos_pAkt pAkt c1 c1 kf_dpMEK pMEKcyt kf_dpMEK pMEKcyt c1 TSC c1 kdphos_pTSC kphos_AktTSC kphos_RSKTSC pAkt pRSK pTSC kphos_AktTSC pAkt TSC kphos_RSKTSC pRSK TSC kdphos_pTSC pTSC c1 Ras_GTP Ras_Shoc2 Shoc2 c1 kb_Ras_Shoc2 kf_Ras_Shoc2 kf_Ras_Shoc2 Ras_GTP Shoc2 kb_Ras_Shoc2 Ras_Shoc2 c1 c2 kexport_pYERK kimport_pYERK pYERK_cyt pYERK_nuc kimport_pYERK pYERK_cyt c2 kexport_pYERK pYERK_nuc c1 kdphos_pY_np_cyt pYERK_cyt kdphos_pY_np_cyt pYERK_cyt c1 c1 kdphos_pTpY_pT_cyt pTpYERK_cyt kdphos_pTpY_pT_cyt pTpYERK_cyt c1 MEK_inhibitor c1 kphos_np_pY pMEK_ERK_cyt kphos_np_pY pMEK_ERK_cyt MEK_inhibitor c1 c1 Km_pERKcyt c1 kb_pSos kcat_pERKcyt kfb_ppppSos pTpYERK_cyt pppSos ppppSos kfb_ppppSos kcat_pERKcyt pppSos pTpYERK_cyt Km_pERKcyt pppSos kb_pSos ppppSos c1 Km_pERKcyt Sos1_2 c1 kb_pSos kcat_pERKcyt kf_pSos pSos pTpYERK_cyt kf_pSos kcat_pERKcyt Sos1_2 pTpYERK_cyt Km_pERKcyt Sos1_2 kb_pSos pSos c1 c2 kexport_pTpYERK kimport_pTpYERK pTpYERK_cyt pTpYERK_nuc kimport_pTpYERK pTpYERK_cyt c2 kexport_pTpYERK pTpYERK_nuc Rheb_GDP Rheb_GTP TSC c1 kact_Rheb kdact_TSCRheb kdact_TSCRheb TSC Rheb_GTP kact_Rheb Rheb_GDP c1 Ras_Shoc2 Ras_Shoc2_cRaf c1 cRaf kb_RasRaf_Shoc2 kf_RasRaf_Shoc2 kf_RasRaf_Shoc2 Ras_Shoc2 cRaf kb_RasRaf_Shoc2 Ras_Shoc2_cRaf c1 c2 kexport_pTERK kimport_pTERK pTERK_cyt pTERK_nuc kimport_pTERK pTERK_cyt c2 kexport_pTERK pTERK_nuc MEK_inhibitor c1 kphos_pT_pTpY pMEKcyt pTERK_cyt kphos_pT_pTpY pMEKcyt MEK_inhibitor c1 pTERK_cyt c1 MEK_inhibitor c1 kphos_pY_pTpY pMEKcyt pYERK_cyt kphos_pY_pTpY pYERK_cyt pMEKcyt MEK_inhibitor c1 c1 c1 kdphos_pT_np_cyt pTERK_cyt kdphos_pT_np_cyt pTERK_cyt c1 c1 kdphos_pTpY_pY_cyt pTpYERK_cyt kdphos_pTpY_pY_cyt pTpYERK_cyt c1 MEK_inhibitor c1 kphos_pY_pTpY_MEKERK pMEK_pYERK kphos_pY_pTpY_MEKERK pMEK_pYERK MEK_inhibitor c1 c1 Km_pERKcyt c1 kb_pSos kcat_pERKcyt kfb_pppSos pTpYERK_cyt ppSos pppSos kfb_pppSos kcat_pERKcyt ppSos pTpYERK_cyt Km_pERKcyt ppSos kb_pSos pppSos c1 Km_pERKcyt c1 kb_pSos kcat_pERKcyt kfb_ppSos pSos pTpYERK_cyt ppSos kfb_ppSos kcat_pERKcyt pSos pTpYERK_cyt Km_pERKcyt pSos kb_pSos ppSos c1 ERKcyt MEK_ERK_cyt MEKcyt c1 kb_MEKERK kf_MEKERK kf_MEKERK MEKcyt ERKcyt kb_MEKERK MEK_ERK_cyt c1 Rheb_GTP c1 cRaf