Kd5 k5 Kd4 k4 Kd2 k2 Kd1 k1 Kd10 k10 Kd9 k9 Kd7 k7 k74 Kd74 Kd59 k59 Kd55 k55 Kd54 k54 Kd53 k53 k52 Kd52 Kd49 k49 Kd47 k47 Kd46 k46 k45 Kd45 Kd42 k42 Kd30 k30 Kd28 k28 Kd27 k27 Kd26 k26 Kd24 k24 Kd13 k13 Kd12 k12 k9 k_9 EGF RE 2 Rd Rp Ri Rp_GS Rp_Shc Rp_pShc Rp_pShc_GS Rp_PI3K Rp_RasGAP cell extra pAkt ppAkt k1 R EGF k_1 RE cell k_10 Rp_pShc_GS k10 Rp pShc_GS cell V31 IRSp_GS Km31 IRSp_GS cell k48 IRSp_SHP2 cell k56 mGABp_pSHP2 cell k56 mGABp_pSHP2_GS cell V51 GABp Km51 GABp cell V51 GABp_PI3K Km51 GABp_PI3K cell V51 GABp_GS Km51 GABp_GS cell V51 GABp_RasGAP Km51 GABp_RasGAP cell k56 GABp_SHP2 cell k56 GABp_pSHP2 cell k_11 pShc_GS k11 pShc GS cell k56 GABp_pSHP2_GS cell k111 mGABp_SHP2 mGABp_pSHP2 mGABp_pSHP2_GS mIRSp_SHP2 mGABp_RasGAP cell k111 mGABp_SHP2 mGABp_pSHP2 mGABp_pSHP2_GS Rp_RasGAP cell k111 mGABp_SHP2 mGABp_pSHP2 mGABp_pSHP2_GS IRp_RasGAP cell k111 mIRSp_SHP2 Rp_RasGAP cell k111 mIRSp_SHP2 IRp_RasGAP cell 2 kcat80 mGABp ppErk Km80 mGABp k_80 imGABp cell k118 imGABp cell k12 Rp PI3K k_12 Rp_PI3K cell k13 Rp RasGAP k_13 Rp_RasGAP cell k17 Rp cell k17 Rp_GS cell k17 Rp_Shc cell k2 RE RE k_2 Rd cell k17 Rp_pShc cell k17 Rp_pShc_GS cell k17 Rp_PI3K cell k17 Rp_RasGAP cell k24 IR I k_24 IRL cell k25 IRL cell k26 IRp PI3K k_26 IRp_PI3K cell k27 IRp RasGAP k_27 IRp_RasGAP cell k28 IRp IRS k_28 IRp_IRS cell k29 IRp_IRS cell k3 Rd cell k_30 IRp_IRSp k30 IRp IRSp cell V31 IRSp Km31 IRSp cell k17 IRp cell k17 IRp_PI3K cell k17 IRp_RasGAP cell k17 IRp_IRS cell k17 IRp_IRSp cell k4 Rp GS k_4 Rp_GS cell kcat40 iSrc Rp alpha40 IRp Km40 iSrc cell V41 aSrc Km41 aSrc cell k42 IRS PIP3 k_42 mIRS cell kcat43 mIRS IRp alpha43 Rp Km43 mIRS cell V31 mIRSp Km31 mIRSp cell k45 mIRSp GS k_45 mIRSp_GS cell k46 mIRSp PI3K k_46 mIRSp_PI3K cell k47 mIRSp SHP2 k_47 mIRSp_SHP2 cell k48 mIRSp_SHP2 cell k49 GAB PIP3 k_49 mGAB cell k5 Rp Shc k_5 Rp_Shc cell kcat50 mGAB Rp alpha50 aSrc Km50 mGAB cell V51 mGABp Km51 mGABp cell k52 mGABp GS k_52 mGABp_GS cell k53 mGABp PI3K k_53 mGABp_PI3K cell k54 mGABp RasGAP k_54 mGABp_RasGAP cell k55 mGABp SHP2 k_55 mGABp_SHP2 cell k56 mGABp_SHP2 cell kcat57 mGABp_SHP2 Rp aSrc Km57 mGABp_SHP2 cell V58 mGABp_pSHP2 Km58 mGABp_pSHP2 cell k59 mGABp_pSHP2 GS k_59 mGABp_pSHP2_GS cell k6 Rp_Shc cell k60 Rp_PI3K IRp_PI3K mIRSp_PI3K mGABp_PI3K tRas_PI3K cell k61 PIP3 cell kcat62 dRas Rp_GS Rp_pShc_GS mIRSp_GS mGABp_GS mGABp_pSHP2_GS Km62 dRas cell kcat63 tRas bRasGAP mGABp_RasGAP Rp_RasGAP IRp_RasGAP Km63 tRas cell k64 tRas PI3K k_64 tRas_PI3K cell kcat65 tRas Raf Km65 Raf cell kcat66 aSrc aRaf Km66 aRaf cell kcat67 aaRaf PKA Km67 aaRaf alpha67 aaRaf pAkt beta67 ppAkt cell kcat68 aaRaf Mek Km68 Mek cell V69 ppMek Km69 ppMek cell k_7 Rp_pShc k7 Rp pShc cell kcat70 Erk ppMek Km70 Erk pErk Km70 Km71 cell kcat71 pErk ppMek Km71 pErk Erk Km71 Km70 cell V72 ppErk Km72 ppErk pErk Km72 Km73 cell V73 pErk Km73 pErk ppErk Km73 Km72 cell k74 PDK1 PIP3 k_74 mPDK1 cell kcat75 mPDK1 Akt Km75 Akt cell V76 pAkt Km76 pAkt cell kcat77 mTOR alpha77 pAkt ppAkt Km77 mTOR k_77 amTOR cell kcat78 amTOR pAkt Km78 pAkt k_78 ppAkt cell kcat79 ppErk GS Km79 GS k_79 iGS cell V8 pShc Km8 pShc cell kcat80 mGAB ppErk Km80 mGAB k_80 imGAB cell kcat81 mIRS amTOR Km81 mIRS k_81 imIRS cell V_82 Rp Km82 Rp cell k83 Ri cell V_84 IRp Km84 IRp cell k85 IRi cell k_42 mIRSp k42 PIP3 IRSp cell k_42 mIRSp_PI3K k42 PIP3 IRSp_PI3K cell k9 Rp_pShc GS k_9 Rp_pShc_GS cell k_42 mIRSp_GS k42 PIP3 IRSp_GS cell k_42 mIRSp_SHP2 k42 PIP3 IRSp_SHP2 cell k_42 mGABp k42 PIP3 GABp cell k_42 mGABp_PI3K k42 PIP3 GABp_PI3K cell k_42 mGABp_GS k42 PIP3 GABp_GS cell k_42 mGABp_RasGAP k49 PIP3 GABp_RasGAP cell k_42 mGABp_SHP2 k42 PIP3 GABp_SHP2 cell k_42 mGABp_pSHP2 k42 PIP3 GABp_pSHP2 cell k_42 mGABp_pSHP2_GS k42 PIP3 GABp_pSHP2_GS cell V31 IRSp_PI3K Km31 IRSp_PI3K cell