$\mathrm{Prot\_k1}(\frac{1-\mathrm{fu\_ASL}}{\mathrm{fu\_ASL}}\mathrm{ASL\_c}-\mathrm{ASL\_b})$ $\mathrm{Prot\_k1}(\frac{1-\mathrm{fu\_ASL}}{\mathrm{fu\_ASL}}\mathrm{ASLoOH\_c}-\mathrm{ASLoOH\_b})$ $\mathrm{Prot\_k1}(\frac{1-\mathrm{fu\_ASL}}{\mathrm{fu\_ASL}}\mathrm{ASLpOH\_c}-\mathrm{ASLpOH\_b})$ $\mathrm{Prot\_k1}(\frac{1-\mathrm{fu\_AS}}{\mathrm{fu\_AS}}\mathrm{AS\_c}-\mathrm{AS\_b})$ $\mathrm{Prot\_k1}(\frac{1-\mathrm{fu\_AS}}{\mathrm{fu\_AS}}\mathrm{ASoOH\_c}-\mathrm{ASoOH\_b})$ $\mathrm{Prot\_k1}(\frac{1-\mathrm{fu\_AS}}{\mathrm{fu\_AS}}\mathrm{ASpOH\_c}-\mathrm{ASpOH\_b})$ $(\mathrm{k\_CR\_ASL\_c}+\mathrm{k\_PON\_OH\_c})\mathrm{ASLoOH\_c}$ $(\mathrm{k\_CR\_ASL\_c}+\mathrm{k\_PON\_OH\_c})\mathrm{ASLpOH\_c}$ $\frac{\frac{\mathrm{CYP3A4\_ASLoOH\_Vmax}}{\mathrm{CYP3A4\_ASLoOH\_Km1}}\mathrm{ASL\_c}}{1+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASpOH\_Km1}}+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASoOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLpOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLoOH\_Km1}}}$ $\frac{\frac{\mathrm{CYP3A4\_ASLpOH\_Vmax}}{\mathrm{CYP3A4\_ASLpOH\_Km1}}\mathrm{ASL\_c}}{1+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASpOH\_Km1}}+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASoOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLpOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLoOH\_Km1}}}$ $\frac{\frac{\mathrm{CYP3A4\_ASoOH\_Vmax}}{\mathrm{CYP3A4\_ASoOH\_Km1}}\mathrm{AS\_c}}{1+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASpOH\_Km1}}+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASoOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLpOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLoOH\_Km1}}}$ $\frac{\frac{\mathrm{CYP3A4\_ASpOH\_Vmax}}{\mathrm{CYP3A4\_ASpOH\_Km1}}\mathrm{AS\_c}}{1+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASpOH\_Km1}}+\frac{\mathrm{AS\_c}}{\mathrm{CYP3A4\_ASoOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLpOH\_Km1}}+\frac{\mathrm{ASL\_c}}{\mathrm{CYP3A4\_ASLoOH\_Km1}}}$ $\mathrm{Export\_AS\_k}\mathrm{AS\_c}$ $\mathrm{Export\_ASL\_k}\mathrm{ASL\_c}$ $\mathrm{Export\_ASLoOH\_k}\mathrm{ASLoOH\_c}$ $\mathrm{Export\_ASLpOH\_k}\mathrm{ASLpOH\_c}$ $\mathrm{Export\_ASoOH\_k}\mathrm{ASoOH\_c}$ $\mathrm{Export\_ASpOH\_k}\mathrm{ASpOH\_c}$ $\mathrm{Import\_AS\_k}\mathrm{AS\_m}$ $\mathrm{Import\_ASL\_k}\mathrm{ASL\_m}$ $\mathrm{Import\_ASLoOH\_k}\mathrm{ASLoOH\_m}$ $\mathrm{Import\_ASLpOH\_k}\mathrm{ASLpOH\_m}$ $\mathrm{Import\_ASoOH\_k}\mathrm{ASoOH\_m}$ $\mathrm{Import\_ASpOH\_k}\mathrm{ASpOH\_m}$ $(\mathrm{k\_CR\_ASL\_c}+\mathrm{k\_PON\_ASL\_c})\mathrm{ASL\_c}$ $\mathrm{k\_CR\_ASL\_m}\mathrm{ASL\_m}$ $\mathrm{k\_CR\_ASL\_m}\mathrm{ASLoOH\_m}$ $\mathrm{k\_CR\_ASL\_m}\mathrm{ASLpOH\_m}$ $\frac{\mathrm{UGT1A3\_AS\_Vmax}\mathrm{AS\_c}}{\mathrm{UGT1A3\_AS\_Km1}+\mathrm{AS\_c}+\frac{\mathrm{AS\_c}\mathrm{AS\_c}}{\mathrm{UGT1A3\_AS\_KI1}}}$