inactive_cRaf kact_RhebRaf kdact_RhebRaf kdact_RhebRaf Rheb_GTP cRaf kact_RhebRaf inactive_cRaf c1 EGF EGFR kf_EGFEGFR kphos_EGFR_mutant kf_EGFEGFR EGF EGFR kphos_EGFR_mutant EGFR RasGAP Ras_GTP c1 kf_RasGAP mutated_Ras kf_RasGAP Ras_GTP mutated_Ras RasGAP c1 ERKcyt ERKnuc c2 kexport_ERK kimport_ERK kimport_ERK ERKcyt c2 kexport_ERK ERKnuc ERKcyt c1 kb_MEKERK kf_MEKERK pMEK_ERK_cyt pMEKcyt kf_MEKERK ERKcyt pMEKcyt kb_MEKERK pMEK_ERK_cyt c1 Ras_GTP Ras_Raf c1 cRaf kb_RasRaf kf_RasRaf kf_RasRaf cRaf Ras_GTP kb_RasRaf Ras_Raf c1 PI3K_inhibitor active_PI3K c1 inactive_cRaf kact_PI3KRaf kact_PI3KRaf active_PI3K PI3K_inhibitor c1 inactive_cRaf c1 RSK c1 kdphos_pRSK kphos_ERKRSK pRSK pTpYERK_cyt kphos_ERKRSK pTpYERK_cyt RSK kdphos_pRSK pRSK c1 EGF_EGFR c1 kf_degra_ERKEGFR pTpYERK_cyt kf_degra_ERKEGFR pTpYERK_cyt EGF_EGFR c1 BRaf BRaf_inhibitor MEKcyt Ras_Raf Ras_Shoc2_cRaf c1 kf_pMEK kphos_BRafMEK kf_pMEK Ras_Raf Ras_Shoc2_cRaf MEKcyt kphos_BRafMEK BRaf BRaf_inhibitor c1 c1 EGFR_Sos RasGEF Ras_GDP c1 kf_RasGEF kf_Sos_Ras kf_Sos_Ras EGFR_Sos Ras_GDP kf_RasGEF RasGEF Ras_GDP c1 EGFR_Sos EGFR_inhibitor EGF_EGFR Sos1_2 c1 kb_Sos kf_Sos kf_Sos EGF_EGFR EGFR_inhibitor c1 Sos1_2 kb_Sos EGFR_Sos c1 EGF_EGFR c1 degra_EGF_pEGFR kb_degra kf_degra kf_degra EGF_EGFR kb_degra degra_EGF_pEGFR c1 RasEffector RassEffector Ras_GTP c1 kb_RasEffector kf_RasEffector kf_RasEffector Ras_GTP RasEffector kb_RasEffector RassEffector c1 EGFR_inhibitor EGF_EGFR PI3K Ras_GTP active_PI3K c1 kact_EGFRRasPI3K kdact_PI3K mutated_PI3K kact_EGFRRasPI3K EGF_EGFR Ras_GTP EGFR_inhibitor c1 PI3K kdact_PI3K active_PI3K mutated_PI3K c1 Rheb_GTP S6K c1 kdphos_pS6K kphos_RhebS6K pS6K kphos_RhebS6K Rheb_GTP S6K kdphos_pS6K pS6K c1 function_1 EGF EGFR kf_EGFEGFR kphos_EGFR_mutant c1 function_8 ERKcyt c1 kb_MEKERK kf_MEKERK pMEK_ERK_cyt pMEKcyt function_9 c2 kexport_pTpYERK kimport_pTpYERK pTpYERK_cyt pTpYERK_nuc function_10 ERKcyt ERKnuc c2 kexport_ERK kimport_ERK c1 function_2 EGF_EGFR c1 degra_EGF_pEGFR kb_degra kf_degra c1 function_11 c1 kf_dpMEK pMEKcyt c1 function_12 RasEffector RassEffector Ras_GTP c1 kb_RasEffector kf_RasEffector c1 function_13 Km_pERKcyt Sos1_2 c1 kb_pSos kcat_pERKcyt kf_pSos