$v\mapsto v$ $\mathrm{Akt}\mathrm{Akt\_S473\_phos\_by\_insulin}\mathrm{Insulin}\mapsto \mathrm{Akt\_S473\_phos\_by\_insulin}\mathrm{Akt}\mathrm{Insulin}$ $\mathrm{Akt\_pS473}\mathrm{Akt\_pS473\_dephos\_by\_mTORC1\_pS2448}\mathrm{mTORC1\_pS2448}\mapsto \mathrm{Akt\_pS473\_dephos\_by\_mTORC1\_pS2448}\mathrm{Akt\_pS473}\mathrm{mTORC1\_pS2448}$ $\mathrm{AMPK\_pT172}\mathrm{AMPK\_pT172\_dephos\_by\_Mito\_membr\_pot\_new}\mathrm{Mito\_membr\_pot\_new}\mapsto \mathrm{AMPK\_pT172\_dephos\_by\_Mito\_membr\_pot\_new}\mathrm{AMPK\_pT172}\mathrm{Mito\_membr\_pot\_new}$ $\mathrm{Amino\_Acids}\mathrm{mTORC1}\mathrm{mTORC1\_S2448\_phos\_by\_AA}\mapsto \mathrm{mTORC1\_S2448\_phos\_by\_AA}\mathrm{mTORC1}\mathrm{Amino\_Acids}$ $\mathrm{AMPK\_pT172}\mathrm{mTORC1\_pS2448}\mathrm{mTORC1\_pS2448\_dephos\_by\_AMPK\_pT172}\mapsto \mathrm{mTORC1\_pS2448\_dephos\_by\_AMPK\_pT172}\mathrm{mTORC1\_pS2448}\mathrm{AMPK\_pT172}$ $\mathrm{Mitophagy}\mathrm{mTORC1\_pS2448}\mathrm{mitophagy\_inactiv\_by\_mTORC1\_pS2448}\mapsto \mathrm{mitophagy\_inactiv\_by\_mTORC1\_pS2448}\mathrm{Mitophagy}\mathrm{mTORC1\_pS2448}$ $\mathrm{Akt\_pS473}\mathrm{FoxO3a}\mathrm{FoxO3a\_phos\_by\_Akt\_pS473}\mapsto \mathrm{FoxO3a\_phos\_by\_Akt\_pS473}\mathrm{FoxO3a}\mathrm{Akt\_pS473}$ $\mathrm{CDKN1A\_transcr\_by\_FoxO3a\_n\_DNA\_damage}\mathrm{DNA\_damage}\mathrm{FoxO3a}\mapsto \mathrm{CDKN1A\_transcr\_by\_FoxO3a\_n\_DNA\_damage}\mathrm{DNA\_damage}\mathrm{FoxO3a}$ $\mathrm{CDKN1B\_transcr\_by\_FoxO3a\_n\_DNA\_damage}\mathrm{DNA\_damage}\mathrm{FoxO3a}\mapsto \mathrm{CDKN1B\_transcr\_by\_FoxO3a\_n\_DNA\_damage}\mathrm{DNA\_damage}\mathrm{FoxO3a}$ $\mathrm{DNA\_damaged\_by\_irradiation}\mathrm{Irradiation}\mapsto \mathrm{DNA\_damaged\_by\_irradiation}\mathrm{Irradiation}$ $\mathrm{DNA\_damaged\_by\_ROS}\mathrm{ROS}\mapsto \mathrm{DNA\_damaged\_by\_ROS}\mathrm{ROS}$ $\mathrm{Mito\_membr\_pot\_new}\mathrm{ROS\_prod\_by\_Mito\_membr\_pot\_new}\mapsto \mathrm{ROS\_prod\_by\_Mito\_membr\_pot\_new}\mathrm{Mito\_membr\_pot\_new}$ $\mathrm{JNK}\mathrm{JNK\_activ\_by\_ROS}\mathrm{ROS}\mapsto \mathrm{JNK\_activ\_by\_ROS}\mathrm{JNK}\mathrm{ROS}$ $\mathrm{Mitophagy}\mathrm{sen\_ass\_beta\_gal\_inc\_by\_Mitophagy}\mapsto \mathrm{sen\_ass\_beta\_gal\_inc\_by\_Mitophagy}\mathrm{Mitophagy}$ $\mathrm{Mito\_mass\_turnover}\mathrm{mTORC1\_pS2448}\mathrm{mito\_biogenesis\_by\_mTORC1\_pS2448}\mapsto \mathrm{mito\_biogenesis\_by\_mTORC1\_pS2448}\mathrm{Mito\_mass\_turnover}\mathrm{mTORC1\_pS2448}$ $\mathrm{Mito\_mass\_new}\mathrm{Mitophagy}\mathrm{mitophagy\_new}\mapsto \mathrm{mitophagy\_new}\mathrm{Mito\_mass\_new}\mathrm{Mitophagy}$ $\mathrm{Mito\_mass\_old}\mathrm{Mitophagy}\mathrm{mitophagy\_old}\mapsto \mathrm{mitophagy\_old}\mathrm{Mito\_mass\_old}\mathrm{Mitophagy}$ $\mathrm{Amino\_Acids}\mathrm{IKKbeta}\mathrm{mTORC1}\mathrm{mTORC1\_S2448\_phos\_by\_AA\_n\_IKKbeta}\mapsto \mathrm{mTORC1\_S2448\_phos\_by\_AA\_n\_IKKbeta}\mathrm{mTORC1}\mathrm{Amino\_Acids}\mathrm{IKKbeta}$ $\mathrm{IKKbeta\_activ\_by\_ROS}\mathrm{ROS}\mapsto \mathrm{IKKbeta\_activ\_by\_ROS}\mathrm{ROS}$ $\mathrm{Mito\_mass\_old}\mathrm{mito\_membr\_pot\_old\_inc}\mapsto \mathrm{mito\_membr\_pot\_old\_inc}\mathrm{Mito\_mass\_old}$ $\mathrm{Mito\_mass\_new}\mathrm{mito\_membr\_pot\_new\_inc}\mapsto \mathrm{mito\_membr\_pot\_new\_inc}\mathrm{Mito\_mass\_new}$ $\mathrm{CDKN1A}\mathrm{Mito\_mass\_new}\mathrm{mito\_dysfunction}\mapsto \mathrm{mito\_dysfunction}\mathrm{Mito\_mass\_new}\mathrm{CDKN1A}$ $\mathrm{Mito\_mass\_turnover}\mathrm{mTORC1\_pS2448}\mathrm{mito\_biogenesis\_by\_AMPK\_pT172}\mapsto \mathrm{mito\_biogenesis\_by\_AMPK\_pT172}\mathrm{Mito\_mass\_turnover}\mathrm{mTORC1\_pS2448}$ $\mathrm{ROS}\mathrm{sen\_ass\_beta\_gal\_inc\_by\_ROS}\mapsto \mathrm{sen\_ass\_beta\_gal\_inc\_by\_ROS}\mathrm{ROS}$ $\mathrm{Mito\_membr\_pot\_old}\mathrm{ROS\_prod\_by\_Mito\_membr\_pot\_old}\mapsto \mathrm{ROS\_prod\_by\_Mito\_membr\_pot\_old}\mathrm{Mito\_membr\_pot\_old}$ $\mathrm{Akt\_pS473}\mathrm{CDKN1B}\mathrm{CDKN1B\_inactiv\_by\_Akt\_pS473}\mapsto \mathrm{CDKN1B\_inactiv\_by\_Akt\_pS473}\mathrm{CDKN1B}\mathrm{Akt\_pS473}$ $\mathrm{Akt\_pS473}\mathrm{CDKN1A}\mathrm{CDKN1A\_inactiv\_by\_Akt\_pS473}\mapsto \mathrm{CDKN1A\_inactiv\_by\_Akt\_pS473}\mathrm{CDKN1A}\mathrm{Akt\_pS473}$ $\mathrm{FoxO3a\_pS253}\mathrm{FoxO3a\_phos\_by\_JNK\_pT183}\mathrm{JNK\_pT183}\mapsto \mathrm{FoxO3a\_phos\_by\_JNK\_pT183}\mathrm{FoxO3a\_pS253}\mathrm{JNK\_pT183}$ $\mathrm{AMPK\_pT172}\mathrm{FoxO3a}\mathrm{mitophagy\_activ\_by\_FoxO3a\_n\_AMPK\_pT172}\mapsto \mathrm{mitophagy\_activ\_by\_FoxO3a\_n\_AMPK\_pT172}\mathrm{FoxO3a}\mathrm{AMPK\_pT172}$ $\mathrm{Akt\_pS473}\mathrm{Amino\_Acids}\mathrm{mTORC1}\mathrm{mTORC1\_S2448\_phos\_by\_AA\_n\_Akt\_pS473}\mapsto \mathrm{mTORC1\_S2448\_phos\_by\_AA\_n\_Akt\_pS473}\mathrm{mTORC1}\mathrm{Amino\_Acids}\mathrm{Akt\_pS473}$ $\mathrm{AMPK\_pT172}\mathrm{AMPK\_pT172\_dephos\_by\_Mito\_membr\_pot\_old}\mathrm{Mito\_membr\_pot\_old}\mapsto \mathrm{AMPK\_pT172\_dephos\_by\_Mito\_membr\_pot\_old}\mathrm{AMPK\_pT172}\mathrm{Mito\_membr\_pot\_old}$ $\mathrm{scale\_Akt\_pS473\_obs}\mathrm{Akt\_pS473}$ $\begin{cases}0 & \text{if $\mathrm{time}< -1$}\\ \begin{cases}0 & \text{if $\mathrm{time}< 0$}\\ \begin{cases}1 & \text{if $\mathrm{time}< 0.003472$}\\ 0 & \text{otherwise}\end{cases} & \text{otherwise}\end{cases} & \text{otherwise}\end{cases}$ $\begin{cases}1 & \text{if $\mathrm{time}< -1$}\\ \begin{cases}1 & \text{if $\mathrm{time}< 0$}\\ 1 & \text{otherwise}\end{cases} & \text{otherwise}\end{cases}$ $\begin{cases}1 & \text{if $\mathrm{time}< -1$}\\ \begin{cases}1 & \text{if $\mathrm{time}< 0$}\\ 1 & \text{otherwise}\end{cases} & \text{otherwise}\end{cases}$ $\mathrm{scale\_DNA\_damage\_gammaH2AX\_obs}\mathrm{DNA\_damage}$ $\mathrm{scale\_mTOR\_pS2448\_obs}\mathrm{mTORC1\_pS2448}$ $\mathrm{scale\_FoxO3a\_pS253\_obs}\mathrm{FoxO3a\_pS253}$ $\mathrm{scale\_AMPK\_pT172\_obs}\mathrm{AMPK\_pT172}$ $\mathrm{scale\_Mito\_Mass\_obs}(\mathrm{Mito\_mass\_new}+\mathrm{Mito\_mass\_old})$ $\mathrm{scale\_CDKN1A\_obs}\mathrm{CDKN1A}$ $\mathrm{scale\_CDKN1B\_obs}\mathrm{CDKN1B}$ $\mathrm{scale\_Mito\_Membr\_Pot\_obs}(\mathrm{Mito\_membr\_pot\_new}+\mathrm{Mito\_membr\_pot\_old})$ $\mathrm{scale\_Mitophagy\_obs}\mathrm{Mitophagy}$ $\mathrm{scale\_FoxO3a\_total\_obs}(\mathrm{FoxO3a}+\mathrm{FoxO3a\_pS253})$ $\mathrm{scale\_ROS\_obs}\mathrm{ROS}$ $\mathrm{scale\_JNK\_pT183\_obs}\mathrm{JNK\_pT183}$ $\mathrm{scale\_SA\_beta\_gal\_obs}\mathrm{SA\_beta\_gal}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_1\_1}(\mathrm{Akt}, \mathrm{Akt\_S473\_phos\_by\_insulin}, \mathrm{Insulin})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_10\_1}(\mathrm{Mitophagy}, \mathrm{mTORC1\_pS2448}, \mathrm{mitophagy\_inactiv\_by\_mTORC1\_pS2448})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_11\_1}(\mathrm{Akt\_pS473}, \mathrm{FoxO3a}, \mathrm{FoxO3a\_phos\_by\_Akt\_pS473})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_12\_1}(\mathrm{FoxO3a\_pS253}, \mathrm{FoxO3a\_phos\_by\_JNK\_pT183}, \mathrm{JNK\_pT183})$ $\mathrm{Cell}\mathrm{FoxO3a\_pS253\_degrad}\mathrm{FoxO3a\_pS253}$ $\mathrm{Cell}\mathrm{function\_2}(\mathrm{FoxO3a\_synthesis})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_15\_1}(\mathrm{CDKN1A\_transcr\_by\_FoxO3a\_n\_DNA\_damage}, \mathrm{DNA\_damage}, \mathrm{FoxO3a})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_16\_1}(\mathrm{Akt\_pS473}, \mathrm{CDKN1A}, \mathrm{CDKN1A\_inactiv\_by\_Akt\_pS473})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_17\_1}(\mathrm{CDKN1B\_transcr\_by\_FoxO3a\_n\_DNA\_damage}, \mathrm{DNA\_damage}, \mathrm{FoxO3a})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_18\_1}(\mathrm{Akt\_pS473}, \mathrm{CDKN1B}, \mathrm{CDKN1B\_inactiv\_by\_Akt\_pS473})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_19\_1}(\mathrm{DNA\_damaged\_by\_irradiation}, \mathrm{Irradiation})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_2\_1}(\mathrm{Akt\_pS473}, \mathrm{Akt\_pS473\_dephos\_by\_mTORC1\_pS2448}, \mathrm{mTORC1\_pS2448})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_20\_1}(\mathrm{DNA\_damaged\_by\_ROS}, \mathrm{ROS})$ $\mathrm{Cell}\mathrm{DNA\_repair}\mathrm{DNA\_damage}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_22\_1}(\mathrm{Mito\_membr\_pot\_new}, \mathrm{ROS\_prod\_by\_Mito\_membr\_pot\_new})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_23\_1}(\mathrm{Mito\_membr\_pot\_old}, \mathrm{ROS\_prod\_by\_Mito\_membr\_pot\_old})$ $\mathrm{Cell}\mathrm{ROS\_turnover}\mathrm{ROS}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_25\_1}(\mathrm{JNK}, \mathrm{JNK\_activ\_by\_ROS}, \mathrm{ROS})$ $\mathrm{Cell}\mathrm{JNK\_pT183\_inactiv}\mathrm{JNK\_pT183}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_27\_1}(\mathrm{ROS}, \mathrm{sen\_ass\_beta\_gal\_inc\_by\_ROS})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_28\_1}(\mathrm{Mitophagy}, \mathrm{sen\_ass\_beta\_gal\_inc\_by\_Mitophagy})$ $\mathrm{Cell}\mathrm{sen\_ass\_beta\_gal\_dec}\mathrm{SA\_beta\_gal}$ $\mathrm{Cell}\mathrm{AMPK\_T172\_phos}\mathrm{AMPK}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_30\_1}(\mathrm{Mito\_mass\_turnover}, \mathrm{mTORC1\_pS2448}, \mathrm{mito\_biogenesis\_by\_mTORC1\_pS2448})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_31\_1}(\mathrm{Mito\_mass\_turnover}, \mathrm{mTORC1\_pS2448}, \mathrm{mito\_biogenesis\_by\_AMPK\_pT172})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_32\_1}(\mathrm{Mito\_mass\_new}, \mathrm{Mitophagy}, \mathrm{mitophagy\_new})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_33\_1}(\mathrm{Mito\_mass\_old}, \mathrm{Mitophagy}, \mathrm{mitophagy\_old})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_34\_1}(\mathrm{CDKN1A}, \mathrm{Mito\_mass\_new}, \mathrm{mito\_dysfunction})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_35\_1}(\mathrm{Mito\_mass\_new}, \mathrm{mito\_membr\_pot\_new\_inc})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_36\_1}(\mathrm{Mito\_mass\_old}, \mathrm{mito\_membr\_pot\_old\_inc})$ $\mathrm{Cell}\mathrm{mito\_membr\_pot\_new\_dec}\mathrm{Mito\_membr\_pot\_new}$ $\mathrm{Cell}\mathrm{mito\_membr\_pot\_old\_dec}\mathrm{Mito\_membr\_pot\_old}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_39\_1}(\mathrm{IKKbeta\_activ\_by\_ROS}, \mathrm{ROS})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_4\_1}(\mathrm{AMPK\_pT172}, \mathrm{AMPK\_pT172\_dephos\_by\_Mito\_membr\_pot\_new}, \mathrm{Mito\_membr\_pot\_new})$ $\mathrm{Cell}\mathrm{IKKbeta\_inactiv}\mathrm{IKKbeta}$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_41\_1}(\mathrm{Amino\_Acids}, \mathrm{IKKbeta}, \mathrm{mTORC1}, \mathrm{mTORC1\_S2448\_phos\_by\_AA\_n\_IKKbeta})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_5\_1}(\mathrm{AMPK\_pT172}, \mathrm{AMPK\_pT172\_dephos\_by\_Mito\_membr\_pot\_old}, \mathrm{Mito\_membr\_pot\_old})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_6\_1}(\mathrm{Amino\_Acids}, \mathrm{mTORC1}, \mathrm{mTORC1\_S2448\_phos\_by\_AA})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_7\_1}(\mathrm{Akt\_pS473}, \mathrm{Amino\_Acids}, \mathrm{mTORC1}, \mathrm{mTORC1\_S2448\_phos\_by\_AA\_n\_Akt\_pS473})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_8\_1}(\mathrm{AMPK\_pT172}, \mathrm{mTORC1\_pS2448}, \mathrm{mTORC1\_pS2448\_dephos\_by\_AMPK\_pT172})$ $\mathrm{Cell}\mathrm{function\_4\_reaction\_9\_1}(\mathrm{AMPK\_pT172}, \mathrm{FoxO3a}, \mathrm{mitophagy\_activ\_by\_FoxO3a\_n\_AMPK\_pT172})$