precursor of anandamide

precursor of linoleoyl ethanolamide

precursor of oleoyl ethanolamide

precursor of palmitoyl ethanolamide

precursor of stearoyl ethanolamide

t 2.4 1

A_b Kd_CB1_A AG2_b Kd_AG2 1 0 A_b Kd_CB1_A AG2_b Kd_AG2

1 -3 S_p M_S

1 -3 L_p M_L

1 -3 P_p M_P

1 -3 PFM_p Vss_PFM

1.5 3 FAAH_r FAAHinh_r FAAH_r

1 0 A_b Km_FAAH_A O_b Km_FAAH_O P_b Km_FAAH_P L_b Km_FAAH_L S_b Km_FAAH_S

PF_p Kp_m_PF

PF_p Kp_r_PF

1 0 slag1_b slag2_b

PFM_gut 1 6 Dose F_PFM

PF_p Kp_b_PF

1 0 A_r Km_FAAH_A O_r Km_FAAH_O P_r Km_FAAH_P L_r Km_FAAH_L S_r Km_FAAH_S

1 0 slag1_r slag2_r

LIVER b_FAAH_Liver Gut b_FAAH_Gut Spleen b_FAAH_Spleen Kidney b_FAAH_Kidney Lungs b_FAAH_Lungs Testis b_FAAH_Testis Leucocytes b_FAAH_Leucocytes

1 -3 A_p M_A

1 -3 O_p M_O

1 0 A_m Km_FAAH_A O_m Km_FAAH_O P_m Km_FAAH_P L_m Km_FAAH_L S_m Km_FAAH_S

LIVER b_NAAA_Liver Gut b_NAAA_Gut Spleen b_NAAA_Spleen Kidney b_NAAA_Kidney Heart b_NAAA_Heart Lungs b_NAAA_Lungs Thymus b_NAAA_Thymus Testis b_NAAA_Thymus Testis

A_r Ki_A O_r Ki_O P_r Ki_P L_r Ki_L S_r Ki_S

NAPE_r Km_NA_PE NOPE_r Km_NO_PE NPPE_r Km_NP_PE NLPE_r Km_NL_PE NSPE_r Km_NS_PE

Pancreas b_NAT_Pancreas Kidney b_NAT_Kidney Heart b_NAT_Heart Lungs b_NAT_Lungs Muscles b_NAT_Muscles Testis b_NAT_Testis Leucocytes b_NAT_Leucocytes