pSos pTpYERK_cyt c1 function_3 EGFR_Sos EGFR_inhibitor EGF_EGFR Sos1_2 c1 kb_Sos kf_Sos c1 function_14 Km_pERKcyt c1 kb_pSos kcat_pERKcyt kfb_ppSos pSos pTpYERK_cyt ppSos c1 function_15 Km_pERKcyt c1 kb_pSos kcat_pERKcyt kfb_pppSos pTpYERK_cyt ppSos pppSos c1 function_16 Km_pERKcyt c1 kb_pSos kcat_pERKcyt kfb_ppppSos pTpYERK_cyt pppSos ppppSos c1 function_4 EGFR_Sos RasGEF Ras_GDP c1 kf_RasGEF kf_Sos_Ras c1 function_17 MEK_inhibitor c1 kphos_np_pY pMEK_ERK_cyt c1 function_18 MEK_inhibitor c1 kphos_pY_pTpY_MEKERK pMEK_pYERK c1 function_19 c1 kdphos_pTpY_pT_cyt pTpYERK_cyt c1 function_20 c1 kdphos_pTpY_pY_cyt pTpYERK_cyt c1 function_21 c1 kdphos_pY_np_cyt pYERK_cyt c1 function_22 c1 kdphos_pT_np_cyt pTERK_cyt c1 function_23 MEK_inhibitor c1 kphos_pY_pTpY pMEKcyt pYERK_cyt c1 function_24 MEK_inhibitor c1 kphos_pT_pTpY pMEKcyt pTERK_cyt c1 function_5 RasGAP Ras_GTP c1 kf_RasGAP mutated_Ras function_25 c2 kexport_pYERK kimport_pYERK pYERK_cyt pYERK_nuc function_26 c2 kexport_pTERK kimport_pTERK pTERK_cyt pTERK_nuc c2 kdphos_pTpY_pY_nuc pTpYERK_nuc c2 kdphos_pTpY_pT_nuc pTpYERK_nuc c2 kdphos_pY_np_nuc pYERK_nuc c2 kdphos_pT_np_nuc pTERK_nuc c1 function_27 BRaf BRaf_inhibitor MEKcyt Ras_Raf Ras_Shoc2_cRaf c1 kf_pMEK kphos_BRafMEK c1 function_28 Ras_GTP Ras_Shoc2 Shoc2 c1 kb_Ras_Shoc2 kf_Ras_Shoc2 c1 function_29 Ras_Shoc2 Ras_Shoc2_cRaf c1 cRaf kb_RasRaf_Shoc2 kf_RasRaf_Shoc2 c1 function_6 Ras_GTP Ras_Raf c1 cRaf kb_RasRaf kf_RasRaf c1 function_30 EGFR_inhibitor EGF_EGFR PI3K Ras_GTP active_PI3K c1 kact_EGFRRasPI3K kdact_PI3K mutated_PI3K c1 function_31 Akt PI3K_inhibitor active_PI3K c1 kdphos_pAkt kphos_PI3KAkt pAkt c1 function_32 TSC c1 kdphos_pTSC kphos_AktTSC kphos_RSKTSC pAkt pRSK pTSC c1 function_33 Rheb_GDP Rheb_GTP TSC c1 kact_Rheb kdact_TSCRheb c1 function_34 Rheb_GTP S6K c1 kdphos_pS6K kphos_RhebS6K pS6K c1 function_35 RSK c1 kdphos_pRSK kphos_ERKRSK pRSK pTpYERK_cyt c1 function_36 Rheb_GTP c1 cRaf inactive_cRaf kact_RhebRaf kdact_RhebRaf c1 function_37 EGF_EGFR c1 kf_degra_ERKEGFR pTpYERK_cyt c1 function_38 PI3K_inhibitor active_PI3K c1 inactive_cRaf kact_PI3KRaf c1 function_7 ERKcyt MEK_ERK_cyt MEKcyt c1 kb_MEKERK kf_MEKERK time 6000 0 0.0016