A_b Ki_A O_b Ki_O P_b Ki_P L_b Ki_L S_b Ki_S

NAPE_b Km_NA_PE NOPE_b Km_NO_PE NPPE_b Km_NP_PE NLPE_b Km_NL_PE NSPE_b Km_NS_PE

1 0 M_PF PFM_p Vss_PFM

Emax_PFM Dose ED50 Dose

kabs_PFM MD

kout_PFM PFM_p kin_PFM PFM_r

klinear_PFM PFM_p Vm_PFM PFM_p Km_PFM PFM_p Vss_PFM Vss_PFM

BRAIN b_FAAH_Brain kcl_A A_b

c_NAAA_ROB kcl_A A_r

MEC ktr_m_p_A A_b A_m A_m A_b Km_p_m_A

BRAIN FAAH_b kcat_FAAH a_FAAH_A A_b Km_FAAH_A FAAH_D_b

MEC FAAH_m kcat_FAAH a_FAAH_A A_m Km_FAAH_A FAAH_D_m

ROB FAAH_r kcat_FAAH a_FAAH_A A_r Km_FAAH_A FAAH_D_r

MEC ktr_m_p_A A_m A_p Ktr_p_m_A A_m A_p Km_p_m_A

PLASMA ktr_r_p A_r A_p Ktr_p_r_A A_r A_p Km_p_m_A

BRAIN PLD_b k_NA_PE NAPE_b Km_NA_PE den_b

ROB PLD_r k_NA_PE NAPE_r Km_NA_PE den_r

BRAIN k_deg_FAAH FAAH_b

MEC k_deg_FAAH FAAH_m

ROB k_deg_FAAH FAAH_r

BRAIN k_inh FAAH_b PF_b

BRAIN k_deg_FAAH FAAHinh_b

MEC k_deg_FAAH FAAHinh_m

ROB k_deg_FAAH FAAHinh_r

MEC k_inh FAAH_m PF_m

ROB k_inh FAAH_r PF_r

BRAIN FAAH_t b_FAAH_Brain k_deg_FAAH

MEC FAAH_t b_FAAH_MEC k_deg_FAAH

FAAH_t c_FAAH_ROB k_deg_FAAH

BRAIN b_FAAH_Brain kcl_L L_b

c_NAAA_ROB kcl_L L_r

MEC ktr_m_p_L L_b L_m

BRAIN FAAH_b kcat_FAAH a_FAAH_L L_b Km_FAAH_L FAAH_D_b

MEC FAAH_m kcat_FAAH a_FAAH_L L_m Km_FAAH_L FAAH_D_m

ROB FAAH_r kcat_FAAH a_FAAH_L L_r Km_FAAH_L FAAH_D_r

MEC ktr_m_p_L L_m L_p Ktr_p_m_L

PLASMA ktr_r_p L_r L_p Ktr_p_r_L

BRAIN PLD_b k_NL_PE NLPE_b Km_NL_PE den_b

ROB PLD_r k_NL_PE NLPE_r Km_NL_PE den_r

BRAIN Vmax_NAT p_A a_NAT_A b_NAT_Brain

Vmax_NAT p_A a_NAT_A c_NAT_ROB

BRAIN Vmax_NAT p_L a_NAT_L b_NAT_Brain

Vmax_NAT p_L a_NAT_L c_NAT_ROB

BRAIN Vmax_NAT p_O a_NAT_O b_NAT_Brain

Vmax_NAT p_O a_NAT_O c_NAT_ROB

BRAIN Vmax_NAT p_P a_NAT_P b_NAT_Brain

Vmax_NAT p_P a_NAT_P c_NAT_ROB

BRAIN Vmax_NAT p_S a_NAT_S b_NAT_Brain

Vmax_NAT p_S a_NAT_S c_NAT_ROB

BRAIN b_FAAH_Brain kcl_O O_b

c_NAAA_ROB kcl_O O_r

MEC ktr_m_p_O O_b O_m

BRAIN FAAH_b kcat_FAAH a_FAAH_O O_b Km_FAAH_O FAAH_D_b

MEC FAAH_m kcat_FAAH a_FAAH_O O_m Km_FAAH_O FAAH_D_m

ROB FAAH_r kcat_FAAH a_FAAH_O O_r Km_FAAH_O FAAH_D_r

PLASMA ktr_r_p O_r O_p Ktr_p_r_O

BRAIN PLD_b k_NO_PE NOPE_b Km_NO_PE den_b

ROB PLD_r k_NO_PE NOPE_r Km_NO_PE den_r

BRAIN b_FAAH_Brain kcl_P P_b

c_NAAA_ROB kcl_P P_r

MEC ktr_m_p_P P_b P_m

BRAIN FAAH_b kcat_FAAH a_FAAH_P P_b Km_FAAH_P FAAH_D_b

MEC FAAH_m kcat_FAAH a_FAAH_P P_m Km_FAAH_P FAAH_D_m

ROB FAAH_r kcat_FAAH a_FAAH_P P_r Km_FAAH_P FAAH_D_r

MEC ktr_m_p_P P_m P_p Ktr_p_m_P

PLASMA ktr_r_p P_r P_p Ktr_p_r_P

BRAIN PLD_b k_NP_PE NPPE_b Km_NP_PE den_b

ROB PLD_r k_NP_PE NPPE_r Km_NP_PE den_r

BRAIN b_FAAH_Brain kcl_S S_b

c_NAAA_ROB kcl_S S_r

MEC ktr_m_p_S S_b S_m

BRAIN FAAH_b kcat_FAAH a_FAAH_S S_b Km_FAAH_S FAAH_D_b

MEC FAAH_m kcat_FAAH a_FAAH_S S_m Km_FAAH_S FAAH_D_m

ROB FAAH_r kcat_FAAH a_FAAH_S S_r Km_FAAH_S FAAH_D_r

MEC ktr_m_p_S S_m S_p Ktr_p_m_S

PLASMA ktr_r_p S_r S_p Ktr_p_r_S

BRAIN PLD_b k_NS_PE NSPE_b Km_NS_PE den_b

ROB PLD_r k_NS_PE NSPE_r Km_NS_PE den_r

MEC ktr_m_p_O O_m O_p Ktr_p_m_O